STAT3 protein interacts with class O forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4+ T cells

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30436-30443

  Oh, Hyun Mee ^a,b   Yu, Cheng Rong ^a   Dambuza, Ivy ^a   Marrero, Bernadette ^a   Egwuagu, Charles E ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE IMMUNE RESPONSE; ANTI-INFLAMMATORIES; CYTOKINES; FORKHEAD TRANSCRIPTIONS; IMMUNE RESPONSE; INFLAMMATORY RESPONSE; LYMPHOCYTE PROLIFERATION; NUCLEAR LOCALIZATION; SUBCELLULAR LOCATION; T CELL ACTIVATION; T CELL PROLIFERATION; T CELLS;

CELL PROLIFERATION; CYTOLOGY; ELECTRIC REACTORS; IMMUNOLOGY; TRANSCRIPTION FACTORS;

CELLS;

CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; INTERLEUKIN 10; INTERLEUKIN 6; PROTEIN 14 3 3; STAT3 PROTEIN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; INTRACELLULAR TRANSPORT; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; T LYMPHOCYTE ACTIVATION;

14-3-3 PROTEINS; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL NUCLEUS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYTOKINES; CYTOPLASM; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL; STAT3 TRANSCRIPTION FACTOR;

EID: 84865738382     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.359661     Document Type: Article

References (29)

1. Liu, J. O. (2005) The yins of T cell activation. Sci. STKE 2005, re1
2. Coffer, P. J., and Burgering, B. M. (2004) Forkhead-box transcription factors and their role in the immune system. Nat. Rev. Immunol. 4, 889-899
3. Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., and Greenberg, M. E. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868
4. Lin, L., Hron, J. D., and Peng, S. L. (2004) Regulation of NF-κB, Th activation, and autoinflammation by the Forkhead transcription factor FoxO3a. Immunity 21, 203-213
5. Kip1 and Bim in response to IL-2. J. Immunol. 168, 5024-5031
6. Silhan, J., Vacha, P., Strnadova, P., Vecer, J., Herman, P., Sulc, M., Teisinger, J., Obsilova, V., and Obsil, T. (2009) 14-3-3 protein masks the DNA binding interface of Forkhead transcription factor FoxO4. J. Biol. Chem. 284, 19349-19360
7. Dijkers, P. F., Medema, R. H., Pals, C., Banerji, L., Thomas, N. S., Lam, E. W., Burgering, B. M., Raaijmakers, J. A., Lammers, J. W., Koenderman, L., and Coffer, P. J. (2000) Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27Kip1. Mol. Cell. Biol. 20, 9138-9148
8. Kaplan, M. H., Daniel, C., Schindler, U., and Grusby, M. J. (1998) STAT proteins control lymphocyte proliferation by regulating p27Kip1 expression. Mol. Cell. Biol. 18, 1996-2003
9. H1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7, 425-428
10. Darnell, J. E., Jr. (1997) STATs and gene regulation. Science 277, 1630-1635
11. Levy, D. E., and Darnell, J. E., Jr. (2002) Nat. Rev. Immunol. 3, 651-662
12. Mertens, C., and Darnell, J. E., Jr. (2007) SnapShot: JAK-STAT signaling. Cell 131, 612
13. Meyer, T., and Vinkemeier, U. (2004) Nucleocytoplasmic shuttling of STAT transcription factors. Eur. J. Biochem. 271, 4606-4612
14. Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E., and Stark, G. R. (2007) Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB. Genes Dev. 21, 1396-1408
15. Gao, S. P., and Bromberg, J. F. (2006) Touched and moved by STAT3. Sci. STKE 2006, pe30
16. Ng, D. C., Lin, B. H., Lim, C. P., Huang, G., Zhang, T., Poli, V., and Cao, X. (2006) STAT3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J. Cell Biol. 172, 245-257
17. Oh, H. M., Yu, C. R., Golestaneh, N., Amadi-Obi, A., Lee, Y. S., Eseonu, A., Mahdi, R. M., and Egwuagu, C. E. (2011) STAT3 protein promotes T cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. J. Biol. Chem. 286, 30888-30897
18. + T cells prevents development of experimental autoimmune diseases. J. Immunol. 180, 6070-6076
19. Amadi-Obi, A., Yu, C. R., Liu, X., Mahdi, R. M., Clarke, G. L., Nussenblatt, R. B., Gery, I., Lee, Y. S., and Egwuagu, C. E. (2007) Th17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/ STAT1. Nat. Med. 13, 711-718
20. Egwuagu, C. E., Yu, C. R., Zhang, M., Mahdi, R. M., Kim, S. J., and Gery, I. (2002) Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance. J. Immunol. 168, 3181-3187
21. Zhao, X., Gan, L., Pan, H., Kan, D., Majeski, M., Adam, S. A., and Unterman, T. G. (2004) Multiple elements regulate nuclear/cytoplasmic shuttling of FoxO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. Biochem. J. 378, 839-849
22. Zhang, J., Chen, F., Li, W., Xiong, Q., Yang, M., Zheng, P., Li, C., Pei, J., and Ge, F. (2012) 14-3-3ζ interacts with STAT3 and regulates its constitutive activation in multiple myeloma cells. PLoS One 7, e29554
23. Fitzgerald, D. C., Zhang, G. X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C. J., Gran, B., Ciric, B., and Rostami, A. (2007) Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372-1379
24. Awasthi, A., Carrier, Y., Peron, J. P., Bettelli, E., Kamanaka, M., Flavell, R. A., Kuchroo, V. K., Oukka, M., and Weiner, H. L. (2007) A dominant function for interleukin 27 in generating interleukin 10-producing antiinflammatory T cells. Nat. Immunol. 8, 1380-1389
25. Murray, P. J. (2005) The primary mechanism of the IL-10-regulated anti-inflammatory response is to selectively inhibit transcription. Proc. Natl. Acad. Sci. U.S.A. 102, 8686-8691
26. Murray, P. J. (2006) STAT3-mediated anti-inflammatory signalling. Biochem. Soc. Trans. 34, 1028-1031
27. Yu, C. R., Lee, Y. S., Mahdi, R. M., Surendran, N., and Egwuagu, C. E. (2012) Therapeutic targeting of STAT3 (signal transducers and activators of transcription 3) pathway inhibits experimental autoimmune uveitis. PLoS One 7, e29742
28. Stumhofer, J. S., Silver, J. S., Laurence, A., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J., O'Shea, J. J., and Hunter, C. A. (2007) Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10. Nat. Immunol. 8, 1363-1371
29. Obsil, T., and Obsilova, V. (2008) Structure/function relationships underlying regulation of FOXO transcription factors. Oncogene 27, 2263-2275