-
1
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
DOI 10.1056/NEJMoa011954
-
Schiller, J.H.; Harrington, D.; Belani, C.P.; Langer.; Sandler, A.; Krook.; Zhu, J.; Johnson, D.H.; Eastern Cooperative Oncology Group. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N. Engl. J. Med., 2002, 346:92-98 (Pubitemid 34438899)
-
(2002)
New England Journal of Medicine
, vol.346
, Issue.2
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
Langer, C.4
Sandler, A.5
Krook, J.6
Zhu, J.7
Johnson, D.H.8
-
2
-
-
79959330502
-
Target therapies in lung cancer
-
Bearz, A.; Berretta, M.; Lleshi, A.; Tirelli, U. Target therapies in lung cancer. J. Biomed. Biotechnol., 2011, 2011:921231
-
(2011)
J. Biomed. Biotechnol.
, vol.2011
, pp. 921231
-
-
Bearz, A.1
Berretta, M.2
Lleshi, A.3
Tirelli, U.4
-
3
-
-
80155190075
-
Biomarkers, prediction, and prognosis in non-small cell lung cancer: A platform for personalized treatment
-
Nov; 12
-
Sudhindra, A.; Ochoa, R.; Santos, E.S. Biomarkers, Prediction, and Prognosis in Non-Small Cell Lung Cancer: A Platform for Personalized Treatment. Clin. Lung Cancer, 2011, Nov; 12(6):360-8.
-
(2011)
Clin. Lung Cancer
, Issue.6
, pp. 360-368
-
-
Sudhindra, A.1
Ochoa, R.2
Santos, E.S.3
-
4
-
-
80054734928
-
Second-line treatment of non-smallcell lung cancer: Chemotherapy or tyrosine kinase inhibitors?
-
Passaro, A.; Cortesi, E.; de Marinis, F. Second-line treatment of non-smallcell lung cancer: chemotherapy or tyrosine kinase inhibitors? Expert Rev. Anticancer Ther., 2011, 11(10):1587-97.
-
(2011)
Expert Rev. Anticancer Ther.
, vol.11
, Issue.10
, pp. 1587-1597
-
-
Passaro, A.1
Cortesi, E.2
De Marinis, F.3
-
5
-
-
73349084270
-
Differential thymidylate synthase expression in different variants of large cell carcinoma of the lung
-
Monica, V.; Scagliotti, G.; Ceppi, P.; Righi, L.; Cambieri, A.; Lo Iacono, M.; Saviozzi, S.; Volante, M.; Novello, S.; Papotti, M. Differential thymidylate synthase expression in different variants of large cell carcinoma of the lung. Clin. Cancer Res., 2009, 15:7547-7552.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 7547-7552
-
-
Monica, V.1
Scagliotti, G.2
Ceppi, P.3
Righi, L.4
Cambieri, A.5
Lo Iacono, M.6
Saviozzi, S.7
Volante, M.8
Novello, S.9
Papotti, M.10
-
6
-
-
80755181069
-
Prospective molecular marker analyses of EGFR and KRAS from a randomized placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
-
Brugger, W.; Triller, N.; Blasinska-Morawiec, M.; Curescu, S.; Sakalauskas, R.; Manikhas, G.M.; Mazieres, J.; Whittom, R.; Ward, C.; Mayne, K.; Trunzer, K.; Cappuzzo, F. Prospective Molecular Marker Analyses of EGFR and KRAS From a Randomized, Placebo-Controlled Study of Erlotinib Maintenance Therapy in Advanced Non-Small-Cell Lung Cancer. J. Clin. Oncol., 2011, 1; 29(31):4113-2
-
(2011)
J. Clin. Oncol.
, vol.1-29
, Issue.31
, pp. 4113-4122
-
-
Brugger, W.1
Triller, N.2
Blasinska-Morawiec, M.3
Curescu, S.4
Sakalauskas, R.5
Manikhas, G.M.6
Mazieres, J.7
Whittom, R.8
Ward, C.9
Mayne, K.10
Trunzer, K.11
Cappuzzo, F.12
-
7
-
-
52749099497
-
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: A systematic review and meta-analysis of studies in advanced non-small-cell-lung-cancer
-
Linardou, H.; Dahabreh, I.J.; Bafaloukous, D.; Kosmidis, P.; Murray, S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell-lung-cancer. Lancet Oncol., 2008, 9:962-972
-
(2008)
Lancet Oncol.
, vol.9
, pp. 962-972
-
-
Linardou, H.1
Dahabreh, I.J.2
Bafaloukous, D.3
Kosmidis, P.4
Murray, S.5
-
8
-
-
33745683527
-
Epidermal growth factor receptor tyrosine kinase inhibitor therapy
-
Janne, P.A.; Engelman, J.S.; Jhonson, B.E. Epidermal growth factor receptor tyrosine kinase inhibitor therapy. Clin. Cancer Res., 2006, 12:3652-3656
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 3652-3656
-
-
Janne, P.A.1
Engelman, J.S.2
Jhonson, B.E.3
-
9
-
-
77953291664
-
The biology and treatment of EML4-ALK non-small cell lung cancer
-
Sasaki, T.; Rodig, S.J.; Chirieac, L.R.; Jänne, P.A. The biology and treatment of EML4-ALK non-small cell lung cancer. Eur. J. Cancer, 2010, 46(10):1773-80.
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.10
, pp. 1773-1780
-
-
Sasaki, T.1
Rodig, S.J.2
Chirieac, L.R.3
Jänne, P.A.4
-
10
-
-
33847127528
-
DNA repair and survival in lung cancer the two faces of janus
-
Gazdar, A.F. DNA repair and survival in lung cancer, the two faces of janus. N. Engl. J. Med., 2007, 356: 800-808
-
(2007)
N. Engl. J. Med.
, vol.356
, pp. 800-808
-
-
Gazdar, A.F.1
-
11
-
-
40249094603
-
ERCC1 predicts the response of cisplatin-based neoadjuvant chemotherapy in non small cell lung cancer
-
Fujii, T.; Toyooka, S.; Ichimura, K.; Fujiwara, Y.; Hotta, K.; Soh, J.; Suehisa, H.; Kobayashi, N.; Aoe, M.; Yoshino, T.; Kiura, K.; Date, H. ERCC1 predicts the response of cisplatin-based neoadjuvant chemotherapy in non small cell lung cancer. Lung Cancer, 2007, 59; 377-384.
-
(2007)
Lung Cancer
, vol.59
, pp. 377-384
-
-
Fujii, T.1
Toyooka, S.2
Ichimura, K.3
Fujiwara, Y.4
Hotta, K.5
Soh, J.6
Suehisa, H.7
Kobayashi, N.8
Aoe, M.9
Yoshino, T.10
Kiura, K.11
Date, H.12
-
12
-
-
42549088992
-
BRCA1: A novel prognostic factor in resected NSCLC
-
Rosell, R.; Skrzypski, M.; Jassem, E.; Taron, M.; Bartolucci, R.; Sanchez, J.J.; Mendez, P.; Chaib, I.; Perez-Roca, L.; Szymanowska, A.; Rzyman, W.; Puma, F.; Kobierska-Gulida, G.; Farabi, R.; Jassem, J. BRCA1: a novel prognostic factor in resected NSCLC. PloS ONE, 2007, 2: 1129.
-
(2007)
PloS ONE
, vol.2
, pp. 1129
-
-
Rosell, R.1
Skrzypski, M.2
Jassem, E.3
Taron, M.4
Bartolucci, R.5
Sanchez, J.J.6
Mendez, P.7
Chaib, I.8
Perez-Roca, L.9
Szymanowska, A.10
Rzyman, W.11
Puma, F.12
Kobierska-Gulida, G.13
Farabi, R.14
Jassem, J.15
-
13
-
-
80052554890
-
Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: The association with treatment efficacy of pemetrexed
-
Chen, C.Y.; Chang, Y.L.; Shih, J.Y.; Lin, J.W.; Chen, K.Y.; Yang, C.H.; Yu, C.J.; Yang, P.C. Thymidylate synthase and dihydrofolate reductase expression in non-small cell lung carcinoma: the association with treatment efficacy of pemetrexed. Lung Cancer, 2011, 74(1):132-8.
-
(2011)
Lung Cancer
, vol.74
, Issue.1
, pp. 132-138
-
-
Chen, C.Y.1
Chang, Y.L.2
Shih, J.Y.3
Lin, J.W.4
Chen, K.Y.5
Yang, C.H.6
Yu, C.J.7
Yang, P.C.8
-
14
-
-
69849108427
-
Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
-
Mandrekar, S.J.; Sargent, D.J. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J. Clin. Oncol., 2009, 20; 27(24):4027-34.
-
(2009)
J. Clin. Oncol.
, vol.20-27
, Issue.24
, pp. 4027-4034
-
-
Mandrekar, S.J.1
Sargent, D.J.2
-
15
-
-
37349107823
-
Platinum resistance related to a functional NER pathway
-
DOI 10.1097/JTO.0b013e31815ba2a1, PII 0124389420071200000001
-
Rosell, R.; Mendez, P.; Isla, D.; Taron, M. Platinum resistance related to a functional NER pathway. J. Thorac. Oncol., 2007, 2(12): 1063-6. (Pubitemid 350307897)
-
(2007)
Journal of Thoracic Oncology
, vol.2
, Issue.12
, pp. 1063-1066
-
-
Rosell, R.1
Mendez, P.2
Isla, D.3
Taron, M.4
-
16
-
-
0002556166
-
DNA repair and the cell cycle as targets in cancer therapy
-
Nature Publishing Group, London
-
Rajewsky, M.; Muller, R. DNA repair and the cell cycle as targets in cancer therapy. The Cancer Handbook. Nature Publishing Group, London, pp. 1507-19, 2002.
-
(2002)
The Cancer Handbook
, pp. 1507-1519
-
-
Rajewsky, M.1
Muller, R.2
-
17
-
-
28844480409
-
The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair
-
DOI 10.1016/j.str.2005.08.014, PII S0969212605003576
-
Trispsianes, K.; Folkers, G.; Ab, E.; Dus, D.; Odijk, H.; Jasper, N.G. et al. The structure of the human ERCC1/XPF interaction domains reveals a complementary role for the two proteins in nucleotide excision repair. Structure, 2005, 13: 1849-58. (Pubitemid 41772953)
-
(2005)
Structure
, vol.13
, Issue.12
, pp. 1849-1858
-
-
Tripsianes, K.1
Folkers, G.2
Ab, E.3
Das, D.4
Odijk, H.5
Jaspers, N.G.J.6
Hoeijmakers, J.H.J.7
Kaptein, R.8
Boelens, R.9
-
18
-
-
0033797293
-
ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells
-
Britten, A.; Liu, D.; Tessier, A.; Hutchison, Murray. D. ERCC1 expression as a molecular marker of cisplatin resistance in human cervical tumor cells. Int. J. Cancer, 2000, 89:453-7.
-
(2000)
Int. J. Cancer
, vol.89
, pp. 453-457
-
-
Britten, A.1
Liu, D.2
Tessier, A.3
Hutchison, M.D.4
-
19
-
-
3142773418
-
Oncogenic HRas up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents
-
Youn, CK.; Kim, M.H.; Cho, H.J.; Kim, H.B.; Chang, I.Y.; Chung, M.H. et al. Oncogenic HRas up-regulates expression of ERCC1 to protect cells from platinum-based anticancer agents. Cancer Res, 2004, 64:4849-57.
-
(2004)
Cancer Res
, vol.64
, pp. 4849-4857
-
-
Youn, C.K.1
Kim, M.H.2
Cho, H.J.3
Kim, H.B.4
Chang, I.Y.5
Chung, M.H.6
-
20
-
-
0031982522
-
ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy
-
Metzger, R.; Leichman, C. G.; Danenberg, K. D.; Danenberg, P. V.; Lenz, H. J.; Hayashi, K.; et al. ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. J. Clin. Oncol., 1998, 16(1), 309-316. (Pubitemid 28041614)
-
(1998)
Journal of Clinical Oncology
, vol.16
, Issue.1
, pp. 309-316
-
-
Metzger, R.1
Leichman, C.G.2
Danenberg, K.D.3
Danenberg, P.V.4
Lenz, H.-J.5
Hayashi, K.6
Groshen, S.7
Salonga, D.8
Cohen, H.9
Laine, L.10
Crookes, P.11
Silberman, H.12
Baranda, J.13
Konda, B.14
Leichman, L.15
-
21
-
-
0026648940
-
ERCC1andERCC2expression in malignant tissues from ovarian cancer patients
-
Dabholkar, M.; Bostick-Bruton, F.; Weber, C.; Bohr, V. A.; Egwuagu, C.; Reed, E. ERCC1andERCC2expression in malignant tissues from ovarian cancer patients. J. Natl. Cancer Inst., 1992, 84(19), 1512-1517.
-
(1992)
J. Natl. Cancer Inst.
, vol.84
, Issue.19
, pp. 1512-1517
-
-
Dabholkar, M.1
Bostick-Bruton, F.2
Weber, C.3
Bohr, V.A.4
Egwuagu, C.5
Reed, E.6
-
22
-
-
2542603960
-
High specificity of quantitative excision repair cross-complementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer
-
DOI 10.1158/1078-0432.CCR-03-0079
-
Warnecke-Eberz, U.; Metzger, R.; Miyazono, F.; Baldus, S.E.; Neiss, S.; Brabender, J. et al. High specificity of quantitative excision repair crosscomplementing 1 messenger RNA expression for prediction of minor histopathological response to neoadjuvant radiochemotherapy in esophageal cancer. Clin. Cancer Res., 2004, 10(11), 3794-3799. (Pubitemid 38697614)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.11
, pp. 3794-3799
-
-
Warnecke-Eberz, U.1
Metzger, R.2
Miyazono, F.3
Baldus, S.E.4
Neiss, S.5
Brabender, J.6
Schaefer, H.7
Doerfler, W.8
Bollschweiler, E.9
Dienes, H.P.10
Mueller, R.P.11
Danenberg, P.V.12
Hoelscher, A.H.13
Schneider, P.M.14
-
23
-
-
0035576102
-
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
-
Shirota, Y.; Stoehlmacher, J.; Brabender, J.; Xiong, Y. P.; Uetake, H.; Danenberg, K. D.; et al. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J. Clin. Oncol., 2001, 19(23), 4298-4304. (Pubitemid 33096777)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.23
, pp. 4298-4304
-
-
Shirota, Y.1
Stoehlmacher, J.2
Brabender, J.3
Xiong, Y.-P.4
Uetake, H.5
Danenberg, K.D.6
Groshen, S.7
Tsao-Wei, D.D.8
Danenberg, P.V.9
Lenz, H.-J.10
-
24
-
-
34247122055
-
Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer
-
DOI 10.1200/JCO.2006.05.9923
-
Bewick, M. A.; Conlon, M. S.; Lafrenie, R. M. Polymorphisms in XRCC1, XRCC3, and CCND1 and survival after treatment for metastatic breast cancer. J. Clin. Oncol, 2006, 24(36), 5645-5651. (Pubitemid 46631304)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.36
, pp. 5645-5651
-
-
Bewick, M.A.1
Conlon, M.S.C.2
Lafrenie, R.M.3
-
25
-
-
0035988959
-
Low ERRC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer
-
Lord, R.V.; Brabender, J.; Gandara, D.; Alberola, V.; Camps, C.; Domine, M.; Cardenal, F.; Sánchez, J.M.; Gumerlock, P.H.; Tarón, M.; Sánchez, J.J.; Danenberg, K.D.; Danenberg, P.V.; Rosell, R. Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer. Clin. Cancer Res., 2002, 8(7): 2286-91. (Pubitemid 34753602)
-
(2002)
Clinical Cancer Research
, vol.8
, Issue.7
, pp. 2286-2291
-
-
Lord, R.V.N.1
Brabender, J.2
Gandara, D.3
Alberola, V.4
Camps, C.5
Domine, M.6
Cardenal, F.7
Sanchez, J.M.8
Gumerlock, P.H.9
Taron, M.10
Sanchez, J.J.11
Danenberg, K.D.12
Danenberg, P.V.13
Rosell, R.14
-
26
-
-
33748435058
-
DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy
-
DOI 10.1056/NEJMoa060570
-
Olaussen, K.; Dunant, A.; Fouret, P.; Brambilla, E.; André, F.; Haddad, V.; et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatinbased adjuvant chemotherapy. N. Engl. J. Med., 2006, 335:983-91. (Pubitemid 44343542)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.10
, pp. 983-991
-
-
Olaussen, K.A.1
Dunant, A.2
Fouret, P.3
Brambilla, E.4
Andre, F.5
Haddad, V.6
Taranchon, E.7
Filipits, M.8
Pirker, R.9
Popper, H.H.10
Stahel, R.11
Sabatier, L.12
Pignon, J.-P.13
Tursz, T.14
Le Chevalier, T.15
Soria, J.-C.16
-
27
-
-
34447573875
-
Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: A phase III trial in non-small-cell lung cancer
-
DOI 10.1200/JCO.2006.09.7915
-
Cobo, M.; Isla, D.; Massuti, B.; Montes, A.; Sanchez, J.M.; Provencio, M.; Viñolas, N.; Paz-Ares, L.; Lopez-Vivanco, G.; Muñoz, M.A.; Felip, E.; Alberola, V.; Camps, C.; Domine, M.; Sanchez, J.J.; Sanchez-Ronco, M.; Danenberg, K.; Taron, M.; Gandara, D.; Rosell, R. Customizing cisplatin based on quantitative excision repair crosscomplementing mRNA ex.pression: a Phase III trial in non-small-cell lung cancer. J. Clin. Oncol., 2007, 25(19): 2747-54. (Pubitemid 47123183)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.19
, pp. 2747-2754
-
-
Cobo, M.1
Isla, D.2
Massuti, B.3
Montes, A.4
Sanchez, J.M.5
Provencio, M.6
Vinolas, N.7
Paz-Ares, L.8
Lopez-Vivanco, G.9
Munoz, M.A.10
Felip, E.11
Alberola, V.12
Camps, C.13
Domine, M.14
Sanchez, J.J.15
Sanchez-Ronco, M.16
Danenberg, K.17
Taron, M.18
Gandara, D.19
Rosell, R.20
more..
-
28
-
-
15844372318
-
ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer
-
DOI 10.1378/chest.127.3.978
-
Simon, G. R.; Sharma, S.; Cantor, A.; Smith, P.; Bepler, G. ERCC1 expression is a predictor of survival in resected patients with non-small cell lung cancer. Chest, 2005, 127(3), 978-983. (Pubitemid 40775532)
-
(2005)
Chest
, vol.127
, Issue.3
, pp. 978-983
-
-
Simon, G.R.1
Sharma, S.2
Cantor, A.3
Smith, P.4
Bepler, G.5
-
29
-
-
37849040128
-
DNA damage: Ubiquitin marks the spot
-
Jan
-
Bennett, E.J.; Harper, J.W. DNA damage: ubiquitin marks the spot. Nat. Struct. Mol. Biol., 2008, Jan; 15(1):20-2.
-
(2008)
Nat. Struct. Mol. Biol.
, vol.15
, Issue.1
, pp. 20-22
-
-
Bennett, E.J.1
Harper, J.W.2
-
30
-
-
0035807219
-
Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway
-
DOI 10.1038/sj.onc.1204812
-
Lafarge, S.; Sylvain, V.; Ferrara, M.; Bignon, Y.J. Inhibition of BRCA1 leads to increased chemoresistance to microtubule-interfering agents, an effect that involves the JNK pathway. Oncogene, 2001, 20: 6597-6606. (Pubitemid 32980286)
-
(2001)
Oncogene
, vol.20
, Issue.45
, pp. 6597-6606
-
-
Lafarge, S.1
Sylvain, V.2
Ferrara, M.3
Bignon, Y.-J.4
-
31
-
-
0141954010
-
BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis
-
Quinn, J.E.; Kennedy, R.D.; Mullan, P.B.; Gilmore, P.M.; Carty, M.; et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res., 2003, 63: 6221-6228. (Pubitemid 37255167)
-
(2003)
Cancer Research
, vol.63
, Issue.19
, pp. 6221-6228
-
-
Quinn, J.E.1
Kennedy, R.D.2
Mullan, P.B.3
Gilmore, P.M.4
Carty, M.5
Johnston, P.G.6
Harkin, D.P.7
-
32
-
-
37549025804
-
BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy
-
Quinn, J.E.; James, C.R.; Stewart, G.E.; Mulligan, J.M.; White, P.; Chang, G.K.; Mullan, P.B.; Johnston, P.G.; Wilson, R.H.; Harkin, D.P. BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy. Clin. Cancer Res., 2007, 13: 7413-7420.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7413-7420
-
-
Quinn, J.E.1
James, C.R.2
Stewart, G.E.3
Mulligan, J.M.4
White, P.5
Chang, G.K.6
Mullan, P.B.7
Johnston, P.G.8
Wilson, R.H.9
Harkin, D.P.10
-
33
-
-
44349090911
-
ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel
-
Wang, L.; Wei, J.; Qian, X.; Yin, H.; Zhao, Y.; Yu, L.; Wang, T.; Liu, B. ERCC1 and BRCA1 mRNA expression levels in metastatic malignant effusions is associated with chemosensitivity to cisplatin and/or docetaxel. BMC Cancer. 2008; 8: 97.
-
(2008)
BMC Cancer
, vol.8
, pp. 97
-
-
Wang, L.1
Wei, J.2
Qian, X.3
Yin, H.4
Zhao, Y.5
Yu, L.6
Wang, T.7
Liu, B.8
-
34
-
-
19544379515
-
BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer
-
DOI 10.1093/hmg/ddh260
-
Taron, M.; Rosell, R.; Felip, E.; Mendez, P.; Souglakos, J.; Ronco, M.S.; Queralt, C.; Majo, J.; Sanchez, J.M.; Sanchez, J.J.; Maestre, J. BRCA1 mRNA expression levels as an indicator of chemoresistance in lung cancer. Hum. Mol. Genet., 2004, 13(20): 2443-9. (Pubitemid 39377848)
-
(2004)
Human Molecular Genetics
, vol.13
, Issue.20
, pp. 2443-2449
-
-
Taron, M.1
Rosell, R.2
Felip, E.3
Mendez, P.4
Souglakos, J.5
Ronco, M.S.6
Queralt, C.7
Majo, J.8
Sanchez, J.M.9
Sanchez, J.J.10
Maestre, J.11
-
35
-
-
67649431893
-
Customized Treatment in Non-Small-Cell Lung Cancer Based on EGFR Mutations and BRCA1 mRNA Expression
-
Rosell, R.; Perez-Roca, L.; Sanchez, J.J.; Cobo, M.; Moran, T.; Chaib, I.; Provencio, M.; Domine, M.; Sala, M.A.; Jimenez, U.; Diz, P.; Barneto, I.; Macias, J.A.; De Las Peñas, R.; Catot, S.; Isla, D.; Sanchez, J.M.; Ibeas, R.; Lopez-Vivanco, G.; Oramas, J.; Mendez, P.; Reguart, N.; Blanco, R.; Taron, M. Customized Treatment in Non-Small-Cell Lung Cancer Based on EGFR Mutations and BRCA1 mRNA Expression, PLoS ONE, 2009, 4(5):e5133.
-
(2009)
PLoS ONE
, vol.4
, Issue.5
-
-
Rosell, R.1
Perez-Roca, L.2
Sanchez, J.J.3
Cobo, M.4
Moran, T.5
Chaib, I.6
Provencio, M.7
Domine, M.8
Sala, M.A.9
Jimenez, U.10
Diz, P.11
Barneto, I.12
MacIas, J.A.13
De Las Peñas, R.14
Catot, S.15
Isla, D.16
Sanchez, J.M.17
Ibeas, R.18
Lopez-Vivanco, G.19
Oramas, J.20
Mendez, P.21
Reguart, N.22
Blanco, R.23
Taron, M.24
more..
-
36
-
-
84872498385
-
-
ClinicalTrial.gov. Multicenter, Predictive, Prospective, Phase III, Open, Randomized, Pharmacogenomic Study in Patients With Advanced Lung Carcinoma (BREC), Accessed Dec 20 2011
-
ClinicalTrial.gov. Multicenter, Predictive, Prospective, Phase III, Open, Randomized, Pharmacogenomic Study in Patients With Advanced Lung Carcinoma (BREC). http://clinicaltrials.gov/ct2/show/NCT00617656 (Accessed Dec 20, 2011).
-
-
-
-
37
-
-
84872494965
-
-
ClinicalTrial.gov. Randomized Customized Adjuvant Chemotherapy (GECPSCAT). ( Accessed Nov 22 2011)
-
ClinicalTrial.gov. Randomized Customized Adjuvant Chemotherapy (GECPSCAT). http://clinicaltrials.gov/ct2/show/NCT00478699 (Accessed Nov 22, 2011).
-
-
-
-
38
-
-
23844445571
-
Thymidylate synthase structure, function and implication in drug discovery
-
DOI 10.2174/0929867054864868
-
Costi, M.P.; Ferrari, S.; Venturelli, A.; Calò, S.; Tondi, D.; Barlocco, D. Thymidylate synthase structure, function and implication in drug discovery. Curr. Med. Chem., 2005, 12:2241-2258. (Pubitemid 41179710)
-
(2005)
Current Medicinal Chemistry
, vol.12
, Issue.19
, pp. 2241-2258
-
-
Costi, M.P.1
Ferrari, S.2
Venturelli, A.3
Calo, S.4
Tondi, D.5
Barlocco, D.6
-
39
-
-
0035576102
-
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy
-
Shirota, Y.; Stoehlmacher, J.; Brabender, J.; Xiong, Y.P.; Uetake, H.; Danenberg, K.D.; Groshen, S.; Tsao-Wei, D.D.; Danenberg, P.V.; Lenz, H.J. ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy. J. Clin. Oncol., 2001, 19:4298-4304. (Pubitemid 33096777)
-
(2001)
Journal of Clinical Oncology
, vol.19
, Issue.23
, pp. 4298-4304
-
-
Shirota, Y.1
Stoehlmacher, J.2
Brabender, J.3
Xiong, Y.-P.4
Uetake, H.5
Danenberg, K.D.6
Groshen, S.7
Tsao-Wei, D.D.8
Danenberg, P.V.9
Lenz, H.-J.10
-
40
-
-
0033395108
-
Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer
-
Shiga, H.; Heath, E.I.; Rasmussen, A.A.; Trock, B.; Johnston, P.G.; Forastiere, A.A.; Langmacher, M.; Baylor, A.; Lee, M.; Cullen, K.J. Prognostic value of p53, glutathione S-transferase pi, and hymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. Clin. Cancer Res., 1999, 5:4097-4104. (Pubitemid 30013791)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.12
, pp. 4097-4104
-
-
Shiga, H.1
Heath, E.I.2
Rasmussen, A.A.3
Trock, B.4
Johnston, P.G.5
Forastiere, A.A.6
Langmacher, M.7
Baylor, A.8
Lee, M.9
Cullen, K.J.10
-
41
-
-
0036183722
-
Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives
-
DOI 10.1097/00001813-200201000-00009
-
Takamura, M.; Nio, Y.; Yamasawa, K.; Dong, M.; Yamaguchi, K.; Itakura, M. Implication of thymidylate synthase in the outcome of patients with invasive ductal carcinoma of the pancreas and efficacy of adjuvant chemotherapy using 5-fluorouracil or its derivatives. Anticancer Drugs. 2002, 13:75-85. (Pubitemid 34169530)
-
(2002)
Anti-Cancer Drugs
, vol.13
, Issue.1
, pp. 75-85
-
-
Takamura, M.1
Nio, Y.2
Yamasawa, K.3
Dong, M.4
Yamaguchi, K.5
Itakura, M.6
-
42
-
-
3042756923
-
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer
-
DOI 10.1016/j.lungcan.2004.01.015, PII S0169500204000558
-
Shintani, Y.; Ohta, M.; Hirabayashi, H.; Tanaka, H.; Iuchi, K.; Nakagawa, K.; Maeda, H.; Kido, T.; Miyoshi, S.; Matsuda, H. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer. Lung Cancer, 2004, 45:189-196. (Pubitemid 38891481)
-
(2004)
Lung Cancer
, vol.45
, Issue.2
, pp. 189-196
-
-
Shintani, Y.1
Ohta, M.2
Hirabayashi, H.3
Tanaka, H.4
Iuchi, K.5
Nakagawa, K.6
Maeda, H.7
Kido, T.8
Miyoshi, S.9
Matsuda, H.10
-
43
-
-
0030891198
-
Ly231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
-
Shih, C.; Chen, V.J.; Gossett, L.S.; Gates, S.B.; MacKellar, W.C.; Habeck, L.L.; Shackelford, K.A.; Mendelsohn, L.G.; Soose, D.J.; Patel, V.F.; Andis, S.L.; Bewley, J.R.; Rayl, E.A.; Moroson, B.A.; Beardsley, G.P.; Kohler, W.; Ratnam, M.; Schultz, R.M. LY231514, a pyrrolo 2, 3-d pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res., 1997, 57: 1116-1123. (Pubitemid 27138611)
-
(1997)
Cancer Research
, vol.57
, Issue.6
, pp. 1116-1123
-
-
Shin, C.1
Chen, V.J.2
Gossett, L.S.3
Gates, S.B.4
MacKellar, W.C.5
Habeck, L.L.6
Shackelford, K.A.7
Mendelsohn, L.G.8
Soose, D.J.9
Patel, V.F.10
Andis, S.L.11
Bewley, J.R.12
Rayl, E.A.13
Moroson, B.A.14
Peter Beardsley, G.15
Kohler, W.16
Ratnam, M.17
Schultz, R.M.18
-
44
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti, G.V.; Parikh, P.; von Pawel, J.; Biesma, B.; Vansteenkiste, J.; Manegold, C.; Serwatowski, P.; Gatzemeier, U.; Digumarti, R.; Zukin, M.; Lee, J.S.; Mellemgaard, A.; Park, K.; Patil, S.; Rolski, J.; Goksel, T.; de Marinis, F.; Simms, L.; Sugarman, K.P.; Gandara D. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J. Clin. Oncol., 2008, 26: 3543-3551.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
Biesma, B.4
Vansteenkiste, J.5
Manegold, C.6
Serwatowski, P.7
Gatzemeier, U.8
Digumarti, R.9
Zukin, M.10
Lee, J.S.11
Mellemgaard, A.12
Park, K.13
Patil, S.14
Rolski, J.15
Goksel, T.16
De Marinis, F.17
Simms, L.18
Sugarman, K.P.19
Gandara, D.20
more..
-
45
-
-
33749587054
-
Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase
-
DOI 10.1002/cncr.22208
-
Ceppi, P.; Volante, M.; Saviozzi, S.; Rapa, I., Novello, S.; Cambieri, A.; Lo Iacono, M.; Cappia, S.; Papotti, M.; Scagliotti, G.V. Squamous cell carcinoma of the lung compared with other histotypes shows higher messenger RNA and protein levels for thymidylate synthase. Cancer, 2006, 107: 1589-1596. (Pubitemid 44546920)
-
(2006)
Cancer
, vol.107
, Issue.7
, pp. 1589-1596
-
-
Ceppi, P.1
Volante, M.2
Saviozzi, S.3
Rapa, I.4
Novello, S.5
Cambieri, A.6
Lo Iacono, M.7
Cappia, S.8
Papotti, M.9
Scagliotti, G.V.10
-
46
-
-
71849118033
-
Significance of thymidylate synthase for resistance to pemetrexed in lung cancer
-
Ozasa, H.; Oguri, T.; Uemura, T.; Miyazaki, M.; Maeno, K.; Sato, S.; Ueda, R. Significance of thymidylate synthase for resistance to pemetrexed in lung cancer. Cancer Sci., 2010, 101: 161-166
-
(2010)
Cancer Sci.
, vol.101
, pp. 161-166
-
-
Ozasa, H.1
Oguri, T.2
Uemura, T.3
Miyazaki, M.4
Maeno, K.5
Sato, S.6
Ueda, R.7
-
47
-
-
77955053922
-
Identification of thymidylate synthase as a potential therapeutic target for lung cancer
-
Takezawa, K.; Okamoto, I.; Tsukioka, S.; Uchida, J.; Kiniwa, M.; Fukuoka, M.; Nakagawa, K. Identification of thymidylate synthase as a potential therapeutic target for lung cancer. Br. J. Cancer., 2010, 103: 354-361
-
(2010)
Br. J. Cancer.
, vol.103
, pp. 354-361
-
-
Takezawa, K.1
Okamoto, I.2
Tsukioka, S.3
Uchida, J.4
Kiniwa, M.5
Fukuoka, M.6
Nakagawa, K.7
-
48
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
DOI 10.1200/JCO.2004.08.001
-
Giaccone, G.; Herbst, R.S.; Manegold, C.; Scagliotti, G.; Rosell, R.; Miller, V.; Natale, R.B.; Schiller. J.H.; Von Pawel, J.; Pluzanska. A.; Gatzemeier, U.; Grous, J.; Ochs, J.S.; Averbuch, S.D.; Wolf, M.K.; Rennie, P.; Fandi, A.; Johnson, D.H. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J. Clin. Oncol., 2004, 22(5):777-84. (Pubitemid 41103588)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Rosell, R.5
Miller, V.6
Natale, R.B.7
Schiller, J.H.8
Von Pawel, J.9
Pluzanska, A.10
Gatzemeier, U.11
Grous, J.12
Ochs, J.S.13
Averbuch, S.D.14
Wolf, M.K.15
Rennie, P.16
Fandi, A.17
Johnson, D.H.18
-
49
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
DOI 10.1200/JCO.2004.07.215
-
Herbst, R.S.; Giaccone, G.; Schiller, J.H.; Natale, R.B.; Miller, V.; Manegold, C.; Scagliotti, G.; Rosell, R.; Oliff, I.; Reeves, J.A.; Wolf, M.K.; Krebs, A.D.; Averbuch, S.D.; Ochs, J.S.; Grous, J.; Fandi, A.; Johnson, D.H. Gefitinib in combination with paclitaxel and carboplatin in advanced nonsmall-cell lung cancer: a phase III trial-INTACT 2. J. Clin. Oncol., 2004, 22(5):785-94. (Pubitemid 41103589)
-
(2004)
Journal of Clinical Oncology
, vol.22
, Issue.5
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
Scagliotti, G.7
Rosell, R.8
Oliff, I.9
Reeves, J.A.10
Wolf, M.K.11
Krebs, A.D.12
Averbuch, S.D.13
Ochs, J.S.14
Grous, J.15
Fandi, A.16
Johnson, D.H.17
-
50
-
-
79957492069
-
American Society of Clinical Oncology provisional clinical opinion: Epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy
-
Keedy, V.L.; Temin, S.; Somerfield, M.R.; Beasley, M.B.; Johnson, D.H.; McShane, L.M.; Milton, D.T.; Strawn, J.R.; Wakelee, H.A.; Giaccone, G. American Society of Clinical Oncology provisional clinical opinion: epidermal growth factor receptor (EGFR) Mutation testing for patients with advanced non-small-cell lung cancer considering first-line EGFR tyrosine kinase inhibitor therapy. J. Clin. Oncol., 2011, 29(15):2121-7.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.15
, pp. 2121-2127
-
-
Keedy, V.L.1
Temin, S.2
Somerfield, M.R.3
Beasley, M.B.4
Johnson, D.H.5
McShane, L.M.6
Milton, D.T.7
Strawn, J.R.8
Wakelee, H.A.9
Giaccone, G.10
-
51
-
-
33645761156
-
Clinical implication of EGFR expression in the development and progression of solid tumors: Focus on non-small cell lung cancer
-
Ettinger, D.S. Clinical implication of EGFR expression in the development and progression of solid tumors: focus on non-small cell lung cancer. Oncologist, 2006, 11 (4): 358-73.
-
(2006)
Oncologist
, vol.11
, Issue.4
, pp. 358-373
-
-
Ettinger, D.S.1
-
52
-
-
77955810928
-
Past present and future of targeted therapy in solid tumors
-
Palazzo, A.; Iacovelli, R.; Cortesi, E. Past, present and future of targeted therapy in solid tumors. Curr. Cancer Drug Targets, 2010, 10 (5): 433-61.
-
(2010)
Curr. Cancer Drug Targets
, vol.10
, Issue.5
, pp. 433-461
-
-
Palazzo, A.1
Iacovelli, R.2
Cortesi, E.3
-
53
-
-
0000686740
-
Human epidermal growth factor: Isolation and chemical and biological properties
-
Cohen, S.; Carpenter, G. Human epidermal growth factor: isolation and chemical and biological properties. Proc. Natl. Acad. Sci. USA, 1975, 72: 1317-1321.
-
(1975)
Proc. Natl. Acad. Sci. USA
, vol.72
, pp. 1317-1321
-
-
Cohen, S.1
Carpenter, G.2
-
54
-
-
0019320348
-
Autocrine secretion and malignant transformation of cells
-
Sporn, M.B.; Todaro, G.J. Autocrine secretion and malignant transformation of cells. N. Engl. J. Med., 1980, 303: 878-880.
-
(1980)
N. Engl. J. Med.
, vol.303
, pp. 878-880
-
-
Sporn, M.B.1
Todaro, G.J.2
-
55
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
DOI 10.1038/nrc1609
-
Hynes, N.E.; Lane, H.A. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer, 2005, 5: 341-354. (Pubitemid 40637826)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
56
-
-
44449127592
-
The epidermal growth factor receptor family: Biology driving targeted therapeutics
-
Wieduwilt, M.J.; Moasser, M.M. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol. Life Sci., 2008, 65:1566-1584.
-
(2008)
Cell Mol. Life Sci.
, vol.65
, pp. 1566-1584
-
-
Wieduwilt, M.J.1
Moasser, M.M.2
-
57
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello, F.; Tortora, G. EGFR antagonists in cancer treatment. N. Engl. J. Med., 2008, 358(11):1160-74.
-
(2008)
N. Engl. J. Med.
, vol.358
, Issue.11
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
58
-
-
0037429737
-
Epidermal growth factor receptor: Mechanisms of activation and signalling
-
DOI 10.1016/S0014-4827(02)00098-8
-
Jorissen, R.N.; Walker, F.; Pouliot, N.; Garrett, T.P.; Ward, C.W.; Burgess, A.W. Epidermal growth factor receptor: mechanisms of activation and signalling. Exp. Cell Res., 2003, 284(1): 31 -53. (Pubitemid 36331965)
-
(2003)
Experimental Cell Research
, vol.284
, Issue.1
, pp. 31-53
-
-
Jorissen, R.N.1
Walker, F.2
Pouliot, N.3
Garrett, T.P.J.4
Ward, C.W.5
Burgess, A.W.6
-
59
-
-
20444498630
-
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
-
DOI 10.1093/jnci/dji112
-
Cappuzzo, F.; Hirsch, F.R.; Rossi, E.; Bartolini, S.; Ceresoli, G.L.; Bemis, L.; Haney, J.; Witta, S.; Danenberg, K.; Domenichini, I.; Ludovini, V.; Magrini, E.; Gregorc, V.; Doglioni, C.; Sidoni, A.; Tonato, M.; Franklin, W.A.; Crino, L.; Bunn, P.A.Jr.; Varella-Garcia, M. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J. Natl. Cancer Inst., 2005, 97:643-655. (Pubitemid 40812628)
-
(2005)
Journal of the National Cancer Institute
, vol.97
, Issue.9
, pp. 643-655
-
-
Cappuzzo, F.1
Hirsch, F.R.2
Rossi, E.3
Bartolini, S.4
Ceresoli, G.L.5
Bemis, L.6
Haney, J.7
Witta, S.8
Danenberg, K.9
Domenichini, I.10
Ludovini, V.11
Magrini, E.12
Gregorc, V.13
Doglioni, C.14
Sidoni, A.15
Tonato, M.16
Franklin, W.A.17
Crino, L.18
Bunn Jr., P.A.19
Varella-Garcia, M.20
more..
-
60
-
-
27244443759
-
Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study
-
Hirsch, F.R.; Varella-Garcia, M.; McCoy, J.; West, H.; Xavier, A.C.; Gumerlock, P.; Bunn, P.A.Jr.; Franklin, W.A.; Crowley, J.; Gandara, D.R.; Southwest Oncology Group. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group study. J. Clin. Oncol., 2005, 23: 6838-6845.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 6838-6845
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
McCoy, J.3
West, H.4
Xavier, A.C.5
Gumerlock, P.6
Bunn Jr., P.A.7
Franklin, W.A.8
Crowley, J.9
Gandara, D.R.10
Oncology Group, S.11
-
61
-
-
0142119289
-
Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
-
DOI 10.1200/JCO.2003.11.069
-
Hirsch, F.R.; Varella-Garcia, M.; Bunn, P.A.Jr.; Di Maria, M.V.; Veve, R.; Bremmes, R.M.; Barón, A.E.; Zeng, C.; Franklin, W.A. Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis. J. Clin. Oncol. 2003, 21: 3798-3807. (Pubitemid 46606235)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.20
, pp. 3798-3807
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
Di Maria, M.V.4
Veve, R.5
Bremnes, R.M.6
Baron, A.E.7
Zeng, C.8
Franklin, W.A.9
-
62
-
-
65349107082
-
KRAS mutations in non-small cell lung cancer
-
Riely, G.J.; Marks, J.; Pao, W. KRAS mutations in non-small cell lung cancer. Proc. Am. Thorac. Soc., 2009, 6 (2):201-5.
-
(2009)
Proc. Am. Thorac. Soc.
, vol.6
, Issue.2
, pp. 201-205
-
-
Riely, G.J.1
Marks, J.2
Pao, W.3
-
63
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
DOI 10.1056/NEJMoa050753
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan, E.H.; Hirsh, V.; Thongprasert, S.; Campos, D.; Maoleekoonpiroj, S.; Smylie, M.; Martins, R.; van Kooten, M.; Dediu, M.; Findlay, B.; Tu, D.; Johnston, D.; Bezjak, A.; Clark, G.; Santabárbara, P.; Seymour, L.; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med., 2005, 353(2):123-32. (Pubitemid 41058344)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Pereira, J.R.2
Ciuleanu, T.3
Eng, H.T.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
64
-
-
22044453790
-
Erlotinib in lung cancer - Molecular and clinical predictors of outcome
-
DOI 10.1056/NEJMoa050736
-
Tsao, M.S.; Sakurada, A.; Cutz, J.C.; Zhu, C.Q.; Kamel-Reid, S.; Squire, J.; Lorimer, I.; Zhang, T.; Liu, N.; Daneshmand, M.; Marrano, P.; da Cunha Santos, G.; Lagarde, A.; Richardson, F.; Seymour, L.; Whitehead, M.; Ding, K.; Pater, J.; Shepherd, F.A. Erlotinib in lung cancer -molecular and clinical predictors of outcome. N. Engl. J. Med. 2005, 353(2):133-44. (Pubitemid 41058345)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 133-144
-
-
Tsao, M.-S.1
Sakurada, A.2
Cutz, J.-C.3
Zhu, C.-Q.4
Kamel-Reid, S.5
Squire, J.6
Lorimer, I.7
Zhang, T.8
Liu, N.9
Daneshmand, M.10
Marrano, P.11
Da Cunha Santos, G.12
Lagarde, A.13
Richardson, F.14
Seymour, L.15
Whitehead, M.16
Ding, K.17
Pater, J.18
Shepherd, F.A.19
-
65
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer
-
Thatcher, N.; Chang, A.; Parikh, P.; Rodrigues Pereira, J.; Ciuleanu, T.; von Pawel, J.; Thongprasert, S.; Tan, E.H.; Pemberton, K.; Archer, V.; Carroll, K. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet, 2005, 366: 527-37.
-
(2005)
Lancet
, vol.366
, pp. 527-537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
66
-
-
33750962024
-
Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2006.06.3958
-
Hirsch, F.R.; Varella-Garcia, M.; Bunn, P.A.Jr.; Franklin, W.A.; Dziadziuszko, R.; Thatcher, N.; Chang, A.; Parikh, P.; Pereira, J.R.; Ciuleanu, T.; von Pawel, J.; Watkins, C.; Flannery, A.; Ellison, G.; Donald, E.; Knight, L.; Parums, D.; Botwood, N.; Holloway, B. Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced nonsmall-cell lung cancer. J. Clin. Oncol., 2006, 24:5034-5042. (Pubitemid 46631407)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.31
, pp. 5034-5042
-
-
Hirsch, F.R.1
Varella-Garcia, M.2
Bunn Jr., P.A.3
Franklin, W.A.4
Dziadziuszko, R.5
Thatcher, N.6
Chang, A.7
Parikh, P.8
Pereira, J.R.9
Ciuleanu, T.10
Von Pawel, J.11
Watkins, C.12
Flannery, A.13
Ellison, G.14
Donald, E.15
Knight, L.16
Parums, D.17
Botwood, N.18
Holloway, B.19
-
67
-
-
56249109644
-
Gefitinib versus docetaxel in previously treated non-smallcell lung cancer (INTEREST): A randomised phase III trial
-
Kim, E.S.; Hirsh, V.; Mok, T.; Socinski, M.A.; Gervais, R.; Wu, Y.L.; Li, L.Y.; Watkins, C.L.; Sellers, M.V.; Lowe, E.S.; Sun, Y.; Liao, M.L.; Osterlind, K.; Reck, M.; Armour, A.A.; Shepherd, F.A.; Lippman, S.M.; Douillard, J.Y. Gefitinib versus docetaxel in previously treated non-smallcell lung cancer (INTEREST): A randomised phase III trial. Lancet, 2008, 372:1809-1818.
-
(2008)
Lancet
, vol.372
, pp. 1809-1818
-
-
Kim, E.S.1
Hirsh, V.2
Mok, T.3
Socinski, M.A.4
Gervais, R.5
Wu, Y.L.6
Li, L.Y.7
Watkins, C.L.8
Sellers, M.V.9
Lowe, E.S.10
Sun, Y.11
Liao, M.L.12
Osterlind, K.13
Reck, M.14
Armour, A.A.15
Shepherd, F.A.16
Lippman, S.M.17
Douillard, J.Y.18
-
68
-
-
77649222572
-
Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: Data from the randomized phase III INTEREST trial
-
Feb 10
-
Douillard, J.Y.; Shepherd, F.A.; Hirsh, V.; Mok, T.; Socinski, M.A.; Gervais, R.; Liao, M.L.; Bischoff, H.; Reck, M.; Sellers, M.V.; Watkins, C.L.; Speake, G.; Armour, A.A.; Kim, E.S. Molecular predictors of outcome with gefitinib and docetaxel in previously treated non-small-cell lung cancer: data from the randomized phase III INTEREST trial. J. Clin. Oncol., 2010, Feb 10; 28(5):744-52.
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.5
, pp. 744-752
-
-
Douillard, J.Y.1
Shepherd, F.A.2
Hirsh, V.3
Mok, T.4
Socinski, M.A.5
Gervais, R.6
Liao, M.L.7
Bischoff, H.8
Reck, M.9
Sellers, M.V.10
Watkins, C.L.11
Speake, G.12
Armour, A.A.13
Kim, E.S.14
-
69
-
-
61449341457
-
Epidermal growth factor receptor related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: An analysis of patients from german centers in the TRUST study
-
Schneider, C.P.; Heigener, D.; Schott-von-Römer, K.; Gütz, S.; Laack, E.; Digel, W.; Guschall, W.R.; Franke, A.; Bodenstein, H.; Schmidtgen, C.; Reck, M. Epidermal growth factor receptor related tumor markers and clinical outcomes with erlotinib in non-small cell lung cancer: an analysis of patients from german centers in the TRUST study. J. Thorac. Oncol., 2008, 3 (12):1446-53.
-
(2008)
J. Thorac. Oncol.
, vol.3
, Issue.12
, pp. 1446-1453
-
-
Schneider, C.P.1
Heigener, D.2
Schott-Von-Römer, K.3
Gütz, S.4
Laack, E.5
Digel, W.6
Guschall, W.R.7
Franke, A.8
Bodenstein, H.9
Schmidtgen, C.10
Reck, M.11
-
70
-
-
0028862909
-
K-ras genotypes and prognosis in non-small-cell lung cancer
-
Rosell, R.; Monzo, M.; Molina, F.; Martinez, E.; Pifarre, A.; Moreno, I.; Mate, J.L.; de Anta, J.M.; Sanchez, M.; Font, A. K-ras genotypes and prognosis in non-small-cell lung cancer. Ann. Oncol., 1995, 6:S15-S20.
-
(1995)
Ann. Oncol.
, vol.6
-
-
Rosell, R.1
Monzo, M.2
Molina, F.3
Martinez, E.4
Pifarre, A.5
Moreno, I.6
Mate, J.L.7
De Anta, J.M.8
Sanchez, M.9
Font, A.10
-
71
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok, T.S.; Wu, Y.L.; Thongprasert, S.; Yang, C.H.; Chu, D.T.; Saijo, N.; Sunpaweravong, P.; Han, B.; Margono, B.; Ichinose, Y.; Nishiwaki, Y.; Ohe, Y.; Yang, J.J.; Chewaskulyong, B.; Jiang, H.; Duffield, E.L.; Watkins, C.L.; Armour, A.A.; Fukuoka, M. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N. Engl. J. Med., 2009, 3; 361(10):947-57
-
(2009)
N. Engl. J. Med.
, vol.3-361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
Sunpaweravong, P.7
Han, B.8
Margono, B.9
Ichinose, Y.10
Nishiwaki, Y.11
Ohe, Y.12
Yang, J.J.13
Chewaskulyong, B.14
Jiang, H.15
Duffield, E.L.16
Watkins, C.L.17
Armour, A.A.18
Fukuoka, M.19
-
72
-
-
79960702788
-
Biomarker analyses and final overall survival results from a phase III, randomized, open-label, first-line study of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer in Asia (IPASS
-
Fukuoka, M.; Wu, Y.L.; Thongprasert, S.; Sunpaweravong, P.; Leong, S.S.; Sriuranpong, V.; Chao, T.Y.; Nakagawa, K.; Chu, D.T.; Saijo, N.; Duffield, E.L.; Rukazenkov, Y.; Speake, G.; Jiang, H.; Armour, A.A.; To, K.F.; Yang, J.C.; Mok, T.S. Biomarker Analyses and Final Overall Survival Results From a Phase III, Randomized, Open-Label, First-Line Study of Gefitinib Versus Carboplatin/Paclitaxel in Clinically Selected Patients With Advanced Non-Small-Cell Lung Cancer in Asia (IPASS). J. Clin. Oncol., 2011, 29 (21): 2866-74.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.21
, pp. 2866-2874
-
-
Fukuoka, M.1
Wu, Y.L.2
Thongprasert, S.3
Sunpaweravong, P.4
Leong, S.S.5
Sriuranpong, V.6
Chao, T.Y.7
Nakagawa, K.8
Chu, D.T.9
Saijo, N.10
Duffield, E.L.11
Rukazenkov, Y.12
Speake, G.13
Jiang, H.14
Armour, A.A.15
To, K.F.16
Yang, J.C.17
Mok, T.S.18
-
73
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou, C.; Wu, Y.L.; Chen, G.; Feng, J.; Liu, X.Q.; Wang, C.; Zhang, S.; Wang, J.; Zhou, S.; Ren, S.; Lu, S.; Zhang, L.; Hu, C.; Hu, C.; Luo, Y.; Chen, L.; Ye, M.; Huang, J.; Zhi, X.; Zhang, Y.; Xiu, Q.; Ma, J.; Zhang, L.; You, C. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol., 2011, 12(8):735-42.
-
(2011)
Lancet Oncol.
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
Zhang, S.7
Wang, J.8
Zhou, S.9
Ren, S.10
Lu, S.11
Zhang, L.12
Hu, C.13
Hu, C.14
Luo, Y.15
Chen, L.16
Ye, M.17
Huang, J.18
Zhi, X.19
Zhang, Y.20
Xiu, Q.21
Ma, J.22
Zhang, L.23
You, C.24
more..
-
74
-
-
80053561215
-
Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial
-
Spanish Lung Cancer Group, (suppl; abstr 7503)
-
Rosell, R.; Gervais, R.; Vergnenegre, A.; Massuti, B.; Felip, E.; Cardenal, F.; Garcia Gomez, R.; Pallares, C.; Sanchez, J.M.; Porta, R.; Cobo, M.; Di Seri, M.; Garrido Lopez, P.; Insa, A.; De Marinis, F.; Corre, R.; Carreras, M.; Carcereny, E., Taron, M.; Paz-Ares, L.G.; Spanish Lung Cancer Group. Erlotinib versus chemotherapy (CT) in advanced non-small cell lung cancer (NSCLC) patients (p) with epidermal growth factor receptor (EGFR) mutations: Interim results of the European Erlotinib Versus Chemotherapy (EURTAC) phase III randomized trial. J. Clin. Oncol., 2011, 29: (suppl; abstr 7503).
-
J. Clin. Oncol.
, vol.2011
, pp. 29
-
-
Rosell, R.1
Gervais, R.2
Vergnenegre, A.3
Massuti, B.4
Felip, E.5
Cardenal, F.6
Garcia Gomez, R.7
Pallares, C.8
Sanchez, J.M.9
Porta, R.10
Cobo, M.11
Di Seri, M.12
Garrido Lopez, P.13
Insa, A.14
De Marinis, F.15
Corre, R.16
Carreras, M.17
Carcereny, E.18
Taron, M.19
Paz-Ares, L.G.20
more..
-
75
-
-
0028198206
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
-
Morris, S.W.; Kirstein, M.N.; Valentine, M.B.; Dittmer, K.G.; Shapiro, D.N.; Saltman, D.L.; Look, A.T. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science, 1994, 4, 263(5151):1281-4. (Pubitemid 24107549)
-
(1994)
Science
, vol.263
, Issue.5151
, pp. 1281-1284
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
Dittmer, K.G.4
Shapiro, D.N.5
Saltman, D.L.6
Look, A.T.7
-
76
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
Soda, M.; Choi, Y.L.; Enomoto, M.; Takada, S.; Yamashita, Y.; Ishikawa, S.; Fujiwara, S.; Watanabe, H.; Kurashina, K.; Hatanaka, H.; Bando, M.; Ohno, S.; Ishikawa, Y.; Aburatani, H.; Niki, T.; Sohara, Y.; Sugiyama, Y.; Mano, H. Identification of the transforming EML4-ALK fusion gene in non-smallcell lung cancer. Nature, 2007, 448(7153):561-6. (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
77
-
-
63949086127
-
KIF5B-ALK a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer
-
May 1
-
Takeuchi, K.; Choi, Y.L.; Togashi, Y.; Soda, M.; Hatano, S.; Inamura, K.; Takada, S.; Ueno, T.; Yamashita, Y.; Satoh, Y.; Okumura, S.; Nakagawa, K.; Ishikawa, Y.; Mano, H. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin. Cancer Res., 2009, May 1; 15(9):3143-9.
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.9
, pp. 3143-3149
-
-
Takeuchi, K.1
Choi, Y.L.2
Togashi, Y.3
Soda, M.4
Hatano, S.5
Inamura, K.6
Takada, S.7
Ueno, T.8
Yamashita, Y.9
Satoh, Y.10
Okumura, S.11
Nakagawa, K.12
Ishikawa, Y.13
Mano, H.14
-
78
-
-
36849065315
-
Global Survey of Phosphotyrosine Signaling Identifies Oncogenic Kinases in Lung Cancer
-
DOI 10.1016/j.cell.2007.11.025, PII S009286740701522X
-
Rikova K.; Guo, A.; Zeng, Q.; Possemato, A.; Yu, J.; Haack, H.; Nardone, J.; Lee, K.; Reeves, C.; Li, Y.; Hu, Y.; Tan, Z.; Stokes, M.; Sullivan, L.; Mitchell, J.; Wetzel, R.; Macneill, J.; Ren, JM.; Yuan, J.; Bakalarski, C.E.; Villen, J.; Kornhauser, J.M.; Smith, B.; Li, D.; Zhou, X.; Gygi, S.P.; Gu, T.L.; Polakiewicz, R.D.; Rush, J.; Comb, M.J. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell, 2007, 131(6):1190-203. (Pubitemid 350235027)
-
(2007)
Cell
, vol.131
, Issue.6
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
Possemato, A.4
Yu, J.5
Haack, H.6
Nardone, J.7
Lee, K.8
Reeves, C.9
Li, Y.10
Hu, Y.11
Tan, Z.12
Stokes, M.13
Sullivan, L.14
Mitchell, J.15
Wetzel, R.16
MacNeill, J.17
Ren, J.M.18
Yuan, J.19
Bakalarski, C.E.20
Villen, J.21
Kornhauser, J.M.22
Smith, B.23
Li, D.24
Zhou, X.25
Gygi, S.P.26
Gu, T.-L.27
Polakiewicz, R.D.28
Rush, J.29
Comb, M.J.30
more..
-
79
-
-
44849093562
-
Oncogene addiction
-
Weinstein, I.B.; Joe, A. Oncogene addiction. Cancer Res., 2008, 68(9):3077-80.
-
(2008)
Cancer Res.
, vol.68
, Issue.9
, pp. 3077-3080
-
-
Weinstein, I.B.1
Joe, A.2
-
80
-
-
63949087355
-
EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset
-
Inamura K.; Takeuchi K.; Togashi, Y.; Hatano, S.; Ninomiya, H.; Motoi, N.; Mun, M.Y.; Sakao, Y.; Okumura, S.; Nakagawa, K.; Soda, M.; Choi, Y.L.; Mano, H.; Ishikawa, Y. EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset. Mod. Pathol., 2009, 22(4):508-15.
-
(2009)
Mod. Pathol.
, vol.22
, Issue.4
, pp. 508-515
-
-
Inamura, K.1
Takeuchi, K.2
Togashi, Y.3
Hatano, S.4
Ninomiya, H.5
Motoi, N.6
Mun, M.Y.7
Sakao, Y.8
Okumura, S.9
Nakagawa, K.10
Soda, M.11
Choi, Y.L.12
Mano, H.13
Ishikawa, Y.14
-
81
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw, A.T.; Yeap, B.Y.; Mino-Kenudson, M.; Digumarthy, S.R.; Costa, D.B.; Heist, R.S.; Solomon, B.; Stubbs, H.; Admane, S.; McDermott, U.; Settleman, J.; Kobayashi, S.; Mark, E.J.; Rodig, S.J.; Chirieac, L.R.; Kwak, E.L.; Lynch, T.J.; Iafrate, A.J. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J. Clin. Oncol., 2009, 27(26):4247-53.
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.26
, pp. 4247-4253
-
-
Shaw, A.T.1
Yeap, B.Y.2
Mino-Kenudson, M.3
Digumarthy, S.R.4
Costa, D.B.5
Heist, R.S.6
Solomon, B.7
Stubbs, H.8
Admane, S.9
McDermott, U.10
Settleman, J.11
Kobayashi, S.12
Mark, E.J.13
Rodig, S.J.14
Chirieac, L.R.15
Kwak, E.L.16
Lynch, T.J.17
Iafrate, A.J.18
-
82
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen, J.P.; Mermel, C.; Zejnullahu, K.; Murphy, C.; Lifshits, E.; Holmes, A.J.; Choi, H.G.; Kim, J.; Chiang, D.; Thomas, R.; Lee, J.; Richards, W.G.; Sugarbaker, D.J.; Ducko, C.; Lindeman, N.; Marcoux, J.P.; Engelman, J.A.; Gray, N.S.; Lee, C.; Meyerson, M.; Jänne, P.A. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin. Cancer Res., 2008, 14(13):4275-83.
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.13
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
Murphy, C.4
Lifshits, E.5
Holmes, A.J.6
Choi, H.G.7
Kim, J.8
Chiang, D.9
Thomas, R.10
Lee, J.11
Richards, W.G.12
Sugarbaker, D.J.13
Ducko, C.14
Lindeman, N.15
Marcoux, J.P.16
Engelman, J.A.17
Gray, N.S.18
Lee, C.19
Meyerson, M.20
Jänne, P.A.21
more..
-
83
-
-
74249123333
-
ALK gene rearrangements: A new therapeutic target in a molecularly defined subset of non-small cell lung cancer
-
Solomon, B.; Varella-Garcia, M.; Camidge, D.R. ALK gene rearrangements: a new therapeutic target in a molecularly defined subset of non-small cell lung cancer. J. Thorac. Oncol., 2009, (12):1450-4.
-
(2009)
J. Thorac. Oncol.
, vol.12
, pp. 1450-1454
-
-
Solomon, B.1
Varella-Garcia, M.2
Camidge, D.R.3
-
84
-
-
80051780280
-
2011 ASCO annual meeting
-
abstr
-
Crinò, L.; Kim, D.; Riely, G.J; Janne, P.A.; Blackhall, F.H.; Camidge, D.R; Hirsh, V.; Mok, T.; Solomon, B.J.; Park, K.; Gadgeel, S.M.; Martins, R.; Han, J.; De Pas, T.M.; Bottomley, A.; Polli, A.; Petersen, J.; Tassell, V.R.; Shaw, A.T. 2011 ASCO Annual Meeting. J. Clin. Oncol., 2011, 29 (suppl): abstr. 7514.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.SUPPL.
, pp. 7514
-
-
Crinò, L.1
Kim, D.2
Riely, G.J.3
Janne, P.A.4
Blackhall, F.H.5
Camidge, D.R.6
Hirsh, V.7
Mok, T.8
Solomon, B.J.9
Park, K.10
Gadgeel, S.M.11
Martins, R.12
Han, J.13
De Pas, T.M.14
Bottomley, A.15
Polli, A.16
Petersen, J.17
Tassell, V.R.18
Shaw, A.T.19
-
85
-
-
84872494133
-
-
ClinicalTrial.gov. An Investigational Drug PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene. (Accessed Jan 4 2012)
-
ClinicalTrial.gov. An Investigational Drug, PF-02341066 Is Being Studied Versus Standard Of Care In Patients With Advanced Non-Small Cell Lung Cancer With A Specific Gene Profile Involving The Anaplastic Lymphoma Kinase (ALK) Gene. http://clinicaltrial.gov/ct2/show/NCT00932893 (Accessed Jan 4, 2012).
-
-
-
-
86
-
-
0029007694
-
The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein
-
Pelicci, G.; Giordano, S.; Zhen, Z.; Salcini, A.E.; Lanfrancone, L.; Bardelli, A.; Panayotou, G.; Waterfield, M.D.; Ponzetto, C.; Pelicci, P.G. The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene, 1995, 10 (8): 1631-8.
-
(1995)
Oncogene
, vol.10
, Issue.8
, pp. 1631-1638
-
-
Pelicci, G.1
Giordano, S.2
Zhen, Z.3
Salcini, A.E.4
Lanfrancone, L.5
Bardelli, A.6
Panayotou, G.7
Waterfield, M.D.8
Ponzetto, C.9
Pelicci, P.G.10
-
87
-
-
0029855280
-
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis
-
DOI 10.1038/384173a0
-
Weidner, K.M.; Di Cesare, S.; Sachs, M.; Brinkmann, V.; Behrens, J.; Birchmeier, W. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature, 1996; 384(6605): 173-6. (Pubitemid 26386473)
-
(1996)
Nature
, vol.384
, Issue.6605
, pp. 173-176
-
-
Weidner, K.M.1
Di Cesare, S.2
Sachs, M.3
Brinkmann, V.4
Behrens, J.5
Birchmeier, W.6
-
88
-
-
0034693753
-
Met receptor tyrosine kinase: Enhanced signaling through adapter proteins
-
Furge, K.A.; Zhang, Y.W.; Vande Woude, G.F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene, 2000, 19 (49): 5582-9.
-
(2000)
Oncogene
, vol.19
, Issue.49
, pp. 5582-5589
-
-
Furge, K.A.1
Zhang, Y.W.2
Vande Woude, G.F.3
-
89
-
-
0035843125
-
Gab1 phosphorylation: A novel mechanism for negative regulation of HGF receptor signaling
-
Gual, P.; Giordano, S.; Anguissola, S.; Parker, P.J.; Comoglio, P.M. Gab1 phosphorylation: a novel mechanism for negative regulation of HGF receptor signaling. Oncogene, 2000, 20 (2): 156-66.
-
(2000)
Oncogene
, vol.20
, Issue.2
, pp. 156-166
-
-
Gual, P.1
Giordano, S.2
Anguissola, S.3
Parker, P.J.4
Comoglio, P.M.5
-
90
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean, J.; Brennan, C.; Shih, J.Y.; Riely, G.; Viale, A.; Wang, L.; Chitale, D.; Motoi, N.; Szoke, J.; Broderick, S.; Balak, M.; Chang, W.C.; Yu, C.J.; Gazdar, A.; Pass, H.; Rusch, V.; Gerald, W.; Huang, SF.; Yang, P.C.; Miller, V.; Ladanyi, M.; Yang, C.H.; Pao, W. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc. Natl. Acad. Sci. USA, 2007, 104(52):20932-7.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, Issue.52
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
Wang, L.6
Chitale, D.7
Motoi, N.8
Szoke, J.9
Broderick, S.10
Balak, M.11
Chang, W.C.12
Yu, C.J.13
Gazdar, A.14
Pass, H.15
Rusch, V.16
Gerald, W.17
Huang, S.F.18
Yang, P.C.19
Miller, V.20
Ladanyi, M.21
Yang, C.H.22
Pao, W.23
more..
-
91
-
-
60549110433
-
MET increased gene copy number and primary resistance to gefitinib therapy in non-smallcell lung cancer patients
-
Cappuzzo, F.; Jänne, P.A.; Skokan, M.; Finocchiaro, G.; Rossi, E.; Ligorio, C.; Zucali, P.A.; Terracciano, L.; Toschi, L.; Roncalli, M.; Destro, A.; Incarbone, M.; Alloisio, M.; Santoro, A.; Varella-Garcia, M. MET increased gene copy number and primary resistance to gefitinib therapy in non-smallcell lung cancer patients. Ann. Oncol., 2009, (2):298-304.
-
(2009)
Ann. Oncol.
, vol.2
, pp. 298-304
-
-
Cappuzzo, F.1
Jänne, P.A.2
Skokan, M.3
Finocchiaro, G.4
Rossi, E.5
Ligorio, C.6
Zucali, P.A.7
Terracciano, L.8
Toschi, L.9
Roncalli, M.10
Destro, A.11
Incarbone, M.12
Alloisio, M.13
Santoro, A.14
Varella-Garcia, M.15
-
92
-
-
75049083402
-
Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitorresistant Chinese non-small cell lung cancer
-
Chen, H.J.; Mok, T.S.; Chen, Z.H.; Guo, A.L.; Zhang, X.C.; Su, J.; Wu, Y.L. Clinicopathologic and molecular features of epidermal growth factor receptor T790M mutation and c-MET amplification in tyrosine kinase inhibitorresistant Chinese non-small cell lung cancer. Pathol. Oncol. Res., 2009, 15(4):651-8.
-
(2009)
Pathol. Oncol. Res.
, vol.15
, Issue.4
, pp. 651-658
-
-
Chen, H.J.1
Mok, T.S.2
Chen, Z.H.3
Guo, A.L.4
Zhang, X.C.5
Su, J.6
Wu, Y.L.7
-
93
-
-
62449250134
-
MET gene amplification or EGFR mutation activate MET in lung. cancers untreated with EGFR tyrosine kinase inhibitors
-
Kubo, T.; Yamamoto, H.; Lockwood, W.W.; Valencia, I.; Soh, J.; Peyton, M.; Jida, M.; Otani, H.; Fujii, T.; Ouchida, M.; Takigawa, N.; Kiura, K.; Shimizu, K.; Date, H.; Minna, J.D.; Varella-Garcia, M.; Lam, W.L.; Gazdar, A.F.; Toyooka, S. MET gene amplification or EGFR mutation activate MET in lung. cancers untreated with EGFR tyrosine kinase inhibitors. Int. J. Cancer, 2009, 124(8):1778-84.
-
(2009)
Int. J. Cancer
, vol.124
, Issue.8
, pp. 1778-1784
-
-
Kubo, T.1
Yamamoto, H.2
Lockwood, W.W.3
Valencia, I.4
Soh, J.5
Peyton, M.6
Jida, M.7
Otani, H.8
Fujii, T.9
Ouchida, M.10
Takigawa, N.11
Kiura, K.12
Shimizu, K.13
Date, H.14
Minna, J.D.15
Varella-Garcia, M.16
Lam, W.L.17
Gazdar, A.F.18
Toyooka, S.19
-
94
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of Met in lung cancer
-
DOI 10.1158/0008-5472.CAN-05-2749
-
Kong-Beltran, M.; Seshagiri, S.; Zha, J.; Zhu, W.; Bhawe, K.; Mendoza, N.; Holcomb, T.; Pujara, K.; Stinson, J.; Fu, L.; Severin, C.; Rangell, L.; Schwall, R.; Amler, L.; Wickramasinghe, D.; Yauch, R. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res., 2006, 66(1):283-9. (Pubitemid 43166034)
-
(2006)
Cancer Research
, vol.66
, Issue.1
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
Zhu, W.4
Bhawe, K.5
Mendoza, N.6
Holcomb, T.7
Pujara, K.8
Stinson, J.9
Fu, L.10
Severin, C.11
Rangell, L.12
Schwall, R.13
Amier, L.14
Wickramasinghe, D.15
Yauch, R.16
-
95
-
-
0141988690
-
C-MET mutational analysis in small cell lung cancer: Novel juxtamembrane domain mutations regulating cytoskeletal functions
-
Ma, P.C.; Kijima, T.; Maulik, G.; Fox, E.A.; Sattler, M.; Griffin, J.D.; Johnson, B.E.; Salgia, R. c-MET mutational analysis in small cell lung cancer: novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res., 2003, 63(19):6272-81. (Pubitemid 37255174)
-
(2003)
Cancer Research
, vol.63
, Issue.19
, pp. 6272-6281
-
-
Ma, P.C.1
Kijima, T.2
Maulik, G.3
Fox, E.A.4
Sattler, M.5
Griffin, J.D.6
Johnson, B.E.7
Salgia, R.8
-
96
-
-
77954586493
-
Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
-
Benedettini, E.; Sholl, L.M.; Peyton, M.; Reilly, J.; Ware, C.; Davis, L.; Vena, N.; Bailey, D.; Yeap, B.Y.; Fiorentino, M.; Ligon, A.H.; Pan, B.S.; Richon, V.; Minna, J.D.; Gazdar, A.F.; Draetta, G.; Bosari, S.; Chirieac, L.R.; Lutterbach, B.; Loda, M. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am. J. Pathol., 2010, 177(1):415-23.
-
(2010)
Am. J. Pathol.
, vol.177
, Issue.1
, pp. 415-423
-
-
Benedettini, E.1
Sholl, L.M.2
Peyton, M.3
Reilly, J.4
Ware, C.5
Davis, L.6
Vena, N.7
Bailey, D.8
Yeap, B.Y.9
Fiorentino, M.10
Ligon, A.H.11
Pan, B.S.12
Richon, V.13
Minna, J.D.14
Gazdar, A.F.15
Draetta, G.16
Bosari, S.17
Chirieac, L.R.18
Lutterbach, B.19
Loda, M.20
more..
-
97
-
-
34249912683
-
C-Met activation in lung adenocarcinoma tissues: An immunohistochemical analysis
-
DOI 10.1111/j.1349-7006.2007.00493.x
-
Nakamura Y.; Niki, T.; Goto, A.; Morikawa, T.; Miyazawa, K.; Nakajima, J.; Fukayama, M. c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis. Cancer Sci., 2007, 98(7):1006-13. (Pubitemid 46865384)
-
(2007)
Cancer Science
, vol.98
, Issue.7
, pp. 1006-1013
-
-
Nakamura, Y.1
Niki, T.2
Goto, A.3
Morikawa, T.4
Miyazawa, K.5
Nakajima, J.6
Fukayama, M.7
-
98
-
-
77952238683
-
Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells
-
Xu, L.; Nilsson, M.B.; Saintigny, P.; Cascone, T.; Herynk, M.H.; Du, Z.; Nikolinakos, P.G.; Yang, Y.; Prudkin, L.; Liu, D.; Lee, J.J.; Johnson, F.M.; Wong, K.K.; Girard, L.; Gazdar, A.F.; Minna, J.D.; Kurie, J.M.; Wistuba, I.I.; Heymach, J.V. Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene, 2010, 6; 29(18):2616-27.
-
(2010)
Oncogene
, vol.6-29
, Issue.18
, pp. 2616-2627
-
-
Xu, L.1
Nilsson, M.B.2
Saintigny, P.3
Cascone, T.4
Herynk, M.H.5
Du, Z.6
Nikolinakos, P.G.7
Yang, Y.8
Prudkin, L.9
Liu, D.10
Lee, J.J.11
Johnson, F.M.12
Wong, K.K.13
Girard, L.14
Gazdar, A.F.15
Minna, J.D.16
Kurie, J.M.17
Wistuba, I.I.18
Heymach, J.V.19
-
99
-
-
78650509347
-
Randomised multicenter double-blind placebo-controlled Phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer
-
abstr. LBA15
-
Spigel D.; Ervin, T.; Ramlau, R.; Daniel, D.; Goldschmidt, J.; Krzakowski, M.; Godbert, B.; Yu, W.; Patel, P.H.; Peterson, A. Randomised multicenter double-blind placebo-controlled Phase II study evaluating MetMAb, an antibody to met receptor, in combination with erlotinib, in patients with advanced non-small-cell lung cancer. Ann. Oncol., 2010, 21 (suppl 8): abstr. LBA15.
-
(2010)
Ann. Oncol.
, Issue.SUPPL. 8
, pp. 21
-
-
Spigel, D.1
Ervin, T.2
Ramlau, R.3
Daniel, D.4
Goldschmidt, J.5
Krzakowski, M.6
Godbert, B.7
Yu, W.8
Patel, P.H.9
Peterson, A.10
-
100
-
-
80051974548
-
Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer
-
Sequist, L.V.; von Pawel, J.; Garmey, E.G.; Akerley, W.L.; Brugger, W.; Ferrari, D.; Chen, Y.; Costa, D.B.; Gerber, D.E.; Orlov, S.; Ramlau, R.; Arthur, S.; Gorbachevsky, I.; Schwartz, B.; Schiller, J.H. Randomized phase II study of erlotinib plus tivantinib versus erlotinib plus placebo in previously treated non-small-cell lung cancer. J. Clin. Oncol., 2011, 29(24):3307-15.
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.24
, pp. 3307-3315
-
-
Sequist, L.V.1
Von Pawel, J.2
Garmey, E.G.3
Akerley, W.L.4
Brugger, W.5
Ferrari, D.6
Chen, Y.7
Costa, D.B.8
Gerber, D.E.9
Orlov, S.10
Ramlau, R.11
Arthur, S.12
Gorbachevsky, I.13
Schwartz, B.14
Schiller, J.H.15
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