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Volumn 90, Issue 6, 2001, Pages 2386-2402

An automated flinch detecting system for use in the formalin nociceptive bioassay

Author keywords

Flinching behavior; Formalin test; Pain models; Spinal sensitization

Indexed keywords

DIZOCILPINE; FORMALDE FRESH; FORMALDEHYDE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

EID: 0035000170     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2001.90.6.2386     Document Type: Article
Times cited : (126)

References (52)
  • 1
    • 0031049721 scopus 로고    scopus 로고
    • Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: Studies with remifentanil and lidocaine
    • Abbadie C, Taylor BK, Peterson MA, and Basbaum AI. Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine. Pain 69: 101-110, 1997.
    • (1997) Pain , vol.69 , pp. 101-110
    • Abbadie, C.1    Taylor, B.K.2    Peterson, M.A.3    Basbaum, A.I.4
  • 2
    • 0028833853 scopus 로고
    • The formalin test: Scoring properties of the first and second phases of the pain response in rats
    • Abbott FV, Franklin KB, and Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain 60: 91-102, 1995.
    • (1995) Pain , vol.60 , pp. 91-102
    • Abbott, F.V.1    Franklin, K.B.2    Westbrook, R.F.3
  • 3
    • 0027516611 scopus 로고
    • Morphine, but not inhalation anesthesia, blocks post-injury facilitation. The role of preemptive suppression of afferent transmission
    • Abram SE and Yaksh TL. Morphine, but not inhalation anesthesia, blocks post-injury facilitation. The role of preemptive suppression of afferent transmission. Anesthesiology 78: 713-721, 1993.
    • (1993) Anesthesiology , vol.78 , pp. 713-721
    • Abram, S.E.1    Yaksh, T.L.2
  • 4
    • 0028157262 scopus 로고
    • Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat
    • Abram SE and Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology 80: 383-391, 25A, 1994.
    • (1994) Anesthesiology , vol.80 , Issue.25 A , pp. 383-391
    • Abram, S.E.1    Yaksh, T.L.2
  • 5
    • 0029111541 scopus 로고
    • Behavioural effects of different intensities of formalin pain in rats
    • Aloisi AM, Albonetti ME, and Carli G. Behavioural effects of different intensities of formalin pain in rats. Physiol Behav 58: 603-610, 1995.
    • (1995) Physiol Behav , vol.58 , pp. 603-610
    • Aloisi, A.M.1    Albonetti, M.E.2    Carli, G.3
  • 7
    • 0032577992 scopus 로고    scopus 로고
    • The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection
    • Bhatnagar S, Dallman MF, Roderick RE, Basbaum AI, and Taylor BK. The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection. Brain Res 797: 313-320, 1998.
    • (1998) Brain Res , vol.797 , pp. 313-320
    • Bhatnagar, S.1    Dallman, M.F.2    Roderick, R.E.3    Basbaum, A.I.4    Taylor, B.K.5
  • 8
    • 0031769344 scopus 로고    scopus 로고
    • AMPA/kainate receptor antagonists as novel analgesic agents
    • Brennan TJ. AMPA/kainate receptor antagonists as novel analgesic agents. Anesthesiology 89: 1049-1051, 1998.
    • (1998) Anesthesiology , vol.89 , pp. 1049-1051
    • Brennan, T.J.1
  • 9
    • 0031930670 scopus 로고    scopus 로고
    • Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat
    • Buerkle H, Marsala M, and Yaksh TL. Effect of continuous spinal remifentanil infusion on behaviour and spinal glutamate release evoked by subcutaneous formalin in the rat. Br J Anaesth 80: 348-353, 1998.
    • (1998) Br J Anaesth , vol.80 , pp. 348-353
    • Buerkle, H.1    Marsala, M.2    Yaksh, T.L.3
  • 10
    • 0030933616 scopus 로고    scopus 로고
    • Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat
    • Chaplan SR, Malmberg AB, and Yaksh TL. Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat. J Pharmacol Exp Ther 280: 829-838, 1997.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 829-838
    • Chaplan, S.R.1    Malmberg, A.B.2    Yaksh, T.L.3
  • 11
    • 0029080379 scopus 로고
    • The orofacial formalin test in rats: Effects of different formalin concentrations
    • Clavelou P, Dallel R, Orliaguet T, Woda A, and Raboisson P. The orofacial formalin test in rats: effects of different formalin concentrations. Pain 62: 295-301, 1995.
    • (1995) Pain , vol.62 , pp. 295-301
    • Clavelou, P.1    Dallel, R.2    Orliaguet, T.3    Woda, A.4    Raboisson, P.5
  • 12
    • 0027156210 scopus 로고
    • The formalin test: A validation of the weighted-scores method of behavioural pain rating
    • Coderre TJ, Fundytus ME, McKenna JE, Dalal S, and Melzack R. The formalin test: a validation of the weighted-scores method of behavioural pain rating. Pain 54: 43-50, 1993.
    • (1993) Pain , vol.54 , pp. 43-50
    • Coderre, T.J.1    Fundytus, M.E.2    McKenna, J.E.3    Dalal, S.4    Melzack, R.5
  • 13
    • 0028917022 scopus 로고
    • Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin
    • Dallel R, Raboisson P, Clavelou P, Saade M, and Woda A. Evidence for a peripheral origin of the tonic nociceptive response to subcutaneous formalin. Pain 61: 11-16, 1995.
    • (1995) Pain , vol.61 , pp. 11-16
    • Dallel, R.1    Raboisson, P.2    Clavelou, P.3    Saade, M.4    Woda, A.5
  • 14
    • 0343534426 scopus 로고    scopus 로고
    • Response properties of dorsal horn neurons: Pharmacology of the dorsal horn
    • edited by Yaksh TL, Lynch C III, Zapol WM, Maze M, Biebuyck JF, and Saidman LJ. Philadelphia, PA: Lippincott-Raven
    • Dickenson AH, Stanfa LC, Chapman V, and Yaksh TL. Response properties of dorsal horn neurons: pharmacology of the dorsal horn. In: Anesthesia: Biologic Foundations, edited by Yaksh TL, Lynch C III, Zapol WM, Maze M, Biebuyck JF, and Saidman LJ. Philadelphia, PA: Lippincott-Raven, 1997, p. 611-624.
    • (1997) Anesthesia: Biologic Foundations , pp. 611-624
    • Dickenson, A.H.1    Stanfa, L.C.2    Chapman, V.3    Yaksh, T.L.4
  • 15
    • 0023501963 scopus 로고
    • Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurons
    • Dickenson AH and Sullivan AF. Peripheral origins and central modulation of subcutaneous formalin-induced activity of rat dorsal horn neurons. Neurosci Lett 83: 207-211, 1987.
    • (1987) Neurosci Lett , vol.83 , pp. 207-211
    • Dickenson, A.H.1    Sullivan, A.F.2
  • 16
    • 0028802694 scopus 로고
    • Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model
    • Dirig DM and Yaksh TL. Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. J Pharmacol Exp Ther 275: 219-227, 1995.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 219-227
    • Dirig, D.M.1    Yaksh, T.L.2
  • 17
    • 0026018301 scopus 로고
    • Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw
    • Dray A and Dickenson A. Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw. Pain 47: 79-83, 1991.
    • (1991) Pain , vol.47 , pp. 79-83
    • Dray, A.1    Dickenson, A.2
  • 18
    • 0017643233 scopus 로고
    • The formalin test: A quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats
    • Dubuisson D and Dennis SG. The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 4: 161-174, 1977.
    • (1977) Pain , vol.4 , pp. 161-174
    • Dubuisson, D.1    Dennis, S.G.2
  • 19
    • 0025987514 scopus 로고
    • Electrophysiological mechanisms in inflammatory pain
    • Handwerker HO. Electrophysiological mechanisms in inflammatory pain. Agents Actions Suppl 32: 91-99, 1991.
    • (1991) Agents Actions Suppl , vol.32 , pp. 91-99
    • Handwerker, H.O.1
  • 20
    • 0028306527 scopus 로고
    • Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat
    • Hunter JC and Singh L. Role of excitatory amino acid receptors in the mediation of the nociceptive response to formalin in the rat. Neurosci Lett 174: 217-221, 1994.
    • (1994) Neurosci Lett , vol.174 , pp. 217-221
    • Hunter, J.C.1    Singh, L.2
  • 21
    • 0030056261 scopus 로고    scopus 로고
    • The formalin test in rat: Validation of an automated system
    • Jett MF and Michelson S. The formalin test in rat: validation of an automated system. Pain 64: 19-25, 1996.
    • (1996) Pain , vol.64 , pp. 19-25
    • Jett, M.F.1    Michelson, S.2
  • 23
    • 0028338331 scopus 로고
    • Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat
    • Malmberg AB, Rafferty MF, and Yaksh TL. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neurosci Lett 173: 193-196, 1994.
    • (1994) Neurosci Lett , vol.173 , pp. 193-196
    • Malmberg, A.B.1    Rafferty, M.F.2    Yaksh, T.L.3
  • 24
    • 0026673173 scopus 로고
    • Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat
    • Malmberg AB and Yaksh TL. Antinociceptive actions of spinal nonsteroidal anti-inflammatory agents on the formalin test in the rat. J Pharmacol Exp Ther 263: 136-146, 1992.
    • (1992) J Pharmacol Exp Ther , vol.263 , pp. 136-146
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 25
    • 0027177760 scopus 로고
    • Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction
    • Malmberg AB and Yaksh TL. Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction. Anesthesiology 79: 270-281, 1993.
    • (1993) Anesthesiology , vol.79 , pp. 270-281
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 26
    • 0027239945 scopus 로고
    • Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats
    • Malmberg AB and Yaksh TL. Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats. Pain 54: 291-300, 1993.
    • (1993) Pain , vol.54 , pp. 291-300
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 27
    • 0028836065 scopus 로고
    • Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hotplate tests in rats
    • Malmberg AB and Yaksh TL. Effect of continuous intrathecal infusion of omega-conopeptides, N-type calcium-channel blockers, on behavior and antinociception in the formalin and hotplate tests in rats. Pain 60: 83-90, 1995.
    • (1995) Pain , vol.60 , pp. 83-90
    • Malmberg, A.B.1    Yaksh, T.L.2
  • 28
    • 0032544521 scopus 로고    scopus 로고
    • A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat
    • Nozaki-Taguchi N and Yaksh TL. A novel model of primary and secondary hyperalgesia after mild thermal injury in the rat. Neurosci Lett 254: 25-28, 1998.
    • (1998) Neurosci Lett , vol.254 , pp. 25-28
    • Nozaki-Taguchi, N.1    Yaksh, T.L.2
  • 29
    • 0030932645 scopus 로고    scopus 로고
    • The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test
    • Peterson MA, Basbaum AI, Abbadie C, Rohde DS, McKay WR, and Taylor BK. The differential contribution of capsaicin-sensitive afferents to behavioral and cardiovascular measures of brief and persistent nociception and to Fos expression in the formalin test. Brain Res 755: 9-16, 1997.
    • (1997) Brain Res , vol.755 , pp. 9-16
    • Peterson, M.A.1    Basbaum, A.I.2    Abbadie, C.3    Rohde, D.S.4    McKay, W.R.5    Taylor, B.K.6
  • 30
    • 0030669566 scopus 로고    scopus 로고
    • Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models
    • Prado WA and Goncalves AS. Antinociceptive effect of intrathecal neostigmine evaluated in rats by two different pain models. Braz J Med Biol Res 30: 1225-1231, 1997.
    • (1997) Braz J Med Biol Res , vol.30 , pp. 1225-1231
    • Prado, W.A.1    Goncalves, A.S.2
  • 31
    • 0024511376 scopus 로고
    • Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block
    • Price DD, Bennett GJ, and Rafii A. Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block. Pain 36: 273-288, 1989.
    • (1989) Pain , vol.36 , pp. 273-288
    • Price, D.D.1    Bennett, G.J.2    Rafii, A.3
  • 32
    • 0029923562 scopus 로고    scopus 로고
    • Formalin-evoked activity in identified primary afferent fibers: Systemic lidocaine suppresses phase-2 activity
    • Puig S and Sorkin LS. Formalin-evoked activity in identified primary afferent fibers: systemic lidocaine suppresses phase-2 activity. Pain 64: 345-355, 1996.
    • (1996) Pain , vol.64 , pp. 345-355
    • Puig, S.1    Sorkin, L.S.2
  • 33
    • 0028963101 scopus 로고
    • Effects of subcutaneous formalin on the activity of trigeminal brain stem nociceptive neurones in the rat
    • Raboisson P, Dallel R, Clavelou P, Sessle BJ, and Woda A. Effects of subcutaneous formalin on the activity of trigeminal brain stem nociceptive neurones in the rat. J Neurol 73: 496-505, 1995.
    • (1995) J Neurol , vol.73 , pp. 496-505
    • Raboisson, P.1    Dallel, R.2    Clavelou, P.3    Sessle, B.J.4    Woda, A.5
  • 36
    • 0029795902 scopus 로고    scopus 로고
    • The antiepileptic agent gabapentin (neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine
    • Singh L, Field MJ, Ferris P, Hunter JC, Oles RJ, Williams RG, and Woodruff GN. The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine. Psychopharmacology (Berl) 127: 1-9, 1996.
    • (1996) Psychopharmacology (Berl) , vol.127 , pp. 1-9
    • Singh, L.1    Field, M.J.2    Ferris, P.3    Hunter, J.C.4    Oles, R.J.5    Williams, R.G.6    Woodruff, G.N.7
  • 38
    • 0031763988 scopus 로고    scopus 로고
    • Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: Endogenous corticosterone does not reduce nociception in the formalin test
    • Taylor BK, Akana SF, Peterson MA, Dallman MF, and Basbaum AI. Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test. Endocrinology 139: 2407-2413, 1998.
    • (1998) Endocrinology , vol.139 , pp. 2407-2413
    • Taylor, B.K.1    Akana, S.F.2    Peterson, M.A.3    Dallman, M.F.4    Basbaum, A.I.5
  • 39
    • 0028848216 scopus 로고
    • Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input
    • Taylor BK, Peterson MA, and Basbaum AI. Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input. J Neurol 15: 7575-7584, 1995.
    • (1995) J Neurol , vol.15 , pp. 7575-7584
    • Taylor, B.K.1    Peterson, M.A.2    Basbaum, A.I.3
  • 40
    • 15444355528 scopus 로고    scopus 로고
    • Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: Effects with remifentanil
    • Taylor BK, Peterson MA, and Basbaum AI. Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: effects with remifentanil. J Pharmacol Exp Ther 280: 876-883, 1997.
    • (1997) J Pharmacol Exp Ther , vol.280 , pp. 876-883
    • Taylor, B.K.1    Peterson, M.A.2    Basbaum, A.I.3
  • 42
    • 0025805581 scopus 로고
    • Standardization of the rat paw formalin test for the evaluation of analgesics
    • Wheeler-Aceto H and Cowan A. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacology (Berl) 104: 35-44, 1991.
    • (1991) Psychopharmacology (Berl) , vol.104 , pp. 35-44
    • Wheeler-Aceto, H.1    Cowan, A.2
  • 43
    • 0025014877 scopus 로고
    • The rat paw formalin test: Comparison of noxious agents
    • Wheeler-Aceto H, Porreca F, and Cowan A. The rat paw formalin test: comparison of noxious agents. Pain 40: 229-238, 1990.
    • (1990) Pain , vol.40 , pp. 229-238
    • Wheeler-Aceto, H.1    Porreca, F.2    Cowan, A.3
  • 44
    • 0021154336 scopus 로고
    • Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat
    • Woolf CJ. Long term alterations in the excitability of the flexion reflex produced by peripheral tissue injury in the chronic decerebrate rat. Pain 18: 325-343, 1984.
    • (1984) Pain , vol.18 , pp. 325-343
    • Woolf, C.J.1
  • 45
    • 0000135444 scopus 로고    scopus 로고
    • Preclinical models of nociception
    • edited by Yaksh TL, Lynch C III, Zapol WM, Maze M, Biebuyck JF, and Saidman LJ. Philadelphia, PA: Lippincott-Raven
    • Yaksh TL. Preclinical models of nociception. In: Anesthesia: Biologic Foundations, edited by Yaksh TL, Lynch C III, Zapol WM, Maze M, Biebuyck JF, and Saidman LJ. Philadelphia, PA: Lippincott-Raven, 1997, vol. I, p. 685-718.
    • (1997) Anesthesia: Biologic Foundations , vol.1 , pp. 685-718
    • Yaksh, T.L.1
  • 46
    • 0018601372 scopus 로고
    • Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia
    • Yaksh TL, Farb DH, Leeman SE, and Jessell TM. Intrathecal capsaicin depletes substance P in the rat spinal cord and produces prolonged thermal analgesia. Science 206: 481-483, 1979.
    • (1979) Science , vol.206 , pp. 481-483
    • Yaksh, T.L.1    Farb, D.H.2    Leeman, S.E.3    Jessell, T.M.4
  • 47
    • 0033529223 scopus 로고    scopus 로고
    • The spinal biology in humans and animals of pain states generated by persistent small afferent input
    • Yaksh TL, Hua XY, Kalcheva I, Nozaki-Taguchi N, and Marsala M. The spinal biology in humans and animals of pain states generated by persistent small afferent input. Proc Natl Acad Sci USA 96: 7680-7686, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7680-7686
    • Yaksh, T.L.1    Hua, X.Y.2    Kalcheva, I.3    Nozaki-Taguchi, N.4    Marsala, M.5
  • 48
    • 0002551630 scopus 로고    scopus 로고
    • Central pharmacology of nociceptive transmission
    • edited by Wall P and Melzack R. Edinburgh, UK: Churchill Livingstone
    • Yaksh TL and Malmberg AB. Central pharmacology of nociceptive transmission. In: Textbook of Pain (4th ed.), edited by Wall P and Melzack R. Edinburgh, UK: Churchill Livingstone, 1999, p. 253-308.
    • (1999) Textbook of Pain (4th Ed.) , pp. 253-308
    • Yaksh, T.L.1    Malmberg, A.B.2
  • 49
    • 0017036162 scopus 로고
    • Chronic catheterization of the spinal sub-arachnoid space
    • Yaksh TL and Rudy TA. Chronic catheterization of the spinal sub-arachnoid space. Physiol Behav 17: 1031-1036, 1976.
    • (1976) Physiol Behav , vol.17 , pp. 1031-1036
    • Yaksh, T.L.1    Rudy, T.A.2
  • 50
    • 0026010260 scopus 로고
    • Stereospecific effects of a non-peptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction
    • Yamamoto T and Yaksh TL. Stereospecific effects of a non-peptidic NK1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction. Life Sci 49: 1955-1963, 1991.
    • (1991) Life Sci , vol.49 , pp. 1955-1963
    • Yamamoto, T.1    Yaksh, T.L.2
  • 51
    • 0344980297 scopus 로고    scopus 로고
    • The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat
    • Yoon MH and Yaksh TL. The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. Anesth Analg 89: 434-439, 1999.
    • (1999) Anesth Analg , vol.89 , pp. 434-439
    • Yoon, M.H.1    Yaksh, T.L.2


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