Molecular dynamics study of MspA arginine mutants predicts slow DNA translocations and ion current blockades indicative of DNA sequence

ACS Nano

Volumn 6, Issue 8, 2012, Pages 6960-6968

  Bhattacharya, Swati ^a   Derrington, Ian M ^c   Pavlenok, Mikhail ^b   Niederweis, Michael ^b   Gundlach, Jens H ^c   Aksimentiev, Aleksei ^a  

^a University of Illinois at Urbana Champaign   (United States)

^b University of Alabama at Birmingham   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

DNA protein interactions; membrane channel; nanopore; protein engineering; sequencing; stochastic sensor

Indexed keywords

DNA-PROTEIN INTERACTION; MEMBRANE CHANNELS; PROTEIN ENGINEERING; SEQUENCING; STOCHASTIC SENSORS;

ARGININE; CELL MEMBRANES; DNA; GENETIC ENGINEERING; MOLECULAR DYNAMICS; NANOPORES; NUCLEOTIDES; PROTEINS;

GENE ENCODING;

ARGININE; DNA; MSPA PROTEIN, MYCOBACTERIUM SMEGMATIS; PORIN;

ARTICLE; BIOLOGICAL MODEL; CHANNEL GATING; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONDUCTOMETRY; DNA SEQUENCE; ELECTRIC CONDUCTIVITY; GENE TRANSLOCATION; GENETIC PROCEDURES; GENETICS; METHODOLOGY; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE SEQUENCE;

ARGININE; BASE SEQUENCE; BIOSENSING TECHNIQUES; COMPUTER SIMULATION; CONDUCTOMETRY; DNA; ELECTRIC CONDUCTIVITY; ION CHANNEL GATING; MODELS, CHEMICAL; MODELS, GENETIC; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PORINS; SEQUENCE ANALYSIS, DNA; TRANSLOCATION, GENETIC;

EID: 84865583099     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn3019943     Document Type: Article

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