메뉴 건너뛰기




Volumn 19, Issue 22, 2012, Pages 3689-3700

Molecular and clinical analysis of predictive biomarkers in non-small-cell lung cancer

Author keywords

ALK; BRCA1; c MET; EGFR; ERCC1; KRAS; NSCLC; Predictive biomarkers

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; BRCA1 PROTEIN; CARBOPLATIN; CISPLATIN; CRIZOTINIB; DOCETAXEL; ECHINODERM MICROTUBULE ASSOCIATED PROTEIN LIKE 4; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; EXCISION REPAIR CROSS COMPLEMENTING PROTEIN 1; FLOXURIDINE PHOSPHATE; GEFITINIB; GELATINASE B; GEMCITABINE; K RAS PROTEIN; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; NUCLEIC ACID BINDING PROTEIN; PACLITAXEL; PEMETREXED; PLACEBO; PROTEIN P53; SCATTER FACTOR MONOCLONAL ANTIBODY; SCATTER FACTOR RECEPTOR; THYMIDYLATE SYNTHASE; TIVANTINIB; TUMOR MARKER; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP F PROTEIN;

EID: 84865288107     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712801661149     Document Type: Review
Times cited : (10)

References (100)
  • 3
    • 80155190075 scopus 로고    scopus 로고
    • Biomarkers, prediction, and prognosis in non-small cell lung cancer: A platform for personalized treatment
    • Nov; 12
    • Sudhindra, A.; Ochoa, R.; Santos, E.S. Biomarkers, Prediction, and Prognosis in Non-Small Cell Lung Cancer: A Platform for Personalized Treatment. Clin. Lung Cancer, 2011, Nov; 12(6):360-8.
    • (2011) Clin. Lung Cancer , Issue.6 , pp. 360-368
    • Sudhindra, A.1    Ochoa, R.2    Santos, E.S.3
  • 4
    • 80054734928 scopus 로고    scopus 로고
    • Second-line treatment of non-smallcell lung cancer: Chemotherapy or tyrosine kinase inhibitors?
    • Passaro, A.; Cortesi, E.; de Marinis, F. Second-line treatment of non-smallcell lung cancer: chemotherapy or tyrosine kinase inhibitors? Expert Rev. Anticancer Ther., 2011, 11(10):1587-97.
    • (2011) Expert Rev. Anticancer Ther. , vol.11 , Issue.10 , pp. 1587-1597
    • Passaro, A.1    Cortesi, E.2    De Marinis, F.3
  • 7
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell-lung-cancer
    • Linardou, H.; Dahabreh, I.J.; Bafaloukous, D.; Kosmidis, P.; Murray, S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell-lung-cancer. Lancet Oncol., 2008, 9:962-972
    • (2008) Lancet Oncol. , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Bafaloukous, D.3    Kosmidis, P.4    Murray, S.5
  • 8
    • 33745683527 scopus 로고    scopus 로고
    • Epidermal growth factor receptor tyrosine kinase inhibitor therapy
    • Janne, P.A.; Engelman, J.S.; Jhonson, B.E. Epidermal growth factor receptor tyrosine kinase inhibitor therapy. Clin. Cancer Res., 2006, 12:3652-3656
    • (2006) Clin. Cancer Res. , vol.12 , pp. 3652-3656
    • Janne, P.A.1    Engelman, J.S.2    Jhonson, B.E.3
  • 9
    • 77953291664 scopus 로고    scopus 로고
    • The biology and treatment of EML4-ALK non-small cell lung cancer
    • Sasaki, T.; Rodig, S.J.; Chirieac, L.R.; Jänne, P.A. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur. J. Cancer, 2010, 46(10):1773-80.
    • (2010) Eur. J. Cancer , vol.46 , Issue.10 , pp. 1773-1780
    • Sasaki, T.1    Rodig, S.J.2    Chirieac, L.R.3    Jänne, P.A.4
  • 10
    • 33847127528 scopus 로고    scopus 로고
    • DNA repair and survival in lung cancer the two faces of janus
    • Gazdar, A.F. DNA repair and survival in lung cancer, the two faces of janus. N. Engl. J. Med., 2007, 356: 800-808
    • (2007) N. Engl. J. Med. , vol.356 , pp. 800-808
    • Gazdar, A.F.1
  • 13
    • 80052554890 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed
    • Chen, C.Y.; Chang, Y.L.; Shih, J.Y.; Lin, J.W.; Chen, K.Y.; Yang, C.H.; Yu, C.J.; Yang, P.C. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed. Lung Cancer, 2011, 74(1):132-8.
    • (2011) Lung Cancer , vol.74 , Issue.1 , pp. 132-138
    • Chen, C.Y.1    Chang, Y.L.2    Shih, J.Y.3    Lin, J.W.4    Chen, K.Y.5    Yang, C.H.6    Yu, C.J.7    Yang, P.C.8
  • 14
    • 69849108427 scopus 로고    scopus 로고
    • Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
    • Mandrekar, S.J.; Sargent, D.J. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J. Clin. Oncol., 2009, 20; 27(24):4027-34.
    • (2009) J. Clin. Oncol. , vol.20-27 , Issue.24 , pp. 4027-4034
    • Mandrekar, S.J.1    Sargent, D.J.2
  • 15
    • 37349107823 scopus 로고    scopus 로고
    • Platinum resistance related to a functional NER pathway
    • DOI 10.1097/JTO.0b013e31815ba2a1, PII 0124389420071200000001
    • Rosell, R.; Mendez, P.; Isla, D.; Taron, M. Platinum resistance related to a functional NER pathway. J. Thorac. Oncol., 2007, 2(12): 1063-6. (Pubitemid 350307897)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.12 , pp. 1063-1066
    • Rosell, R.1    Mendez, P.2    Isla, D.3    Taron, M.4
  • 16
    • 0002556166 scopus 로고    scopus 로고
    • DNA repair and the cell cycle as targets in cancer therapy
    • Nature Publishing Group, London
    • Rajewsky, M.; Muller, R. DNA repair and the cell cycle as targets in cancer therapy. The Cancer Handbook. Nature Publishing Group, London, pp. 1507-19, 2002.
    • (2002) The Cancer Handbook , pp. 1507-1519
    • Rajewsky, M.1    Muller, R.2
  • 17
    • 28844480409 scopus 로고    scopus 로고
    • The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair
    • DOI 10.1016/j.str.2005.08.014, PII S0969212605003576
    • Trispsianes, K.; Folkers, G.; Ab, E.; Dus, D.; Odijk, H.; Jasper, N.G. et al. The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure, 2005, 13: 1849-58. (Pubitemid 41772953)
    • (2005) Structure , vol.13 , Issue.12 , pp. 1849-1858
    • Tripsianes, K.1    Folkers, G.2    Ab, E.3    Das, D.4    Odijk, H.5    Jaspers, N.G.J.6    Hoeijmakers, J.H.J.7    Kaptein, R.8    Boelens, R.9
  • 18
    • 0033797293 scopus 로고    scopus 로고
    • ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells
    • Britten, A.; Liu, D.; Tessier, A.; Hutchison, Murray. D. ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells. Int. J. Cancer, 2000, 89:453-7.
    • (2000) Int. J. Cancer , vol.89 , pp. 453-457
    • Britten, A.1    Liu, D.2    Tessier, A.3    Hutchison, M.D.4
  • 19
    • 3142773418 scopus 로고    scopus 로고
    • Oncogenic HRas up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents
    • Youn, CK.; Kim, M.H.; Cho, H.J.; Kim, H.B.; Chang, I.Y.; Chung, M.H. et al. Oncogenic HRas up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents. Cancer Res, 2004, 64:4849-57.
    • (2004) Cancer Res , vol.64 , pp. 4849-4857
    • Youn, C.K.1    Kim, M.H.2    Cho, H.J.3    Kim, H.B.4    Chang, I.Y.5    Chung, M.H.6
  • 24
    • 34247122055 scopus 로고    scopus 로고
    • Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer
    • DOI 10.1200/JCO.2006.05.9923
    • Bewick, M. A.; Conlon, M. S.; Lafrenie, R. M. Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. J. Clin. Oncol, 2006, 24(36), 5645-5651. (Pubitemid 46631304)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.36 , pp. 5645-5651
    • Bewick, M.A.1    Conlon, M.S.C.2    Lafrenie, R.M.3
  • 28
    • 15844372318 scopus 로고    scopus 로고
    • ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer
    • DOI 10.1378/chest.127.3.978
    • Simon, G. R.; Sharma, S.; Cantor, A.; Smith, P.; Bepler, G. ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest, 2005, 127(3), 978-983. (Pubitemid 40775532)
    • (2005) Chest , vol.127 , Issue.3 , pp. 978-983
    • Simon, G.R.1    Sharma, S.2    Cantor, A.3    Smith, P.4    Bepler, G.5
  • 29
    • 37849040128 scopus 로고    scopus 로고
    • DNA damage: Ubiquitin marks the spot
    • Jan
    • Bennett, E.J.; Harper, J.W. DNA damage: ubiquitin marks the spot. Nat. Struct. Mol. Biol., 2008, Jan; 15(1):20-2.
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , Issue.1 , pp. 20-22
    • Bennett, E.J.1    Harper, J.W.2
  • 30
    • 0035807219 scopus 로고    scopus 로고
    • Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
    • DOI 10.1038/sj.onc.1204812
    • Lafarge, S.; Sylvain, V.; Ferrara, M.; Bignon, Y.J. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene, 2001, 20: 6597-6606. (Pubitemid 32980286)
    • (2001) Oncogene , vol.20 , Issue.45 , pp. 6597-6606
    • Lafarge, S.1    Sylvain, V.2    Ferrara, M.3    Bignon, Y.-J.4
  • 33
    • 44349090911 scopus 로고    scopus 로고
    • ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel
    • Wang, L.; Wei, J.; Qian, X.; Yin, H.; Zhao, Y.; Yu, L.; Wang, T.; Liu, B. ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel. BMC Cancer. 2008; 8: 97.
    • (2008) BMC Cancer , vol.8 , pp. 97
    • Wang, L.1    Wei, J.2    Qian, X.3    Yin, H.4    Zhao, Y.5    Yu, L.6    Wang, T.7    Liu, B.8
  • 36
    • 84872498385 scopus 로고    scopus 로고
    • ClinicalTrial.gov. Multicenter, Predictive, Prospective, Phase III, Open, Randomized, Pharmacogenomic Study in Patients With Advanced Lung Carcinoma (BREC), Accessed Dec 20 2011
    • ClinicalTrial.gov. Multicenter, Predictive, Prospective, Phase III, Open, Randomized, Pharmacogenomic Study in Patients With Advanced Lung Carcinoma (BREC). http://clinicaltrials.gov/ct2/show/NCT00617656 (Accessed Dec 20, 2011).
  • 37
    • 84872494965 scopus 로고    scopus 로고
    • ClinicalTrial.gov. Randomized Customized Adjuvant Chemotherapy (GECPSCAT). ( Accessed Nov 22 2011)
    • ClinicalTrial.gov. Randomized Customized Adjuvant Chemotherapy (GECPSCAT). http://clinicaltrials.gov/ct2/show/NCT00478699 (Accessed Nov 22, 2011).
  • 38
    • 23844445571 scopus 로고    scopus 로고
    • Thymidylate synthase structure, function and implication in drug discovery
    • DOI 10.2174/0929867054864868
    • Costi, M.P.; Ferrari, S.; Venturelli, A.; Calò, S.; Tondi, D.; Barlocco, D. Thymidylate synthase structure, function and implication in drug discovery. Curr. Med. Chem., 2005, 12:2241-2258. (Pubitemid 41179710)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.19 , pp. 2241-2258
    • Costi, M.P.1    Ferrari, S.2    Venturelli, A.3    Calo, S.4    Tondi, D.5    Barlocco, D.6
  • 41
    • 0036183722 scopus 로고    scopus 로고
    • Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives
    • DOI 10.1097/00001813-200201000-00009
    • Takamura, M.; Nio, Y.; Yamasawa, K.; Dong, M.; Yamaguchi, K.; Itakura, M. Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives. Anticancer Drugs. 2002, 13:75-85. (Pubitemid 34169530)
    • (2002) Anti-Cancer Drugs , vol.13 , Issue.1 , pp. 75-85
    • Takamura, M.1    Nio, Y.2    Yamasawa, K.3    Dong, M.4    Yamaguchi, K.5    Itakura, M.6
  • 42
    • 3042756923 scopus 로고    scopus 로고
    • Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer
    • DOI 10.1016/j.lungcan.2004.01.015, PII S0169500204000558
    • Shintani, Y.; Ohta, M.; Hirabayashi, H.; Tanaka, H.; Iuchi, K.; Nakagawa, K.; Maeda, H.; Kido, T.; Miyoshi, S.; Matsuda, H. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer. Lung Cancer, 2004, 45:189-196. (Pubitemid 38891481)
    • (2004) Lung Cancer , vol.45 , Issue.2 , pp. 189-196
    • Shintani, Y.1    Ohta, M.2    Hirabayashi, H.3    Tanaka, H.4    Iuchi, K.5    Nakagawa, K.6    Maeda, H.7    Kido, T.8    Miyoshi, S.9    Matsuda, H.10
  • 45
    • 33749587054 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
    • DOI 10.1002/cncr.22208
    • Ceppi, P.; Volante, M.; Saviozzi, S.; Rapa, I., Novello, S.; Cambieri, A.; Lo Iacono, M.; Cappia, S.; Papotti, M.; Scagliotti, G.V. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer, 2006, 107: 1589-1596. (Pubitemid 44546920)
    • (2006) Cancer , vol.107 , Issue.7 , pp. 1589-1596
    • Ceppi, P.1    Volante, M.2    Saviozzi, S.3    Rapa, I.4    Novello, S.5    Cambieri, A.6    Lo Iacono, M.7    Cappia, S.8    Papotti, M.9    Scagliotti, G.V.10
  • 46
    • 71849118033 scopus 로고    scopus 로고
    • Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
    • Ozasa, H.; Oguri, T.; Uemura, T.; Miyazaki, M.; Maeno, K.; Sato, S.; Ueda, R. Significance of thymidylate synthase for resistance to pemetrexed in lung cancer. Cancer Sci., 2010, 101: 161-166
    • (2010) Cancer Sci. , vol.101 , pp. 161-166
    • Ozasa, H.1    Oguri, T.2    Uemura, T.3    Miyazaki, M.4    Maeno, K.5    Sato, S.6    Ueda, R.7
  • 50
    • 79957492069 scopus 로고    scopus 로고
    • American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy
    • Keedy, V.L.; Temin, S.; Somerfield, M.R.; Beasley, M.B.; Johnson, D.H.; McShane, L.M.; Milton, D.T.; Strawn, J.R.; Wakelee, H.A.; Giaccone, G. American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J. Clin. Oncol., 2011, 29(15):2121-7.
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 , pp. 2121-2127
    • Keedy, V.L.1    Temin, S.2    Somerfield, M.R.3    Beasley, M.B.4    Johnson, D.H.5    McShane, L.M.6    Milton, D.T.7    Strawn, J.R.8    Wakelee, H.A.9    Giaccone, G.10
  • 51
    • 33645761156 scopus 로고    scopus 로고
    • Clinical implication of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer
    • Ettinger, D.S. Clinical implication of EGFR expression in the development and progression of solid tumors: focus on non-small cell lung cancer. Oncologist, 2006, 11 (4): 358-73.
    • (2006) Oncologist , vol.11 , Issue.4 , pp. 358-373
    • Ettinger, D.S.1
  • 52
    • 77955810928 scopus 로고    scopus 로고
    • Past present and future of targeted therapy in solid tumors
    • Palazzo, A.; Iacovelli, R.; Cortesi, E. Past, present and future of targeted therapy in solid tumors. Curr. Cancer Drug Targets, 2010, 10 (5): 433-61.
    • (2010) Curr. Cancer Drug Targets , vol.10 , Issue.5 , pp. 433-461
    • Palazzo, A.1    Iacovelli, R.2    Cortesi, E.3
  • 53
    • 0000686740 scopus 로고
    • Human epidermal growth factor: Isolation and chemical and biological properties
    • Cohen, S.; Carpenter, G. Human epidermal growth factor: isolation and chemical and biological properties. Proc. Natl. Acad. Sci. USA, 1975, 72: 1317-1321.
    • (1975) Proc. Natl. Acad. Sci. USA , vol.72 , pp. 1317-1321
    • Cohen, S.1    Carpenter, G.2
  • 54
    • 0019320348 scopus 로고
    • Autocrine secretion and malignant transformation of cells
    • Sporn, M.B.; Todaro, G.J. Autocrine secretion and malignant transformation of cells. N. Engl. J. Med., 1980, 303: 878-880.
    • (1980) N. Engl. J. Med. , vol.303 , pp. 878-880
    • Sporn, M.B.1    Todaro, G.J.2
  • 55
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • Hynes, N.E.; Lane, H.A. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer, 2005, 5: 341-354. (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 56
    • 44449127592 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family: Biology driving targeted therapeutics
    • Wieduwilt, M.J.; Moasser, M.M. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol. Life Sci., 2008, 65:1566-1584.
    • (2008) Cell Mol. Life Sci. , vol.65 , pp. 1566-1584
    • Wieduwilt, M.J.1    Moasser, M.M.2
  • 57
    • 40849147041 scopus 로고    scopus 로고
    • EGFR antagonists in cancer treatment
    • Ciardiello, F.; Tortora, G. EGFR antagonists in cancer treatment. N. Engl. J. Med., 2008, 358(11):1160-74.
    • (2008) N. Engl. J. Med. , vol.358 , Issue.11 , pp. 1160-1174
    • Ciardiello, F.1    Tortora, G.2
  • 60
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study
    • Hirsch, F.R.; Varella-Garcia, M.; McCoy, J.; West, H.; Xavier, A.C.; Gumerlock, P.; Bunn, P.A.Jr.; Franklin, W.A.; Crowley, J.; Gandara, D.R.; Southwest Oncology Group. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study. J. Clin. Oncol., 2005, 23: 6838-6845.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3    West, H.4    Xavier, A.C.5    Gumerlock, P.6    Bunn Jr., P.A.7    Franklin, W.A.8    Crowley, J.9    Gandara, D.R.10    Oncology Group, S.11
  • 61
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • DOI 10.1200/JCO.2003.11.069
    • Hirsch, F.R.; Varella-Garcia, M.; Bunn, P.A.Jr.; Di Maria, M.V.; Veve, R.; Bremmes, R.M.; Barón, A.E.; Zeng, C.; Franklin, W.A. Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 2003, 21: 3798-3807. (Pubitemid 46606235)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.20 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3    Di Maria, M.V.4    Veve, R.5    Bremnes, R.M.6    Baron, A.E.7    Zeng, C.8    Franklin, W.A.9
  • 62
    • 65349107082 scopus 로고    scopus 로고
    • KRAS mutations in non-small cell lung cancer
    • Riely, G.J.; Marks, J.; Pao, W. KRAS mutations in non-small cell lung cancer. Proc. Am. Thorac. Soc., 2009, 6 (2):201-5.
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , Issue.2 , pp. 201-205
    • Riely, G.J.1    Marks, J.2    Pao, W.3
  • 65
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer
    • Thatcher, N.; Chang, A.; Parikh, P.; Rodrigues Pereira, J.; Ciuleanu, T.; von Pawel, J.; Thongprasert, S.; Tan, E.H.; Pemberton, K.; Archer, V.; Carroll, K. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet, 2005, 366: 527-37.
    • (2005) Lancet , vol.366 , pp. 527-537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Rodrigues Pereira, J.4    Ciuleanu, T.5    Von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10    Carroll, K.11
  • 69
    • 61449341457 scopus 로고    scopus 로고
    • Epidermal growth factor receptor related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: An analysis of patients from german centers in the TRUST study
    • Schneider, C.P.; Heigener, D.; Schott-von-Römer, K.; Gütz, S.; Laack, E.; Digel, W.; Guschall, W.R.; Franke, A.; Bodenstein, H.; Schmidtgen, C.; Reck, M. Epidermal growth factor receptor related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: an analysis of patients from german centers in the TRUST study. J. Thorac. Oncol., 2008, 3 (12):1446-53.
    • (2008) J. Thorac. Oncol. , vol.3 , Issue.12 , pp. 1446-1453
    • Schneider, C.P.1    Heigener, D.2    Schott-Von-Römer, K.3    Gütz, S.4    Laack, E.5    Digel, W.6    Guschall, W.R.7    Franke, A.8    Bodenstein, H.9    Schmidtgen, C.10    Reck, M.11
  • 75
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris, S.W.; Kirstein, M.N.; Valentine, M.B.; Dittmer, K.G.; Shapiro, D.N.; Saltman, D.L.; Look, A.T. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, 1994, 4, 263(5151):1281-4. (Pubitemid 24107549)
    • (1994) Science , vol.263 , Issue.5151 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3    Dittmer, K.G.4    Shapiro, D.N.5    Saltman, D.L.6    Look, A.T.7
  • 79
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • Weinstein, I.B.; Joe, A. Oncogene addiction. Cancer Res., 2008, 68(9):3077-80.
    • (2008) Cancer Res. , vol.68 , Issue.9 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 83
    • 74249123333 scopus 로고    scopus 로고
    • ALK gene rearrangements: A new therapeutic target in a molecularly defined subset of non-small cell lung cancer
    • Solomon, B.; Varella-Garcia, M.; Camidge, D.R. ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer. J. Thorac. Oncol., 2009, (12):1450-4.
    • (2009) J. Thorac. Oncol. , vol.12 , pp. 1450-1454
    • Solomon, B.1    Varella-Garcia, M.2    Camidge, D.R.3
  • 85
    • 84872494133 scopus 로고    scopus 로고
    • ClinicalTrial.gov. An Investigational Drug PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene. (Accessed Jan 4 2012)
    • ClinicalTrial.gov. An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene. http://clinicaltrial.gov/ct2/show/NCT00932893 (Accessed Jan 4, 2012).
  • 87
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
    • DOI 10.1038/384173a0
    • Weidner, K.M.; Di Cesare, S.; Sachs, M.; Brinkmann, V.; Behrens, J.; Birchmeier, W. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature, 1996; 384(6605): 173-6. (Pubitemid 26386473)
    • (1996) Nature , vol.384 , Issue.6605 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 88
    • 0034693753 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase: Enhanced signaling through adapter proteins
    • Furge, K.A.; Zhang, Y.W.; Vande Woude, G.F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene, 2000, 19 (49): 5582-9.
    • (2000) Oncogene , vol.19 , Issue.49 , pp. 5582-5589
    • Furge, K.A.1    Zhang, Y.W.2    Vande Woude, G.F.3
  • 89
    • 0035843125 scopus 로고    scopus 로고
    • Gab1 phosphorylation: A novel mechanism for negative regulation of HGF receptor signaling
    • Gual, P.; Giordano, S.; Anguissola, S.; Parker, P.J.; Comoglio, P.M. Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling. Oncogene, 2000, 20 (2): 156-66.
    • (2000) Oncogene , vol.20 , Issue.2 , pp. 156-166
    • Gual, P.1    Giordano, S.2    Anguissola, S.3    Parker, P.J.4    Comoglio, P.M.5
  • 92
    • 75049083402 scopus 로고    scopus 로고
    • Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitorresistant Chinese non-small cell lung cancer
    • Chen, H.J.; Mok, T.S.; Chen, Z.H.; Guo, A.L.; Zhang, X.C.; Su, J.; Wu, Y.L. Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitorresistant Chinese non-small cell lung cancer. Pathol. Oncol. Res., 2009, 15(4):651-8.
    • (2009) Pathol. Oncol. Res. , vol.15 , Issue.4 , pp. 651-658
    • Chen, H.J.1    Mok, T.S.2    Chen, Z.H.3    Guo, A.L.4    Zhang, X.C.5    Su, J.6    Wu, Y.L.7
  • 95
    • 0141988690 scopus 로고    scopus 로고
    • C-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
    • Ma, P.C.; Kijima, T.; Maulik, G.; Fox, E.A.; Sattler, M.; Griffin, J.D.; Johnson, B.E.; Salgia, R. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res., 2003, 63(19):6272-81. (Pubitemid 37255174)
    • (2003) Cancer Research , vol.63 , Issue.19 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3    Fox, E.A.4    Sattler, M.5    Griffin, J.D.6    Johnson, B.E.7    Salgia, R.8
  • 97
    • 34249912683 scopus 로고    scopus 로고
    • C-Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis
    • DOI 10.1111/j.1349-7006.2007.00493.x
    • Nakamura Y.; Niki, T.; Goto, A.; Morikawa, T.; Miyazawa, K.; Nakajima, J.; Fukayama, M. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci., 2007, 98(7):1006-13. (Pubitemid 46865384)
    • (2007) Cancer Science , vol.98 , Issue.7 , pp. 1006-1013
    • Nakamura, Y.1    Niki, T.2    Goto, A.3    Morikawa, T.4    Miyazawa, K.5    Nakajima, J.6    Fukayama, M.7
  • 99
    • 78650509347 scopus 로고    scopus 로고
    • Randomised multicenter double-blind placebo-controlled Phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer
    • abstr. LBA15
    • Spigel D.; Ervin, T.; Ramlau, R.; Daniel, D.; Goldschmidt, J.; Krzakowski, M.; Godbert, B.; Yu, W.; Patel, P.H.; Peterson, A. Randomised multicenter double-blind placebo-controlled Phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer. Ann. Oncol., 2010, 21 (suppl 8): abstr. LBA15.
    • (2010) Ann. Oncol. , Issue.SUPPL. 8 , pp. 21
    • Spigel, D.1    Ervin, T.2    Ramlau, R.3    Daniel, D.4    Goldschmidt, J.5    Krzakowski, M.6    Godbert, B.7    Yu, W.8    Patel, P.H.9    Peterson, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.