Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway

Journal of Bone and Mineral Metabolism

Volumn 26, Issue 5, 2008, Pages 478-484

  Ohta, Yoichi ^a   Nakagawa, Keisuke ^a   Imai, Yuuki ^a   Katagiri, Takenobu ^b   Koike, Tatsuya ^a   Takaoka, Kunio ^a  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Bone morphogenetic protein (BMP); CRE binding protein (CREB); Cyclic adenosine 3 ,5 monophosphate (cAMP); Cyclic AMP response element (CRE); Protein kinase A (PKA)

Indexed keywords

BINDING PROTEIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 4; BUCLADESINE; CRE RECOMBINASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; LUCIFERASE; PROTEIN BONE MORPHOGENETIC PROTEIN RESPONSIVE ELEMENT; SMAD PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; ENZYME ACTIVITY; GENE EXPRESSION; MOUSE; MYOBLAST; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BUCLADESINE; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; MICE; PROMOTER REGIONS (GENETICS); RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 50949116529     PISSN: 09148779     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00774-008-0850-8     Document Type: Article

References (24)

1. K. Miyazono 1999 Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteins Bone (NY) 25 91 93
2. H. Horiuchi N. Saito T. Kinoshita S. Wakabayashi T. Tsutsumimoto K. Takaoka 2001 Enhancement of bone morphogenetic protein-2-induced new bone formation in mice by the phosphodiesterase inhibitor pentoxifylline Bone (NY) 28 290 294
3. T. Tsutsumimoto S. Wakabayashi T. Kinoshita H. Horiuchi K. Takaoka 2002 A phosphodiesterase inhibitor, pentoxifylline, enhances the bone morphogenetic protein-4 (BMP-4)-dependent differentiation of osteoprogenitor cells Bone (NY) 31 396 401
4. H. Horiuchi N. Saito T. Kinoshita S. Wakabayashi T. Tsutsumimoto S. Otsuru K. Takaoka 2004 Enhancement of recombinant human bone morphogenetic protein-2 (rhBMP-2)-induced new bone formation by concurrent treatment with parathyroid hormone and a phosphodiesterase inhibitor, pentoxifylline J Bone Miner Metab 22 329 334
5. R. Sasaoka H. Terai H. Toyoda Y. Imai R. Sugama K. Takaoka 2004 A prostanoid receptor EP4 agonist enhances ectopic bone formation induced by recombinant human bone morphogenetic protein-2 Biochem Biophys Res Commun 318 704 709
6. H. Toyoda H. Terai R. Sasaoka K. Oda K. Takaoka 2005 Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist Bone (NY) 37 555 562
7. R. Sugama T. Koike Y. Imai C. Nomura-Furuwatari K. Takaoka 2006 Bone morphogenetic protein activities are enhanced by 3′,5′-cyclic adenosine monophosphate through suppression of Smad6 expression in osteoprogenitor cells Bone (NY) 38 206 214
8. S. Akiyama T. Katagiri M. Namiki N. Yamaji N. Yamamoto K. Miyama H. Shibuya N. Ueno J.M. Wozney T. Suda 1997 Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts Exp Cell Res 235 362 369
9. T. Katagiri M. Imada T. Yanai T. Suda N. Takahashi R. Kamijo 2002 Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis Genes Cells 7 949 960
10. T. Lopez-Rovira E. Chalaux J. Massague J.L. Rosa F. Ventura 2002 Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene J Biol Chem 277 3176 3185
11. O. Korchynskyi P. ten Dijke 2002 Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter J Biol Chem 277 4883 4891
12. K. Takaoka H. Yoshikawa J. Hashimoto K. Ono M. Matsui H. Nakazato 1994 Transfilter bone induction by Chinese hamster ovary (CHO) cells transfected by DNA encoding bone morphogenetic protein-4 Clin Orthop Relat Res 300 269 273
13. S. Ahn M. Olive S. Aggarwal D. Krylov D.D. Ginty C. Vinson 1998 A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos Mol Cell Biol 18 967 977
14. 2 EP4 agonist (ONO-4819) accelerates BMP-induced osteoblastic differentiation Bone (NY) 41 543 548
15. A. Nishihara J.I. Hanai N. Okamoto J. Yanagisawa S. Kato K. Miyazono M. Kawabata 1998 Role of p300, a transcriptional coactivator, in signalling of TGF-beta Genes Cells 3 613 623
16. X.H. Feng Y. Zhang R.Y. Wu R. Derynck 1998 The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation Genes Dev 12 2153 2163
17. R. Janknecht N.J. Wells T. Hunter 1998 TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300 Genes Dev 12 2114 2119
18. C. Pouponnot L. Jayaraman J. Massague 1998 Physical and functional interaction of SMADs and p300/CBP J Biol Chem 273 22865 22868
19. T. Furumatsu M. Tsuda N. Taniguchi Y. Tajima H. Asahara 2005 Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment J Biol Chem 280 8343 8350
20. N. Ghosh-Choudhury P.K. Singha K. Woodruff P. Stclair S. Bsoul S.L. Werner G. Ghosh-Choudhury 2006 Concerted action of Smad and CREB-binding protein regulates bone morphogenetic protein-2-stimulated osteoblastic colony-stimulating factor-1 expression J Biol Chem 281 20160 20170
21. L.W. Yuan J.E. Gambee 2001 Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin Biochim Biophys Acta 1541 161 169
22. H. Dobnig R.T. Turner 1995 Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells Endocrinology 136 3632 3638
23. R.M. Neer C.D. Arnaud J.R. Zanchetta R. Prince G.A. Gaich J.Y. Reginster A.B. Hodsman E.F. Eriksen S. Ish-Shalom H.K. Genant O. Wang B.H. Mitlak 2001 Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis N Engl J Med 344 1434 1441
24. T. Ishizuya S. Yokose M. Hori T. Noda T. Suda S. Yoshiki A. Yamaguchi 1997 Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells J Clin Invest 99 2961 2970