AT 2 receptor-mediated vasodilatation is unmasked by AT 1 receptor blockade in conscious SHR

British Journal of Pharmacology

Volumn 142, Issue 5, 2004, Pages 821-830

  Li, Xiao C ^a   Widdop, Robert E ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

Angiotensin II; AT 1 receptor antagonist; AT 2 receptor; Hypertension; Rat; Regional vasodilatation

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; CANDESARTAN; NICOTINOYLTYROSYL(N BENZYLOXYCARBONYLARGINYL)LYSYLHISTIDYLPROLYLISOLEUCINE; BENZIMIDAZOLE DERIVATIVE; OLIGOPEPTIDE; TETRAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONDUCTANCE; CONTROLLED STUDY; DRUG ANTAGONISM; HEMODYNAMICS; KIDNEY BLOOD FLOW; MALE; MEAN ARTERIAL PRESSURE; MEASUREMENT; MESENTERY BLOOD FLOW; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; RAT STRAIN; REGULATORY MECHANISM; SPONTANEOUSLY HYPERTENSIVE RAT; STATISTICAL SIGNIFICANCE; VASODILATATION; ANIMAL; BLOOD FLOW; COMPARATIVE STUDY; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; WISTAR KYOTO RAT;

ANIMALS; BENZIMIDAZOLES; DRUG INTERACTIONS; HEMODYNAMIC PROCESSES; OLIGOPEPTIDES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; REGIONAL BLOOD FLOW; TETRAZOLES; VASODILATION;

EID: 3242892150     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705838     Document Type: Article

References (35)

1. ARIMA, S., ENDO, Y., YAOITA, H., OMATA, K., OGAWA, S., TSUNODA, S., ABE, M., TAKEUCH, K., ABE, K. & ITO, S. (1997). Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused afferent arteriole. J. Clin. Invest., 100, 2816-2823.
2. 2 receptor stimulation enhances antihypertensive effect of AT1 receptor antagonist in hypertensive rats. Hypertension, 34, 1112-1116.
3. BONNET, F., COOPER, M.E., CAREY, R.M., CASLEY, D. & CAO, Z. (2001). Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin infusion. J. Hypertens., 19, 1075-1081.
4. CAREY, R.M., HOWELL, N.L., JIN, X.-H. & SIRAGY, H.M. (2001a). Angiotensin type 2 receptor-mediated hypotension in angiotensin type 1 receptor-blocked rats. Hypertension, 38, 1272-1277.
5. 2 receptor in blood pressure regulation and therapeutic implications. Am. J. Hypertens., 14, 98S-102S.
6. DE GASPARO, M., CATT, K.J., INAGAMI, T., WRIGHT, J.W. & UNGER, T.H. (2000). International Union of Pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev., 52, 415-472.
7. 2+-activated (Bkca) channels. Hypertension, 37, 301-307.
8. 2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism. Hypertension, 31, 349-355.
9. HEIN, L., BARSH, G.S., PRATT, R.E., DZAU, V.J. & KOBILKA, B.K. (1995). Behavioural and cardiovascular effects of disrupting the angiotensin II type 2 receptor gene in mice. Nature, 377, 744-747.
10. ICHIKI, T., LABOSKY, P.A., SHIOTA, C., OKUYAMA, S., IMAGAWA, Y., FOGO, A., NIIMURA, F., ICHIKAWA, I., HOGAN, B.L.M. & INAGAMI, T. (1995). Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. Nature, 377, 748-750.
11. LI, X.C. & WIDDOP, R.E. (1995). Regional hemodynamic effects of the AT1 receptor antagonist candesartan in conscious renal hypertensive rats. Hypertension, 26, 989-997.
12. 1 receptor antagonist in conscious spontaneously hypertensive rats. Clin. Exp. Pharmacol. Physiol., 28 (Suppl), A45.
13. LI, X.C. & WIDDOP, R.E. (1996). Angiotensin type 1 receptor antagonists candesartan and EXP 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats. Clin. Sci., 91, 147-154.
14. LIU, Y., YANG, X., SHAROV, V.G., NASS, O., SABBAH, H.N., PETERSON, E. & CARRETERO, O.A. (1997). Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 2 receptor antagonists in rats with heart failure: role of kinins and angiotensin II type 2 receptors. J. Clin. Invest., 99, 1926-1935.
15. LUDBROOK, J. (1994). Repeated measurements and multiple comparisons in cardiovascular research. Cardiovasc. Res., 28, 303-311.
16. 2 receptor ligands CGP 42112B and PD 123319 in the sodium-depleted rat. Eur. J. Pharmacol., 249, 85-93.
17. 2 receptor ligands CGP 42112B and PD 123319 after blockade of the renin-angiotensin system. Eur. J. Pharmacol., 259, 27-36.
18. 2 receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension, 34, 659-665.
19. MATSUBARA, H. (1998). Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases. Circ. Res., 83, 1182-1191.
20. MOORE, A.F., HEIDERSTADT, N.T., HUANG, E., HOWELL, N.L., WANG, Z.-Q., SIRAGY, H.M. & CAREY, R.M. (2001). Selective inhibition of the renal angiotensin type 2 receptor increases blood pressure in conscious rats. Hypertension, 37, 1285-1291.
21. MUNZENMAIER, D. & GREENE, A. (1996). Opposing actions of angiotensin II on microvascular growth and arterial blood pressure. Hypertension, 27, 760-765.
22. NORA, E.H., MUNZENMAIER, D.H., HANSEN-SMITH, F.M., LOMBARD, J.H. & GREENE, A.S. (1998). Localization of the ANG II type 2 receptor in the microcirculation of skeletal muscle. Am. J. Physiol., 275, H1395-H1403.
23. OTSUKA, S., SUGANO, M., MAKINO, N., SAWADA, S., HATA, T. & NIHO, Y. (1998). Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive rats. Hypertension, 32, 467-472.
24. 2 receptor-mediated vasodilatation in the heart: effect of myocardial infarction. Am. J. Physiol., 281, H2590-H2596.
25. SCHUIJT, M.P., DE VRIES, R., SAXENA, P.R. & DANSER, A.H.J. (1999). No vasoactive role of the angiotensin type 2 receptor in normotensive Wistar rats. J. Hypertens., 17, 1879-1884.
26. 2) receptor mediates renal production of nitric oxide in conscious rats. J. Clin. Invest., 100, 264-269.
27. 2 receptor in a renal wrap hypertension model. Hypertension, 33, 1237-1242.
28. SIRAGY, H.M., DE GASPARO, M. & CAREY, R.M. (2000). Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats. Hypertension, 35, 1074-1077.
29. 2 receptors in angiotensin II-stimulated contraction of small mesenteric arteries in young SHR. Hypertension, 33 (Part II), 366-372.
30. TSUTSUMI, Y., MATSUBARA, H., MASAKI, H., KURIHARA, H., MURASAWA, S., TAKAI, S., MIYAZAKI, M., NOZAWA, Y., OZONO, R., NAKAGAWA, K., MIWA, T., KAWADA, N., MORI, Y., SHIBASAKI, Y., TANAKA, Y., FUJIYAMA, S., KOYAMA, Y., FUJIYAMA, A., TAKAHASHI, H. & IWASAKA, T. (1999). Angiotensin II type 2 overexpression activates the vascular kinin system and causes vasodilatation. J. Clin. Invest., 104, 925-935.
31. VISWANATHAN, M., TSUTSUMI, K., CORREA, F.M.A. & SAAVEDRA, J.M. (1991). Changes in expression of angiotensin receptor subtypes in the rat aorta during development. Biochem. Biophys. Res. Commun., 179, 1361-1367.
32. 1 receptor antagonist, EXP 3174. Br. J. Pharmacol., 107, 873-880.
33. 2 receptors: cardiovascular hope or hype? Br. J. Pharmacol., 140, 809-824.
34. 1 receptor blockade. Hypertension, 40, 516-520.
35. 2 receptors. Br. J. Pharmacol., 125, 1429-1436.