T-2 toxin enhances catabolic activity of hypertrophic chondrocytes through ROS-NF-κB-HIF-2α pathway

Toxicology in Vitro

Volumn 26, Issue 7, 2012, Pages 1106-1113

  Tian, Juan ^a,b   Yan, Jidong ^a,b   Wang, Wei ^a,b   Zhong, Nannan ^a,b   Tian, Lifang ^a,b   Sun, Jian ^a,b   Min, Zixin ^a,b   Ma, Jie ^a   Lu, Shemin ^a,b  

^a MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Chondrocyte; HIF 2 ; MMPs; NF B; ROS; T 2 Toxin

Indexed keywords

3 (4 TERT BUTYLPHENYLSULFONYL) 2 PROPENENITRILE; ACETYLCYSTEINE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; T 2 TOXIN;

ADAMTS4 GENE; ADAMTS5 GENE; AGGRECAN GENE; ANIMAL CELL; ARTICLE; CARTILAGE CELL; CATABOLISM; CELL ACTIVITY; CELL DIFFERENTIATION; CELL FUNCTION; CHONDROGENESIS; COL I GENE; COL II GENE; COL IX GENE; COL X GENE; CONTROLLED STUDY; CYTOTOXICITY; GENE; GENE EXPRESSION REGULATION; HIF 1ALPHA GENE; HIF 2ALPHA GENE; HYPERTROPHY; INTRACELLULAR SIGNALING; METABOLIC REGULATION; MMP 12 GENE; MMP 13 GENE; MMP 3 GENE; MMP 9 GENE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RUNX2 GENE; SOX9 GENE; TOXIN ANALYSIS; TRANSACTIVATION; TRANSCRIPTION INITIATION;

ACETYLCYSTEINE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELL LINE; CELL SURVIVAL; CHONDROCYTES; CHONDROGENESIS; FREE RADICAL SCAVENGERS; HYPERTROPHY; METABOLISM; MICE; NF-KAPPA B; NITRILES; REACTIVE OXYGEN SPECIES; SULFONES; T-2 TOXIN;

EID: 84866016075     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.07.002     Document Type: Article

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