8-oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves

Journal of the American Chemical Society

Volumn 133, Issue 16, 2011, Pages 6343-6351

  Kannan, Arunkumar ^a   Fostvedt, Erik ^b   Beal, Peter A ^b   Burrows, Cynthia J ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEINS; ALKYL GROUPS; CELLULAR DELIVERY; CHEMICALLY MODIFIED; DOUBLE-STRANDED RNA; INHIBITORY EFFECT; LUCIFERASE ASSAYS; MINOR GROOVES; RNA INTERFERENCE; STERIC EFFECT; TARGET BINDING;

ALKYLATION; RNA;

NUCLEIC ACIDS;

8 OXOGUANOSINE; ADENINE; ALKYL GROUP; BENZYL DERIVATIVE; CYTOSINE; DOUBLE STRANDED RNA; GUANINE DERIVATIVE; GUANOSINE DERIVATIVE; LUCIFERASE; MESSENGER RNA; N2 ALKYL 8 OXO 7,8 DIHYDROGUANINE; NUCLEOTIDE; PROPANE; PROTEIN; PROTEIN KINASE R; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL MODIFICATION; ENZYME ASSAY; FEMALE; GENE TARGETING; HUMAN; HUMAN CELL; PROTEIN BINDING; PROTEIN SYNTHESIS; RNA INTERFERENCE; RNA SEQUENCE; STEREOCHEMISTRY;

ALKYLATION; BASE SEQUENCE; EIF-2 KINASE; GUANOSINE; PROTEIN BINDING; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 79954992106     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2003878     Document Type: Article

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