Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication

Journal of Medicinal Chemistry

Volumn 41, Issue 14, 1998, Pages 2579-2587

  Kong, Jian She ^a   Venkatraman, Shankar ^a   Furness, Kelly ^a   Nimkar, Sanjay ^a   Shepherd, Timothy A ^b   Wang, Q May ^b   Aubé, Jeffrey ^a   Hanzlik, Robert P ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CYSTEINE PROTEINASE INHIBITOR; GLUTAMINE; METHIONINE SULFONE; PEPTIDE DERIVATIVE; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL FREE SYSTEM; COMMON COLD; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INACTIVATION; HELA CELL; HUMAN; HUMAN CELL; HUMAN RHINOVIRUS; NONHUMAN; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE, TRANSFORMED; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; GLUTAMINE; HELA CELLS; HUMANS; PEPTIDES; RHINOVIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 0032474754     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980114+     Document Type: Article

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