Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors

ChemMedChem

Volumn 7, Issue 9, 2012, Pages 1594-1600

  Ettari, Roberta ^a   Micale, Nicola ^b   Grazioso, Giovanni ^a   Bova, Floriana ^b   Schirmeister, Tanja ^c   Grasso, Silvana ^b   Zappalà, Maria ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Cysteine proteases; Docking; Falcipain 2; Inhibitors; Peptidomimetics

Indexed keywords

4 [2 [3 (4 CHLORO 2 TRIFLUOROMETHYLPHENYLCARBAMOYLOXYMETHYL) 2 OXO 5 PHENYL 2,3 DIHYDROBENZO[E][1,4]DIAZEPIN 1 YL]ACETOXY]BUT 2 ENOIC ACID; BENZYL 4 [2 [3 [[4 CHLORO 2 (TRIFLUOROMETHYL)PHENYLCARBAMOYLOXY]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; CYSTEINE PROTEINASE INHIBITOR; ESTER DERIVATIVE; ETHYL 4 [2 [3 [(4 METHOXYPHENYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ETHYL 4 [2 [3 [(BUTYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ETHYL 4 [2 [3 [(CYCLOHEXYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ETHYL 4 [2 [3 [(NAPHTHALEN 1 YLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ETHYL 4 [2 [3 [[4 CHLORO 2 (TRIFLUOROMETHYL)PHENYLCARBAMOYLOXY]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; FALCIPAIN 2; ISOBUTYL 4 [2 [3 [(4 METHOXYPHENYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ISOBUTYL 4 [2 [3 [(BUTYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ISOBUTYL 4 [2 [3 [(CYCLOHEXYLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; ISOBUTYL 4 [2 [3 [(NAPHTHALEN 1 YLCARBAMOYLOXY)METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT-2-ENOATE; ISOBUTYL 4 [2 [3 [[ 4 CHLORO 2 (TRIFLUOROMETHYL)PHENYLCARBAMOYLOXY]METHYL] 2 OXO 5 PHENYL 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 1 YL]ACETAMIDO]BUT 2 ENOATE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PEPTIDOMIMETIC AGENT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG POTENCY; ELECTROPHILICITY; ENZYME INHIBITION; MALARIA; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; SYNTHESIS;

ANTIMALARIALS; CATALYTIC DOMAIN; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; HUMANS; MALARIA, FALCIPARUM; MOLECULAR DOCKING SIMULATION; PEPTIDOMIMETICS; PLASMODIUM FALCIPARUM;

EID: 84865585931     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200274     Document Type: Article

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