Genetic ablation of calcium-independent phospholipase A2γ (iPLA2γ) attenuates calcium-induced opening of the mitochondrial permeability transition pore and resultant cytochrome c release

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 29837-29850

  Moon, Sung Ho ^a   Jenkins, Christopher M ^a   Kiebish, Michael A ^a   Sims, Harold F ^a   Mancuso, David J ^a   Gross, Richard W ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL-COA; CARNITINE; CYTOCHROME C; ENANTIOSELECTIVE; GENETIC ABLATION; L-CARNITINE; LIVER MITOCHONDRIA; LONG CHAINS; METABOLIC CHANNELING; MICROMOLAR CONCENTRATION; MITOCHONDRIAL BIOENERGETICS; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; MOUSE LIVER; PHOSPHOLIPASE A; T-BUTYL HYDROPEROXIDE; THIOETHERS; WILD TYPES;

BIOCHEMISTRY; CELL DEATH; MAMMALS; MITOCHONDRIA; PLANTS (BOTANY);

CALCIUM;

6 (BROMOMETHYLENE) 3 (1 NAPHTHALENYL) 2H TETRAHYDROPYRAN 2 ONE; ACYL COENZYME A; ARSENOSOBENZENE; CALCIUM; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CALCIUM INDEPENDENT PHOSPHOLIPASE A2 GAMMA; CARNITINE; CYTOCHROME C; ENZYME INHIBITOR; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PALMITOYL COENZYME A; REACTIVE OXYGEN METABOLITE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOENERGY; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; LIVER MITOCHONDRION; LOSS OF FUNCTION MUTATION; MALE; MITOCHONDRION SWELLING; MOLECULAR GENETICS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN SECRETION; SWELLING;

ANIMALS; CALCIUM; CARNITINE; CARNITINE O-PALMITOYLTRANSFERASE; CELL DEATH; CYTOCHROMES C; ENERGY METABOLISM; ENZYME INHIBITORS; GROUP VI PHOSPHOLIPASES A2; LIPID METABOLISM; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; PALMITOYL COENZYME A; RABBITS;

MUS;

EID: 84865526078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.373654     Document Type: Article

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