Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation

Genes to Cells

Volumn 17, Issue 9, 2012, Pages 768-777

  Okita, Yasutaka ^a,b   Matsumoto, Akinobu ^a,b   Yumimoto, Kanae ^a,b   Isoshita, Rieko ^a,b   Nakayama, Keiichi I ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN FBXW7; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL STRUCTURE; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENZYME SUBSTRATE; FIBROBLAST; GENE OVEREXPRESSION; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN SUBUNIT; SOMATIC CELL;

ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; EMBRYONIC STEM CELLS; F-BOX PROTEINS; FIBROBLASTS; GENE DELETION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; INDUCED PLURIPOTENT STEM CELLS; MICE; OCTAMER TRANSCRIPTION FACTOR-3; PROTO-ONCOGENE PROTEINS C-MYC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRETINOIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84865563344     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2012.01626.x     Document Type: Article

References (47)

1. Adhikary, S. & Eilers, M. (2005) Transcriptional regulation and transformation by Myc proteins. Nat. Rev. Mol. Cell Biol. 6, 635-645.
2. Babaei-Jadidi, R., Li, N., Saadeddin, A., Spencer-Dene, B., Jandke, A., Muhammad, B., Ibrahim, E.E., Muraleedharan, R., Abuzinadah, M., Davis, H., Lewis, A., Watson, S., Behrens, A., Tomlinson, I. & Nateri, A.S. (2011) FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation. J. Exp. Med. 208, 295-312.
3. Busino, L., Millman, S.E., Scotto, L., Kyratsous, C.A., Basrur, V., O'Connor, O., Hoffmann, A., Elenitoba-Johnson, K.S. & Pagano, M. (2012) Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma. Nat. Cell Biol. 14, 375-385.
4. Esteban, M.A., Wang, T., Qin, B., et al. (2010) Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell 6, 71-79.
5. Fbw7 modulates the NFκB signaling pathway by targeting NFκB2 for ubiquitination and destruction. Cell Rep. 1, 434-443.
6. Gupta-Rossi, N., Le Bail, O., Gonen, H., Brou, C., Logeat, F., Six, E., Ciechanover, A. & Israel, A. (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J. Biol. Chem. 276, 34371-34378.
7. Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K. & Yamanaka, S. (2009) Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 460, 1132-1135.
8. Hubbard, E.J., Wu, G., Kitajewski, J. & Greenwald, I. (1997) sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev. 11, 3182-3193.
9. FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471, 104-109.
10. Kalaszczynska, I., Geng, Y., Iino, T., Mizuno, S., Choi, Y., Kondratiuk, I., Silver, D.P., Wolgemuth, D.J., Akashi, K. & Sicinski, P. (2009) Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells. Cell 138, 352-365.
11. Fbw7 ubiquitin ligase. Science 294, 173-177.
12. Kozar, K., Ciemerych, M.A., Rebel, V.I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R.T., Akashi, K. & Sicinski, P. (2004) Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477-491.
13. Li, H., Collado, M., Villasante, A., Strati, K., Ortega, S., Canamero, M., Blasco, M.A. & Serrano, M. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 460, 1136-1139.
14. Li, Y., Zhang, Q., Yin, X., et al. (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res. 21, 196-204.
15. Maekawa, M., Yamaguchi, K., Nakamura, T., Shibukawa, R., Kodanaka, I., Ichisaka, T., Kawamura, Y., Mochizuki, H., Goshima, N. & Yamanaka, S. (2011) Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 474, 225-229.
16. Maherali, N., Sridharan, R., Xie, W., Utikal, J., Eminli, S., Arnold, K., Stadtfeld, M., Yachechko, R., Tchieu, J., Jaenisch, R., Plath, K. & Hochedlinger, K. (2007) Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1, 55-70.
17. Malumbres, M., Sotillo, R., Santamaria, D., Galan, J., Cerezo, A., Ortega, S., Dubus, P. & Barbacid, M. (2004) Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118, 493-504.
18. Mao, J.H., Kim, I.J., Wu, D., Climent, J., Kang, H.C., DelRosario, R. & Balmain, A. (2008) FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 321, 1499-1502.
19. Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H. & Nakayama, K.I. (2011) Fbxw7-dependent degradation of Notch is required for control of 'stemness' and neuronal-glial differentiation in neural stem cells. J. Biol. Chem. 286, 13754-13764.
20. Matsuoka, S., Oike, Y., Onoyama, I., et al. (2008) Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev. 22, 986-991.
21. Meissner, A., Wernig, M. & Jaenisch, R. (2007) Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat. Biotechnol. 25, 1177-1181.
22. Miyoshi, N., Ishii, H., Nagano, H., et al. (2011) Reprogramming of mouse and human cells to pluripotency using mature microRNAs. Cell Stem Cell 8, 633-638.
23. Moberg, K.H., Bell, D.W., Wahrer, D.C., Haber, D.A. & Hariharan, I.K. (2001) Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines. Nature 413, 311-316.
24. Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K., Ichisaka, T., Aoi, T., Okita, K., Mochiduki, Y., Takizawa, N. & Yamanaka, S. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26, 101-106.
25. Nakagawa, M., Takizawa, N., Narita, M., Ichisaka, T. & Yamanaka, S. (2010) Promotion of direct reprogramming by transformation-deficient Myc. Proc. Natl Acad. Sci. USA 107, 14152-14157.
26. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85, 707-720.
27. Nakayama, K.I. & Nakayama, K. (2006) Ubiquitin ligases: cell-cycle control and cancer. Nat. Rev. Cancer 6, 369-381.
28. Fbw7 antagonizes apoptotic JNK signaling. Science 303, 1374-1378.
29. Oberg, C., Li, J., Pauley, A., Wolf, E., Gurney, M. & Lendahl, U. (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J. Biol. Chem. 276, 35847-35853.
30. Okita, K., Ichisaka, T. & Yamanaka, S. (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448, 313-317.
31. Cdc4 acts antagonistically to the PGC-1α transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev. 22, 252-264.
32. Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K.I. (2011) Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J. Clin. Invest. 121, 342-354.
33. Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., de Alboran, I.M., Nakayama, K. & Nakayama, K.I. (2007) Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis. J. Exp. Med. 204, 2875-2888.
34. Otto, T., Horn, S., Brockmann, M., Eilers, U., Schüttrumpf, L., Popov, N., Kenney, A.M., Schulte, J.H., Beijersbergen, R., Christiansen, H., Berwanger, B. & Eilers, M. (2009) Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma. Cancer Cell 15, 67-78.
35. Strohmaier, H., Spruck, C.H., Kaiser, P., Won, K.A., Sangfelt, O. & Reed, S.I. (2001) Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line. Nature 413, 316-322.
36. Fbw7. Cell Metab. 1, 379-391.
37. Takahashi, K. & Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
38. FBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia. J. Exp. Med. 204, 1825-1835.
39. Thompson, B.J., Jankovic, V., Gao, J., Buonamici, S., Vest, A., Lee, J.M., Zavadil, J., Nimer, S.D. & Aifantis, I. (2008) Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7. J. Exp. Med. 205, 1395-1408.
40. Welcker, M. & Clurman, B.E. (2008) FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat. Rev. Cancer 8, 83-93.
41. Welcker, M., Orian, A., Jin, J., Grim, J.E., Harper, J.W., Eisenman, R.N. & Clurman, B.E. (2004) The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc. Natl Acad. Sci. USA 101, 9085-9090.
42. Wernig, M., Meissner, A., Cassady, J.P. & Jaenisch, R. (2008) c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Cell Stem Cell 2, 10-12.
43. Wernig, M., Meissner, A., Foreman, R., Brambrink, T., Ku, M., Hochedlinger, K., Bernstein, B.E. & Jaenisch, R. (2007) In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448, 318-324.
44. Wertz, I.E., Kusam, S., Lam, C., et al. (2011) Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7. Nature 471, 110-114.
45. Wu, G., Lyapina, S., Das, I., Li, J., Gurney, M., Pauley, A., Chui, I., Deshaies, R.J. & Kitajewski, J. (2001) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol. Cell. Biol. 21, 7403-7415.
46. Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K. & Nakayama, K.I. (2004) Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J. 23, 2116-2125.
47. Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T. & Yamanaka, S. (2009) Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 5, 237-241.