메뉴 건너뛰기




Volumn 7, Issue 8, 2012, Pages 1454-1461

Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases

Author keywords

[No Author keywords available]

Indexed keywords

LUCIFERASE; NUCLEASE; NUCLEIC ACID BASE; RNA INDUCED SILENCING COMPLEX; SMALL INTERFERING RNA;

EID: 84865274147     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300174c     Document Type: Article
Times cited : (23)

References (44)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., and Mello, C. C. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391, 806-811
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 11244328982 scopus 로고    scopus 로고
    • RNA interference and the use of small interfering RNA to study gene function in mammalian systems
    • Bantounas, I., Phylactou, L. A., and Uney, J. B. (2004) RNA interference and the use of small interfering RNA to study gene function in mammalian systems J. Mol. Endocrinol. 33, 545-557
    • (2004) J. Mol. Endocrinol. , vol.33 , pp. 545-557
    • Bantounas, I.1    Phylactou, L.A.2    Uney, J.B.3
  • 3
    • 0037062951 scopus 로고    scopus 로고
    • RNA interference
    • Hannon, G. J. (2002) RNA interference Nature 418, 244-251
    • (2002) Nature , vol.418 , pp. 244-251
    • Hannon, G.J.1
  • 4
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister, G. and Tuschl, T. (2004) Mechanisms of gene silencing by double-stranded RNA Nature 431, 343-349
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 6
    • 58749113430 scopus 로고    scopus 로고
    • A three-dimensional view of the molecular machinery of RNA interference
    • Jinek, M. and Doudna, J. A. (2009) A three-dimensional view of the molecular machinery of RNA interference Nature 457, 405-412
    • (2009) Nature , vol.457 , pp. 405-412
    • Jinek, M.1    Doudna, J.A.2
  • 7
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner, P. J. F., Ameres, S. L., Kueng, S., and Martinez, J. (2006) Cleavage of the siRNA passenger strand during RISC assembly in human cells EMBO Rep. 7, 314-320
    • (2006) EMBO Rep. , vol.7 , pp. 314-320
    • Leuschner, P.J.F.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 8
    • 34248682403 scopus 로고    scopus 로고
    • RNAi therapeutics: Principles, prospects and challenges
    • Aagaard, L. and Rossi, J. J. (2007) RNAi therapeutics: Principles, prospects and challenges Adv. Drug Delivery Rev. 59, 75-86
    • (2007) Adv. Drug Delivery Rev. , vol.59 , pp. 75-86
    • Aagaard, L.1    Rossi, J.J.2
  • 9
    • 33645148088 scopus 로고    scopus 로고
    • The silent treatment: SiRNAs as small molecule drugs
    • Dykxhoorn, D. M., Palliser, D., and Lieberman, J. (2006) The silent treatment: siRNAs as small molecule drugs Gene Ther. 13, 541-552
    • (2006) Gene Ther. , vol.13 , pp. 541-552
    • Dykxhoorn, D.M.1    Palliser, D.2    Lieberman, J.3
  • 10
    • 52049090811 scopus 로고    scopus 로고
    • Chemically modified siRNA: Tools and applications
    • Watts, J. K., Deleavey, G. F., and Damha, M. J. (2008) Chemically modified siRNA: Tools and applications Drug Discovery Today 13, 842-855
    • (2008) Drug Discovery Today , vol.13 , pp. 842-855
    • Watts, J.K.1    Deleavey, G.F.2    Damha, M.J.3
  • 11
    • 22344454846 scopus 로고    scopus 로고
    • Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA
    • Judge, A. D., Sood, V., Shaw, J. R., Fang, D., McClintock, K., and MacLachlan, I. (2005) Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA Nat. Biotechnol. 23, 457-462
    • (2005) Nat. Biotechnol. , vol.23 , pp. 457-462
    • Judge, A.D.1    Sood, V.2    Shaw, J.R.3    Fang, D.4    McClintock, K.5    MacLachlan, I.6
  • 12
    • 77249096959 scopus 로고    scopus 로고
    • Exploring chemical modifications for siRNA therapeutics: A structural and functional outlook
    • Shukla, S., Sumaria, C. S., and Pradeepkumar, P. I. (2010) Exploring chemical modifications for siRNA therapeutics: A structural and functional outlook ChemMedChem 5, 328-349
    • (2010) ChemMedChem , vol.5 , pp. 328-349
    • Shukla, S.1    Sumaria, C.S.2    Pradeepkumar, P.I.3
  • 13
    • 8844262560 scopus 로고    scopus 로고
    • RNA interference and chemically modified small interfering RNAs
    • Manoharan, M. (2004) RNA interference and chemically modified small interfering RNAs Curr. Opin. Chem. Biol. 8, 570-579
    • (2004) Curr. Opin. Chem. Biol. , vol.8 , pp. 570-579
    • Manoharan, M.1
  • 14
    • 80052748882 scopus 로고    scopus 로고
    • Chemical modification of siRNA bases to probe and enhance RNA interference
    • Peacock, H., Kannan, A., Beal, P. A., and Burrows, C. J. (2011) Chemical modification of siRNA bases to probe and enhance RNA interference J. Org. Chem. 76, 7295-7300
    • (2011) J. Org. Chem. , vol.76 , pp. 7295-7300
    • Peacock, H.1    Kannan, A.2    Beal, P.A.3    Burrows, C.J.4
  • 15
    • 0041331496 scopus 로고    scopus 로고
    • SiRNA function in RNAi: A chemical modification analysis
    • Chiu, Y.-L. and Rana, T. M. (2003) siRNA function in RNAi: A chemical modification analysis RNA 9, 1034-1048
    • (2003) RNA , vol.9 , pp. 1034-1048
    • Chiu, Y.-L.1    Rana, T.M.2
  • 17
    • 33746739544 scopus 로고    scopus 로고
    • The roles of hydrogen bonding and sterics in RNA interference
    • Somoza, A., Chelliserrykattil, J., and Kool, E. T. (2006) The roles of hydrogen bonding and sterics in RNA interference Angew. Chem., Int. Ed. 45, 4994-4997
    • (2006) Angew. Chem., Int. Ed. , vol.45 , pp. 4994-4997
    • Somoza, A.1    Chelliserrykattil, J.2    Kool, E.T.3
  • 18
    • 53849148990 scopus 로고    scopus 로고
    • Steric effects in RNA interference: Probing the influence of nucleobase size and shape
    • Somoza, A., Silverman, A. P., Miller, R. M., Chelliserrykattil, J., and Kool, E. T. (2008) Steric effects in RNA interference: Probing the influence of nucleobase size and shape Chem.-Eur. J. 14, 7978-7987
    • (2008) Chem.-Eur. J. , vol.14 , pp. 7978-7987
    • Somoza, A.1    Silverman, A.P.2    Miller, R.M.3    Chelliserrykattil, J.4    Kool, E.T.5
  • 19
    • 59649122911 scopus 로고    scopus 로고
    • RNA major groove modifications improve siRNA stability and biological activity
    • Terrazas, M. and Kool, E. T. (2009) RNA major groove modifications improve siRNA stability and biological activity Nucleic Acids Res. 37, 346-353
    • (2009) Nucleic Acids Res. , vol.37 , pp. 346-353
    • Terrazas, M.1    Kool, E.T.2
  • 21
    • 79954992106 scopus 로고    scopus 로고
    • 8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves
    • Kannan, A., Fostvedt, E., Beal, P. A., and Burrows, C. J. (2011) 8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves J. Am. Chem. Soc. 133, 6343-6351
    • (2011) J. Am. Chem. Soc. , vol.133 , pp. 6343-6351
    • Kannan, A.1    Fostvedt, E.2    Beal, P.A.3    Burrows, C.J.4
  • 22
    • 0033634682 scopus 로고    scopus 로고
    • Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference
    • Parrish, S., Fleenor, J., Xu, S., Mello, C., and Fire, A. (2000) Functional anatomy of a dsRNA trigger: Differential requirement for the two trigger strands in RNA interference Mol. Cell 6, 1077-1087
    • (2000) Mol. Cell , vol.6 , pp. 1077-1087
    • Parrish, S.1    Fleenor, J.2    Xu, S.3    Mello, C.4    Fire, A.5
  • 23
    • 34447507937 scopus 로고    scopus 로고
    • Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA
    • Sipa, K., Sochacka, E., Kazmierczak-Baranska, J., Maszewska, M., Janicka, M., Nowak, G., and Nawrot, B. (2007) Effect of base modifications on structure, thermodynamic stability, and gene silencing activity of short interfering RNA RNA 13, 1301-1316
    • (2007) RNA , vol.13 , pp. 1301-1316
    • Sipa, K.1    Sochacka, E.2    Kazmierczak-Baranska, J.3    Maszewska, M.4    Janicka, M.5    Nowak, G.6    Nawrot, B.7
  • 24
    • 4644365696 scopus 로고    scopus 로고
    • Expanded-size bases in naturally sized DNA: Evaluation of steric effects in Watson-Crick pairing
    • Gao, J., Liu, H., and Kool, E. T. (2004) Expanded-size bases in naturally sized DNA: Evaluation of steric effects in Watson-Crick pairing J. Am. Chem. Soc. 126, 11826-11831
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 11826-11831
    • Gao, J.1    Liu, H.2    Kool, E.T.3
  • 25
    • 33947196814 scopus 로고    scopus 로고
    • Synthesis and properties of size-expanded DNAs: Toward designed, functional genetic systems
    • Krueger, A. T., Lu, H., Lee, A. H. F., and Kool, E. T. (2007) Synthesis and properties of size-expanded DNAs: Toward designed, functional genetic systems Acc. Chem. Res. 40, 141-150
    • (2007) Acc. Chem. Res. , vol.40 , pp. 141-150
    • Krueger, A.T.1    Lu, H.2    Lee, A.H.F.3    Kool, E.T.4
  • 26
    • 79951663717 scopus 로고    scopus 로고
    • The components of xRNA: Synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides
    • Hernández, A. R. and Kool, E. T. (2011) The components of xRNA: Synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides Org. Lett. 13, 676-679
    • (2011) Org. Lett. , vol.13 , pp. 676-679
    • Hernández, A.R.1    Kool, E.T.2
  • 27
    • 0017313973 scopus 로고
    • Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin -benzoadenosine and enzymatic evaluation of derivatives of the benzopurines
    • Leonard, N. J., Sprecker, M. A., and Morrice, A. G. (1976) Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin -benzoadenosine and enzymatic evaluation of derivatives of the benzopurines J. Am. Chem. Soc. 98, 3987-3994
    • (1976) J. Am. Chem. Soc. , vol.98 , pp. 3987-3994
    • Leonard, N.J.1    Sprecker, M.A.2    Morrice, A.G.3
  • 29
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang, Y., Sheng, G., Juranek, S., Tuschl, T., and Patel, D. J. (2008) Structure of the guide-strand-containing argonaute silencing complex Nature 456, 209-213
    • (2008) Nature , vol.456 , pp. 209-213
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 30
    • 57749206034 scopus 로고    scopus 로고
    • Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
    • Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., and Patel, D. J. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex Nature 456, 921-926
    • (2008) Nature , vol.456 , pp. 921-926
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Tuschl, T.5    Patel, D.J.6
  • 31
    • 70349961432 scopus 로고    scopus 로고
    • Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes
    • Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., and Patel, D. J. (2009) Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes Nature 461, 754-761
    • (2009) Nature , vol.461 , pp. 754-761
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Wardle, G.S.5    Tuschl, T.6    Patel, D.J.7
  • 32
    • 70350714365 scopus 로고    scopus 로고
    • Synthesis of pyridine, pyrimidine and pyridinone C -nucleoside phosphoramidites for probing cytosine function in RNA
    • Lu, J., Li, N.-S., Koo, S. C., and Piccirilli, J. A. (2009) Synthesis of pyridine, pyrimidine and pyridinone C -nucleoside phosphoramidites for probing cytosine function in RNA J. Org. Chem. 74, 8021-8030
    • (2009) J. Org. Chem. , vol.74 , pp. 8021-8030
    • Lu, J.1    Li, N.-S.2    Koo, S.C.3    Piccirilli, J.A.4
  • 33
    • 77953479619 scopus 로고    scopus 로고
    • Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2
    • Frank, F., Sonenberg, N., and Nagar, B. (2010) Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2 Nature 465, 818-822
    • (2010) Nature , vol.465 , pp. 818-822
    • Frank, F.1    Sonenberg, N.2    Nagar, B.3
  • 34
    • 23144438396 scopus 로고    scopus 로고
    • Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage
    • Yuan, Y.-R., Pei, Y., Ma, J.-B., Kuryavyi, Y., Zhadina, M., Meister, G., Chen, H.-Y., Dauter, Z., Tuschl, T., and Patel, D. J. (2005) Crystal structure of A. aeolicus Argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage Mol. Cell 19, 405-419
    • (2005) Mol. Cell , vol.19 , pp. 405-419
    • Yuan, Y.-R.1    Pei, Y.2    Ma, J.-B.3    Kuryavyi, Y.4    Zhadina, M.5    Meister, G.6    Chen, H.-Y.7    Dauter, Z.8    Tuschl, T.9    Patel, D.J.10
  • 35
  • 36
    • 2442679207 scopus 로고    scopus 로고
    • Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain
    • Ma, J.-B., Ye, K., and Patel, D. J. (2004) Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain Nature 429, 318-322
    • (2004) Nature , vol.429 , pp. 318-322
    • Ma, J.-B.1    Ye, K.2    Patel, D.J.3
  • 37
    • 22144489833 scopus 로고    scopus 로고
    • RNAi: The nuts and bolts of the RISC machine
    • Filipowicz, W. (2005) RNAi: The nuts and bolts of the RISC machine Cell 122, 17-20
    • (2005) Cell , vol.122 , pp. 17-20
    • Filipowicz, W.1
  • 38
    • 14644393684 scopus 로고    scopus 로고
    • Perspectives: Machines for RNAi
    • Tomari, Y. and Zamore, P. D. (2005) Perspectives: Machines for RNAi Genes Dev. 19, 517-529
    • (2005) Genes Dev. , vol.19 , pp. 517-529
    • Tomari, Y.1    Zamore, P.D.2
  • 39
  • 40
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova, A., Reynolds, A., and Jayasena, S. D. (2003) Functional siRNAs and miRNAs exhibit strand bias Cell 115, 209-216
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 41
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: Basic structural and functional features of small interfering RNA
    • Chiu, Y.-L. and Rana, T. M. (2002) RNAi in human cells: Basic structural and functional features of small interfering RNA Mol. Cell 10, 549-561
    • (2002) Mol. Cell , vol.10 , pp. 549-561
    • Chiu, Y.-L.1    Rana, T.M.2
  • 44
    • 13444252456 scopus 로고    scopus 로고
    • Helix-forming properties of size-expanded DNA, an alternative four-base genetic form
    • Liu, H., Gao, J., and Kool, E. T. (2005) Helix-forming properties of size-expanded DNA, an alternative four-base genetic form J. Am. Chem. Soc. 127, 1396-1402
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 1396-1402
    • Liu, H.1    Gao, J.2    Kool, E.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.