Inhibition of type i interferon-mediated antiviral action in human glioma cells by the IKK inhibitors BMS-345541 and TPCA-1

Journal of Interferon and Cytokine Research

Volumn 32, Issue 8, 2012, Pages 368-377

  Du, Ziyun ^a   Whitt, Michael A ^a   Baumann, Jessica ^a   Garner, Jo Meagan ^a   Morton, Christopher L ^b   Davidoff, Andrew M ^a,b   Pfeffer, Lawrence M ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(AMINOCARBONYL)AMINO] 5 (4 FLUOROPHENYL) 3 THIOPHENECARBOXAMIDE; 4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; I KAPPA B; I KAPPA B KINASE INHIBITOR; INTERFERON; INTERLEUKIN 8; MEMBRANE PROTEIN; PROTEIN GBP1; PROTEIN MX1; PRTEIN ISG15; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; DRUG EFFICACY; ENCEPHALOMYOCARDITIS VIRUS; ENZYME INHIBITION; GENE EXPRESSION; GLIOMA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VESICULAR STOMATITIS VIRUS;

AMIDES; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPATHOGENIC EFFECT, VIRAL; ENCEPHALOMYOCARDITIS VIRUS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; HUMANS; I-KAPPA B KINASE; IMIDAZOLES; INTERFERON TYPE I; INTERLEUKIN-8; NF-KAPPA B; QUINOXALINES; THIOPHENES; VESICULAR STOMATITIS INDIANA VIRUS;

EID: 84865356359     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0002     Document Type: Article

References (43)

1. Barber GN. 2005. VSV-tumor selective replication and protein translation. Oncogene 24(52):7710-7719. (Pubitemid 41670673)
2. Basagoudanavar SH, Thapa RJ, Nogusa S, Wang J, Beg AA, Balachandran S. 2011. Distinct roles for the NF-kappa B RelA subunit during antiviral innate immune responses. J Virol 85(6):2599-2610.
3. Beg AA, Baltimore D. 1996. An essential role for NF-kB in preventing TNF-a-induced cell death. Science 274:782-784. (Pubitemid 26398258)
4. Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D. 1995. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kB. Nature 376:167-170.
5. Belardelli F, Ferrantini M, Proietti E, Kirkwood JM. 2002. Interferon-alpha in tumor immunity and immunotherapy. Cytokine Growth Factor Rev 13(2):119-134. (Pubitemid 34229387)
6. Ben-Neriah Y, Karin M. 2011. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nature immunology 12(8): 715-723.
7. Burke JR, Pattoli MA, Gregor KR, Brassil PJ, MacMaster JF, McIntyre KW, Yang X, Iotzova VS, Clarke W, Strnad J, Qiu Y, Zusi FC. 2003. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem 278(3):1450-1456. (Pubitemid 36801370)
8. Claudio E, Brown K, Park S, Wang H, Siebenlist U. 2002. BAFFinduced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat Immunol 3(10):958-965. (Pubitemid 35154010)
9. Coope HJ, Atkinson PG, Huhse B, Belich M, Janzen J, Holman MJ, Klaus GG, Johnston LH, Ley SC. 2002. CD40 regulates the processing of NF-kappaB2 p100 to p52. Embo J 21(20):5375-5385. (Pubitemid 35231017)
10. Darnell JEJ, Kerr IM, Stark GR. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421. (Pubitemid 24217131)
11. Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. 2002. The lymphotoxinbeta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity 17(4):525-535. (Pubitemid 35223540)
12. Du Z, Wei L, Murti A, Pfeffer SR, Fan M, Yang CH, Pfeffer LM. 2007. Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. J Cell Biochem 102(5):1087-1094. (Pubitemid 350220030)
13. Hacker H, Karin M. 2006. Regulation and function of IKK and IKK-related kinases. Sci STKE 2006(357):re13.
14. Luftig M, Yasui T, Soni V, Kang MS, Jacobson N, Cahir-McFarland E, Seed B, Kieff E. 2004. Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. Proc Natl Acad Sci U S A 101(1):141-146. (Pubitemid 38084217)
15. Lundblad D, Lundgren E. 1981. Block of glioma cell line in S by interferon. Int J Cancer 27(6):749-754. (Pubitemid 11125610)
16. Meylan E, Tschopp J, Karin M. 2006. Intracellular pattern recognition receptors in the host response. Nature 442(7098): 39-44. (Pubitemid 44064203)
17. Miki Y. 1982. Anti-neoplastic effect of human fibroblast interferon on human malignant gliomas transplanted into nude mice and its clinical application. Neurol Med Chir (Tokyo) 22(10):785-796. (Pubitemid 13172060)
18. Muller JR, Siebenlist U. 2003. Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. J Biol Chem 278(14):12006-12012. (Pubitemid 36800176)
19. Nederman T, Carlsson J, Malmqvist M. 1981. Penetration of substances into tumor tissue-a methodological study on cellular spheroids. In Vitro 17(4):290-298. (Pubitemid 12251547)
20. Noser JA, Mael AA, Sakuma R, Ohmine S, Marcato P, Lee PW, Ikeda Y. 2007. The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. Mol Ther 15(8):1531-1536. (Pubitemid 47099310)
21. Perez LJ, Diaz De Arce H. 2009. A RT-PCR for the detection of Encephalomycaditis Virus infections in Pigs. Braz J Microbiol 40:988-993.
22. Pfeffer LM, Dinarello CA, Herberman RB, Williams BR, Borden EC, Bordens R, Walter MR, Nagabhushan TL, Trotta PP, Pestka S. 1998. Biological properties of recombinant alphainterferons: 40th anniversary of the discovery of interferons. Cancer Res 58(12):2489-2499. (Pubitemid 28275413)
23. Pfeffer LM, Mullersman JE, Pfeffer SR, Murti A, Shi W, Yang CH. 1997. STAT3 as an adapter to couple phosphatidylinositol-3 kinase to the IFNAR-1 chain of the type I IFN receptor. Science 276:1418-1420. (Pubitemid 27235410)
24. Podolin PL, Callahan JF, Bolognese BJ, Li YH, Carlson K, Davis TG, Mellor GW, Evans C, Roshak AK. 2005. Attenuation of murine collagen-induced arthritis by a novel, potent, selective small molecule inhibitor of IkappaB Kinase 2, TPCA-1 (2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide), occurs via reduction of proinflammatory cytokines and antigen-induced T cell Proliferation. J Pharmacol Exp Ther 312(1):373-381. (Pubitemid 40096491)
25. Pomerantz JL, Baltimore D. 2002. Two pathways to NF-kappaB. Mol Cell 10(4):693-695.
26. Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. 2001. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293(5534):1495-1499. (Pubitemid 32801552)
27. Stojdl DF, Lichty B, Knowles S, Marius R, Atkins H, Sonenberg N, Bell JC. 2000. Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus. Nat Med 6(7):821-825. (Pubitemid 30469434)
28. Stojdl DF, Lichty BD, tenOever BR, Paterson JM, Power AT, Knowles S, Marius R, Reynard J, Poliquin L, Atkins H, Brown EG, Durbin RK, Durbin JE, Hiscott J, Bell JC. 2003. VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents. Cancer Cell 4(4):263-275. (Pubitemid 37329791)
29. Strnad J, Burke JR. 2007. IkappaB kinase inhibitors for treating autoimmune and inflammatory disorders: Potential and challenges. Trends Pharmacol Sci 28(3):142-148. (Pubitemid 46283590)
30. Van Antwerp DJ, Martin SJ, Kafri T, Green DR, Verma IM. 1996. Suppression of TNF-a-induced apotosis by NF-kB. Science 274:787-789.
31. van den Pol AN, Ozduman K, Wollmann G, Ho WS, Simon I, Yao Y, Rose JK, Ghosh P. 2009. Viral strategies for studying the brain, including a replication-restricted self-amplifying delta-G vesicular stomatis virus that rapidly expresses transgenes in brain and can generate a multicolor golgi-like expression. J Comp Neurol 516(6):456-481.
32. Wang C-Y, Mayo MW, Baldwin Jr. AS. 1996. TNF- and cancer therapy-induced apoptosis: Potentiation by inhibition of NFkB. Science 274:784-787. (Pubitemid 26398259)
33. Wei L, Sandbulte MR, Thomas PG, Webby RJ, Homayouni R, Pfeffer LM. 2006. NFkB negatively regulates interferoninduced gene expression and anti-influenza activity. J Biol Chem 281(17):11678-11684. (Pubitemid 43855425)
34. Wollmann G, Robek MD, van den Pol AN. 2007. Variable deficiencies in the interferon response enhance susceptibility to vesicular stomatitis virus oncolytic actions in glioblastoma cells but not in normal human glial cells. J Virol 81(3):1479-1491. (Pubitemid 46167869)
35. Wollmann G, Rogulin V, Simon I, Rose JK, van den Pol AN. 2010. Some attenuated variants of vesicular stomatitis virus show enhanced oncolytic activity against human glioblastoma cells relative to normal brain cells. J Virol 84(3):1563-1573.
36. Xiao G, Fong A, Sun SC. 2004. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 279(29):30099-30105. (Pubitemid 38937932)
37. Xiao G, Harhaj EW, Sun SC. 2001. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 7(2):401-409. (Pubitemid 32206507)
38. Yang CH, Murti A, Basu L, Kim JG, Pfeffer LM. 2000. IFNa/b promotes cell survival by activating NF-kB. Proc Natl Acad Sci USA 97:13631-13636.
39. Yang CH, Murti A, Pfeffer SR, Kim JG, Donner DB, Pfeffer LM. 2001. Interferon a/b promotes cell survival by activating NF-kB through phosphatidylinositol-3 kinase and Akt. J Biol Chem 276:13756-13761.
40. Yang CH, Wei L, Pfeffer SR, Du Z, Murti A, Valentine WJ, Zheng Y, Pfeffer LM. 2007. Identification of CXCL11 as a STAT3-dependent gene induced by IFN. J Immunol 178(2):986-992. (Pubitemid 46095172)
41. Yang CH, Yue J, Fan M, Pfeffer LM. 2010. IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer Res 70(20):8108-8116.
42. Yang CH, Yue J, Pfeffer SR, Handorf CR, Pfeffer LM. 2011. MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells. J Biol Chem 286(45):39172-39178.
43. Yang J, Amiri KI, Burke JR, Schmid JA, Richmond A. 2006. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: Involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res 12(3 Pt 1): 950-960. (Pubitemid 43259878)