MED25 Is a Mediator Component of HNF4α-Driven Transcription Leading to Insulin Secretion in Pancreatic Beta-Cells

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Han, Eun Hee ^a   Rha, Geun Bae ^a,b   Chi, Young In ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; PROTEIN MED25; RNA POLYMERASE II; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REPORTER GENE;

AMINO ACID MOTIFS; ANIMALS; BINDING SITES; DIABETES MELLITUS, TYPE 2; GLUCOSE; HELA CELLS; HEPATOCYTE NUCLEAR FACTOR 4; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MEDIATOR COMPLEX; MICE; MODELS, MOLECULAR; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84865598963     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044007     Document Type: Article

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