Ginseng (Panax quinquefolius) attenuates leptin-induced cardiac hypertrophy through inhibition of p115Rho guanine nucleotide exchange factor-RhoA/Rho- associated, coiled-coil containing protein kinase-dependent mitogen-activated protein kinase pathway activation

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 3, 2011, Pages 746-756

  Moey, Melissa ^a   Rajapurohitam, Venkatesh ^a   Zeidan, Asad ^b   Karmazyn, Morris ^a  

^a WESTERN UNIVERSITY   (Canada)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CARDIAC AGENT; COFILIN 2; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE P38; P115RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; P63RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; PANAX QUINQUEFOLIUS EXTRACT; PLANT EXTRACT; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; GENE EXPRESSION; GINSENG; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; NEWBORN; NONHUMAN; PANAX QUINQUEFOLIUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT;

ACTINS; ANIMALS; CARDIOMEGALY; CARDIOTONIC AGENTS; COFILIN 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEART VENTRICLES; HUMANS; LEPTIN; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANAX; PHOSPHORYLATION; PHYTOTHERAPY; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LEPTIN; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN;

EID: 81555204274     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.182600     Document Type: Article

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