Unbalanced expression of sphingosine 1-phosphate receptors in diabetic nephropathy

Experimental and Toxicologic Pathology

Volumn 62, Issue 1, 2010, Pages 53-60

  Imasawa, Toshiyuki ^a   Kitamura, Hiroshi ^a   Ohkawa, Ryunosuke ^b   Satoh, Yumiko ^b   Miyashita, Akiko ^a   Yatomi, Yutaka ^b  

^a Department of Internal Medicine   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Diabetic nephropathy; Endothelial injury; Sphingosine 1 phosphate; Streptozotocin; Vascular homeostasis

Indexed keywords

PLATELET DERIVED GROWTH FACTOR B; RECEPTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 2 PHOSPHATE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DIABETIC NEUROPATHY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; FEMALE; GLOMERULUS; HISTOPATHOLOGY; HOMEOSTASIS; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; KIDNEY CORTEX; MESANGIUM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; VASCULARIZATION;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; ENDOTHELIUM; FEMALE; GENE EXPRESSION REGULATION; KIDNEY GLOMERULUS; MESANGIAL CELLS; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, LYSOSPHINGOLIPID;

RATTUS;

EID: 71849113841     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2009.02.068     Document Type: Article

References (29)

1. Armulik A., Abramsson A., and Betsholtz C. Endothelial/pericyte interactions. Circ Res 97 (2005) 512-523
2. Donati C., Meacci E., Nuti F., Becciolini L., Farnararo M., and Bruni P. Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. FASEB J 19 (2005) 449-451
3. Feistritzer C., and Riewald M. Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation. Blood 105 (2005) 3178-3184
4. Finigan J.H., Dudek S.M., Singleton P.A., Chiang E.T., Jacobson J.R., Camp S.M., et al. Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 280 (2005) 17286-17293
5. Fioretto P., and Mauer M. Histopathology of diabetic nephropathy. Semin Nephrol 27 (2007) 195-207
6. Garcia J.G., Liu F., Verin A.D., Birukova A., Dechert M.A., Gerthoffer W.T., et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest 108 (2001) 689-701
7. Hanafusa N., Yatomi Y., Yamada K., Hori Y., Nangaku M., Okuda T., et al. Sphingosine 1-phosphate stimulates rat mesangial cell proliferation from outside the cells. Nephrol Dial Transplant 17 (2002) 580-586
8. Hink U., Li H., Mollnau H., Oelze M., Matheis E., Hartmann M., et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88 (2001) E14-E22
9. Hisano N., Yatomi Y., Satoh K., Akimoto S., Mitsumata M., Fujino M.A., et al. Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. Blood 93 (1999) 4293-4299
10. Inoki I., Takuwa N., Sugimoto N., Yoshioka K., Takata S., Kaneko S., et al. Negative regulation of endothelial morphogenesis and angiogenesis by S1P2 receptor. Biochem Biophys Res Commun 346 (2006) 293-300
11. Katsuma S., Shiojima S., Hirasawa A., Suzuki Y., Takagaki K., Murai M., et al. Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade. Pharmacogenomics J 1 (2001) 211-217
12. Katsuma S., Ruike Y., Yano T., Kimura M., Hirasawa A., and Tsujimoto G. Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells. FEBS Lett 579 (2005) 2576-2582
13. Kluk M.J., and Hla T. Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 89 (2001) 496-502
14. Kwon Y.G., Min J.K., Kim K.M., Lee D.J., Billiar T.R., and Kim Y.M. Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. J Biol Chem 276 (2001) 10627-10633
15. Lee M.J., Thangada S., Claffey K.P., Ancellin N., Liu C.H., Kluk M., et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99 (1999) 301-312
16. Levine Y.C., Li G.K., and Michel T. Agonist-modulated regulation of AMP-activated protein kinase in endothelial cells: Evidence for a AMPKuRac1uAktueNOS pathway. J Biol Chem 282 (2007) 20351-20364
17. Liu Y., Wada R., Yamashita T., Mi Y., Deng C.X., Hobson J.P., et al. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 106 (2000) 951-961
18. Ohmori T., Yatomi Y., Osada M., Kazama F., Takafuta T., Ikeda H., et al. Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2. Cardiovasc Res 58 (2003) 170-177
19. Okamoto H., Takuwa N., Yokomizo T., Sugimoto N., Sakurada S., Shigematsu H., et al. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol Cell Biol 20 (2000) 9247-9261
20. Osada M., Yatomi Y., Ohmori T., Aoki S., Hosogaya S., and Ozaki Y. Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. J Biochem 142 (2007) 351-355
21. Pappu R., Schwab S.R., Cornelissen I., Pereira J.P., Regard J.B., Xu Y., et al. Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate. Science 316 (2007) 295-298
22. Ryu Y., Takuwa N., Sugimoto N., Sakurada S., Usui S., Okamoto H., et al. Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. Circ Res 90 (2002) 325-332
23. Sanchez T., Skoura A., Wu M.T., Casserly B., Harrington E.O., and Hla T. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol 27 (2007) 1312-1318
24. Singleton P.A., Dudek S.M., Ma S.F., and Garcia J.G. Transactivation of sphingosine 1-phosphate receptors is essential for vascular barrier regulation. Novel role for hyaluronan and CD44 receptor family. J Biol Chem 281 (2006) 34381-34393
25. Skoura A., Sanchez T., Claffey K., Mandala S.M., Proia R.L., and Hla T. Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina. J Clin Invest 117 (2007) 2506-2516
26. Sugimoto N., Takuwa N., Okamoto H., Sakurada S., and Takuwa Y. Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform. Mol Cell Biol 23 (2003) 1534-1545
27. Tuomilehto J., Borch-Johnsen K., Molarius A., Forsén T., Rastenyte D., Sarti C., et al. Incidence of cardiovascular disease in Type 1 (insulin-dependent) diabetic subjects with and without diabetic nephropathy in Finland. Diabetologia 41 (1998) 784-790
28. Yatomi Y., Ohmori T., Rile G., Kazama F., Okamoto H., Sano T., et al. Sphingosine 1-phosphate as a major bioactive lysophospholipid that is released from platelets and interacts with endothelial cells. Blood 96 (2000) 3431-3438
29. Yatomi Y. Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. Curr Pharm Des 12 (2006) 575-587