Leptin-induced Cardiomyocyte Hypertrophy Reveals both Calcium-dependent and Calcium-independent/RhoA-dependent Calcineurin Activation and NFAT Nuclear Translocation

Cellular Signalling

Volumn 24, Issue 12, 2012, Pages 2283-2290

  Rajapurohitam, Venkatesh ^a   Izaddoustdar, Farzad ^a   Martinez Abundis, Eduardo ^a   Karmazyn, Morris ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Calcineurin; Cardiomyocyte hypertrophy; Intracellular calcium; Intracellular sodium; Leptin; P38 MAP kinase; RhoA ROCK

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA ACTIN; CALCINEURIN; CALCIUM ION; EXOENZYME C3; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SODIUM ION; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT3;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART MUSCLE CELL; HYPERTROPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; CALCINEURIN; CALCIUM; CARDIOMEGALY; CELL NUCLEUS; CELLS, CULTURED; LEPTIN; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCYTES, CARDIAC; NFATC TRANSCRIPTION FACTORS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE; TACROLIMUS; THIOUREA; TRANSLOCATION, GENETIC;

RATTUS;

EID: 84865628637     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.07.025     Document Type: Article

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