Aging and epigenetics: Longitudinal changes in gene-specific DNA methylation

Epigenetics

Volumn 7, Issue 1, 2012, Pages 63-70

  Madrigano, Jaime ^a,b   Baccarelli, Andrea ^b   Mittleman, Murray A ^b,c   Sparrow, David ^d,e   Vokonas, Pantel S ^d   Tarantini, Letizia ^f   Schwartz, Joel ^b  

^a Columbia University ^*  (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

^f UNIVERSITY OF MILAN   (Italy)

Author keywords

Aging; DNA methylation; Epigenesis; Genetic

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; TOLL LIKE RECEPTOR 2;

ADULT; AGED; AGING; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL EXAMINATION; DNA DETERMINATION; DNA METHYLATION; EPIGENETICS; FEMALE; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE;

AGED; AGING; BOSTON; COHORT STUDIES; DNA METHYLATION; EPIGENESIS, GENETIC; HUMANS; LONGITUDINAL STUDIES; MALE; UNITED STATES; UNITED STATES DEPARTMENT OF VETERANS AFFAIRS;

EID: 84930478542     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.7.1.18749     Document Type: Article

References (37)

1. Goldberg AD, Allis CD, Bernstein E. Epigenetics: A landscape takes shape. Cell 2007; 128:635-8; PMID:17320500; http://dx.doi.org/10.1016/j.cell.2007.02.006.
2. Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2003; 2:245-61; PMID:12726774; http://dx.doi.org/10.1016/S1568-1637(03)00010-2.
3. Gravina S, Vijg J. Epigenetic factors in aging and longevity. Pflugers Arch 2010; 459:247-58; PMID:19768466; http://dx.doi.org/10.1007/s00424-009-0730-7.
4. Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset alzheimer's disease. PLoS ONE 2008; 3:2698; PMID:18628954; http://dx.doi.org/10.1371/journal.pone.0002698.
5. Wierda RJ, Geutskens SB, Jukema JW, Quax PH, van den Elsen PJ. Epigenetics in atherosclerosis and inflammation. J Cell Mol Med 2010; 14:1225-1240; PMID:20132414; http://dx.doi.org/10.1111/j.1582-4934.2010.01022.x.
6. Turunen MP, Aavik E, Yla-Herttuala S. Epigenetics and atherosclerosis. Biochim Biophys Acta 2009; 1790:886-91.
7. Pogribny IP, Beland FA. DNA hypomethylation in the origin and pathogenesis of human diseases. Cell Mol Life Sci 2009; 66:2249-2261; PMID:19326048; http://dx.doi.org/10.1007/s00018-009-0015-5.
8. Murgatroyd C, Wu Y, Bockmuhl Y, Spengler D. The janus face of DNA methylation in aging. Aging (Albany NY) 2010; 2:107-110; PMID:20354272.
9. Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 2005; 102:10604-10609; PMID:16009939; http://dx.doi.org/10.1073/pnas.0500398102.
10. Bollati V, Schwartz J, Wright R, Litonjua A, Tarantini L, Suh H, et al. Decline in genomic DNA methylation through aging in a cohort of elderly subjects. Mech Ageing Dev 2009; 130:234-9; PMID:19150625; http://dx.doi.org/10.1016/j.mad.2008.12.003.
11. Jintaridth P, Mutirangura A. Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol Genomics 2010.
12. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, et al. Intra-individual change over time in DNA methylation with familial clustering. JAMA 2008; 299:2877-83; PMID:18577732; http://dx.doi.org/10.1001/jama.299.24.2877.
13. Aceview. http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/index.html
14. Romanov GA, Vanyushin BF. Methylation of reiterated sequences in mammalian DNAs. effects of the tissue type, age, malignancy and hormonal induction. Biochim Biophys Acta 1981; 653:204-218; PMID:7225396.
15. Drinkwater RD, Blake TJ, Morley AA, Turner DR. Human lymphocytes aged in vivo have reduced levels of methylation in transcriptionally active and inactive DNA. Mutat Res 1989; 219:29-37; PMID:2911269.
16. Fuke C, Shimabukuro M, Petronis A, Sugimoto J, Oda T, Miura K, et al. Age related changes in 5-methylcytosine content in human peripheral leukocytes and placentas: An HPLC-based study. Ann Hum Genet 2004; 68:196-204; PMID:15180700; http://dx.doi.org/10.1046/j.1529-8817.2004.00081.x.
17. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 1994; 7:536-540; PMID:7951326; http://dx.doi.org/10.1038/ng0894-536.
18. Issa JP, Vertino PM, Boehm CD, Newsham IF, Baylin SB. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci USA 1996; 93:11757-11762; PMID:8876210; http://dx.doi.org/10.1073/pnas.93.21.11757.
19. Shen L, Kondo Y, Hamilton SR, Rashid A, Issa JP. P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology 2003; 124:626-633; PMID:12612901; http://dx.doi.org/10.1053/gast.2003.50102.
20. So K, Tamura G, Honda T, Homma N, Waki T, Togawa N, et al. Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. Cancer Sci 2006; 97:1155-1158; PMID:16952303; http://dx.doi.org/10.1111/j.1349-7006.2006.00302.x.
21. Bornman DM, Mathew S, Alsruhe J, Herman JG, Gabrielson E. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am J Pathol 2001; 159:831-835; PMID:11549575; http://dx.doi.org/10.1016/S0002-9440(10)61758-0.
22. Choi EK, Uyeno S, Nishida N, Okumoto T, Fujimura S, Aoki Y, et al. Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver. Mutat Res 1996; 354:123-128; PMID:8692198; http://dx.doi.org/10.1016/0027-5107(96)00056-5.
23. Takatsu M, Uyeno S, Komura J, Watanabe M, Ono T. Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament. Mech Ageing Dev 1999; 110:37-48; PMID:10580690; http://dx.doi.org/10.1016/S0047-6374(99)00041-X.
24. Ahuja N, Li Q, Mohan AL, Baylin SB, Issa JP. Aging and DNA methylation in colorectal mucosa and cancer. Cancer Res 1998; 58:5489-5494; PMID:9850084.
25. Christensen BC, Houseman EA, Marsit CJ, Zheng S, Wrensch MR, Wiemels JL, et al. Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet 2009; 5:1000602; PMID:19680444; http://dx.doi.org/10.1371/journal.pgen.1000602.
26. Ware JH, Dockery DW, Louis TA, Xu XP, Ferris BG Jr, Speizer FE. Longitudinal and cross-sectional estimates of pulmonary function decline in never-smoking adults. Am J Epidemiol 1990; 132:685-700; PMID:2403109.
27. Muñoz A, Gange SJ. Methodological issues for biomarkers and intermediate outcomes in cohort studies. Epidemiol Rev 1998; 20:29-42; PMID:9762507.
28. Chan GC, Fish JE, Mawji IA, Leung DD, Rachlis AC, Marsden PA. Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells. J Immunol 2005; 175:3846-61; PMID:16148131.
29. Blalock EM, Grondin R, Chen KC, Thibault O, Thibault V, Pandya JD, et al. Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys. J Neurosci 2010; 30:6058-6071; PMID:20427664; http://dx.doi.org/10.1523/JNEUROSCI.3956-09.2010.
30. Conlan MG, Folsom AR, Finch A, Davis CE, Sorlie P, Marcucci G, et al. Associations of factor VIII and von willebrand factor with age, race, sex and risk factors for atherosclerosis. the atherosclerosis risk in communities (ARIC) study. Thromb Haemost 1993; 70:380-385; PMID:8259533.
31. Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, et al. Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem 2009; 284:22840-22852; PMID:19553674; http://dx.doi.org/10.1074/jbc.M109.032888.
32. Bell B, Rose C, Damon A. The normative aging study: An interdisciplinary and longitudinal study of health and aging. Aging Hum Dev 1972; 3:4-17.
33. Park SK, O'Neill MS, Vokonas PS, Sparrow D, Schwartz J. Effects of air pollution on heart rate variability: The VA normative aging study. Environ Health Perspect 2005; 113:304-9; PMID:15743719; http://dx.doi.org/10.1289/ehp.7447.
34. Ferris BG. Epidemiology standardization project (american thoracic society). Am Rev Respir Dis 1978; 118:1-120; PMID:742764.
35. Bollati V, Baccarelli A, Hou L, Bonzini M, Fustinoni S, Cavallo D, et al. Changes in DNA methylation patterns in subjects exposed to low-dose benzene. Cancer Res 2007; 67:876-80; PMID:17283117; http://dx.doi.org/10.1158/0008-5472.CAN-06-2995.
36. Zhu ZZ, Hou L, Bollati V, Tarantini L, Marinelli B, Cantone L, et al. Predictors of global methylation levels in blood DNA of healthy subjects: A combined analysis. Int J Epidemiol 2010.
37. Baccarelli A, Wright R, Bollati V, Litonjua A, Zanobetti A, Tarantini L, et al. Ischemic heart disease and stroke in relation to blood DNA methylation. Epidemiology 2010; 21:819-88; PMID:20805753; http://dx.doi.org/10.1097/EDE.0b013e3181f20457.