메뉴 건너뛰기




Volumn 131, Issue 9, 2012, Pages 1998-2007

Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines

Author keywords

AKT; BCAR1; BCAR3; BCAR4; EGFR; phosphorylation; signaling pathway; tamoxifen resistance

Indexed keywords

BCAR3 PROTEIN; BCAR4 PROTEIN; CRK ASSOCIATED SUBSTRATE PROTEIN; CYCLINE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; FOCAL ADHESION KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 7; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN BCL 2; PROTEIN HRAS; PROTEIN KINASE B; PROTEIN SHC; PROTIEN HEF1; PROTIEN MCF7; STAT5 PROTEIN; STAT6 PROTEIN; TAMOXIFEN; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

EID: 84865558963     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.27489     Document Type: Article
Times cited : (23)

References (55)
  • 1
    • 85203363507 scopus 로고    scopus 로고
    • Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: Patient-level meta-analysis of randomised trials
    • Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, McGale P, Pan HC, Taylor C, Wang YC, Dowsett M, Ingle J, et al. Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011; 378: 771-84.
    • (2011) Lancet , vol.378 , pp. 771-784
    • Davies, C.1    Godwin, J.2    Gray, R.3    Clarke, M.4    Cutter, D.5    Darby, S.6    McGale, P.7    Pan, H.C.8    Taylor, C.9    Wang, Y.C.10    Dowsett, M.11    Ingle, J.12
  • 3
    • 33847793068 scopus 로고    scopus 로고
    • Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial
    • DOI 10.1093/jnci/djk049
    • Cuzick J, Forbes JF, Sestak I, Cawthorn S, Hamed H, Holli K, Howell A, International Breast Cancer Intervention Study II. Long-term results of tamoxifen prophylaxis for breast cancer-96-month follow-up of the randomized IBIS-I trial. J Natl Cancer Inst 2007; 99: 272-82. (Pubitemid 47073490)
    • (2007) Journal of the National Cancer Institute , vol.99 , Issue.4 , pp. 272-282
    • Cuzick, J.1    Forbes, J.F.2    Sestak, I.3    Cawthorn, S.4    Hamed, H.5    Holli, K.6    Howell, A.7
  • 7
    • 12144269500 scopus 로고    scopus 로고
    • Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer
    • Osborne CK, Shou J, Massarweh S, Schiff R,. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005; 11: 865s-870s. (Pubitemid 40111098)
    • (2005) Clinical Cancer Research , vol.11 , Issue.2
    • Osborne, C.K.1    Shou, J.2    Massarweh, S.3    Schiff, R.4    Come, S.5    Santen, R.6    Johnston, S.7
  • 8
    • 0035101145 scopus 로고    scopus 로고
    • Cellular and molecular pharmacology of antiestrogen action and resistance
    • Clarke R, Leonessa F, Welch JN, Skaar TC,. Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev 2001; 53: 25-71. (Pubitemid 32173107)
    • (2001) Pharmacological Reviews , vol.53 , Issue.1 , pp. 25-71
    • Clarke, R.1    Leonessa, F.2    Welch, J.N.3    Skaar, T.C.4
  • 9
    • 0028020839 scopus 로고
    • Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations
    • DOI 10.1210/me.8.11.1474
    • Van Agthoven T, Van Agthoven TLA, Dekker A, Foekens JA, Dorssers LCJ,. Induction of estrogen independence of ZR-75-1 human breast cancer cells by epigenetic alterations. Mol Endocrinol 1994; 8: 1474-83. (Pubitemid 24370196)
    • (1994) Molecular Endocrinology , vol.8 , Issue.11 , pp. 1474-1483
    • Van Agthoven, T.1    Van Agthoven, T.L.A.2    Dekker, A.3    Foekens, J.A.4    Dorssers, L.C.J.5
  • 10
    • 0027185314 scopus 로고
    • Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: Identification of bcar-1, a common integration site
    • DOI 10.1210/me.7.7.870
    • Dorssers LCJ, Van Agthoven T, Dekker A, Van Agthoven TLA, Kok EM,. Induction of antiestrogen resistance in human breast cancer cells by random insertional mutagenesis using defective retroviruses: identification of bcar-1, a common integration site. Mol Endocrinol 1993; 7: 870-8. (Pubitemid 23220637)
    • (1993) Molecular Endocrinology , vol.7 , Issue.7 , pp. 870-878
    • Dorssers, L.C.J.1    Van Agthoven, T.2    Dekker, A.3    Van Agthoven, T.L.A.4    Kok, E.M.5
  • 11
    • 33745839812 scopus 로고    scopus 로고
    • Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells
    • DOI 10.1158/1541-7786.MCR-05-0156
    • Meijer D, Van Agthoven T, Bosma PT, Nooter K, Dorssers LCJ,. Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells. Mol Cancer Res 2006; 4: 379-86. (Pubitemid 44035157)
    • (2006) Molecular Cancer Research , vol.4 , Issue.6 , pp. 379-386
    • Meijer, D.1    Van Agthoven, T.2    Bosma, P.T.3    Nooter, K.4    Dorssers, L.C.J.5
  • 14
    • 41349112108 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer
    • DOI 10.1677/ERC-07-0080
    • Meijer D, Sieuwerts AM, Look MP, Van Agthoven T, Foekens JA, Dorssers LCJ,. Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer. Endocr Relat Cancer 2008; 15: 101-11. (Pubitemid 351449731)
    • (2008) Endocrine-Related Cancer , vol.15 , Issue.1 , pp. 101-111
    • Meijer, D.1    Sieuwerts, A.M.2    Look, M.P.3    Van Agthoven, T.4    Foekens, J.A.5    Dorssers, L.C.J.6
  • 21
    • 33644821930 scopus 로고    scopus 로고
    • Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor pathway
    • Dorssers LCJ, Van Agthoven T, Brinkman A, Veldscholte J, Smid M, Dechering KJ,. Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor pathway. Breast Cancer Res 2005; 7: R82-R92.
    • (2005) Breast Cancer Res , vol.7
    • Dorssers, L.C.J.1    Van Agthoven, T.2    Brinkman, A.3    Veldscholte, J.4    Smid, M.5    Dechering, K.J.6
  • 22
    • 0034684997 scopus 로고    scopus 로고
    • BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells
    • Brinkman A, Van der Flier S, Kok EM, Dorssers LCJ,. BCAR1, a human homologue of the adapter protein p130Cas and antiestrogen resistance in breast cancer cells. J Natl Cancer Inst 2000; 92: 112-20. (Pubitemid 30089867)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.2 , pp. 112-120
    • Brinkman, A.1    Van Der Flier, S.2    Kok, E.M.3    Dorssers, L.C.J.4
  • 23
    • 0032525138 scopus 로고    scopus 로고
    • Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells
    • DOI 10.1093/emboj/17.10.2799
    • Van Agthoven T, Van Agthoven TLA, Dekker A, Van der Spek PJ, Vreede L, Dorssers LCJ,. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells. EMBO J 1998; 17: 2799-808. (Pubitemid 28227126)
    • (1998) EMBO Journal , vol.17 , Issue.10 , pp. 2799-2808
    • Van Agthoven, T.1    Van Agthoven, T.L.A.2    Dekker, A.3    Van Der Spek, P.J.4    Vreede, L.5    Dorssers, L.C.J.6
  • 24
    • 0026786658 scopus 로고
    • Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells
    • Van Agthoven T, Van Agthoven TLA, Portengen H, Foekens JA, Dorssers LCJ,. Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-1 human breast cancer cells. Cancer Res 1992; 52: 5082-88.
    • (1992) Cancer Res , vol.52 , pp. 5082-5088
    • Van Agthoven, T.1    Van Agthoven, T.L.A.2    Portengen, H.3    Foekens, J.A.4    Dorssers, L.C.J.5
  • 26
    • 0028223731 scopus 로고
    • Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry
    • Van Agthoven T, Timmermans M, Foekens JA, Dorssers LCJ, Henzen-Logmans SC,. Differential expression of estrogen, progesterone, and epidermal growth factor receptors in normal, benign, and malignant human breast tissues using dual staining immunohistochemistry. Am J Pathol 1994; 144: 1238-46. (Pubitemid 24172086)
    • (1994) American Journal of Pathology , vol.144 , Issue.6 , pp. 1238-1246
    • Van Agthoven, T.1    Timmermans, M.2    Foekens, J.A.3    Dorssers, L.C.J.4    Henzen-Logmans, S.C.5
  • 27
    • 0030819407 scopus 로고    scopus 로고
    • Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors
    • Johnston SR, Lu B, Dowsett M, Liang X, Kaufmann M, Scott GK, Osborne CK, Benz CC,. Comparison of estrogen receptor DNA binding in untreated and acquired antiestrogen-resistant human breast tumors. Cancer Res 1997; 57: 3723-7. (Pubitemid 27381215)
    • (1997) Cancer Research , vol.57 , Issue.17 , pp. 3723-3727
    • Johnston, S.R.D.1    Lu, B.2    Dowsett, M.3    Liang, X.4    Kaufmann, M.5    Scott, G.K.6    Osborne, C.K.7    Benz, C.C.8
  • 28
    • 77952397929 scopus 로고    scopus 로고
    • Estrogen receptor mutations and changes in downstream gene expression and signaling
    • Barone I, Brusco L, Fuqua SA,. Estrogen receptor mutations and changes in downstream gene expression and signaling. Clin Cancer Res 2010; 16: 2702-8.
    • (2010) Clin Cancer Res , vol.16 , pp. 2702-2708
    • Barone, I.1    Brusco, L.2    Fuqua, S.A.3
  • 30
    • 79955044468 scopus 로고    scopus 로고
    • Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells
    • Godinho M, Meijer D, Setyono-Han B, Dorssers LC, van Agthoven TV,. Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells. J Cell Physiol 2011; 226: 1741-9.
    • (2011) J Cell Physiol , vol.226 , pp. 1741-1749
    • Godinho, M.1    Meijer, D.2    Setyono-Han, B.3    Dorssers, L.C.4    Van Agthoven, T.V.5
  • 31
    • 0027938209 scopus 로고
    • Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
    • DOI 10.1016/0092-8674(94)90543-6
    • Hunter T, Pines J,. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 1994; 79: 573-82. (Pubitemid 24363801)
    • (1994) Cell , vol.79 , Issue.4 , pp. 573-582
    • Hunter, T.1    Pines, J.2
  • 32
    • 0035576786 scopus 로고    scopus 로고
    • HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer
    • Dowsett M, Harper-Wynne C, Boeddinghaus I, Salter J, Hills M, Dixon M, Ebbs S, Gui G, Sacks N, Smith I,. HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer. Cancer Res 2001; 61: 8452-8. (Pubitemid 33131124)
    • (2001) Cancer Research , vol.61 , Issue.23 , pp. 8452-8458
    • Dowsett, M.1    Harper-Wynne, C.2    Boeddinghaus, I.3    Salter, J.4    Hills, M.5    Dixon, M.6    Ebbs, S.7    Gui, G.8    Sacks, N.9    Smith, I.10
  • 33
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • Hynes NE, Lane HA,. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5: 341-54. (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 34
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC,. AKT/PKB signaling: navigating downstream. Cell 2007; 129: 1261-74. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 35
    • 0142219882 scopus 로고    scopus 로고
    • AND-34/BCAR3, a GDP Exchange Factor Whose Overexpression Confers Antiestrogen Resistance, Activates Rac, PAK1, and the Cyclin D1 Promoter
    • Cai D, Iyer A, Felekkis KN, Near RI, Luo Z, Chernoff J, Albanese C, Pestell RG, Lerner A,. AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter. Cancer Res 2003; 63: 6802-8. (Pubitemid 37322962)
    • (2003) Cancer Research , vol.63 , Issue.20 , pp. 6802-6808
    • Cai, D.1    Iyer, A.2    Felekkis, K.N.3    Near, R.I.4    Luo, Z.5    Chernoff, J.6    Albanese, C.7    Pestell, R.G.8    Lerner, A.9
  • 37
    • 1042302005 scopus 로고    scopus 로고
    • The stats of cancer - New molecular targets come of age
    • Yu H, Jove R,. The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 2004; 4: 97-105. (Pubitemid 38198738)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 40
    • 77950605242 scopus 로고    scopus 로고
    • CAS proteins in normal and pathological cell growth control
    • Tikhmyanova N, Little JL, Golemis EA,. CAS proteins in normal and pathological cell growth control. Cell Mol Life Sci 2010; 67: 1025-48.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1025-1048
    • Tikhmyanova, N.1    Little, J.L.2    Golemis, E.A.3
  • 41
    • 34447122558 scopus 로고    scopus 로고
    • Cas membrane localization and membrane ruffling
    • DOI 10.1158/0008-5472.CAN-06-3455
    • Schrecengost RS, Riggins RB, Thomas KS, Guerrero MS, Bouton AH,. Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. Cancer Res 2007; 67: 6174-82. (Pubitemid 47037498)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6174-6182
    • Schrecengost, R.S.1    Riggins, R.B.2    Thomas, K.S.3    Guerrero, M.S.4    Bouton, A.H.5
  • 43
    • 0033537975 scopus 로고    scopus 로고
    • NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway
    • Lu Y, Brush J, Stewart TA,. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway. J Biol Chem 1999; 274: 10047-52.
    • (1999) J Biol Chem , vol.274 , pp. 10047-10052
    • Lu, Y.1    Brush, J.2    Stewart, T.A.3
  • 44
    • 0033566368 scopus 로고    scopus 로고
    • AND-34, a novel p130(Cas)-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines
    • Cai D, Clayton LK, Smolyar A, Lerner A,. AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol 1999; 163: 2104-12. (Pubitemid 29382216)
    • (1999) Journal of Immunology , vol.163 , Issue.4 , pp. 2104-2112
    • Cai, D.1    Clayton, L.K.2    Smolyar, A.3    Lerner, A.4
  • 45
    • 33847626335 scopus 로고    scopus 로고
    • Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling
    • DOI 10.1016/j.gene.2006.12.016, PII S0378111906007773
    • Vervoort VS, Roselli S, Oshima RG, Pasquale EB,. Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling. Gene 2007; 391: 161-70. (Pubitemid 46356795)
    • (2007) Gene , vol.391 , Issue.1-2 , pp. 161-170
    • Vervoort, V.S.1    Roselli, S.2    Oshima, R.G.3    Pasquale, E.B.4
  • 46
    • 12244263457 scopus 로고    scopus 로고
    • Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation
    • DOI 10.1242/jcs.00207
    • Sakakibara A, Ohba Y, Kurokawa K, Matsuda M, Hattori S,. Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J Cell Sci 2002; 115: 4915-24. (Pubitemid 36054643)
    • (2002) Journal of Cell Science , vol.115 , Issue.24 , pp. 4915-4924
    • Sakakibara, A.1    Ohba, Y.2    Kurokawa, K.3    Matsuda, M.4    Hattori, S.5
  • 47
    • 34547932906 scopus 로고    scopus 로고
    • AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology
    • DOI 10.1002/jcp.21059
    • Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A,. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol 2007; 212: 655-65. (Pubitemid 47267535)
    • (2007) Journal of Cellular Physiology , vol.212 , Issue.3 , pp. 655-665
    • Near, R.I.1    Zhang, Y.2    Makkinje, A.3    Vanden Borre, P.4    Lerner, A.5
  • 48
    • 33646557326 scopus 로고    scopus 로고
    • P130Cas: A versatile scaffold in signaling networks
    • DOI 10.1016/j.tcb.2006.03.003, PII S0962892406000833
    • Defilippi P, Di Stefano P, Cabodi S,. p130Cas: a versatile scaffold in signaling networks. Trends Cell Biol 2006; 16: 257-63. (Pubitemid 43728873)
    • (2006) Trends in Cell Biology , vol.16 , Issue.5 , pp. 257-263
    • Defilippi, P.1    Di Stefano, P.2    Cabodi, S.3
  • 49
    • 79952698124 scopus 로고    scopus 로고
    • BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas
    • Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A,. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal 2011; 23: 1030-40.
    • (2011) Cell Signal , vol.23 , pp. 1030-1040
    • Vanden Borre, P.1    Near, R.I.2    Makkinje, A.3    Mostoslavsky, G.4    Lerner, A.5
  • 50
    • 84856592577 scopus 로고    scopus 로고
    • Tumor control versus adverse events with targeted anticancer therapies
    • Keefe DM, Bateman EH,. Tumor control versus adverse events with targeted anticancer therapies. Nat Rev Clin Oncol 2011; 9: 98-109.
    • (2011) Nat Rev Clin Oncol , vol.9 , pp. 98-109
    • Keefe, D.M.1    Bateman, E.H.2
  • 52
    • 80755127903 scopus 로고    scopus 로고
    • Mutations in the phosphatidylinositol 3-kinase pathway: Role in tumor progression and therapeutic implications in breast cancer
    • Miller TW, Rexer BN, Garrett JT, Arteaga CL,. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast Cancer Res 2011; 13: 224.
    • (2011) Breast Cancer Res , vol.13 , pp. 224
    • Miller, T.W.1    Rexer, B.N.2    Garrett, J.T.3    Arteaga, C.L.4
  • 55
    • 26444555647 scopus 로고    scopus 로고
    • Clinical proteomics: From biomarker discovery and cell signaling profiles to individualized personal therapy
    • DOI 10.1007/s10540-005-2851-3
    • Calvo KR, Liotta LA, Petricoin EF,. Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy. Biosci Rep 2005; 25: 107-25. (Pubitemid 41437713)
    • (2005) Bioscience Reports , vol.25 , Issue.1-2 , pp. 107-125
    • Calvo, K.R.1    Liotta, L.A.2    Petricoin, E.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.