The role of individual carbohydrate-binding sites in the function of the potent anti-HIV lectin griffithsin

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2613-2625

  Xue, Jie ^a   Gao, Yongguang ^a   Hoorelbeke, Bart ^b   Kagiampakis, Ioannis ^a   Zhao, Bo ^a   Demeler, Borries ^c   Balzarini, Jan ^b   LiWang, Patricia J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^c University of Texas Health Science Center   (United States)

Author keywords

analytical ultracentrifugation; carbohydrate binding site (CBS); griffithsin (GRFT); HIV entry inhibitor; lectin; mannose titration; microbicide; nuclear magnetic resonance (NMR); surface plasmon resonance (SPR)

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CARBOHYDRATE BINDING PROTEIN; GLYCOPROTEIN GP 120; GRIFFITHSIN; LECTIN; MANNOSE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOHYDRATE BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CORRELATION ANALYSIS; CULTURE MEDIUM; DRUG STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OLIGOMERIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; ULTRACENTRIFUGATION; VIRION; VIRUS ENTRY; VIRUS NEUTRALIZATION; WILD TYPE;

ANTI-HIV AGENTS; BINDING SITES; CARBOHYDRATES; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; MAGNETIC RESONANCE SPECTROSCOPY; MANNOSE; MODELS, MOLECULAR; MUTATION; PLANT LECTINS;

EID: 84865973864     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300194b     Document Type: Article

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