Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin

Proteins: Structure, Function and Genetics

Volumn 67, Issue 3, 2007, Pages 661-670

  Ziółkowska, Natasza E ^a   Shenoy, Shilpa R ^a   O'Keefe, Barry R ^a   McMahon, James B ^a   Palmer, Kenneth E ^b   Dwek, Raymond A ^c   Wormald, Mark R ^c   Wlodawer, Alexander ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Anti HIV; Anti viral; Carbohydrate modeling; Lectin; Oligosaccharide binding

Indexed keywords

ALGAL PROTEIN; ANTIVIRUS AGENT; GRIFFITHSIN; LECTIN; MALTOSE; MANNOSE; MONOSACCHARIDE; N ACETYLGLUCOSAMINE; OLIGOSACCHARIDE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG BINDING; ENTHALPY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALGAL PROTEINS; ANTIVIRAL AGENTS; BINDING SITES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; LECTINS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OLIGOSACCHARIDES; PROTEIN BINDING; THERMODYNAMICS;

GRIFFITHSIA; RHODOPHYTA;

EID: 34247244607     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21336     Document Type: Article

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