메뉴 건너뛰기




Volumn 280, Issue 1-2, 2011, Pages 44-52

Alteration of blood brain barrier permeability by T-2 toxin: Role of MMP-9 and inflammatory cytokines

Author keywords

Blood brain barrier permeability; Inflammatory cytokines; MMP; Reactive oxygen species,; T 2 toxin

Indexed keywords

EVANS BLUE; GELATINASE A; GELATINASE B; GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; T 2 TOXIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 78650518373     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.11.006     Document Type: Article
Times cited : (68)

References (49)
  • 1
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 2
    • 0032752658 scopus 로고    scopus 로고
    • Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat
    • Agarwal R., Shukla G.S. Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat. Neurochem. Res. 1999, 24:1507-1514.
    • (1999) Neurochem. Res. , vol.24 , pp. 1507-1514
    • Agarwal, R.1    Shukla, G.S.2
  • 3
    • 33645869560 scopus 로고    scopus 로고
    • Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis
    • Agrawal S., Anderson P., Durbeej M., van Rooijen N., Ivars F., Opdenakker G., Sorokin L.M. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J. Exp. Med. 2006, 203:1007-1019.
    • (2006) J. Exp. Med. , vol.203 , pp. 1007-1019
    • Agrawal, S.1    Anderson, P.2    Durbeej, M.3    van Rooijen, N.4    Ivars, F.5    Opdenakker, G.6    Sorokin, L.M.7
  • 4
    • 50949134432 scopus 로고    scopus 로고
    • Effects of T-2 toxin on cytokine production by mice peritoneal macrophages and lymph node T-cells
    • Ahmadi K., Riazipour M. Effects of T-2 toxin on cytokine production by mice peritoneal macrophages and lymph node T-cells. Iran J. Immunol. 2008, 5:177-180.
    • (2008) Iran J. Immunol. , vol.5 , pp. 177-180
    • Ahmadi, K.1    Riazipour, M.2
  • 5
    • 13844296991 scopus 로고    scopus 로고
    • T-2 toxin-induced apoptosis in rat keratinocyte primary cultures
    • Albarenque S.M., Doi K. T-2 toxin-induced apoptosis in rat keratinocyte primary cultures. Exp. Mol. Pathol. 2005, 78:144-149.
    • (2005) Exp. Mol. Pathol. , vol.78 , pp. 144-149
    • Albarenque, S.M.1    Doi, K.2
  • 6
    • 0034803648 scopus 로고    scopus 로고
    • Kinetics of cytokines mRnas expression in the dorsal skin of WBN/ILA-Ht rats following topical application of T-2 toxin
    • Albarenque S.M., Suzuki K., Nakayama H., Doi K. Kinetics of cytokines mRnas expression in the dorsal skin of WBN/ILA-Ht rats following topical application of T-2 toxin. Exp. Toxicol. Pathol. 2001, 53:271-274.
    • (2001) Exp. Toxicol. Pathol. , vol.53 , pp. 271-274
    • Albarenque, S.M.1    Suzuki, K.2    Nakayama, H.3    Doi, K.4
  • 8
    • 0026802262 scopus 로고
    • The toxicity of macrocyclic trichothecenes administered directly into the rat brain
    • Bergmann F., Yagen B., Jarvis B.B. The toxicity of macrocyclic trichothecenes administered directly into the rat brain. Toxicon 1992, 30:1291-1294.
    • (1992) Toxicon , vol.30 , pp. 1291-1294
    • Bergmann, F.1    Yagen, B.2    Jarvis, B.B.3
  • 9
    • 0029980044 scopus 로고    scopus 로고
    • Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis
    • Boje K.M. Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis. Brain Res. 1996, 720:75-83.
    • (1996) Brain Res. , vol.720 , pp. 75-83
    • Boje, K.M.1
  • 11
    • 0023859029 scopus 로고
    • Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: an important mechanism of action
    • Bunner D.L., Morris E.R. Alteration of multiple cell membrane functions in L-6 myoblasts by T-2 toxin: an important mechanism of action. Toxicol. Appl. Pharmacol. 1988, 92:113-121.
    • (1988) Toxicol. Appl. Pharmacol. , vol.92 , pp. 113-121
    • Bunner, D.L.1    Morris, E.R.2
  • 12
    • 0023946488 scopus 로고
    • Potential for dietary amino acid precursors of neurotransmitters to overcome neurochemical changes in acute T-2 toxicosis in rats
    • Cavan K.R., MacDonald E.J., Smith T.K. Potential for dietary amino acid precursors of neurotransmitters to overcome neurochemical changes in acute T-2 toxicosis in rats. J. Nutr. 1988, 118:901-907.
    • (1988) J. Nutr. , vol.118 , pp. 901-907
    • Cavan, K.R.1    MacDonald, E.J.2    Smith, T.K.3
  • 13
    • 67649979797 scopus 로고    scopus 로고
    • Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells
    • Chaudhari M., Jayaraj R., Bhaskar A.S., Lakshmana Rao P.V. Oxidative stress induction by T-2 toxin causes DNA damage and triggers apoptosis via caspase pathway in human cervical cancer cells. Toxicology 2009, 262:153-161.
    • (2009) Toxicology , vol.262 , pp. 153-161
    • Chaudhari, M.1    Jayaraj, R.2    Bhaskar, A.S.3    Lakshmana Rao, P.V.4
  • 14
    • 67649319228 scopus 로고    scopus 로고
    • Oxidative damage and gene expression profile of antioxidant enzymes after T-2 toxin exposure in mice
    • Chaudhari M., Jayaraj R., Santhosh S.R., Lakshmana Rao P.V. Oxidative damage and gene expression profile of antioxidant enzymes after T-2 toxin exposure in mice. J. Biochem. Mol. Toxicol. 2009, 23:212-221.
    • (2009) J. Biochem. Mol. Toxicol. , vol.23 , pp. 212-221
    • Chaudhari, M.1    Jayaraj, R.2    Santhosh, S.R.3    Lakshmana Rao, P.V.4
  • 15
    • 0019399569 scopus 로고
    • Effects of T-2 toxin on brain catecholamines and selected blood components in growing chickens
    • Chi M.S., El-Halawani M.E., Waibel P.E., Mirocha C.J. Effects of T-2 toxin on brain catecholamines and selected blood components in growing chickens. Poultry Sci. 1981, 60:137-141.
    • (1981) Poultry Sci. , vol.60 , pp. 137-141
    • Chi, M.S.1    El-Halawani, M.E.2    Waibel, P.E.3    Mirocha, C.J.4
  • 16
    • 40049095589 scopus 로고    scopus 로고
    • E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice
    • Doring A., Wild M., Vestweber D., Deutsch U., Engelhardt B. E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL mice. J. Immunol. 2007, 179:8470-8479.
    • (2007) J. Immunol. , vol.179 , pp. 8470-8479
    • Doring, A.1    Wild, M.2    Vestweber, D.3    Deutsch, U.4    Engelhardt, B.5
  • 17
    • 0037396482 scopus 로고    scopus 로고
    • Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier
    • Eugenin E.A., Berman J.W. Chemokine-dependent mechanisms of leukocyte trafficking across a model of the blood-brain barrier. Methods 2003, 29:351-361.
    • (2003) Methods , vol.29 , pp. 351-361
    • Eugenin, E.A.1    Berman, J.W.2
  • 18
    • 7244251521 scopus 로고    scopus 로고
    • Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain
    • Ferrari C.C., Depino A.M., Prada F., Muraro N., Campbell S., Podhajcer O., Perry V.H., Anthony D.C., Pitossi F.J. Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. Am. J. Pathol. 2004, 165:1827-1837.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1827-1837
    • Ferrari, C.C.1    Depino, A.M.2    Prada, F.3    Muraro, N.4    Campbell, S.5    Podhajcer, O.6    Perry, V.H.7    Anthony, D.C.8    Pitossi, F.J.9
  • 19
    • 0034655765 scopus 로고    scopus 로고
    • The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice
    • Fujimura M., Morita-Fujimura Y., Noshita N., Sugawara T., Kawase M., Chan P.H. The cytosolic antioxidant copper/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice. J. Neurosci. 2000, 20:2817-2824.
    • (2000) J. Neurosci. , vol.20 , pp. 2817-2824
    • Fujimura, M.1    Morita-Fujimura, Y.2    Noshita, N.3    Sugawara, T.4    Kawase, M.5    Chan, P.H.6
  • 20
    • 77955661048 scopus 로고    scopus 로고
    • Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity
    • Gupta N., Lomash V., Lakshmana Rao P.V. Expression profile of Japanese encephalitis virus induced neuroinflammation and its implication in disease severity. J. Clin. Virol. 2010, 49:4-10.
    • (2010) J. Clin. Virol. , vol.49 , pp. 4-10
    • Gupta, N.1    Lomash, V.2    Lakshmana Rao, P.V.3
  • 21
    • 28844498785 scopus 로고    scopus 로고
    • Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction
    • Haorah J., Knipe B., Leibhart J., Ghorpade A., Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J. Leukoc. Biol. 2005, 78:1223-1232.
    • (2005) J. Leukoc. Biol. , vol.78 , pp. 1223-1232
    • Haorah, J.1    Knipe, B.2    Leibhart, J.3    Ghorpade, A.4    Persidsky, Y.5
  • 22
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidized and reduced glutathione in tissues
    • Hissin P.J., Hilf R. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 1976, 74:214-226.
    • (1976) Anal. Biochem. , vol.74 , pp. 214-226
    • Hissin, P.J.1    Hilf, R.2
  • 23
    • 58149252168 scopus 로고    scopus 로고
    • Analysis of mechanisms of T-2 toxin toxicity using yeast DNA microarrays
    • Iwahashi Y., Kitagawa E., Iwahashi H. Analysis of mechanisms of T-2 toxin toxicity using yeast DNA microarrays. Int. J. Mol. Sci. 2008, 9:2585-2600.
    • (2008) Int. J. Mol. Sci. , vol.9 , pp. 2585-2600
    • Iwahashi, Y.1    Kitagawa, E.2    Iwahashi, H.3
  • 24
    • 33947525763 scopus 로고    scopus 로고
    • Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction
    • Kamada H., Yu F., Nito C., Chan P.H. Influence of hyperglycemia on oxidative stress and matrix metalloproteinase-9 activation after focal cerebral ischemia/reperfusion in rats: relation to blood-brain barrier dysfunction. Stroke 2007, 38:1044-1049.
    • (2007) Stroke , vol.38 , pp. 1044-1049
    • Kamada, H.1    Yu, F.2    Nito, C.3    Chan, P.H.4
  • 26
    • 33745989229 scopus 로고    scopus 로고
    • T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses
    • Li M., Cuff C.F., Pestka J.J. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-gamma responses. Toxicol. Appl. Pharmacol. 2006, 214:318-325.
    • (2006) Toxicol. Appl. Pharmacol. , vol.214 , pp. 318-325
    • Li, M.1    Cuff, C.F.2    Pestka, J.J.3
  • 27
    • 0020852777 scopus 로고
    • Analysis for Fusarium toxins in various samples implicated in biological warfare in Southeast Asia
    • Mirocha C.J., Pawlosky R.A., Chatterjee K., Watson S., Hayes W. Analysis for Fusarium toxins in various samples implicated in biological warfare in Southeast Asia. J. Assoc. Off. Anal. Chem. 1983, 66:1485-1499.
    • (1983) J. Assoc. Off. Anal. Chem. , vol.66 , pp. 1485-1499
    • Mirocha, C.J.1    Pawlosky, R.A.2    Chatterjee, K.3    Watson, S.4    Hayes, W.5
  • 28
    • 0028092958 scopus 로고
    • Nitric oxide synthases: roles, tolls, and controls
    • Nathan C., Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 1994, 78:915-918.
    • (1994) Cell , vol.78 , pp. 915-918
    • Nathan, C.1    Xie, Q.W.2
  • 29
    • 0018189269 scopus 로고
    • Reaction of linoleic acid hydroperoxide with thiobarbituric acid
    • Ohkawa H., Ohishi N., Yagi K. Reaction of linoleic acid hydroperoxide with thiobarbituric acid. J. Lipid Res. 1978, 19:1053-1057.
    • (1978) J. Lipid Res. , vol.19 , pp. 1053-1057
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 30
    • 0028855583 scopus 로고
    • The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta
    • Pinsky D.J., Cai B., Yang X., Rodriguez C., Sciacca R.R., Cannon P.J. The lethal effects of cytokine-induced nitric oxide on cardiac myocytes are blocked by nitric oxide synthase antagonism or transforming growth factor beta. J. Clin. Invest. 1995, 95:677-685.
    • (1995) J. Clin. Invest. , vol.95 , pp. 677-685
    • Pinsky, D.J.1    Cai, B.2    Yang, X.3    Rodriguez, C.4    Sciacca, R.R.5    Cannon, P.J.6
  • 31
    • 67650153191 scopus 로고    scopus 로고
    • Involvement of ROS in BBB dysfunction
    • Pun P.B., Lu J., Moochhala S. Involvement of ROS in BBB dysfunction. Free Radic. Res. 2009, 43:348-364.
    • (2009) Free Radic. Res. , vol.43 , pp. 348-364
    • Pun, P.B.1    Lu, J.2    Moochhala, S.3
  • 32
    • 10544246489 scopus 로고    scopus 로고
    • Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro Implications for atherosclerotic plaque stability
    • Rajagopalan S., Meng X.P., Ramasamy S., Harrison D.G., Galis Z.S. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro Implications for atherosclerotic plaque stability. J. Clin. Invest. 1996, 98:2572-2579.
    • (1996) J. Clin. Invest. , vol.98 , pp. 2572-2579
    • Rajagopalan, S.1    Meng, X.P.2    Ramasamy, S.3    Harrison, D.G.4    Galis, Z.S.5
  • 33
    • 33845665284 scopus 로고    scopus 로고
    • Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells
    • Reijerkerk A., Kooij G., van der Pol S.M., Khazen S., Dijkstra C.D., de Vries H.E. Diapedesis of monocytes is associated with MMP-mediated occludin disappearance in brain endothelial cells. FASEB J. 2006, 20:2550-2552.
    • (2006) FASEB J. , vol.20 , pp. 2550-2552
    • Reijerkerk, A.1    Kooij, G.2    van der Pol, S.M.3    Khazen, S.4    Dijkstra, C.D.5    de Vries, H.E.6
  • 34
    • 0020419961 scopus 로고
    • Presence of four Fusarium mycotoxins and synthetic material in 'yellow rain'. Evidence for the use of chemical weapons in Laos
    • Rosen R.T., Rosen J.D. Presence of four Fusarium mycotoxins and synthetic material in 'yellow rain'. Evidence for the use of chemical weapons in Laos. Biomed. Mass Spectrom. 1982, 9:443-450.
    • (1982) Biomed. Mass Spectrom. , vol.9 , pp. 443-450
    • Rosen, R.T.1    Rosen, J.D.2
  • 35
    • 0031693557 scopus 로고    scopus 로고
    • Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain
    • Rosenberg G.A., Estrada E.Y., Dencoff J.E. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 1998, 29:2189-2195.
    • (1998) Stroke , vol.29 , pp. 2189-2195
    • Rosenberg, G.A.1    Estrada, E.Y.2    Dencoff, J.E.3
  • 36
    • 0026595227 scopus 로고
    • Acute neurobehavioural toxicity of trichothecene T-2 toxin in the rat
    • Sirkka U., Nieminen S.A., Ylitalo P. Acute neurobehavioural toxicity of trichothecene T-2 toxin in the rat. Pharmacol. Toxicol. 1992, 70:111-114.
    • (1992) Pharmacol. Toxicol. , vol.70 , pp. 111-114
    • Sirkka, U.1    Nieminen, S.A.2    Ylitalo, P.3
  • 37
    • 0031201771 scopus 로고    scopus 로고
    • Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine
    • Smith T.K., McMillan E.G., Castillo J.B. Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine. J. Anim. Sci. 1997, 75:2184-2191.
    • (1997) J. Anim. Sci. , vol.75 , pp. 2184-2191
    • Smith, T.K.1    McMillan, E.G.2    Castillo, J.B.3
  • 38
    • 61649117446 scopus 로고    scopus 로고
    • Light cycler 480 Real-Time PCR System: innovative solutions for relative quantification
    • Tellmann G., Olivier G. Light cycler 480 Real-Time PCR System: innovative solutions for relative quantification. Biochemica 2006, 16-18.
    • (2006) Biochemica , pp. 16-18
    • Tellmann, G.1    Olivier, G.2
  • 39
    • 0021222728 scopus 로고
    • Toxicological features of T-2 toxin and related trichothecenes
    • Ueno Y. Toxicological features of T-2 toxin and related trichothecenes. Fundam. Appl. Toxicol. 1984, 4:S124-132.
    • (1984) Fundam. Appl. Toxicol. , vol.4
    • Ueno, Y.1
  • 41
    • 0027403107 scopus 로고
    • Effect of dietary T-2 toxin on biogenic monoamines in discrete areas of the rat brain
    • Wang J., Fitzpatrick D.W., Wilson J.R. Effect of dietary T-2 toxin on biogenic monoamines in discrete areas of the rat brain. Food Chem. Toxicol. 1993, 31:191-197.
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 191-197
    • Wang, J.1    Fitzpatrick, D.W.2    Wilson, J.R.3
  • 42
    • 0032211469 scopus 로고    scopus 로고
    • Effects of the trichothecene mycotoxin T-2 toxin on neurotransmitters and metabolites in discrete areas of the rat brain
    • Wang J., Fitzpatrick D.W., Wilson J.R. Effects of the trichothecene mycotoxin T-2 toxin on neurotransmitters and metabolites in discrete areas of the rat brain. Food Chem. Toxicol. 1998, 36:947-953.
    • (1998) Food Chem. Toxicol. , vol.36 , pp. 947-953
    • Wang, J.1    Fitzpatrick, D.W.2    Wilson, J.R.3
  • 44
    • 0021683445 scopus 로고
    • Analysis for trichothecenes in samples from Southeast Asia associated with "Yellow Rain"
    • Watson S.A., Mirocha C.J., Hayes A.W. Analysis for trichothecenes in samples from Southeast Asia associated with "Yellow Rain" Fundam. Appl. Toxicol. 1984, 4:700-717.
    • (1984) Fundam. Appl. Toxicol. , vol.4 , pp. 700-717
    • Watson, S.A.1    Mirocha, C.J.2    Hayes, A.W.3
  • 45
    • 0024510624 scopus 로고
    • Acute and chronic effects of the trichothecene mycotoxin T-2 on rat brain regional concentrations of serotonin, tryptophan, and tyrosine
    • Weekley L.B., O'Rear C.E., Kimbrough T.D., Llewellyn G.C. Acute and chronic effects of the trichothecene mycotoxin T-2 on rat brain regional concentrations of serotonin, tryptophan, and tyrosine. Vet. Hum. Toxicol. 1989, 31:221-224.
    • (1989) Vet. Hum. Toxicol. , vol.31 , pp. 221-224
    • Weekley, L.B.1    O'Rear, C.E.2    Kimbrough, T.D.3    Llewellyn, G.C.4
  • 46
    • 0024315427 scopus 로고
    • Effects of T-2 mycotoxin on gastrointestinal tissues: a review of in vivo and in vitro models
    • Williams P.P. Effects of T-2 mycotoxin on gastrointestinal tissues: a review of in vivo and in vitro models. Arch. Environ. Contam. Toxicol. 1989, 18:374-387.
    • (1989) Arch. Environ. Contam. Toxicol. , vol.18 , pp. 374-387
    • Williams, P.P.1
  • 47
    • 0022505545 scopus 로고
    • T-2 toxin effect on the ultrastructure of myocardial microvasculature
    • Yarom R., Yagen B. T-2 toxin effect on the ultrastructure of myocardial microvasculature. Br. J. Exp. Pathol. 1986, 67:55-63.
    • (1986) Br. J. Exp. Pathol. , vol.67 , pp. 55-63
    • Yarom, R.1    Yagen, B.2
  • 49
    • 40949153084 scopus 로고    scopus 로고
    • Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury
    • Yu F., Kamada H., Niizuma K., Endo H., Chan P.H. Induction of mmp-9 expression and endothelial injury by oxidative stress after spinal cord injury. J. Neurotrauma 2008, 25:184-195.
    • (2008) J. Neurotrauma , vol.25 , pp. 184-195
    • Yu, F.1    Kamada, H.2    Niizuma, K.3    Endo, H.4    Chan, P.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.