Differential subcellular targeting of recombinant human α1-proteinase inhibitor influences yield, biological activity and in planta stability of the protein in transgenic tomato plants

Plant Science

Volumn 196, Issue , 2012, Pages 53-66

  Jha, Shweta ^a   Agarwal, Saurabh ^a   Sanyal, Indraneel ^a   Jain, G K ^b   Amla, D V ^a  

^a CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Human 1 proteinase inhibitor; N glycosylation; Protein stability; Subcellular localization; Therapeutic recombinant protein; Transgenic tomato plants

Indexed keywords

ALPHA 1 ANTITRYPSIN; PANCREATIC ELASTASE; RECOMBINANT PROTEIN;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; CELL VACUOLE; DRUG ANTAGONISM; ENDOPLASMIC RETICULUM; FEASIBILITY STUDY; GENETICS; GLYCOSYLATION; HUMAN; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; KINETICS; MASS SPECTROMETRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN STABILITY; RAT; SWINE; TOMATO; TRANSGENIC PLANT; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ALPHA 1-ANTITRYPSIN; ANIMALS; AREA UNDER CURVE; BASE SEQUENCE; BLOTTING, WESTERN; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM; FEASIBILITY STUDIES; GLYCOSYLATION; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SPACE; KINETICS; LYCOPERSICON ESCULENTUM; MOLECULAR SEQUENCE DATA; PANCREATIC ELASTASE; PLANTS, GENETICALLY MODIFIED; PROTEIN STABILITY; RATS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SWINE; VACUOLES;

LYCOPERSICON ESCULENTUM; RATTUS; SUS;

EID: 84865320813     PISSN: 01689452     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plantsci.2012.07.004     Document Type: Article

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