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Volumn 12, Issue 12, 2006, Pages 3652-3656

Biological markers for non-small cell lung cancer patient selection for epidermal growth factor receptor tyrosine kinase inhibitor therapy

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; BIOLOGICAL MARKER; CARBOPLATIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; HISTONE DEACETYLASE INHIBITOR; ONCOPROTEIN; PACLITAXEL; PANITUMUMAB; PLACEBO; PROTEIN KINASE B; TRANSCRIPTION FACTOR; UVOMORULIN; VIMENTIN;

EID: 33745683527     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-0261     Document Type: Review
Times cited : (53)

References (45)
  • 1
    • 10744223655 scopus 로고    scopus 로고
    • A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer
    • Coombes RC, Hall E, Gibson LJ, et al. A randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer. N Engl J Med 2004;350:1081-92.
    • (2004) N Engl J Med , vol.350 , pp. 1081-1092
    • Coombes, R.C.1    Hall, E.2    Gibson, L.J.3
  • 2
    • 26844559765 scopus 로고    scopus 로고
    • Trastuzumab in the treatment of breast cancer
    • Hortobagyi GN. Trastuzumab in the treatment of breast cancer. N Engl J Med 2005;353:1734-6.
    • (2005) N Engl J Med , vol.353 , pp. 1734-1736
    • Hortobagyi, G.N.1
  • 3
    • 17844372539 scopus 로고    scopus 로고
    • Critical update and emerging trends in epidermal growth factor receptor targeting in cancer
    • Baselga J, Arteaga CL. Critical update and emerging trends in epidermal growth factor receptor targeting in cancer. J Clin Oncol 2005;23:2445-59.
    • (2005) J Clin Oncol , vol.23 , pp. 2445-2459
    • Baselga, J.1    Arteaga, C.L.2
  • 4
    • 12744255161 scopus 로고    scopus 로고
    • Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer
    • Perez-Soler R. Phase II clinical trial data with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib (OSI-774) in non-small-cell lung cancer. Clin Lung Cancer 2004;6 Suppl 1:320-3.
    • (2004) Clin Lung Cancer , vol.6 , Issue.SUPPL. 1 , pp. 320-323
    • Perez-Soler, R.1
  • 5
    • 0012381722 scopus 로고    scopus 로고
    • Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial)
    • Fukuoka M, Yano S, Giaccone G, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J Clin Oncol 2003;21:2237-46.
    • (2003) J Clin Oncol , vol.21 , pp. 2237-2246
    • Fukuoka, M.1    Yano, S.2    Giaccone, G.3
  • 6
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
    • Kris MG, Natale RB, Herbst RS, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 2003;290:2149-58.
    • (2003) JAMA , vol.290 , pp. 2149-2158
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3
  • 7
    • 22044438962 scopus 로고    scopus 로고
    • Asian ethnicity and adenocarcinoma histology continues to predict response to gefitinib in patients treated for advanced non-small cell carcinoma of the lung in North America
    • Ho C, Murray N, Laskin J, et al. Asian ethnicity and adenocarcinoma histology continues to predict response to gefitinib in patients treated for advanced non-small cell carcinoma of the lung in North America. Lung Cancer 2005;49:225-31.
    • (2005) Lung Cancer , vol.49 , pp. 225-231
    • Ho, C.1    Murray, N.2    Laskin, J.3
  • 8
    • 1842509828 scopus 로고    scopus 로고
    • Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer
    • Miller VA, Kris MG, Shah N, et al. Bronchioloalveolar pathologic subtype and smoking history predict sensitivity to gefitinib in advanced non-small-cell lung cancer. J Clin Oncol 2004;22:1103-9.
    • (2004) J Clin Oncol , vol.22 , pp. 1103-1109
    • Miller, V.A.1    Kris, M.G.2    Shah, N.3
  • 9
    • 11444261363 scopus 로고    scopus 로고
    • The female gender has a positive effect on survival independent of background life expectancy following surgical resection of primary non-small cell lung cancer: A study of absolute and relative survival over 15 years
    • Batevik R, Grong K, Segadal L, Stangeland L. The female gender has a positive effect on survival independent of background life expectancy following surgical resection of primary non-small cell lung cancer: a study of absolute and relative survival over 15 years. Lung Cancer 2005;47:173-81.
    • (2005) Lung Cancer , vol.47 , pp. 173-181
    • Batevik, R.1    Grong, K.2    Segadal, L.3    Stangeland, L.4
  • 10
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues PJ, Ciuleanu T, et al. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 2005;353:123-32.
    • (2005) N Engl J Med , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues, P.J.2    Ciuleanu, T.3
  • 11
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa survival evaluation in lung cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa survival evaluation in lung cancer). Lancet 2005;366:1527-37.
    • (2005) Lancet , vol.366 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 12
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004;350:2129-39.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 13
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 14
    • 28844449401 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: Molecular analysis of the IDEAL/INTACT gefitinib trials
    • Bell DW, Lynch TJ, Haserlat SM, et al. Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the IDEAL/INTACT gefitinib trials. J Clin Oncol 2005;23:8081-92.
    • (2005) J Clin Oncol , vol.23 , pp. 8081-8092
    • Bell, D.W.1    Lynch, T.J.2    Haserlat, S.M.3
  • 15
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 2004;101:13306-11.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 16
    • 20044364940 scopus 로고    scopus 로고
    • Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
    • Shigematsu H, Lin L, Takahashi T, et al. Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 2005;97:339-46.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 339-346
    • Shigematsu, H.1    Lin, L.2    Takahashi, T.3
  • 17
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y, Rosell R, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas. Clin Cancer Res 2005;11:5878-85.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3
  • 18
    • 19944433797 scopus 로고    scopus 로고
    • The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers
    • Tokumo M, Toyooka S, Kiura K, et al. The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. Clin Cancer Res 2005;11:1167-73.
    • (2005) Clin Cancer Res , vol.11 , pp. 1167-1173
    • Tokumo, M.1    Toyooka, S.2    Kiura, K.3
  • 19
    • 24944497744 scopus 로고    scopus 로고
    • Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
    • Eberhard DA, Johnson BE, Amler LC, et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 2005;23:5900-9.
    • (2005) J Clin Oncol , vol.23 , pp. 5900-5909
    • Eberhard, D.A.1    Johnson, B.E.2    Amler, L.C.3
  • 20
    • 22044453790 scopus 로고    scopus 로고
    • Erlotinib in lung cancer-molecular and clinical predictors of outcome
    • Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer-molecular and clinical predictors of outcome. N Engl J Med 2005;353:133-44.
    • (2005) N Engl J Med , vol.353 , pp. 133-144
    • Tsao, M.S.1    Sakurada, A.2    Cutz, J.C.3
  • 21
    • 24344459713 scopus 로고    scopus 로고
    • Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients
    • Cortes-Funes H, Gomez C, Rosell R, et al. Epidermal growth factor receptor activating mutations in Spanish gefitinib-treated non-small-cell lung cancer patients. Ann Oncol 2005;16:1081-6.
    • (2005) Ann Oncol , vol.16 , pp. 1081-1086
    • Cortes-Funes, H.1    Gomez, C.2    Rosell, R.3
  • 22
    • 20244389188 scopus 로고    scopus 로고
    • Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
    • Han SW, Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol 2005;23:2493-501.
    • (2005) J Clin Oncol , vol.23 , pp. 2493-2501
    • Han, S.W.1    Kim, T.Y.2    Hwang, P.G.3
  • 23
    • 20244388126 scopus 로고    scopus 로고
    • Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    • Mitsudomi T, Kosaka T, Endoh H, et al. Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence. J Clin Oncol 2005;23:2513-20.
    • (2005) J Clin Oncol , vol.23 , pp. 2513-2520
    • Mitsudomi, T.1    Kosaka, T.2    Endoh, H.3
  • 24
    • 27244451321 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer
    • Takano T, Ohe Y, Sakamoto H, et al. Epidermal growth factor receptor gene mutations and increased copy numbers predict gefitinib sensitivity in patients with recurrent non-small-cell lung cancer. J Clin Oncol 2005;23:6829-37.
    • (2005) J Clin Oncol , vol.23 , pp. 6829-6837
    • Takano, T.1    Ohe, Y.2    Sakamoto, H.3
  • 25
    • 20444498630 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
    • Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 2005;97:643-55.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 643-655
    • Cappuzzo, F.1    Hirsch, F.R.2    Rossi, E.3
  • 26
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study
    • Hirsch FR, Varella-Garcia M, McCoy J, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 2005;23:6838-45.
    • (2005) J Clin Oncol , vol.23 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3
  • 27
    • 32944481596 scopus 로고    scopus 로고
    • Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib
    • Riely GJ, Pao W, Pham D, et al. Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 2006;12:839-44.
    • (2006) Clin Cancer Res , vol.12 , pp. 839-844
    • Riely, G.J.1    Pao, W.2    Pham, D.3
  • 28
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • Hirsch FR, Varella-Garcia M, Bunn PA, Jr., et al. Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis. J Clin Oncol 2003;21:3798-807.
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr., P.A.3
  • 29
    • 33745688033 scopus 로고    scopus 로고
    • Prognostic significance of EGFR FISH and EGFR IHC in non-small cell lung cancer patients treated with chemotherapy alone
    • In press
    • Dziadziuszko R, Holm B, Skov BG, et al. Prognostic significance of EGFR FISH and EGFR IHC in non-small cell lung cancer patients treated with chemotherapy alone. Proc Am Soc Clin Oncol. In press 2006.
    • (2006) Proc Am Soc Clin Oncol
    • Dziadziuszko, R.1    Holm, B.2    Skov, B.G.3
  • 30
    • 33244487093 scopus 로고    scopus 로고
    • Molecular analysis of EGFR gene copy number, EGFR expression, and Akt activation status in advanced non-small cell lung cancer (aNSCLC) treated with gefitinib or placebo (ISEL trial)
    • Hirsch FR, Varella-Garcia M, Bunn PA, et al. Molecular analysis of EGFR gene copy number, EGFR expression, and Akt activation status in advanced non-small cell lung cancer (aNSCLC) treated with gefitinib or placebo (ISEL trial). Clin Cancer Res 2005;24:90318.
    • (2005) Clin Cancer Res , vol.24 , pp. 90318
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn, P.A.3
  • 31
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti EGFR treatment in colorectal cancer: A cohort study
    • Moroni M, Veronese S, Benvenuti S, et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to anti EGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005;6:279-86.
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3
  • 32
    • 18644377457 scopus 로고    scopus 로고
    • The role of EGF-R expression on patient survival in lung cancer: A systematic review with meta-analysis
    • Meert AP, Martin B, Delmotte P, et al. The role of EGF-R expression on patient survival in lung cancer: a systematic review with meta-analysis. Eur Respir J 2002;20:975-81.
    • (2002) Eur Respir J , vol.20 , pp. 975-981
    • Meert, A.P.1    Martin, B.2    Delmotte, P.3
  • 33
    • 0242668485 scopus 로고    scopus 로고
    • Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ("Iressa", ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL1 and 2
    • Bailey LR, Kris M, Wolf M, et al. Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ("Iressa", ZD1839) monotherapy for pretreated advanced non-small-cell lung cancer: IDEAL1 and 2. Proc Am Assoc Cancer Res 2003;44:1362-1.
    • (2003) Proc Am Assoc Cancer Res , vol.44 , pp. 1362-1371
    • Bailey, L.R.1    Kris, M.2    Wolf, M.3
  • 34
    • 33745702215 scopus 로고    scopus 로고
    • FISH and immunohistochemistry can be used to select NSCLC patients, who will not benefit from gefitinib treatment
    • Hirsch FR, McCoy J, Cappuzzo F, et al. FISH and immunohistochemistry can be used to select NSCLC patients, who will not benefit from gefitinib treatment. Lung Cancer 2005;49:538.
    • (2005) Lung Cancer , vol.49 , pp. 538
    • Hirsch, F.R.1    McCoy, J.2    Cappuzzo, F.3
  • 35
    • 22144471081 scopus 로고    scopus 로고
    • Randomized phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): An Eastern Cooperative Oncology Group (ECOG) Trial E4599
    • Sandler AB, Gray R, Brahmer J, et al. Randomized phase II/III trial of paclitaxel (P) plus carboplatin (C) with or without bevacizumab (NSC #704865) in patients with advanced non-squamous non-small cell lung cancer (NSCLC): an Eastern Cooperative Oncology Group (ECOG) Trial E4599. Abstract LBA4. Proc Am Soc Clin Oncol 2005;23:250.
    • (2005) Abstract LBA4. Proc Am Soc Clin Oncol , vol.23 , pp. 250
    • Sandler, A.B.1    Gray, R.2    Brahmer, J.3
  • 36
    • 4444332925 scopus 로고    scopus 로고
    • Aktphosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer
    • Cappuzzo F, Magrini E, Ceresoli GL, et al. Aktphosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2004;96:1133-41.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1133-1141
    • Cappuzzo, F.1    Magrini, E.2    Ceresoli, G.L.3
  • 37
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • Thomson S, Buck E, Petti F, et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005;65:9455-62.
    • (2005) Cancer Res , vol.65 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3
  • 38
    • 31544452076 scopus 로고    scopus 로고
    • Restoring e-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines
    • Witta SE, Gemmill RM, Hirsch FR, et al. Restoring e-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006;66:944-50.
    • (2006) Cancer Res , vol.66 , pp. 944-950
    • Witta, S.E.1    Gemmill, R.M.2    Hirsch, F.R.3
  • 39
    • 29344465338 scopus 로고    scopus 로고
    • Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients
    • Yauch RL, Januario T, Eberhard DA, et al. Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res 2005;1511:8686-98.
    • (2005) Clin Cancer Res , vol.1511 , pp. 8686-8698
    • Yauch, R.L.1    Januario, T.2    Eberhard, D.A.3
  • 40
    • 24644445676 scopus 로고    scopus 로고
    • Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients
    • Cappuzzo F, Varella-Garcia M, Shigematsu H, et al. Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients. J Clin Oncol 2005;23:5007-18.
    • (2005) J Clin Oncol , vol.23 , pp. 5007-5018
    • Cappuzzo, F.1    Varella-Garcia, M.2    Shigematsu, H.3
  • 41
    • 28644444702 scopus 로고    scopus 로고
    • HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients
    • Cappuzzo F, Toschi L, Domenichini I, et al. HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients. Br J Cancer 2005;93:1334-40.
    • (2005) Br J Cancer , vol.93 , pp. 1334-1340
    • Cappuzzo, F.1    Toschi, L.2    Domenichini, I.3
  • 42
    • 14844366111 scopus 로고    scopus 로고
    • ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
    • Engelman JA, Janne PA, Mermel C, et al. ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines. Proc Natl Acad Sci U S A 2005;102:3788-93.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3788-3793
    • Engelman, J.A.1    Janne, P.A.2    Mermel, C.3
  • 43
    • 13844317894 scopus 로고    scopus 로고
    • EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
    • Kobayashi S, Boggon TJ, Dayaram T, et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005;352:786-92.
    • (2005) N Engl J Med , vol.352 , pp. 786-792
    • Kobayashi, S.1    Boggon, T.J.2    Dayaram, T.3
  • 44
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, et al. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med 2005;2:e73.
    • (2005) PLoS Med , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3
  • 45
    • 21144439000 scopus 로고    scopus 로고
    • Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
    • Kwak EL, Sordella R, Bell DW, et al. Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A 2005;102:7665-70.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 7665-7670
    • Kwak, E.L.1    Sordella, R.2    Bell, D.W.3


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