Gender aspects in cardiovascular pharmacology

Journal of Cardiovascular Translational Research

Volumn 2, Issue 3, 2009, Pages 258-266

  Oertelt Prigione, Sabine ^a   Regitz Zagrosek, Vera ^b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Gender Differences; Gender Medicine; Management; Pharmacology; Sex Differences; Therapy

Indexed keywords

ACETYLSALICYLIC ACID; ALDOSTERONE ANTAGONIST; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIARRHYTHMIC AGENT; ANTICOAGULANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGITALIS; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FIBRINOLYTIC AGENT; METOPROLOL; ORAL CONTRACEPTIVE AGENT; PROPRANOLOL; CARDIOVASCULAR AGENT;

ADD ON THERAPY; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; COUGHING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; GASTROINTESTINAL MOTILITY; GYNECOMASTIA; HEART FAILURE; HUMAN; HYPOTENSION; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE; STOMACH PH; STROKE; UNSPECIFIED SIDE EFFECT; CARDIOVASCULAR DISEASES; EVIDENCE BASED MEDICINE; FEMALE; HEALTH DISPARITY; MALE; TREATMENT OUTCOME;

CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; EVIDENCE-BASED MEDICINE; FEMALE; HEALTH STATUS DISPARITIES; HUMANS; MALE; SEX FACTORS; TREATMENT OUTCOME;

EID: 68749108028     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-009-9114-9     Document Type: Review

References (69)

1. KP Alexander AY Chen LK Newby JB Schwartz RF Redberg JS Hochman 2006 Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative Circulation 114 13 1380 1387
2. GD Anderson 2005 Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics Journal of Womens Health 14 1 19 29
3. M Anthony 2005 Male/female differences in pharmacology: safety issues with QT-prolonging drugs Journal of Womens Health 14 1 47 52
4. PA Arias-Loza V Jazbutyte T Pelzer 2008 Genetic and pharmacologic strategies to determine the function of estrogen receptor alpha and estrogen receptor beta in cardiovascular system Gender Medicine 5 Suppl A S34 S45
5. E Baraona CS Abittan K Dohmen M Moretti G Pozzato ZW Chayes 2001 Gender differences in pharmacokinetics of alcohol Alcoholism, Clinical and Experimental Research 25 4 502 507
6. Brinkman-Van der Linden CM EC Havenaar CR Van Ommen GJ Van Kamp LJ Gooren W Van Dijk 1996 Oral estrogen treatment induces a decrease in expression of sialyl Lewis x on alpha 1-acid glycoprotein in females and male-to-female transsexuals Glycobiology 6 4 407 412
7. DA Brown JM Lynch CJ Armstrong NM Caruso LB Ehlers MS Johnson 2005 Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat Journal of Physiology 564 Pt 2 619 630
8. R Bruno N Vivier G Montay A Le Liboux LK Powe JC Delumeau 1997 Population pharmacokinetics of riluzole in patients with amyotrophic lateral sclerosis Clinical Pharmacology and Therapeutics 62 5 518 526 (Pubitemid 28214929)
9. D Camper-Kirby S Welch A Walker I Shiraishi KD Setchell E Schaefer 2001 Myocardial Akt activation and gender: increased nuclear activity in females versus males Circulation Research 88 10 1020 1027
10. JD Carroll EP Carroll T Feldman DM Ward RM Lang D [tmp] McGaughey 1992 Sex-associated differences in left ventricular function in aortic stenosis of the elderly Circulation 86 4 1099 1107
11. JA Cerrutti A Brandoni NB Quaglia AM Torres 2002 Sex differences in p-aminohippuric acid transport in rat kidney: role of membrane fluidity and expression of OAT1 Molecular and Cellular Biochemistry 233 1-2 175 179
12. P Ciana M Raviscioni P Mussi E Vegeto I Que MG Parker 2003 In vivo imaging of transcriptionally active estrogen receptors Natural Medicines 9 1 82 86
13. MD Drici BC Knollmann WX Wang RL Woosley 1998 Cardiac actions of erythromycin: influence of female sex JAMA 280 20 1774 1776
14. XJ Du 2004 Gender modulates cardiac phenotype development in genetically modified mice Cardiovascular Research 63 3 510 519
15. DP Edwards 2005 Regulation of signal transduction pathways by estrogen and progesterone Annual Review of Physiology 67 335 376
16. L Ereshefsky SR Saklad MD Watanabe CM Davis MW Jann 1991 Thiothixene pharmacokinetic interactions: a study of hepatic enzyme inducers, clearance inhibitors, and demographic variables Journal of Clinical Psychopharmacology 11 5 296 301
17. PT Fitzgerald MJ Ackerman 2005 Drug-induced torsades de pointes: the evolving role of pharmacogenetics Heart Rhythm 2 2 Suppl S30 S37
18. F Franconi S Brunelleschi L Steardo V Cuomo 2007 Gender differences in drug responses Pharmacological Research 55 2 81 95
19. M Frezza C di Padova G Pozzato M Terpin E Baraona CS Lieber 1990 High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism New England Journal of Medicine 322 2 95 99
20. M Gandhi F Aweeka RM Greenblatt TF Blaschke 2004 Sex differences in pharmacokinetics and pharmacodynamics Annual Review Pharmacology and Toxicology 44 499 523
21. SE Gaudry DS Sitar DD Smyth JK [tmp] McKenzie FY Aoki 1993 Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine Clinical Pharmacology and Therapeutics 54 1 23 27
22. JK Ghali IL Pina SS Gottlieb PC Deedwania JC Wikstrand 2002 Metoprolol CR/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF) Circulation 105 13 1585 1591
23. M Gochfeld 2007 Framework for gender differences in human and animal toxicology Environmental Research 104 1 4 21
24. C Grohe S Kahlert K Lobbert H Vetter 1998 Expression of oestrogen receptor alpha and beta in rat heart: role of local oestrogen synthesis Journal of Endocrinology 156 2 R1 R7
25. FP Guengerich 1999 Cytochrome P-450 3A4: regulation and role in drug metabolism Annual Review of Pharmacology and Toxicology 39 1 17
26. K Haram K Augensen S Elsayed 1983 Serum protein pattern in normal pregnancy with special reference to acute-phase reactants British Journal of Obstetrics and Gynaecology 90 2 139 145
27. KH Humphries CR Kerr SJ Connolly G Klein JA Boone M Green 2001 New-onset atrial fibrillation: sex differences in presentation, treatment, and outcome Circulation 103 19 2365 2370
28. CM Hunt WR Westerkam GM Stave 1992 Effect of age and gender on the activity of human hepatic CYP3A Biochemical Pharmacology 44 2 275 283
29. WR Hutson RL Roehrkasse A Wald 1989 Influence of gender and menopause on gastric emptying and motility Gastroenterology 96 1 11 17
30. T Kadokami CF [tmp] McTiernan T Kubota CS Frye AM Feldman 2000 Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression Journal of Clinical Investigation 106 4 589 597
31. W Kalow BK Tang 1991 Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities Clinical Pharmacology and Therapeutics 50 5 Pt 1 508 519
32. MJ Kendall CP Quarterman DB Jack L Beeley 1982 Metoprolol pharmacokinetics and the oral contraceptive pill British Journal of Clinical Pharmacology 14 1 120 122
33. L Labbe C Sirois S Pilote M Arseneault NM Robitaille J Turgeon 2000 Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates Pharmacogenetics 10 5 425 438
34. LB Lan JT Dalton EG Schuetz 2000 Mdr1 limits CYP3A metabolism in vivo Molecular Pharmacology 58 4 863 869
35. J Lees JE Hallak JF Deakin SM Dursun 2004 Gender differences and the effects of ketamine in healthy volunteers Journal of Psychopharmacology 18 3 337 339
36. LA Leinwand 2003 Sex is a potent modifier of the cardiovascular system Journal of Clinical Investigation 112 3 302 307
37. SE Litwin SE Katz CM Litwin JP Morgan PS Douglas 1999 Gender differences in postinfarction left ventricular remodeling Cardiology 91 3 173 183
38. S Mahmoodzadeh S Eder J Nordmeyer E Ehler O Huber P Martus 2006 Estrogen receptor alpha up-regulation and redistribution in human heart failure FASEB Journal 20 7 926 934
39. RR Makkar BS Fromm RT Steinman MD Meissner MH Lehmann 1993 Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs JAMA 270 21 2590 2597
40. B Mearadji C Penning MK Vu PJ van der Schaar AS van Petersen IM Kamerling 2001 Influence of gender on proximal gastric motor and sensory function American Journal of Gastroenterology 96 7 2066 2073 (Pubitemid 32660898)
41. ME Mendelsohn RH Karas 1999 The protective effects of estrogen on the cardiovascular system New England Journal of Medicine 340 23 1801 1811
42. ME Mendelsohn RH Karas 2005 Molecular and cellular basis of cardiovascular gender differences Science 308 5728 1583 1587
43. R Metivier G Penot MR Hubner G Reid H Brand M Kos 2003 Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter Cell 115 6 751 763
44. L Mosca CL Banka EJ Benjamin K Berra C Bushnell RJ Dolor 2007 Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update Circulation 115 11 1481 1501 (Pubitemid 46648385)
45. J Nordmeyer S Eder S Mahmoodzadeh P Martus J Fielitz J Bass 2004 Upregulation of myocardial estrogen receptors in human aortic stenosis Circulation 110 20 3270 3275
46. S Nuedling RH Karas ME Mendelsohn JA Katzenellenbogen BS Katzenellenbogen R Meyer 2001 Activation of estrogen receptor beta is a prerequisite for estrogen-dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes FEBS Letters 502 3 103 108
47. I Os B Bratland B Dahlof K Gisholt JO Syvertsen S Tretli 1992 Female sex as an important determinant of lisinopril-induced cough Lancet 339 8789 372
48. B Pitt F Zannad WJ Remme R Cody A Castaigne A Perez 1999 The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators New England Journal of Medicine 341 10 709 717
49. SS Rathore JP Curtis Y Wang MR Bristow HM Krumholz 2003 Association of serum digoxin concentration and outcomes in patients with heart failure JAMA 289 7 871 878 (Pubitemid 37430346)
50. SS Rathore Y Wang HM Krumholz 2002 Sex-based differences in the effect of digoxin for the treatment of heart failure New England Journal of Medicine 347 18 1403 1411
51. V Regitz-Zagrosek 2006 Therapeutic implications of the gender-specific aspects of cardiovascular disease Nature Reviews. Drug Discovery 5 5 425 438
52. V Regitz-Zagrosek E Lehmkuhl HB Lehmkuhl R Hetzer 2004 Gender aspects in heart failure. Pathophysiology and medical therapy Archives Des Maladies Du Coeur Et Des Vaisseaux 97 9 899 908
53. PM Ridker NR Cook IM Lee D Gordon JM Gaziano JE Manson 2005 A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women New England Journal of Medicine 352 13 1293 1304
54. GM Rubanyi K Kauser A Johns 2002 Role of estrogen receptors in the vascular system Vascular Pharmacology 38 2 81 88
55. R Schmidt F Baumann H Hanschmann F Geissler R Preiss 2001 Gender difference in ifosfamide metabolism by human liver microsomes European Journal of Drug Metabolism and Pharmacokinetics 26 3 193 200
56. JB Schwartz 2003 The influence of sex on pharmacokinetics Clinical Pharmacokinetics 42 2 107 121
57. AJ Singer LJ Brandt 1991 Pathophysiology of the gastrointestinal tract during pregnancy American Journal of Gastroenterology 86 12 1695 1712
58. MT Skaanild C Friis 1999 Cytochrome P450 sex differences in minipigs and conventional pigs Pharmacology and Toxicology 85 4 174 180
59. CL Smith OM Conneely BW O'Malley 1993 Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone Proceedings of the National Academy of Sciences of the United States of America 90 13 6120 6124
60. E Tanaka 1998 Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes Journal of Clinical Pharmacy and Therapeutics 23 6 403 416
61. R Tatchum-Talom KM Eyster DS Martin 2005 Sexual dimorphism in angiotensin II-induced hypertension and vascular alterations Canadian Journal of Physiology and Pharmacology 83 5 413 422
62. CH Tuck S Holleran L Berglund 1997 Hormonal regulation of lipoprotein(a) levels: effects of estrogen replacement therapy on lipoprotein(a) and acute phase reactants in postmenopausal women Arteriosclerosis, Thrombosis, and Vascular Biology 17 9 1822 1829
63. T Walle K Walle RS Mathur YY Palesch EC Conradi 1994 Propranolol metabolism in normal subjects: association with sex steroid hormones Clinical Pharmacology and Therapeutics 56 2 127 132 (Pubitemid 24274178)
64. EO Weinberg M Mirotsou J Gannon VJ Dzau RT Lee RE Pratt 2003 Sex dependence and temporal dependence of the left ventricular genomic response to pressure overload Physiological Genomics 12 2 113 127
65. K Wilson 1984 Sex-related differences in drug disposition in man Clinical Pharmacokinetics 9 3 189 202
66. LM Wing CM Reid P Ryan LJ Beilin MA Brown GL Jennings 2003 A comparison of outcomes with angiotensin-converting-enzyme inhibitors and diuretics for hypertension in the elderly New England Journal of Medicine 348 7 583 592
67. D Wolbrette G Naccarelli A Curtis M Lehmann A Kadish 2002 Gender differences in arrhythmias Clinical Cardiology 25 2 49 56
68. DK Wysowski L Swartz 2005 Adverse drug event surveillance and drug withdrawals in the United States, 1969-2002: the importance of reporting suspected reactions Archives of Internal Medicine 165 12 1363 1369
69. HB Xin T Senbonmatsu DS Cheng YX Wang JA Copello GJ Ji 2002 Oestrogen protects FKBP12.6 null mice from cardiac hypertrophy Nature 416 6878 334 338