Involvement of CtBP2 in LPS-induced microglial activation

Journal of Molecular Histology

Volumn 43, Issue 3, 2012, Pages 327-334

  Zhang, Guowei ^a   Yan, Yaohua ^b   Kang, Lihua ^a   Cao, Qi ^c   Ke, Kaifu ^b   Wu, Xinmin ^b   Gao, Yilu ^b   Hang, Qinglei ^a   Li, Chunmiao ^a   Zhu, Lin ^a   Yuan, Qin ^a   Wu, Qiyun ^a   Cheng, Chun ^a  

^a NANTONG MEDICAL COLLEGE   (China)

^b NANTONG UNIVERSITY   (China)

^c UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

CtBP2; Inflammatory; Lipopolysaccharide; Microglia

Indexed keywords

C TERMINAL BINDING PROTEIN 2; LIPOPOLYSACCHARIDE; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL PROLIFERATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; GENE SEQUENCE; GENE SILENCING; GLIA CELL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ASTROCYTES; BLOTTING, WESTERN; CELL LINE; EYE PROTEINS; GENE EXPRESSION; GENE SILENCING; INFLAMMATION; INJECTIONS, SPINAL; LIPOPOLYSACCHARIDES; MICROGLIA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPINAL CORD; TRANSFECTION;

RATTUS;

EID: 84865657787     PISSN: 15672379     EISSN: 15672387     Source Type: Journal    
DOI: 10.1007/s10735-012-9399-x     Document Type: Article

References (45)

1. Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801 (Pubitemid 43261452)
2. Amat JA, Ishiguro H, Nakamura K, Norton WT (1996) Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia 16:368-382 (Pubitemid 26309460)
3. Blander JM, Medzhitov R (2004) Regulation of phagosome maturation by signals from toll-like receptors. Science 304:1014-1018 (Pubitemid 38638100)
4. Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69 (Pubitemid 46011999)
5. Boyd JM, Subramanian T, Schaeper U, La Regina M, Bayley S, Chinnadurai G (1993) A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis. EMBO J 12:469-478 (Pubitemid 23073693)
6. Brannon M, Brown JD, Bates R, Kimelman D, Moon RT (1999) XCtBP is a XTcf-3 corepressor with roles throughout Xenopus development. Development 126:3159-3170 (Pubitemid 29378179)
7. Carmody RJ, Ruan Q, Palmer S, Hilliard B, Chen YH (2007) Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science 317:675-678 (Pubitemid 47229968)
8. Chao CC, Hu S, Peterson PK (1995) Glia, cytokines, and neurotoxicity. Crit Rev Neurobiol 9:189-205
9. Cheepsunthorn P, Radov L, Menzies S, Reid J, Connor JR (2001) Characterization of a novel brain-derived microglial cell line isolated from neonatal rat brain. Glia 35:53-62 (Pubitemid 32656753)
10. Chinnadurai G (2002) CtBP, an unconventional transcriptional corepressor in development and oncogenesis. Mol Cell 9: 213-224 (Pubitemid 34195548)
11. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999) The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 18:3316-3323 (Pubitemid 29286977)
12. Deconinck AE, Mead PE, Tevosian SG, Crispino JD, Katz SG, Zon LI, Orkin SH (2000) FOG acts as a repressor of red blood cell development in Xenopus. Development 127:2031-2040 (Pubitemid 30386668)
13. Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane T, Cheng G (2004) Toll like receptors induce a phagocytic gene program through p38. J Exp Med 199:81-90 (Pubitemid 38076480)
14. Felts PA, Woolston AM, Fernando HB, Asquith S, Gregson NA, Mizzi OJ, Smith KJ (2005) Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide. Brain 128:1649-1666 (Pubitemid 41373684)
15. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D (1993) The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 7:1354-1363 (Pubitemid 23210884)
16. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140:918-934
17. Hildebrand JD, Soriano P (2002) Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development. Mol Cell Biol 22:5296-5307 (Pubitemid 34755743)
18. Kato H, Takahashi A, Itoyama Y (2003) Cell cycle protein expression in proliferating microglia and astrocytes following transient global cerebral ischemia in the rat. Brain Res Bull 60:215-221 (Pubitemid 36561542)
19. Keutgens A, Shostak K, Close P, Zhang X, Hennuy B, Aussems M, Chapelle JP, Viatour P, Gothot A, Fillet M, Chariot A (2010) The repressing function of the oncoprotein BCL-3 requires CtBP, while its polyubiquitination and degradation involve the E3 ligase TBLR1. Mol Cell Biol 30:4006-4021
20. Kreutzberg GW (1996) Microglia: A sensor for pathological events in the CNS. Trends Neurosci 19:312-318 (Pubitemid 26349059)
21. Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S (2003) IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-alpha production in macrophages. Blood 102:4123-4129 (Pubitemid 37486997)
22. Lee KS, Yang WI (1992) Comparison of brain tumor growth kinetics by proliferating cell nuclear antigen (PCNA) and bromodeoxyuridine (BrdU) labeling. Yonsei Med J 33:265-271 (Pubitemid 23048486)
23. Leung TH, Hoffmann A, Baltimore D (2004) One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimmers. Cell 118:453-464 (Pubitemid 39485665)
24. Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (1999) Binding of CtIP to the BRCA1 repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J Biol Chem 274:11334-11338
25. Luo XG, Ding JQ, Chen SD (2010) Microglia in the aging brain: Relevance to neurodegeneration. Mol Neurodegener 5:12
26. Marik C, Felts PA, Bauer J, Lassmann H, Smith KJ (2007) Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity? Brain 130:2800-2815 (Pubitemid 350033973)
27. Merrill JE (1992) Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: Normal and pathological. Dev Neurosci 14:1-10
28. Morris GF, Mathews MB (1989) Regulation of proliferating cell nuclear antigen during the cell cycle. J Biol Chem 264:13856-13864 (Pubitemid 19198480)
29. Nguyen MD, Julien JP, Rivest S (2002) Innate immunity: The missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 3:216-227 (Pubitemid 135706591)
30. Olson JK, Miller SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple tlrs. J Immunol 173:3916-3924 (Pubitemid 39280755)
31. Postigo AA, Dean DC (1999) ZEB represses transcription through interaction with the corepressor CtBP. Proc Natl Acad Sci USA 96:6683-6688 (Pubitemid 29274943)
32. Raetz CR, Whitfield C (2002) Lipopolysaccharide endotoxins. Annu Rev Biochem 71:635-700 (Pubitemid 34800232)
33. Ransohoff RM, Perry VH (2009) Microglial physiology: Unique stimuli, specialized responses. Annu Rev Immunol 27:119-145
34. Rivieccio MA, John GR, Song X, Suh HS, Zhao Y, Lee SC, Brosnan CF (2005) The cytokine IL-1b activates IFN response factor 3 in human fetal astrocytes in culture. J Immunol 174:3719-3726 (Pubitemid 40354083)
35. Saijo K, Winner B, Carson CT, Collier JG, Boyer L, Rosenfeld MG, Gage FH, Glass CK (2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137:47-59
36. Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK (2011) An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell 145:584-595
37. Schaeper U, Boyd JM, Verma S, Uhlmann E, Subramanian T, Chinnadurai G (1995) Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation. Proc Natl Acad Sci USA 92:10467-10471
38. Shih YT, Hsu YY, Chang FR, Wu YC, Lo YC (2010) 6-Hydroxycleroda-3,13- dien-15,16-olide protects neuronal cells from lipopolysaccharide-induced neurotoxicity through the inhibition of microglia-mediated inflammation. Planta Med 76:120-127
39. Sofroniew MV, Vinters HV (2010) Astrocytes: Biology and pathology. Acta Neuropathol 119:7-35
40. Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139 (Pubitemid 35337371)
41. Trinchieri G, Sher A (2007) Cooperation of toll-like receptor signals in innate immune defence. Nat Rev Immunol 7:179-190
42. Wang J, Lee S, Teh CE, Bunting K, Ma L, Shannon MF (2009) The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells. Int Immunol 21:227-235
43. Wessells J, Baer M, Young HA, Claudio E, Brown K, Siebenlist U, Johnson PF (2004) BCL-3 and NF-kappaB p50 attenuate lipopolysaccharide-induced inflammatory responses in macrophages. J Biol Chem 279:49995-50003 (Pubitemid 39577809)
44. Yu X, Baer R (2000) Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor. J Biol Chem 275:18541-18549 (Pubitemid 30414816)
45. Zhou HF, Liu XY, Niu DB, Li FQ, He QH, Wang XM (2005) Triptolide protects dopaminergic neurons from inflammationmediated damage induced by lipopolysaccharide intranigral injection. Neurobiol Dis 18:441-449