Application of high-resolution ESI and MALDI mass spectrometry to metabolite profiling of small interfering RNA duplex

Journal of Mass Spectrometry

Volumn 47, Issue 8, 2012, Pages 1015-1022

  Shimizu, Hisao ^a   Jinno, Fumihiro ^a   Morohashi, Akio ^a   Yamazaki, Yuzo ^b   Yamada, Masaki ^b   Kondo, Takahiro ^a   Asahi, Satoru ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b SHIMADZU CORPORATION   (Japan)

Author keywords

electrospray ionization; high resolution mass spectrometry; in source decay; matrix assisted laser desorption ionization; siRNA metabolite

Indexed keywords

BIOLOGICAL MATRIXES; FRAGMENT IONS; HIGH RESOLUTION; HIGH RESOLUTION MASS SPECTROMETRY; HUMAN SERUM; IN-SOURCE DECAYS; IN-VITRO; ION EXCHANGE CHROMATOGRAPHY; MALDI-MASS SPECTROMETRY; MALDI-TOF; MASS ACCURACY; MASS DIFFERENCE; MATRIX ASSISTED LASER DESORPTION; MATRIX ASSISTED LASER DESORPTION/IONIZATION; METABOLITE PROFILING; ON-LINE COUPLING; ORBITRAP; REVERSED-PHASE COLUMNS; SMALL INTERFERING RNA; SMALL INTERFERING RNA (SIRNA);

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; RNA;

METABOLITES;

SMALL INTERFERING RNA;

ACCURACY; ARTICLE; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; METABOLITE; MOLECULAR WEIGHT; PRIORITY JOURNAL; RNA SEQUENCE;

ACETOPHENONES; BASE SEQUENCE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; HUMANS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; RNA, SMALL INTERFERING; SEQUENCE ANALYSIS, RNA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84865273452     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.3054     Document Type: Article

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