Inhibition of c-jun N-terminal kinase prevents blood-brain barrier disruption and normalizes the expression of tight junction proteins clautin-5 and ZO-1 in a rat model of subarachnoid hemorrhage

Acta Neurochirurgica

Volumn 154, Issue 8, 2012, Pages 1469-1476

  Chen, Duo ^a   Wei, Xiang Tai ^a   Guan, Jun Hong ^a   Yuan, Jiang Wei ^a   Peng, Yu Tao ^a   Song, Lei ^a   Liu, Yun Hui ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Claudin 5; JNK; Subarachnoid hemorrhage; Tight junction; ZO 1

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CLAUDIN 5; ISOENZYME; JANUS KINASE 1; JANUS KINASE 3; PROTEIN ZO1; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ELECTRON MICROSCOPY; ENZYME ACTIVITY; ENZYME INHIBITION; HISTOPATHOLOGY; MALE; MORTALITY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; WESTERN BLOTTING;

ANIMALS; ANTHRACENES; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN; CLAUDIN-5; DISEASE MODELS, ANIMAL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84865721141     PISSN: 00016268     EISSN: 09420940     Source Type: Journal    
DOI: 10.1007/s00701-012-1328-y     Document Type: Article

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