A mitochondrial-targeted cyclosporin A with high binding affinity for cyclophilin D yields improved cytoprotection of cardiomyocytes

Biochemical Journal

Volumn 441, Issue 3, 2012, Pages 901-907

  Dube, Henry ^a   Selwood, David ^a   Malouitre, Sylvanie ^b   Capano, Michela ^b   Simone, Michela I ^a,c   Crompton, Martin ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Cyclophilin D (CyP D); Cyclosporin; Ischaemia; Mitochondrial targeting; Reperfusion injury (RI); Triphenylphosphonium (TPP +)

Indexed keywords

CYCLOPHILIN D; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; GLUCOSE; OXYGEN; PHOSPHONIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PROTECTION; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG TARGETING; HEART MUSCLE CELL; ISCHEMIA; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT;

ANIMALS; CELLS, CULTURED; CYCLOPHILINS; CYCLOSPORINE; CYTOPROTECTION; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; MITOCHONDRIA, HEART; MODELS, BIOLOGICAL; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

RATTUS;

EID: 84855958407     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111301     Document Type: Article

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