Mouse lung epithelial cell lines - Tools for the study of differentiation and the neoplastic phenotype

Toxicology

Volumn 123, Issue 1-2, 1997, Pages 53-100

  Malkinson, Alvin M ^a   Dwyer Nield, Lori D ^a   Rice, Pamela L ^a   Dinsdale, David ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b MRC TOXICOLOGY UNIT   (United Kingdom)

Author keywords

Differentiation; Lung epithelial cell lines; Neoplastic phenotype

Indexed keywords

ETHYLNITROSOUREA; URETHAN; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL CULTURE; CELL LINE; CYTOGENETICS; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; MOUSE; MUTATION; NONHUMAN; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; REVIEW; XENOBIOTIC METABOLISM;

ADENOCARCINOMA; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; EPITHELIAL CELLS; GLUCOCORTICOIDS; LUNG; LUNG NEOPLASMS; MICE; MUTATION; PHENOTYPE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0030823559     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(97)00108-X     Document Type: Review

References (171)

1. Adamson, I.Y.R., Bowden, D.H., 1974. The type 2 cell as progenitor of alveolar epithelial regeneration: a cytodynamic study in mice after exposure to oxygen. Lab. Invest. 30, 35-42.
2. Aronow, B.J., Lund, S.D., Brown, T.L., Harmony, J.A.K., Witte, D.P., 1993. Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection. Proc. Natl. Acad. Sci. USA 90, 725-729.
3. Banoub, R.W., Fernstrom, M., Malkinson, A.M., Ruch, R.J., 1996. Enhancement of gap junctional intercellular communication by dibutyryl cyclic AMP in mouse lung epithelial cells. Anticancer Res. 16, 3715-3720.
4. 3H-dexamethasone binding in fetal lung. Develop. Biol. 105, 351-364.
5. + + -stimulated proteolysis of mouse lung cAMP-dependent protein kinases. Arch. Biochem. Biophys. 228, 209-219.
6. Belinsky, S.A., Devereux, T.R., Foley, J.F., White, C.M., Maronpot, R.R., Anderson, M.W., 1992. The role of the alveolar type 2 cell in the development and progression of pulmonary tumors in the A/J mouse. Cancer Res. 52, 3164-3173.
7. Belinsky, S.A., Lechner, J.F., Johnson, N.F., 1995. An improved method for the isolation of type II and Clara cells from mice. In Vitro 31, 361-366.
8. Bentel, J.M., Lykke, A.W.J., Smith, G.J., 1985. Cloned murine non-malignant spontaneously transformed and chemical tumor-derived cell lines related to the type 2 pneumocyte. Cell Biol. Int. Rep. 9, 1115-1122.
9. Berard, J., LaBoune, F., Makuna, M., Masse, S., Kothary, R., Bradley, W.E.C., 1996. Lung tumors in mice expressing an antisense rarβ2 transgene. FASEB J. 10, 1091-1097.
10. Blenis, J., 1993. Signal transduction via the Map kinases: Proceed at your own RSK. Proc. Natl. Acad. Sci. (USA) 90, 5889-5892.
11. Bolton, J.L., Thompson, J.A., Allentoff, A.J., Miley, F.B., Malkinson, A.M., 1993. Metabolic activation of butylated hydroxytoluene by mouse bronchiolar and Clara cells. Toxicol. Appl. Pharmacol. 123, 43-49.
12. Bos, J.L., 1989. Ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689.
13. Burke-Gaffney, A., Hellewell, P.G., 1997. Endogenous nitric oxide limits cytokine-induced damage of murine lung epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 272, L707-L713.
14. Butley, M.S., Stoner, G.D., Beer, D.G., Beer, D.S., Mason, R.J., Malkinson, A.M., 1985. Changes in cyclic AMP-dependent protein kinases during the progression of urethan-induced mouse lung tumors. Cancer Res. 45, 3677-3685.
15. Cesen, K.T., Malkinson, A.M., Ruch, R.J., 1996. Downregulation of gap junctional intercellular communication in mouse and human lung carcinoma cells and restoration of a more normal phenotype by connexin 43 transfection. Toxicologist 30, 209.
16. Chaudhuri, R.K., Sigler, K., Dupont, E., Trosko, J.E., Malkinson, A.M., Ruch, R.J., 1993. Gap junctional intercellular communication in mouse lung epithelial cell lines: effects of cell transformation and tumor promoters. Cancer Lett. 71, 11-18.
17. Crandall, E.D., Kim, K.J., 1991. Alveolar epithelial barrier properties. In: Crystal, R.G. (Ed.), The Lung: Scientific Foundations, Raven, New York, pp. 273-288.
18. DeMayo, F.J., Finegold, M.J., Hanson, T.N., Stanley, L.A., Smith, B., Bullock, D.W., 1991. Expression of SV40 T antigen under control of rabbit uteroglobin promoter in transgenic mice. Am. J. Physiol. Lung Cell Mol. Physiol. 261, L70-L76.
19. Devereux, T.J., Serabjit-Singh, L.J., Slaughter, S.R., Wolf, C.R., Philpot, R.M., Fouts, J.R., 1981. Identification of cytochrome P-450 isozymes in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung. Exp. Lung Res. 2, 221-230.
20. Droms, K.A., 1995. Dexamethasome enhances colonization of soft agar by tumorigenic mouse lung-derived cell lines. Cancer Lett. 95, 99-103.
21. Droms, K.A., 1996. β-adrenergic signalling in neoplastic lung type 2 cells: glucocorticoid-dependent and -independent effects. Brit. J. Cancer 74, 432-438.
22. Droms, K.A., Fernandez, C.A., Thaete, L.G., Malkinson, A.M., 1988. Effects of adrenalectomy and corticosterone administration on mouse lung tumor susceptibility and histogenesis. J. Natl. Cancer Inst. 80, 365-369.
23. 32P)-GTP into a 45 kD protein in lung tumors. Biochem. Biophys. Res. Commun. 144, 591-597.
24. 32P}GTP photolabeling of Gsα in tumorigenic lung epithelial cell lines: association with decreased hormone responsiveness and loss of contact-inhibited growth. Exp. Cell. Res. 182, 330-339.
25. Droms, K.A., Hanson, L.A., Malkinson, A.M., Beer, D.G., 1993. Altered dexamethasone responsiveness and loss of growth control in tumorigenic mouse lung cell lines. Int. J. Cancer 53, 1017-1022.
26. Droms, K.A., Malkinson, A.M., 1991a. Mechanism of glucocorticoid involvement in mouse lung tumorigenesis. Exp. Lung Res. 17, 371-387.
27. Droms, K.A., Malkinson, A.M., 1991b. Phorbol ester-induced tumor promotion by down-regulation of protein kinase C. Molec. Carcinog. 4, 1-2.
28. Duke, R.C., Cohen, J.J., 1992. Morphological and biochemical assays of apoptosis. In: Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., Shevach, E.M., Strober, W. (Eds.), Current Protocols in Immunology, Wiley Interscience, New York, pp. 3.17.1-3.17.16.
29. Dwyer, L.D., Miller, A.C.K., Parks, A.L., Jaken, S., Malkinson, A.M., 1994. Calpain-induced down-regulation of activated protein kinase C-α affects lung epithelial cell morphology. Am. J. Physiol. Lung Cell Mol. Physiol. 266, L569-L576.
30. Dwyer-Nield, L., Miller, A.C.K., Neighbors, B.W., Dinsdale, D., Malkinson, A.M., 1996. Cytoskeletal architecture in mouse lung epithelial cells is regulated by protein kinase Ca and calpain II. Am. J. Physiol. Lung Cell Mol. Physiol. 270, L526-534.
31. Evans, M.J., Cabral-Anderson, L.J., Freeman, C., 1978. Role of Clara cell in renewal of bronchiolar epithelium. Lab. Invest. 38, 648-655.
32. Festing, M.F.W., Yang, A.L., Malkinson, A.M., 1994. At least four genes are associated with susceptibility to urethane-induced pulmonary adenomas in mice. Genet. Res. 64, 99-106.
33. Fidler, I.J., 1973. Selection of successive tumor lines for metastasis. Nature New Biol. 242, 148-149.
34. Filmus, J., Robles, A.I., Shi, W., Wang, M.J., Columbo, L.L., Conti, C.J., 1994. Induction of cyclin D overexpression by activated ras. Oncogene 9, 3627-3633.
35. Forkert, P.G., Parkinson, A., Thaete, L.G., Malkinson, A.M., 1993. Resistance of murine lung tumors to xenobiotic-induced cytotoxicity. Cancer Res. 53, 393-401.
36. Franks, L.M., Carbonell, A.W., Hemmings, V.J., Riddle, P.N., 1976. Metastasizing tumors from serum-supplemented and serum-free cell lines from a C57BL mouse lung tumor. Cancer Res. 36, 1049-1055.
37. Franks, L.M., Layton, M.G., 1994. Ultrastructural tumor differentiation and organ specificity in high and low metastatic lines from a mouse lung carcinoma. Br. J. Cancer 49, 423-429.
38. Gabathuler, R., Reid, G., Kolaitis, G., Driscoll, J., Jeffries, W.A., 1994. Comparison of cell lines deficient in antigen presentation reveals a functional role for TAP-1 alone in antigen processing. J. Exp. Med. 180, 1415-1425.
39. Gazdar, A.F., Linnoila, R.I., 1988. The pathology of lung cancer: changing concepts and newer diagnostic techniques. Semin. Oncol. 15, 215-225.
40. Glasser, S.W., Korfhagen, T.R., Wert, S.E., Whitsett, J.A., 1994. Transgenic models for study of pulmonary development and disease. Am. J. Physiol. Lung Cell Mol. Physiol. 267, L489-L497.
41. Goldsworthy, T.L., Butterworth, B.E., Maronpot, R.R., 1993. Concepts, labeling procedures, and design of cell proliferation studies relating to carcinogenesis. Envir. Health Perspec. 101 (suppl. 5), 59-66.
42. Goodrich, D.W., Wang, N.P., Qian, Y.W., Lee, E.Y.H.P., Lee, W.H., 1991. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Cell 67, 293-302.
43. Grady, H.G., Stewart, H.L., 1940. Histogenesis of induced pulmonary tumors in strain A mice. Am. J. Pathol. 16, 417-432.
44. Graves, L.M., Burnfeld, K.E., Raines, E.W., Potts, B.C., Macdonald, S.G., Ross, R., Krebs, E.G., 1993. Protein-kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen activated protein kinase in human arterial smooth muscle cells. Proc. Natl. Acad. Sci. USA 90, 300-304.
45. Green, J.C., Jones, B.C., Reed, G.A., 1994. Effects of sulfite on the uptake and binding of benzo(a)pyrene diol epoxide in cultured murine respiratory epithelial cells. Environ. Health Perspec. 102, 216-220.
46. Guan, X., Hardenbrook, J., Fernstrom, M.J., Chaudhuri, R., Malkinson, A.M., Ruch, R.J., 1995. Downregulation by butylated hydroxytoluene of the number and function of gap junctions in epithelial cell lines derived from mouse lung and rat liver. Carcinogenesis 16, 2575-2582.
47. Haley, B.E., 1977. Adenosine 3′-5′ cyclic monophosphate binding sites. Meth. Enzymol. 46, 339-346.
48. Hanson, L.A., Nuzum, E.O., Jones, B.C., Malkinson, A.M., Beer, D.G., 1991. Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and cell lines. Exp. Lung Res. 17, 371-387.
49. Harrison, J.H., Hoyt, D.G., Lazo, J.S., 1989. Acute pulmonary toxicity of bleocycin. DNA scission and matrix protein messenger RNA levels in a bleomycin-sensitive and bleomycin-resistant strain of mice. Mol. Pharmacol. 36, 231-238.
50. Hawk, M.A., Cesen, K.T., Sigler, J.C., Stoner, G.D., Ruch, R.J., 1996. Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin. Cancer Lett. 109, 1-6.
51. ink4b in mouse lung tumor cell lines. Oncogene. 13, 1885-1891.
52. Herzog, C.R., Wiseman, R.W., You, M., 1994. Deletion mapping of putative tumor suppressor gene on chromosome 4 in mouse lung tumors. Cancer Res. 54, 4007-4010.
53. Horio, Y., Schrump, D.S., Chen, A., Rice, P., Malkinson, A.M., Roth, J.A., 1996. K-ras and p53 mutations are early and late events, respectively, in urethane induced pulmonary carcinogenesis. Molec. Carcinog. 17, 217-223.
54. Ikeda, K., Clark, J.C., Bachurski, C.J., Wikenheiser, K.A., Cuppoletti, J., Mohanti, S., Morris, R.E., Whitsett, J.A., 1994. Immortalization of subpopulations of respiratory epithelial cells from transgenic mice bearing SV40 large T antigen. Am. J. Physiol. Lung Cell Mol. Physiol. 267, L309-L317.
55. Ichikawa, T., Yano, Y., Ochida, M., Otani, S., Hagiwana, K., Yano, T., 1996. The activation of the K-ras gene at an early stage of lung tumorigenesis in mice. Cancer Lett. 107, 165-170.
56. 2 microglobulin and antigenic peptides. J. Immunol. 151, 2964-2985.
57. Jetten, A.M., Nervi, C., Vollberg, T.M., 1992. Control of differentiation in tracheobronchial and epidermal epithelial cells: role of retinoids. JNCI Monograph 13, 93-100.
58. Johnson, T.A., Li, J., Beer, D.G., 1996. Influence of the glucocorticoid receptor on c-fos inducibility in activated raj-containing mouse lung cells. Molec. Carcinog. 17, 70-77.
59. Kauffman, S.L., 1981. Histogenesis of the papillary Clara cell adenoma. Am. J. Pathol. 103, 174-180.
60. Kennel, S.J., 1979. Characterization of a tumor cell surface protein with heterologous antisera to a spontaneous BALB/C lung carcinoma. Cancer Res. 39, 2934-2939.
61. Kennel, S.J., Foote, L.J., Flynn, K.M., 1986. Tumor antigens on benign adenomas and on murine lung carcinomas quantitated by a two-site monoclonal antibody assay. Cancer Res. 46, 707-712.
62. Kishimoto, A., Mikawa, K., Hashimoto, K., Yasuda, I., Tanaka, S., Tominaga, M., Kuruda, T., Nishizuka, Y., 1989. Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J. Biol. Chem. 264, 4088-4092.
63. 2 microglobulin by interferon γ. EMBO J. 8, 475-481.
64. Kumar, R.K, Li, W., O'Grady, R., 1995. Maintenance of differentiated phenotype by mouse type 2 pneumocytes in serum-free primary culture. Exp. Lung Res. 21, 79-94.
65. Lange-Carter, C.A., 1991. Alterations in the cAMP Signal Transduction Pathway in Mouse Lung Tumorigenesis. Ph.D. Thesis, University of Colorado.
66. 32P]-GTP into GSa from metastatic variants of B16 melanoma cells. Cancer Res. 49, 3173-3177.
67. Lange-Carter, C.A., Droms, K.A., Vuillequez, J.J., Malkinson, A.M., 1992. Differential responsiveness to agents which stimulate cAMP production in normal versus neoplastic mouse lung epithelial cells. Cancer Lett. 67, 139-144.
68. Lange-Carter, C.A., Fossli, T., Jahnsen, T., Malkinson, A.M., 1990. Decreased expression of the type I isozyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin. J. Biol. Chem. 265, 7814-7818.
69. Lange-Carter, C.A., Malkinson, A.M., 1991a. Altered regulation of mRNA levels encoding the type I isozyme of cAMP-dependent protein kinase in neoplastic mouse lung epithelial cells. J. Biol. Chem. 266, 22529-22536.
70. Lange-Carter, C.A., Malkinson, A.M., 1991b. Alterations in the cAMP signal transduction pathway in mouse lung tumorigenesis. Exp. Lung Res. 17, 341-358.
71. Lange-Carter, C.A., Malkinson, A.M., 1991c. Differential regulation of the stability of cAMP-dependent protein kinase mRNA in normal vs neoplastic mouse lung epithelial cells. Cancer Res. 51, 6699-6703.
72. Lange-Carter, C.A., Vuillequez, J.J., Malkinson, A.M., 1993. 8-Cl-adenosine mediates 8-Cl-cAMP induced down-regulation of cAMP-dependent protein kinase in normal and neoplastic mouse lung epithelial cells by a cAMP-independent mechanism. Cancer Res. 53, 393-401.
73. Lavinguer, A., Maltby, V., Mock, D., Rossart, J., Paulson, T., Bernstein, A., 1989. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol. Cell. Biol. 9, 3982-3991.
74. Layton, M.G., Franks, L.M., 1984. Heterogeneity in a spontaneous mouse lung carcinoma: selection and characterization of stable metastatic variants. Br. J. Cancer 49, 415-421.
75. Layton, M.G., Franks, L.M., 1986. Selective suppression of metastasis but not tumorigenicity of a mouse lung carcinoma by cell hybridization. Int. J. Cancer 37, 723-730.
76. Lee, M.J., Dinsdale, D., 1995. The subcellular distribution of NADPH-cytochrome P450 reductase and isoenzymes of cytochrome-P450 in the lungs of rats and mice. Biochem. Pharmacol. 49, 1387-1394.
77. Leigh, D.A., Ferguson, V., Bentel, J.M., Miller, J.O., Smith, G.J., 1990. Activated K-ras proto-oncogene in spontaneously transformed and chemical tumor derived cell lines related to the mouse lung alveologenic carcinoma. Molec. Carcinog. 3, 387-392.
78. Leslie, C.C., McCormick-Shannon, K., Mason, R.J., Shannon, J.M., 1993. Proliferation of rat alveolar epithelial cells in low density primary culture. Am. J. Resp. Cell Mol. Biol. 9, 64-72.
79. Levine, A., Momand, J., 1990. Tumor suppresser genes: the p53 and retinoblastoma sensitivity genes and gene products. Biochim. Biophys. Acta 1032, 119-136.
80. Levitt, R.C., 1994. Molecular genetic methods for mapping disease genes. Am. Resp. Crit. Care Med. 150, 594-599.
81. Li, E.E., Heflich, R.H., Bucci, T.J., Manjanatha, M.G., Blaydes, B.S., Delclos, K.B., 1994. Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice. Carcinogenesis 15, 1377-1385.
82. Li, J., Beer, D.G., 1993. Ki-ras mRNA regulation in untransformed mouse lung cells. Molec. Carcinog. 8, 193-201.
83. Li, J., Beer, D.G., 1995. Effect of increased glucocorticoid responsiveness in transfected mouse lung cells. Molec. Carcinog. 13, 135-145.
84. Li, J., Johnson, T.A., Hanson, L.A., Beer, D.G., 1996. Loss of glucocorticoid-dependent growth inhibition in transfected mouse lung cells. Molec. Carcinog. 16, 213-220.
85. Lindenschmidt, R.C., Margaretten, N., Griesemer, R.A., Witschi, H.P., 1986. Modification of lung tumor growth by hyperoxia. Cancer Res. 7, 1581-1586.
86. Malkinson, A.M., 1989. The genetic basis of susceptibility to lung tumors in mice. Toxicology 54, 241-271.
87. Malkinson, A.M., 1991. Genetic studies on lung tumor susceptibility and histogenesis in mice. Environ. Health Perspec. 93, 149-159.
88. Malkinson, A.M., 1992. Primary lung tumors in mice: An experimentally manipulable model of human adenocarcinoma. Cancer Res. 52, 2670s-2676s.
89. Malkinson, A.M., Beer, D.S., 1984. Pharmacologic and genetic studies on the modulatory effects of butylated hydroxytoluene on mouse lung adenoma formation. J. Natl. Cancer Inst. 73, 925-933.
90. Malkinson, A.M., Beer, D.S., Sadler, A.J., Coffman, D.S., 1985a. A decrease in the protein kinase C-catalyzed phosphorylation of an endogenous 36K lung protein following treatment of mice with the tumor modulatory agent, butylated hydroxytoluene. Cancer Res. 45, 5751-5756.
91. Malkinson, A.M., Nesbitt, M.N., Skamene, E., 1985b. Susceptibility to urethan-induced pulmonary adenomas between A/J and C57BL/6J mice: use of AXB and BXA recombinant inbred lines indicating a three-locus genetic model. J. Natl Cancer Inst. 75, 971-974.
92. Malkinson, A.M., Belinsky, S.A., 1996. The use of animal models in preclinical studies. In: Pass, H.L., Mitchell, J.B., Johnson, D.H., Turrisi, A.T. (Eds.), Lung Cancer: Principles and Practice, Lippincott-Raven, Philadelphia, pp. 273-284.
93. Malkinson, A.M., Conway, K., Bartlett, S., Butley, M.S., Conroy, C., 1984. Strain differences among inbred mice in protein kinase C activity. Biochem. Biophys. Res. Commun. 122, 492-498.
94. Malkinson, A.M., Girard, P.R., Kuo, J.F., 1987. Strain-specific postnatal changes in the activity and tissue levels of protein kinase C. Biochem. Biophys. Res. Commun. 145, 733-739.
95. Malkinson, A.M., Miley, F.B., Chichester, C.H., Plopper, C.G., 1993. Isolation of nonciliated bronchiolar (Clara) epithelial cells from mouse lung. In: Tyson, C.A., Frazier, J.M. (Eds.), In Vitro Biological Systems, Meth. Toxicol. IA, pp. 123-133.
96. Malkinson, A.M., Siegel, D., Forrest, G.L., Gazdar, A.F., Oie, H.K., Chan, D.C., Bunn, P.A., Mabry, M., Dykes, D.J., Harrison, S.D. Jr., Ross, D., 1992. Elevated DT-diaphorase activity and mRNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin C. Cancer Res. 52, 4754-4757.
97. Malkinson, A.M., Thaete, L.G., Blumenthal, E.J., Thompson, J.A., 1989. Evidence for an obligatory role of tert -butyl hydroxylation on the induction of pneumotoxicity in mice by butylated hydroxytoluene (BHT). Toxicol. Appl. Pharmacol. 101, 196-204.
98. Markus, I., Smith, G.J., 1990. Cytogenetic profile of in vitro spontaneously transformed and chemical tumor-derived cell lines related to the mouse lung alveologenic carcinoma. Cancer Res. 50, 164-168.
99. Martin, F.M., Witschi, H.P., 1985. Cadmium-induced lung injury: cell kinetics and long-term effects. Toxicol. Appl. Pharmacol. 80, 215-227.
100. Mason, R.J., Williams, M.C., Brandt, A.E., Widdicombe, J.H., Sanders, M., Misfeldt, D.S., Berry, L., 1982. Transepithelial transport by pulmonary alveolar type II cells in primary culture. Proc. Natl. Acad. Sci. USA 79, 6033-6037.
101. Massey, T.E., Geddes, B.A., Forkert, P.G., 1987. Isolation of nonciliated bronchiolar epithelial (Clara) cells and alveolar type II cells from mouse lungs. Can J. Physiol Pharmacol. 65, 2368-2374.
102. Miller, A.C.K., Dwyer, L.D., Auerbach, C.E., Miley, F.B., Dinsdale, D., Malkinson, A.M., 1994. Strain-related differences in the pneumotoxic effects of chronically-administered butylated hydroxytoluene on protein kinase C and calpain. Toxicology 90, 141-159.
103. Miller, A.C.K., Dwyer, L.D., Malkinson, A.M., 1995. Very early changes in pulmonary protein kinase Ca and calpain II contents following injection of butylated hydroxytoluene into mice. Toxicology 97, 141-149.
104. Miyashita, N., Moriwaki, K., 1987. H-2 controlled genetic susceptibility to pulmonary adenomas induced by urethane and 4-nitro-quinoline-1-oxide in A/Wy congenic strains. Jpn. J. Cancer 78, 494-498.
105. Moran, J.L., Siegel, D., Sun, X.-M., Ross, D., 1996. Induction of apoptosis by benzene metabolites in HL60 and CD34+ human bone marrow progenitor cells. Molec. Pharmacol. 50, 610-615.
106. Morris, C.M., Smith, G.J., 1992. Altered levels and protein kinase C-mediated phosphorylation of substrates in normal and transformed mouse lung epithelial cells. Exp. Cell. Res. 200, 149-155.
107. Neighbors, B.W., Lange-Carter, C.A., Malkinson, A.M., 1992. 8-Chloro-adenosine treatment of lung epithelial cells decreases the content of K-ras protein and inhibits growth. Mol. Biol. Cell. 3, 24a.
108. Nicks, K.M., Droms, K.A., Fossli, T., Malkinson, A.M., 1989. Altered functions of protein kinase C and cyclic AMP-dependent protein kinase in a cell line derived from a mouse lung tumor. Cancer Res. 49, 5191-5198.
109. Nuzum, E.O., Malkinson, A.M., Beer, D.G., 1990. Specific K-ras codon 61 mutations may determine the development of mouse lung adenomas or adenocarcinomas. Molec. Carcinog. 3, 287-295.
110. Oomen, L.C.J.M., Calafat, J., Ten Have-Opbroek, A.A.W., Egberts, J., Demant, P., 1992. Derivation of tumorigenic and non-tumorigenic mouse alveolar type-II cell lines from fetal type II cells after a combined in vivo/in vitro carcinogen treatment. Int. J. Cancer 52, 290-297.
111. Oomen, L.C.J.M., Demant, P., Hart, A.A.M., Emmelot, P., 1983. Multiple genes in the H-2 complex affect differently the number and growth rate of transplacentally induced lung tumors in mice. Int. J. Cancer 31, 447-454.
112. Oreffo, V.I.C., Malkinson, A.M., 1995. Decreased expression of MCC (mutated in colorectal cancer) and APC (adenomatous polyposis coli) tumor suppressor genes in urethane-induced mouse lung tumours. Proc. Am. Assoc. Cancer Res. 36, 191.
113. Oreffo, V.I.C., Morgan, A., Richards, R.J., 1990. Isolation of Clara cells from the mouse lung. Envir. Health Perspect. 85, 51-64.
114. Paigen, K., 1995. A miracle enough: the power of mice. Nature Med. 1, 215-220.
115. Pan, Y.H.L., Nuzum, E.O., Hanson, L.A., Beer, D.G., 1990. K-ras activation and expression in transformed mouse lung cell lines. Molec. Carcinog. 3, 279-286.
116. Parsa, I., Kauffman, S.L., 1983. Malignant Clara cell line derived from ethylnitrosourea-induced murine lung adenoma. Cancer Lett. 1, 311-316.
117. Polly, P., Nicholson, R.C., 1994. High levels of c-myc gene expression precede point mutational activation of Ki-ras in mouse lung cancer. Cancer Lett. 76, 87-92.
118. Prehn, R.T., 1962. Specific isoantigenicities among chemically induced tumors. Ann. N.Y. Acad. Sci. 101, 107-113.
119. Prestera, T., Holtzclaw, W.D., Zhang, Y.S., Talalay, P., 1993. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc. Natl. Acad. Sci. USA 90, 2965-2969.
120. Rapp, U.R., Todaro, G.J., 1980. Generation of oncogenic mouse type C viruses: In vitro selection of carcinoma-inducing variants. Proc. Natl. Acad. Sci. USA 77, 624-628.
121. Reiners, J.J. Jr., Cantu, A.R., Pavone, A., Smith, S.C., Gardner, C.R., Laskin, D.C., 1990. Flourescence assay for per-cell estimation of cytochrome P-450-dependent monooxygenase activity in keratinocyte suspensions and cultures. Anal. Biochem. 188, 317-324.
122. Reiners, J.J. Jr., Pavone, A., Cantu, A.R., Auerbach, C., Malkinson, A.M., 1992. Expression of cytochrome P-450 in proliferating and quiescent cultures of murine lung epithelial cells. Biochem. Biophys. Res. Commun. 183, 193-198.
123. Rice, P.L., Dwyer-Nield, L.D., Miller, A.C.K., Kazlauskas, A., Malkinson, A., 1996. Reduced concentrations of signal transducing effector molecules in multistage carcinogenesis in mice. Proc. Amer. Assoc. Cancer Res. 37, 51.
124. Rizzino, A., Gonda, M.A., Rapp, U.R., 1982. Dome formation by a retrovirus-induced lung adenocarcinoma cell line. Cancer Res. 42, 1881-1887.
125. Robbins, R.A., Sisson, J.H., Springall, D.R., Nelson, K.J., Taylor, J.A., Mason, N.A., Polak, J.M., Townley, R.G., 1997. Human lung mononuclear cells induce nitric oxide synthase in murine airway epithelial cell in vitro: role of TNFa and IL-1β. Am. J. Respir. Crit. Care Med. 155, 268-273.
126. Robbins, R.A., Springall, D.R., Warren, J.B., Kwon, O.J., Buttery, L.D.K., Wilson, A.J., Adcock, I.M., Riveros-Moreno, V., Moncada, S., Polak, J., Barnes, P.B., 1994. Inducible nitric oxide synthase is increased in murine lung epithelial cells by cytokine stimulation. Biochem. Biophys. Res. Commun. 198, 835-843.
127. Roger, P.P., Reuse, S., Maenhaut, C., Dumont, J., 1995. Multiple facets of modulation of growth by cyclic AMP. Vit. Horm. 51, 59-101.
128. Ross, D., Beall, H., Traver, R.D., Siegel, D., Phillips, R.M., Gibson, N.W., 1994. Bioactivation of quinones by DT-diaphorase. Molecular, biochemical and chemical studies. Oncol. Res. 6, 493-500.
129. Sandberg, M., Skalhegg, B., Jahnsen, T., 1990. The two mRNA forms for the type Iα regulatory subunit of cAMP-dependent protein kinase from human testis are due to the use of different polyadenylation site signals. Biochem. Biophys. Res. Commun. 167, 323-330.
130. Sandgren, E.P., Quaife, C.J., Pinkert, C.A., Palmiter, R.D., Brinster, R.L., 1989. Oncogene-induced liver neoplasia in transgenic mice. Oncogene 4, 715-724.
131. Sandmoller, A., Halter, R., Suske, G., Paul, D., Beato, M., 1995. A transgenic mouse model for lung adenocarcinoma. Cell Growth Diff. 6, 97-103.
132. Schrump, D.S., Chen, A., Consoli, U., 1997. Inhibition of lung cancer proliferation by antisense cyclin D. Clin. Cancer Res. 3, 131-135.
133. Scott, J.D., McCartney, S., 1994. Localization of A-kinase through anchoring proteins. Molec. Endocrinol. 8, 5-11.
134. Shannon, J.M., Jennings, S.D., Nielsen, L.D., 1992. Modification of alveolar type II differentiated function in vitro. Am. J. Physiol. Lung Cell Mol. Physiol. 262, L427-L436.
135. Sherr, C.J., 1995. D-type cyclins. Trends Biochem. Sci. 20, 187-190.
136. Sibelle, C., Gould, K., Hammerling, G., Townsend, A., 1992. A defect in the presentation of intracellular viral antigens is restored by interferon-y in cell lines with impaired major histocompatibility complex class I assembly. Eur. J. Immunol. 22, 433-440.
137. Siegel, D., Malkinson, A.M., Ross, D., 1988. Butylated hydroxytoluene (BHT)-mediated increases in NAD(P)H-quinone-oxidoreductase (QR) in mouse lung. Evidence for the alveolar type 2 cell as a site of QR activity. Toxicol. Appl. Pharmacol. 96, 68-74.
138. Smith, G.J., Bennett, F.A., Steele, J.G., Bentel, J.M., 1986. Onset of neoplastic phenotype in an epithelial cell strain from adult BALB/c mouse lung alveolus. J. Natl. Cancer Inst. 76, 73-79.
139. Smith, G.J., Lykke, A.W.J., 1985. Characterization of a neoplastic epithelial cell strain derived by dexamethasone treatment of cultured normal mouse type 2 pneumocytes. J. Pathol. 147, 165-172.
140. Smith, G.J., Morris, C., Leigh, D., Rhodes, G.G., Wong, A., 1991. EGF-receptor and extracellular matrix changes in mouse pulmomary carcinogenesis. Exp. Lung Res. 17, 327-340.
141. Stanley, L., 1995. Molecular aspects of chemical carcinogenesis - the role of oncogenes and tumor suppressor genes. Toxicology 96, 175-194.
142. Steele, J.G., Dalton, B.A., Underwood, P.A., Smith, G.J., 1991. Differences in adhesion to tissue culture plastic of clonally related transformed and control subline from an epithelial cell strain. J. Cell Sci. 100, 195-203.
143. Steele, J.G., Rowlatt, C., Sandall, J.K., Franks, L.M., 1983. Cell surface properties of high and low metastatic cell lines selected from a spontaneous mouse lung carcinoma. Int. J. Cancer 32, 769-779.
144. Steele, J.G., Savolainen, T.A., Dalton, B.A., Smith, L.A., Smith, G.J., 1990. Adhesion to laminin and expression of laminin in clonally-related transformed and control sublines from an alveolar epithelial cell strain. Cancer Res. 50, 3383-3389.
145. Steele, J.G., Savolainen, T.A., Smith, G.J., 1988. Expression of fibronectin on clonally related transformed and control sublines from an epithelial cell strain and a tumor line of mouse alveolus. Cancer Res. 48, 4933-4940.
146. Stewart, H.L., Dunn, T.B., Snell K.C., Deringer, M.K., 1979. Tumors of the Respiratory Tract. In: Turusov, V.S. (Ed.), Pathology of Tumors in Laboratory Animals, Vol. II, Tumors of the Mouse, IARC, Lyon, pp. 251-288.
147. Stone, S., Jiang, P., Dayawath, P., Tavtigian, S.V., Katcher, H., Parry, D., Peters, G., Kamb, A., 1995. Complex structure and regulation of the p16 (MTS1) locus. Cancer Res. 55, 2988-2994.
148. Stoner, G.D., Hallman, M., Troxell, M.C., 1978. Lecithin biosynthesis in a clonal line of lung adenoma cells with type II alveolar cell properties. Exp. Mol. Pathol. 29, 102-114.
149. Stoner, G.D., Kikkawa, Y., Kniazeff, A.J., Miyai, K., Wagner, R.M., 1975. Clonal isolation of epithelial cells from mouse lung adenoma. Cancer Res. 35, 2177-2185.
150. Suda, X., Aizawa, S., Hirai, S., Inoue, T., Furuta, Y., Suzuki, M., Ikawa, Y., 1987. Driven by the same Ig enhancer and SV40 T promoter ras induced lung adenomatous tumors, myc-induced pre-B cell lymphomas and SV40 large T gene induced a variety of tumors in transgenic mice. EMBO J. 6, 4055-4065.
151. Thaete, L.G., Ahnen, D.J., Malkinson, A.M., 1989. Proliferating cell nuclear antigen (PCNA/cyclin) immunocytochemistry as a labeling index in mouse lung tissues. Cell Tissue Res. 256, 167-173.
152. Thaete, L.G., Siegel, D., Malkinson, A.M., Ross, D., 1991. NAD(P)H: quinone oxidoreductase (DT-Diaphorase) activities in normal and neoplastic mouse lung epithelia. Int. J. Cancer 49, 145-149.
153. Thompson, D.C., Battaglia, T., Dwyer, L., Malkinson, A.M., 1995. Mouse lung epithelial cell lines vary in their ability to generate nitric oxide in response to cytokines. Am. J. Resp. Crit. Care 151, A176.
154. Thompson, D.C., Nguyen, C., Nieusma, J.L., Malkinson, A.M., 1996. Regulation of nitric oxide toxicity in lung epithelial cells. Am. J. Resp. Crit. Care Med. 153, A175.
155. Thompson, D.C., Nguyen, C., Malkinson, A.M., 1997. Nitric oxide toxicity in normal and neoplastic murine lung epithelial cells. Am. J. Resp. Crit. Care Med. 155, A826.
156. Thompson, J.A., Schullek, K.M., Fernandez, C.A., Malkinson, A.M., 1989. A metabolite of butylated hydroxytoluene with potent tumor promoting activity in mouse lung. Carcinogenesis 10, 773-775.
157. Tolwinski, N. S., Kano-Sueoka, T., 1997. Hyaluronidase generates a single-cell suspension from cultured mouse lung epithelial cells. Biotechniques 22, 856-860.
158. Tremblay, P.J., Pothier, F., Hoang, J., Tremblay, G., Brownstein, S., Liszauer, A., Jolicoeur, P., 1989. Transgenic mice carrying the MMTV ras fusion gene: distinct effects in various tissues. Mol. Cell Biol. 9, 854-859.
159. Trosko, J.E., Chang, C.C., Madhukar, B.V., Klaunig, J.E., 1990. Chemical, oncogene and growth factor inhibition of gap junctional intercellular communication: an integrative hypothesis of carcinogenesis. Pathobiology 58, 265-278.
160. Walker, S.R., Hale, S., Malkinson, A.M., Mason, R.J., 1989. Properties of isolated non-ciliated bronchiolar cells from mouse lung. Exp. Lung Res. 15, 553-573.
161. Wattenberg, L.W., Estenson, R.D., 1996. Chemopreventative effects of myo-inositol and dexamethasone on benzo[a]pyrene and 4-(methylnitrosoamino)-1-butanone-induced pulmonary carcinogenesis in female A/J mice. Cancer Res. 56, 5132-5135.
162. Wikenheiser, K.A., Clark, J.C., Linnoila, I., Stahlman, M.T., Whitsett, J.A., 1992. Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res. 52, 5342-5352.
163. Wikenheiser, K.A., Vorbroker, D.K., Rice, W.R., Clark, J.C., Bachurski, C.J., Oie, H.K., Whitsett, J.A., 1993. Production of immortalized distal respiratory epithelial cell lines from surfactant protein C/simian virus 40 large tumor antigen transgenic mice. Proc. Natl. Acad. Sci. USA 90, 11029-11033.
164. Witschi, H., Williamson, D., Lock, S., 1977. Enhancement of urethan tumorigenesis in mouse lung by butylated hydrosytoluene. J. Natl. Cancer Inst. 58, 301-305.
165. Wu, M.-C., Sundaresan, V., Sundaresan, M., Rabbits, P., 1997. Genome wide search for genetic damage in p53 transgenic mouse lung tumors reveals consistent loss of chromosome 4. Eur. J. Cancer, in press.
166. You, M., Candrian, U., Maronpot, R.R., Stoner, G.D., Anderson, M.W., 1989. Activation of the Ki-ras protooncogene in spontaneously occurring and chemically-induced lung tumors of the strain A mouse. Proc. Natl. Acad. Sci. USA 86, 3070-3074.
167. Young, S., Parker, P.J., Ulrich, A., Stabel, S., 1987. Down-regulation of protein kinase C is due to an increased rate of degradation. Biochem. J. 244, 775-779.
168. Yuhas, J.M., Pazmino, N.H., 1974. Inhibition of subcutaneously growing line 1 carcinomas due to metastatic spread. Cancer Res. 34, 2005-2010.
169. Yuhas, J.M., Pazmino, N.H., Proctor, J.O., Toya, R.E., 1974. A direct relationship between immune competence and the subcutaneous growth rate of a malignant murine lung tumor. Cancer Res. 34, 722-728.
170. Yuhas, J.M., Pazmino, N.H., Wagner, E., 1975a. Development of concomitant immunity in mice bearing the weakly immunogenic line 1 lung carcinoma. Cancer Res. 35, 237-241.
171. Yuhas, J.M., Toya, R.E., Wagner, E., 1975b. Specific and non-specific stimulation of resistance to the growth and metastasis of the line 1 lung carcinoma. Cancer Res. 35, 242-244.