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Volumn 13, Issue 4, 2012, Pages 399-411

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

Author keywords

Calorie restriction; Diet; Methionine restriction; Mitochondria; Reactive oxygen species

Indexed keywords

ACTIN; APOPTOSIS INDUCING FACTOR; CYTOCHROME C OXIDASE; FREE RADICAL; MANGANESE SUPEROXIDE DISMUTASE; METHIONINE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PORIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR NRF2; UBIQUINOL CYTOCHROME C REDUCTASE;

EID: 84865362095     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-012-9384-5     Document Type: Article
Times cited : (63)

References (62)
  • 3
    • 0036328867 scopus 로고    scopus 로고
    • 2 generation in isolated mitochondria
    • DOI 10.1023/A:1016039604958
    • 2 generation in isolated mitochondria. J Bioenerg Biomembr 34:227-233 (Pubitemid 34847805)
    • (2002) Journal of Bioenergetics and Biomembranes , vol.34 , Issue.3 , pp. 227-233
    • Barja, G.1
  • 4
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • DOI 10.1016/j.tins.2004.07.005, PII S0166223604002334
    • Barja G (2004a) Free radicals and aging. Trends Neurosci 27:595-600 (Pubitemid 39221395)
    • (2004) Trends in Neurosciences , vol.27 , Issue.10 , pp. 595-600
    • Barja, G.1
  • 5
    • 2542446099 scopus 로고    scopus 로고
    • Aging in vertebrates, and the effect of caloric restriction: A mitochondrial free radical production-DNA damage mechanism?
    • DOI 10.1017/S1464793103006213
    • Barja G (2004b) Aging in vertebrates and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism? Biol Rev 79:235-251 (Pubitemid 38685141)
    • (2004) Biological Reviews of the Cambridge Philosophical Society , vol.79 , Issue.2 , pp. 235-251
    • Barja, G.1
  • 6
    • 0031721246 scopus 로고    scopus 로고
    • Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon
    • Barja G, Herrero A (1998) Localization at Complex I and mechanism of the higher free radical production of brain non-synaptic mitochondria in the short-lived rat than in the longevous pigeon. J Bioenerg Biomembr 30:235-243 (Pubitemid 28405165)
    • (1998) Journal of Bioenergetics and Biomembranes , vol.30 , Issue.3 , pp. 235-243
    • Barja, G.1    Herrero, A.2
  • 8
    • 43249123912 scopus 로고    scopus 로고
    • Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver
    • Caro P, Gómez J, López-Torres M, Sánchez I, Naudí A, Jove M, Pamplona R, Barja G (2008) Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver. Bioger-ontology 9:183-196
    • (2008) Bioger-ontology , vol.9 , pp. 183-196
    • Caro, P.1    Gómez, J.2    López-Torres, M.3    Sánchez, I.4    Naudí, A.5    Jove, M.6    Pamplona, R.7    Barja, G.8
  • 9
    • 77649206830 scopus 로고    scopus 로고
    • Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex i during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria
    • Caro P, Gomez J, Sanchez I, Naudi A, Ayala V, Lopez-Torres M, Pamplona R, Barja G (2009a) Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria. Rejuv Res 12:421-434
    • (2009) Rejuv Res , vol.12 , pp. 421-434
    • Caro, P.1    Gomez, J.2    Sanchez, I.3    Naudi, A.4    Ayala, V.5    Lopez-Torres, M.6    Pamplona, R.7    Barja, G.8
  • 10
    • 69249205647 scopus 로고    scopus 로고
    • Effect of 40% restriction of dietary amino acids-except methio-nine-on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver
    • Caro P, Gomez J, Sanchez I, Garcia R, López-Torres M, Naudí A, Portero-Otin M, Pamplona R, Barja G (2009b) Effect of 40% restriction of dietary amino acids-except methio-nine-on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver. Biogerontol 10:579-592
    • (2009) Biogerontol , vol.10 , pp. 579-592
    • Caro, P.1    Gomez, J.2    Sanchez, I.3    Garcia, R.4    López-Torres, M.5    Naudí, A.6    Portero-Otin, M.7    Pamplona, R.8    Barja, G.9
  • 14
    • 72949117234 scopus 로고    scopus 로고
    • Amino acid imbalance explains extension of life span by dietary restriction in Drosophila
    • Grandison RC, Piper MDW, Partridge L (2009) Amino acid imbalance explains extension of life span by dietary restriction in Drosophila. Nature 462:1061-1064
    • (2009) Nature , vol.462 , pp. 1061-1064
    • Grandison, R.C.1    Piper, M.D.W.2    Partridge, L.3
  • 15
    • 23844488868 scopus 로고    scopus 로고
    • The role of oxidative stress in relation to caloric restriction and longevity
    • DOI 10.1210/en.2005-0378
    • Gredilla R, Barja G (2005) The role of oxidative stress in relation to caloric restriction and longevity. Endocrinology 146:3713-3717 (Pubitemid 41175737)
    • (2005) Endocrinology , vol.146 , Issue.9 , pp. 3713-3717
    • Gredilla, R.1    Barja, G.2
  • 16
    • 0035403165 scopus 로고    scopus 로고
    • Caloric restriction decreases mitochondrial free radical generation at Complex i and lowers oxidative damage to mitochon-drial DNA in the rat heart
    • Gredilla R, Sanz A, Lopez-Torres M, Barja G (2001) Caloric restriction decreases mitochondrial free radical generation at Complex I and lowers oxidative damage to mitochon-drial DNA in the rat heart. FASEB J 15:1589-1591
    • (2001) FASEB J , vol.15 , pp. 1589-1591
    • Gredilla, R.1    Sanz, A.2    Lopez-Torres, M.3    Barja, G.4
  • 17
    • 33846796263 scopus 로고    scopus 로고
    • Mitochondrial longevity pathways
    • Hajnoczky G, Hoek JB (2007) Mitochondrial longevity pathways. Science 315:607-609
    • (2007) Science , vol.315 , pp. 607-609
    • Hajnoczky, G.1    Hoek, J.B.2
  • 18
    • 0015319592 scopus 로고
    • The biological clock: The mitochondria
    • Harman D (1972) The biological clock: the mitochondria. J Am Geriatr Soc 20:145-147
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 21
    • 67651159365 scopus 로고    scopus 로고
    • Transcriptional control of mito-chondrial biogenesis and function
    • Hock MB, Kralli A (2009) Transcriptional control of mito-chondrial biogenesis and function. Annu Rev Physiol 71:177-203
    • (2009) Annu Rev Physiol , vol.71 , pp. 177-203
    • Hock, M.B.1    Kralli, A.2
  • 22
    • 80053641483 scopus 로고    scopus 로고
    • Increased transulfuration mediates longevity and dietary restriction in Drosophila
    • Kabil H, Kabil O, Banerjee R, Harshman LG, Pletcher SD (2011) Increased transulfuration mediates longevity and dietary restriction in Drosophila. PNAS 108:16831-16836
    • (2011) PNAS , vol.108 , pp. 16831-16836
    • Kabil, H.1    Kabil, O.2    Banerjee, R.3    Harshman, L.G.4    Pletcher, S.D.5
  • 24
    • 84855217371 scopus 로고    scopus 로고
    • Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system
    • Kastle M, Grune T (2011) Protein oxidative modification in the aging organism and the role of the ubiquitin proteasomal system. Curr Pharm Des 17:4007-4022
    • (2011) Curr Pharm des , vol.17 , pp. 4007-4022
    • Kastle, M.1    Grune, T.2
  • 25
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89-116
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 26
    • 0001104278 scopus 로고
    • Evolution of mitochondrial DNA in Drosophila suboscura
    • Latorre A, Moya A, Ayala A (1986) Evolution of mitochondrial DNA in Drosophila suboscura. PNAS 83:8649-8653
    • (1986) PNAS , vol.83 , pp. 8649-8653
    • Latorre, A.1    Moya, A.2    Ayala, A.3
  • 27
    • 84862286951 scopus 로고    scopus 로고
    • Translational regulation in nutrige-nomics
    • Liu B, Qian SB (2011) Translational regulation in nutrige-nomics. Adv Nutr 2:511-519
    • (2011) Adv Nutr , vol.2 , pp. 511-519
    • Liu, B.1    Qian, S.B.2
  • 29
    • 49449112344 scopus 로고    scopus 로고
    • Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction. Possible implications for humans
    • López-Torres M, Barja G (2008) Lowered methionine ingestion as responsible for the decrease in rodent mitochondrial oxidative stress in protein and dietary restriction. Possible implications for humans. Biochim Biophys Acta 1780: 1337-1347
    • (2008) Biochim Biophys Acta , vol.1780 , pp. 1337-1347
    • López-Torres, M.1    Barja, G.2
  • 30
    • 0036569788 scopus 로고    scopus 로고
    • Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria
    • DOI 10.1016/S0891-5849(02)00773-6, PII S0891584902007736
    • López-Torres M, Gredilla R, Sanz A, Barja G (2002) Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria. Free Rad Biol Med 32:882-889 (Pubitemid 34439258)
    • (2002) Free Radical Biology and Medicine , vol.32 , Issue.9 , pp. 882-889
    • Lopez-Torres, M.1    Gredilla, R.2    Sanz, A.3    Barja, G.4
  • 32
    • 50649099122 scopus 로고    scopus 로고
    • Aging and survival: The genetics of life span extension by dietary restriction
    • Mair W, Dillin A (2008) Aging and survival: the genetics of life span extension by dietary restriction. Annu Rev Biochem 77:727-754
    • (2008) Annu Rev Biochem , vol.77 , pp. 727-754
    • Mair, W.1    Dillin, A.2
  • 33
    • 33746302753 scopus 로고    scopus 로고
    • Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction
    • DOI 10.1111/j.1474-9726.2006.00220.x
    • Malloy VL, Krajcik RA, Bailey SJ, Hristopoulos G, Plummer JD, Orentreich N (2006) Methionine restriction decreases visceral fat mass and preserves insulin action in aging male Fischer 344 rats independent of energy restriction. Aging Cell 5:305-314 (Pubitemid 44103246)
    • (2006) Aging Cell , vol.5 , Issue.4 , pp. 305-314
    • Malloy, V.L.1    Krajcik, R.A.2    Bailey, S.J.3    Hristopoulos, G.4    Plummer, J.D.5    Orentreich, N.6
  • 34
    • 23844464540 scopus 로고    scopus 로고
    • Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance
    • DOI 10.1111/j.1474-9726.2005.00152.x
    • Miller RA, Buehner G, Chang Y, Harper JM, Sigler R, Smith-Wheelock M (2005) Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:119-125 (Pubitemid 41602745)
    • (2005) Aging Cell , vol.4 , Issue.3 , pp. 119-125
    • Miller, R.A.1    Buehner, G.2    Chang, Y.3    Harper, J.M.4    Sigler, R.5    Smith-Wheelock, M.6
  • 35
    • 33646748876 scopus 로고    scopus 로고
    • Restriction of amino acids extends lifespan in Drosophila melanogaster
    • DOI 10.1016/j.mad.2006.02.005, PII S0047637406000704
    • Min KJ, Tatar M (2006) Restriction of amino acids extends lifespan in Drosophila melanogaster. Mech Ageing Dev 127:643-646 (Pubitemid 43744514)
    • (2006) Mechanisms of Ageing and Development , vol.127 , Issue.7 , pp. 643-646
    • Min, K.-J.1    Tatar, M.2
  • 36
    • 37549032051 scopus 로고    scopus 로고
    • Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain
    • Naudí A, Caro P, Jové M, Gómez J, Boada J, Ayala V, Portero-Otín M, Barja G, Pamplona R (2007) Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain. Rejuv Res 10:473-484
    • (2007) Rejuv Res , vol.10 , pp. 473-484
    • Naudí, A.1    Caro, P.2    Jové, M.3    Gómez, J.4    Boada, J.5    Ayala, V.6    Portero-Otín, M.7    Barja, G.8    Pamplona, R.9
  • 37
    • 21944452085 scopus 로고    scopus 로고
    • Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women
    • Newby PK, Tucker KL, Wolk A (2005) Risk of overweight and obesity among semivegetarian, lactovegetarian, and vegan women. Am J Clin Nutr 81:1267-1274 (Pubitemid 41710226)
    • (2005) American Journal of Clinical Nutrition , vol.81 , Issue.6 , pp. 1267-1274
    • Newby, P.K.1    Tucker, K.L.2    Wolk, A.3
  • 39
    • 79958051212 scopus 로고    scopus 로고
    • Advanced lipoxidation end-products
    • Pamplona R (2011) Advanced lipoxidation end-products. Chem Biol Interact 192:14-20
    • (2011) Chem Biol Interact , vol.192 , pp. 14-20
    • Pamplona, R.1
  • 40
    • 83255191671 scopus 로고    scopus 로고
    • An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms
    • Pamplona R, Barja G (2011) An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms. Biogerontology 12:409-435
    • (2011) Biogerontology , vol.12 , pp. 409-435
    • Pamplona, R.1    Barja, G.2
  • 41
    • 0036236733 scopus 로고    scopus 로고
    • Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: A homeoviscous-longevity adaptation?
    • Pamplona R, Barja G, Portero-Otín M (2002) Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation. Ann N Y Acad Sci 959:475-490 (Pubitemid 34457587)
    • (2002) Annals of the New York Academy of Sciences , vol.959 , pp. 475-490
    • Pamplona, R.1    Barja, G.2    Portero-Otin, M.3
  • 42
    • 11144321344 scopus 로고    scopus 로고
    • Lessons learned from gene expression profile studies of aging and caloric restriction
    • DOI 10.1016/j.arr.2004.09.003, PII S1568163704000364
    • Park SK, Prolla TA (2005) Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res Rev 4:55-65 (Pubitemid 40037554)
    • (2005) Ageing Research Reviews , vol.4 , Issue.1 , pp. 55-65
    • Park, S.-K.1    Prolla, T.A.2
  • 43
    • 78049260471 scopus 로고    scopus 로고
    • Mitochondrial function, mitochondrial DNA and ageing: A reappraisal
    • Passarino G, Rose G, Bellizzi D (2010) Mitochondrial function, mitochondrial DNA and ageing: a reappraisal. Biogeron-tology 11:575-588
    • (2010) Biogeron-tology , vol.11 , pp. 575-588
    • Passarino, G.1    Rose, G.2    Bellizzi, D.3
  • 45
    • 80655136471 scopus 로고    scopus 로고
    • Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function
    • Petti AA, Crutchfield CA, Rabinowitz JD, Botstein D (2011) Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. PNAS 108:E1089-E1098
    • (2011) PNAS , vol.108
    • Petti, A.A.1    Crutchfield, C.A.2    Rabinowitz, J.D.3    Botstein, D.4
  • 47
    • 33748951792 scopus 로고    scopus 로고
    • Does apoptosis-inducing factor (AIF) have both life and death functions in cells?
    • DOI 10.1002/bies.20444
    • Porter AG, Urbano AG (2006) Does apoptosis-inducing factor (AIF) have both life and death functions in cells? Bioassays 28:834-843 (Pubitemid 44433745)
    • (2006) BioEssays , vol.28 , Issue.8 , pp. 834-843
    • Porter, A.G.1    Urbano, A.G.L.2
  • 49
    • 77954957710 scopus 로고    scopus 로고
    • Genetic, epige-netic and posttranslational mechanisms of aging
    • Robert L, Labat-Robert J, Robert AM (2010) Genetic, epige-netic and posttranslational mechanisms of aging. Bioger-ontol 11:387-399
    • (2010) Bioger-ontol , vol.11 , pp. 387-399
    • Robert, L.1    Labat-Robert, J.2    Robert, A.M.3
  • 51
    • 33846370148 scopus 로고    scopus 로고
    • Estimation of the rate of production of oxygen radicals by mitochondria
    • Conn M (ed) Academic Press, New York
    • Sanz A, Barja G (2006) Estimation of the rate of production of oxygen radicals by mitochondria. In: Conn M (ed) Handbook of models for human aging. Academic Press, New York, pp 183-189
    • (2006) Handbook of Models for Human Aging , pp. 183-189
    • Sanz, A.1    Barja, G.2
  • 52
    • 13844256455 scopus 로고    scopus 로고
    • Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver
    • DOI 10.1007/s10863-004-9001-7
    • Sanz A, Caro P, Barja G (2004) Protein restriction without strong caloric restriction decreases mitochondrial oxygen radical production and oxidative DNA damage in rat liver. J Bioenerg Biomembr 36:545-552 (Pubitemid 40249041)
    • (2004) Journal of Bioenergetics and Biomembranes , vol.36 , Issue.6 , pp. 545-552
    • Sanz, A.1    Caro, P.2    Barja, G.3
  • 53
    • 33845635647 scopus 로고    scopus 로고
    • Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage
    • DOI 10.1007/s10863-006-9051-0
    • Sanz A, Gómez J, Caro P, Barja G (2006a) Carbohydrate restriction does not change mitochondrial free radical generation and oxidative DNA damage. J Bioenerg Bio-membr 38:327-333 (Pubitemid 44952976)
    • (2006) Journal of Bioenergetics and Biomembranes , vol.38 , Issue.5-6 , pp. 327-333
    • Sanz, A.1    Gomez, J.2    Caro, P.3    Barja, G.4
  • 54
    • 33744534981 scopus 로고    scopus 로고
    • Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage
    • DOI 10.1196/annals.1354.024
    • Sanz A, Caro P, Gómez J, Barja G (2006b) Effect of lipid restriction on mitochondrial free radical production and oxidative DNA damage. Ann N Y Acad Sci 1067:200-209 (Pubitemid 43810005)
    • (2006) Annals of the New York Academy of Sciences , vol.1067 , Issue.1 , pp. 200-209
    • Sanz, A.1    Caro, P.2    Sanchez, J.G.3    Barja, G.4
  • 56
    • 0028342438 scopus 로고
    • Oxi-dative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction
    • Sohal RS, Ku HH, Agarwal S, Forster MJ, Lal H (1994) Oxi-dative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction. Mech Ageing Dev 74:121-133
    • (1994) Mech Ageing Dev , vol.74 , pp. 121-133
    • Sohal, R.S.1    Ku, H.H.2    Agarwal, S.3    Forster, M.J.4    Lal, H.5
  • 57
    • 0037160091 scopus 로고    scopus 로고
    • Topology of superoxide production from different sites in the mitochondrial electron transport chain
    • DOI 10.1074/jbc.M207217200
    • St-Pierre J, Buckingmham JA, Roebuck SJ, Brand MD (2002) Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem 277:44784-44790 (Pubitemid 36159072)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 44784-44790
    • St-Pierre, J.1    Buckingham, J.A.2    Roebuck, S.J.3    Brand, M.D.4
  • 58
    • 67649660052 scopus 로고    scopus 로고
    • Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age
    • Sun L, Amir A, Akha S, Millar RA, Harper J (2009) Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age. J Gerontol A Biol Sci Med Sci 64A:711-722
    • (2009) J Gerontol A Biol Sci Med Sci , vol.64 A , pp. 711-722
    • Sun, L.1    Amir, A.2    Akha, S.3    Millar, R.A.4    Harper, J.5
  • 59
    • 43549122104 scopus 로고    scopus 로고
    • Insulin-like signaling, nutrient homeostasis, and life span
    • DOI 10.1146/annurev.physiol.70.113006.100533
    • Taguchi A, White MF (2008) Insulin-like signalling, nutrient homeostasis, and life span. Annu Rev Physiol 70:191-212 (Pubitemid 351738177)
    • (2008) Annual Review of Physiology , vol.70 , pp. 191-212
    • Taguchi, A.1    White, M.F.2
  • 60
    • 79961008706 scopus 로고    scopus 로고
    • Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I)
    • Treberg JR, Quinlan CL, Brand MD (2011) Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I). J Biol Chem 286:27103-27110
    • (2011) J Biol Chem , vol.286 , pp. 27103-27110
    • Treberg, J.R.1    Quinlan, C.L.2    Brand, M.D.3
  • 62
    • 44249101675 scopus 로고    scopus 로고
    • Meats, processed meats, obesity, weight gain and occurrence of diabetes among adults: Findings from adventist health studies
    • DOI 10.1159/000121365
    • Vang A, Singh PN, Lee JW, Haddad EH, Brinegar CH (2008) Meats, processed meats, obesity, weight gain and occurrence of diabetes among adults: findings from Adventist Health Studies. Ann Nutr Metab 52:96-104 (Pubitemid 351723131)
    • (2008) Annals of Nutrition and Metabolism , vol.52 , Issue.2 , pp. 96-104
    • Vang, A.1    Singh, P.N.2    Lee, J.W.3    Haddad, E.H.4    Brinegar, C.H.5


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