Isolation and characterization of Griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp.

Journal of Biological Chemistry

Volumn 280, Issue 10, 2005, Pages 9345-9353

  Mori, Toshiyuki ^a   O'Keefe, Barry R ^a   Sowder II, Raymond C ^b   Bringans, Scott ^a   Gardella, Roberta ^b   Berg, Shannon ^b   Cochran, Pamela ^b   Turpin, Jim A ^c,d   Buckheit Jr , Robert W ^c,e   McMahon, James B ^a   Boyd, Michael R ^a,f  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c SOUTHERN RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e ImQuest Biosciences   (United States)

^f UNIVERSITY OF SOUTH ALABAMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALGAE; AMINES; AMINO ACIDS; CELLS; ESCHERICHIA COLI; GLUCOSE;

AMINO ACID SEQUENCE; DNA SEQUENCE; EPITOPE; GRIFFITHSIN (GRFT);

PROTEINS;

ALGAL PROTEIN; CD4 ANTIGEN; COAT PROTEIN; EPITOPE; GLUCOSE; GLYCOPROTEIN GP 120; LECTIN; MANNOSE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 2G12; MONOCLONAL ANTIBODY 48D; MONOSACCHARIDE; N ACETYLGLUCOSAMINE; PROTEIN GRIFFITHSIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CELL FUSION; DNA SEQUENCE; DRUG MECHANISM; ESCHERICHIA COLI; GLYCOSYLATION; GRIFFITHSIA; HOST CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN MOTIF; RED ALGA; VIRUS STRAIN; VIRUS TRANSMISSION;

ALGAE, RED; ALGAL PROTEINS; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CELL FUSION; CELL LINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HIV-1; HUMANS; LECTINS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA;

ALGAE; ESCHERICHIA COLI; GRIFFITHSIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RHODOPHYTA;

EID: 20144370949     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411122200     Document Type: Article

References (50)

1. UN Program on HIV/AIDS (2004) Report on the Global AIDS Epidemic, 4th Global Report, www.unaids.org/bangkok2004/report.html
2. NIAID (2004) Fact Sheet: HIV Infection in Women, www.niaid.nih.gov/ factsheets/womenhiv.html
3. Stratov, I., DeRose, R., Purcell, D. F., and Kent, S. J. (2004) Curr. Drug Targets 5, 71-88
4. Garber, D. A., and Feinberg, M. B. (2003) AIDS Rev. 5, 131-139
5. Tramont, E. C., and Johnston, M. I. (2003) Expert Opin. Emerg. Drugs 8, 37-45
6. Piot, P. (2001) AIDS 15, Suppl. 1, 4
7. Cragg, G. M., and Newman, D. J. (2002) in Ethnomedicine and Drug Discovery (Iwu, M. M., and Wootton, J., eds) 1st Ed., pp. 23-37, Elsevier Science Publishers B.V., Amsterdam
8. Boyd, M. E. (1988) in AIDS: Etiology, Diagnosis, Treatment, and Prevention (DeVita, V. T., Hellman, S., and Rosenberg, S. A., eds) 2nd Ed., pp. 305-319, J. B. Lippincott, Philadelphia
9. O'Keefe, B. R. (2001) J. Nat. Prod. 64, 1373-1381
10. Boyd, M. R., Gustafson, K. R., McMahon, J. B., Shoemaker, R. H., O'Keefe, B. R., Mori, T., Gulakowski, R. J., Wu, L., Rivera, M. I., Laurencot, C. M., Currens, M. J., Cardellina, J. H., II, Buckheit, R. W., Jr., Nara, P. L., Pannell, L. K., Sowder, R. C., II, and Henderson, L. E. (1997) Antimicrob. Agents Chemother. 41, 1521-1530
11. Bokesch, H. R., O'Keefe, B. R., McKee, T. C., Pannell, L. K., Patterson, G. M., Gardella, R. S., Sowder, R. C., II, Turpin, J., Watson, K., Buckheit, R. W., Jr., and Boyd, M. R. (2003) Biochemistry 42, 2578-2584
12. Ganzon-Fortes, E. T. (1997) J. Appl. Phycol. 9, 525-532
13. Gretz, M. R., Mollet, J., and Falshaw, R. (1997) in Techniques in Glycobiology (Townsend, R. R., and Hotchkiss, A. T., eds) pp. 613-628, Marcel Dekker/CRC Press Inc., New York
14. Kaixian, Q., Franklin, M., and Borowitzka, M. A. (1993) Appl. Biochem. Biotechnol. 43, 133-139
15. Carra, P. O. (1965) Biochem. J. 94, 171-174
16. Gulakowski, R. J., McMahon, J. B., Staley, P. G., Moran, R. A., and Boyd, M. R. (1991) J. Virol. Methods 33, 87-100
17. Mori, T., Gustafson, K. R., Pannell, L. K., Shoemaker, R. H., Wu, L., McMahon, J. B., and Boyd, M. R. (1998) Protein Expression Purif. 12, 151-158
18. Weislow, O. S., Kiser, R., Fine, D. L., Bader, J., Shoemaker, R. H., and Boyd, M. R. (1989) J. Natl. Cancer Inst. 81, 577-586
19. Buckheit, R. W., Jr., Roberson, J. L., Lackman-Smith, C., Wyatt, J. R., Vickers, T. A., and Ecker, D. J. (1994) AIDS Res. Hum. Retroviruses 10, 1497-1506
20. Gartner, S., and Popovic, M. (1990) in Techniques in HIV Research (Aldovini, A., and Walker, B., eds) pp. 59-63, Stockton Press, New York
21. Buckheit, R. W., Jr., Hollingshead, M. G., Germany-Decker, J., White, E. L., McMahon, J. B., Allen, L. B., Ross, L. J., Decker, W. D., Westbrook, L., Shannon, W. M., Weislow, O., Bader, J. P., and Boyd, M. R. (1993) Antiviral Res. 21, 247-265
22. Clanton, D. J., Moran, R. A., McMahon, J. B., Weislow, O. S., Buckheit, R. W., Jr., Hollingshead, M. G., Ciminale, V., Felber, B. K., Pavlakis, G. N., and Bader, J. P. (1992) J. Acquired Immune Defic. Syndr. 5, 771-781
23. Mori, T., and Boyd, M. R. (2001) Antimicrob. Agents Chemother. 45, 664-672
24. Esser, M. T., Mori, T., Mondor, I., Sattentau, Q. J., Dey, B., Berger, E. A., Boyd, M. R., and Lifson, J. D. (1999) J. Virol. 73, 4360-4371
25. Moore, J. P., and Jarrett, R. F. (1988) AIDS Res. Hum. Retroviruses 4, 369-379
26. Altschul, S. F., Madden, T. L., Schaffer, A. A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D. J. (1997) Nucleic Acids Res. 25, 3389-3402
27. Haslin, C., Lahaye, M., Pellegrini, M., and Chermann, J. C. (2001) Planta Med. 67, 301-305
28. Liao, W. R., Lin, J. Y., Shieh, W. Y., Jeng, W. L., and Huang, R. (2003) J. Ind. Microbiol. Biotechnol. 30, 433-439
29. Lee, Y. K., Hong, C. B., Suh, Y., and Lee, I. K. (2002) Mol. Cell 13, 12-20
30. Hong, P. W., Flummerfelt, K. B., de Parseval, A., Gurney, K., Elder, J. H., and Lee, B. (2002) J. Virol. 76, 12855-12865
31. Charan, R. D., Munro, M. H., O'Keefe, B. R., Sowder, R., McKee, T. C., Currens, M. J., Pannell, L. K., and Boyd, M. R. (2000) J. Nat. Prod. 63, 1170-1174
32. De Clercq, E. (2000) Med. Res. Rev. 20, 323-349
33. Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J., and Hendrickson, W. A. (1998) Nature 393, 648-659
34. Scanlan, C. N., Pantophlet, R., Wormald, M. R., Ollmann Saphire, E., Stanfield, R., Wilson, I. A., Katinger, H., Dwek, R. A., Rudd, P. M., and Burton, D. R. (2002) J. Virol. 76, 7306-7321
35. O'Keefe, B. R., Shenoy, S. R., Xie, D., Zhang, W., Muschik, J. M., Currens, M. J., Chaiken, I., and Boyd, M. R. (2000) Mol. Pharmacol. 58, 982-992
36. Bolmstedt, A. J., O'Keefe, B. R., Shenoy, S. R., McMahon, J. B., and Boyd, M. R. (2001) Mol. Pharmacol. 59, 949-954
37. Mitchell, D. A., Fadden, A. J., and Drickamer, K. (2001) J. Biol. Chem. 276, 28939-28945
38. O'Keefe, B. R., Smee, D. F., Turpin, J. A., Saucedo, C. J., Gustafson, K. R., Mori, T., Blakeslee, D., Buckheit, R., and Boyd, M. R. (2003) Antimicrob. Agents Chemother. 47, 2518-2525
39. Barrientos, L. G., O'Keefe, B. R., Bray, M., Sanchez, A., Gronenborn, A. M., and Boyd, M. R. (2003) Antiviral Res. 58, 47-56
40. Yang, Z. Y., Huang, Y., Ganesh, L., Leung, K., Kong, W. P., Schwartz, O., Subbarao, K., and Nabel, G. J. (2004) J. Virol. 78, 5642-5650
41. Bewley, C. A., and Otero-Quintero, S. (2001) J. Am. Chem. Soc. 123, 3892-3902
42. Bewley, C. A., Cai, M., Ray, S., Ghirlando, R., Yamaguchi, M., and Muramoto, K. (2004) J. Mol. Biol. 339, 901-914
43. Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Smith, M. W., Allikmets, R., Goedert, J. J., Buchbinder, S. P., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R., and O'Brien, S. J. (1996) Science 273, 1856-1862
44. Hill, C. M., and Littman, D. R. (1996) Nature 382, 668-669
45. Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A., and Landau, N. R. (1996) Cell 86, 367-377
46. Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., and Remaut, E. (2000) Science 289, 1352-1355
47. Beninati, C., Oggioni, M. R., Boccanera, M., Spinosa, M. R., Maggi, T., Conti, S., Magliani, W., De Bernardis, F., Teti, G., Cassone, A., Pozzi, G., and Polonelli, L. (2000) Nat. Biotechnol. 18, 1060-1064
48. Kruger, C., Hu, Y., Pan, Q., Marcotte, H., Hultberg, A., Delwar, D., van Dalen, P. J., Pouwels, P. H., Leer, R. J., Kelly, C. G., van Dollenweerd, C., Ma, J. K., and Hammarstrom, L. (2002) Nat. Biotechnol. 20, 702-706
49. Giomarelli, B., Prowedi, R., Meacci, F., Maggi, T., Medaglini, D., Pozzi, G., Mori, T., McMahon, J. B., Gardella, R., and Boyd, M. R. (2002) AIDS 16, 1351-1356
50. Chang, T. L., Chang, C. H., Simpson, D. A., Xu, Q., Martin, P. K., Lagenaur, L. A., Schoolnik, G. K., Ho, D. D., Hillier, S. L., Holodniy, M., Lewicki, J. A., and Lee, P. P. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11672-11677