Differential Proteomics and Functional Research following Gene Therapy in a Mouse Model of Leber Congenital Amaurosis

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Zheng, Qinxiang ^a   Ren, Yueping ^a   Tzekov, Radouil ^b   Zhang, Yuanping ^c   Chen, Bo ^d   Hou, Jiangping ^a   Zhao, Chunhui ^a   Zhu, Jiali ^a   Zhang, Ying ^a   Dai, Xufeng ^a   Ma, Shan ^e   Li, Jia ^e   Pang, Jijing ^a,f   Qu, Jia ^a   Li, Wensheng ^a,g  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b ROSKAMP INSTITUTE   (United States)

^c KUNMING MEDICAL UNIVERSITY   (China)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^g NATIONAL EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHA CRYSTALLIN; GLUCOSE OXIDASE; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; PEROXIREDOXIN 6; REACTIVE OXYGEN METABOLITE; RPE65 PROTEIN; UNCLASSIFIED DRUG; VISUAL PIGMENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; COHORT ANALYSIS; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; ELECTRORETINOGRAPHY; EYE MOVEMENT; GENE; IMMUNOFLUORESCENCE; LEBER CONGENITAL AMAUROSIS; MOUSE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEOMICS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETINA; RPE65 GENE; SUBRETINAL DRUG ADMINISTRATION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CIS-TRANS-ISOMERASES; COLOR VISION; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ELECTRORETINOGRAPHY; EYE PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC THERAPY; GLUCOSE OXIDASE; GREEN FLUORESCENT PROTEINS; HUMANS; HYDROGEN PEROXIDE; LEBER CONGENITAL AMAUROSIS; LENTIVIRUS; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; NIGHT VISION; PEROXIREDOXIN VI; PROTEOMICS; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION;

MUS;

EID: 84865660829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044855     Document Type: Article

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