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Volumn 9, Issue 11, 2001, Pages 2773-2785

Synthesis of novel GABA uptake inhibitors. Part 6: Preparation and evaluation of N-Ω asymmetrically substituted nipecotic acid derivatives

(7) Andersen, Knud Erik a Lau, Jesper a Lundt, Behrend F a Petersen, Hans a Huusfeldt, Per O a Suzdak, Peter D a Swedberg, Michael D B a

a NOVO NORDISK A S (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 [[[1,2 BIS(2 FLUOROPHENYL)ETHYLIDENE]AMINO]OXY]ETHYL] 3 PIPERIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; ANTICONVULSIVE AGENT; TIAGABINE; UNCLASSIFIED DRUG; 1 (4,4 DIPHENYL 3 BUTENYL)NIPECOTIC ACID; 1 [2 [4,4' BIS(TRIFLUOROMETHYL)BENZHYDRYLOXY]ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; ALKENE DERIVATIVE; ALKYL GROUP; GUVACINE; NIPECOTIC ACID; NIPECOTIC ACID DERIVATIVE; NNC 050328;

4 AMINOBUTYRIC ACID UPTAKE; ANIMAL CELL; ANIMAL MODEL; CLONIC SEIZURE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; ISOTOPE LABELING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RAT; REVIEW; STRUCTURE ACTIVITY RELATION; SYNAPTOSOME; TECHNIQUE; ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; IC 50; IN VIVO STUDY; LIPOPHILICITY;

OXY;

EID: 0034800909 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(01)00148-1 Document Type: Article

Times cited : (40)

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