Gender differences in chemical carcinogenesis in national toxicology program 2-year bioassays

Toxicologic Pathology

Volumn 40, Issue 8, 2012, Pages 1160-1168

  Kadekar, Sandeep ^a   Peddada, Shyamal ^b   Silins, Ilona ^a   French, John E ^b   Högberg, Johan ^a   Stenius, Ulla ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

2 year bioassay; carcinogens; gender; NTP; tumor

Indexed keywords

ANDROGEN RECEPTOR; CARCINOGEN; ESTROGEN RECEPTOR;

ANIMAL TISSUE; ARTICLE; BIOASSAY; BLADDER TUMOR; BONE MARROW TUMOR; CANCER INCIDENCE; CANCER LOCALIZATION; CHEMICAL CARCINOGENESIS; DATA BASE; DISEASE PREDISPOSITION; FEMALE; GENOTOXICITY; HYPOPHYSIS TUMOR; KIDNEY TUMOR; LEUKEMIA; LUNG TUMOR; LYMPHOMA; MALE; MESOTHELIUM; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE; SKIN TUMOR;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE SUSCEPTIBILITY; FEMALE; MALE; MICE; MICE, INBRED STRAINS; NEOPLASMS; RATS; RATS, INBRED STRAINS; SEX FACTORS;

RATTUS;

EID: 84865612164     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312446527     Document Type: Article

References (55)

1. Andersen M. E., Clewell H. J., Bermudez E., Dodd D. E., Willson G. A., Campbell J. L., Thomas R. S.. Formaldehyde: Integrating dosimetry, cytotoxicity, and genomics to understand dose-dependent transitions for an endogenous compound. Toxicol Sci. 2010 ; 118: 716-31
2. Anderson G. D.. Sex and racial differences in pharmacological response: Where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J Womens Health (Larchmt). 2005 ; 14: 19-29
3. Anisimov V. N., Ukraintseva S. V., Yashin A. I.. Cancer in rodents: does it tell us about cancer in humans?. Nat Rev Cancer. 2005 ; 5: 807-19
4. Birk T., Mundt K. A., Guldner K., Parsons W., Luippold R. S.. Mortality in the German porcelain industry 1985-2005: First results of an epidemiological cohort study. J Occup Environ Med. 2009 ; 51: 373-85
5. Brown D. F., Dababo M. A., Hladik C. L., Eagan K. P., White C. L., Rushing E. J.. Hormone receptor immunoreactivity in hemangioblastomas and clear cell renal cell carcinomas. Mod Pathol. 1998 ; 11: 55-59
6. Chandanos E., Lagergren J.. Oestrogen and the enigmatic male predominance of gastric cancer. Eur J Cancer. 2008 ; 44: 2397-403
7. Chatterjee B., Demyan W. F., Song C. S., Garg B. D., Roy A. K.. Loss of androgenic induction of alpha 2u-globulin gene family in the liver of NIH black rats. Endocrinology. 1989 ; 125: 1385-88
8. Cook M. B., Dawsey S. M., Freedman N. D., Inskip P. D., Wichner S. M., Quraishi S. M., Devesa S. S., McGlynn K. A.. Sex disparities in cancer incidence by period and age. Cancer Epidemiol Biomarkers Prev. 2009 ; 18: 1174-82
9. Edgren G., Liang L., Adami H. O., Chang E. T.. Enigmatic sex disparities in cancer incidence. Eur J Epidemiol. 2012 ; 27: 187-96
10. Feng Z., Hu W., Teresky A. K., Hernando E., Cordon-Cardo C., Levine A. J.. Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations. Proc Natl Acad Sci U S A. 2007 ; 104: 16633-38
11. Folkerd E. J., Dowsett M.. Influence of sex hormones on cancer progression. J Clin Oncol. 2010 ; 28: 4038-44
12. Gochfeld M.. Framework for gender differences in human and animal toxicology. Environ Res. 2007 ; 104: 4-21
13. Guerra C., Schuhmacher A. J., Canamero M., Grippo P. J., Verdaguer L., Perez-Gallego L., Dubus P., Sandgren E. P., Barbacid M.. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 2007 ; 11: 291-302
14. Haber L. T., Maier A., Kroner O. L., Kohrman M. J.. Evaluation of human relevance and mode of action for tunica vaginalis mesotheliomas resulting from oral exposure to acrylamide. Regul Toxicol Pharmacol. 2009 ; 53: 134-49
15. Hard G. C., Johnson K. J., Cohen S. M.. A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment. Crit Rev Toxicol. 2009 ; 39: 332-46
16. Haseman J. K., Ney E., Nyska A., Rao G. N.. Effect of diet and animal care/housing protocols on body weight, survival, tumor incidences, and nephropathy severity of F344 rats in chronic studies. Toxicol Pathol. 2003 ; 31: 674-81
17. Hoenerhoff M. J., Hong H. H., Ton T. V., Lahousse S. A., Sills R. C.. A review of the molecular mechanisms of chemically induced neoplasia in rat and mouse models in National Toxicology Program bioassays and their relevance to human cancer. Toxicol Pathol. 2009 ; 37: 835-48
18. Huff J.. Predicting chemicals causing cancer in animals as human carcinogens. Occup Environ Med. 2010 ; 67: 720
19. Huff J., Jacobson M. F., Davis D. L.. The limits of two-year bioassay exposure regimens for identifying chemical carcinogens. Environ Health Perspect. 2008 ; 116: 1439-42
20. International Agency for Research on Cancer. (2010). Cancer Incidence in Five Continents, IARC Scientific Publications No. 155. International Agency for Research on Cancer, Lyon, France.
21. King-Herbert A. P., Sills R. C., Bucher J. R.. Commentary: Update on animal models for NTP studies. Toxicol Pathol. 2010 ; 38: 180-81
22. Kirsch-Volders M., Bonassi S., Herceg Z., Hirvonen A., Moller L., Phillips D. H.. Gender-related differences in response to mutagens and carcinogens. Mutagenesis. 2010 ; 25: 213-21
23. Kiyohara C., Ohno Y.. Sex differences in lung cancer susceptibility: a review. Gend Med. 2010 ; 7: 381-401
24. Knox M., Colli J. L.. Characterizing changes in kidney and renal pelvis cancer incidence from 1998 to 2006 in the United States. Int Urol Nephrol. 2011 ; 43: 359-63
25. Kong B., Michalski C. W., Erkan M., Friess H., Kleeff J.. From tissue turnover to the cell of origin for pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2011 ; 8: 467-72
26. Langner C., Ratschek M., Rehak P., Schips L., Zigeuner R.. Steroid hormone receptor expression in renal cell carcinoma: An immunohistochemical analysis of 182 tumors. J Urol. 2004 ; 171: 611-14
27. Larsson S. C., Wolk A.. Red and processed meat consumption and risk of pancreatic cancer: Meta-analysis of prospective studies. Br J Cancer. 2012 ; 106: 603-7
28. Leavens T. L., Borghoff S. J.. Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to alpha2u-globulin. Toxicol Sci. 2009 ; 109: 321-35
29. Lhoste E. F., Longnecker D. S.. Effect of bombesin and caerulein on early stages of carcinogenesis induced by azaserine in the rat pancreas. Cancer Res. 1987 ; 47: 3273-77
30. Lin J. H., Giovannucci E.. Sex hormones and colorectal cancer: What have we learned so far?. J Natl Cancer Inst. 2010 ; 102: 1746-47
31. Longnecker D.. Experimental pancreatic cancer: role of species, sex and diet. Bull Cancer. 1990 ; 77: 27-37
32. Longnecker D. S., Sumi C.. Effects of sex steroid hormones on pancreatic cancer in the rat. Int J Pancreatol. 1990 ; 7: 159-65
33. Ma W. L., Hsu C. L., Wu M. H., Wu C. T., Wu C. C., Lai J. J., Jou Y. S., Chen C. W., Yeh S., Chang C.. Androgen receptor is a new potential therapeutic target for the treatment of hepatocellular carcinoma. Gastroenterology. 2008 ; 135 955: 947 e941-55 45
34. Maronpot R. R., Flake G., Huff J. Relevance of animal carcinogenesis findings to human cancer predictions and prevention. Toxicol Pathol. 2004 ; 32 (Suppl 1). 40-48
35. Miyamoto H., Yang Z., Chen Y. T., Ishiguro H., Uemura H., Kubota Y., Nagashima Y., Chang Y. J., Hu Y. C., Tsai M. Y., Yeh S., Messing E. M., Chang C.. Promotion of bladder cancer development and progression by androgen receptor signals. J Natl Cancer Inst. 2007 ; 99: 558-68
36. Mollerup S., Berge G., Baera R., Skaug V., Hewer A., Phillips D. H., Stangeland L., Haugen A.. Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. Int J Cancer. 2006 ; 119: 741-44
37. Toxicology and carcinogenesis studies of bromochloroacetic acid (CAS No. 5589-96-8) in F344/N rats and B6C3F1 mice (drinking water studies). Natl Toxicol Program Tech Rep Ser. 2009 ; (540). 1-270
38. Naugler W. E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A. M., Karin M.. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science. 2007 ; 317: 121-24
39. Oertelt-Prigione S., Regitz-Zagrosek V.. Gender aspects in cardiovascular pharmacology. J Cardiovasc Transl Res. 2009 ; 2: 258-66
40. Okitsu K., Kanda T., Imazeki F., Yonemitsu Y., Ray R. B., Chang C., Yokosuka O.. Involvement of interleukin-6 and androgen receptor signaling in pancreatic cancer. Genes Cancer. 2010 ; 1: 859-67
41. Olivo-Marston S. E., Mechanic L. E., Mollerup S., Bowman E. D., Remaley A. T., Forman M. R., Skaug V., Zheng Y. L., Haugen A., Harris C. C.. Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. Carcinogenesis. 2010 ; 31: 1778-86
42. Pinton G., Thomas W., Bellini P., Manente A. G., Favoni R. E., Harvey B. J., Mutti L., Moro L.. Estrogen receptor beta exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib. PLoS One. 2010 ; 5: e14110
43. Pressler H., Sissung T. M., Venzon D., Price D. K., Figg W. D.. Expression of OATP family members in hormone-related cancers: Potential markers of progression. PLoS One. 2011 ; 6: e20372
44. Puri S., Hebrok M.. Cellular plasticity within the pancreas-lessons learned from development. Dev Cell. 2010 ; 18: 342-56
45. Rivera J. A., Graeme-Cook F., Werner J., Z'Graggen K., Rustgi A. K., Rattner D. W., Warshaw A. L., Fernandez-del Castillo C.. A rat model of pancreatic ductal adenocarcinoma: Targeting chemical carcinogens. Surgery. 1997 ; 122: 82-90
46. Santen R. J., Allred D. C., Ardoin S. P., Archer D. F., Boyd N., Braunstein G. D., Burger H. G., Colditz G. A., Davis S. R., Gambacciani M., Gower B. A., Henderson V. W., Jarjour W. N., Karas R. H., Kleerekoper M., Lobo R. A., Manson J. E., Marsden J., Martin K. A., Martin L., Pinkerton J. V., Rubinow D. R., Teede H., Thiboutot D. M., Utian W. H.. Postmenopausal hormone therapy: An Endocrine Society scientific statement. J Clin Endocrinol Metab. 2010 ; 95: s1 - s66
47. Teng X. Y., Liu G. Q., Diao X. L., Wu Z. Y., Li L., Zhang W., Zhang X., Su Q.. CAG repeats in the androgen receptor gene are shorter in patients with pulmonary, esophageal or bladder carcinoma and longer in women with uterine leiomyoma. Oncol Rep. 2010 ; 23: 811-18
48. Tsuei D. J., Lee P. H., Peng H. Y., Lu S. L., Su D. S., Jeng Y. M., Hsu H. C., Hsu S. H., Wu J. F., Ni Y. H., Chang M. H.. Male germ cell-specific RNA binding protein RBMY: A new oncogene explaining male predominance in liver cancer. PLoS One. 2011 ; 6: e26948
49. Uppstad H., Osnes G. H., Cole K. J., Phillips D. H., Haugen A., Mollerup S.. Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells. Lung Cancer. 2011 ; 71: 264-70
50. Wolf A. S., Richards W. G., Tilleman T. R., Chirieac L., Hurwitz S., Bueno R., Sugarbaker D. J.. Characteristics of malignant pleural mesothelioma in women. Ann Thorac Surg. 2010 ; 90: 949-56
51. Yoon G., Kim J. Y., Choi Y. K., Won Y. S., Lim I. K.. Direct activation of TGF-beta1 transcription by androgen and androgen receptor complex in Huh7 human hepatoma cells and its tumor in nude mice. J Cell Biochem. 2006 ; 97: 393-411
52. Yu M. W., Cheng S. W., Lin M. W., Yang S. Y., Liaw Y. F., Chang H. C., Hsiao T. J., Lin S. M., Lee S. D., Chen P. J., Liu C. J., Chen C. J.. Androgen-receptor gene CAG repeats, plasma testosterone levels, and risk of hepatitis B-related hepatocellular carcinoma. J Natl Cancer Inst. 2000 ; 92: 2023-28
53. Zender L., Kubicka S.. Androgen receptor and hepatocarcinogenesis: What do we learn from HCC mouse models?. Gastroenterology. 2008 ; 135: 738-40
54. Zenser T. V., Lakshmi V. M., Davis B. B.. N-glucuronidation of benzidine and its metabolites: Role in bladder cancer. Drug Metab Dispos. 1998 ; 26: 856-59
55. Zhou J., Enewold L., Stojadinovic A., Clifton G. T., Potter J. F., Peoples G. E., Zhu K.. Incidence rates of exocrine and endocrine pancreatic cancers in the United States. Cancer Causes Control. 2010 ; 21: 853-61