Habitual flavonoid intakes are positively associated with bone mineral density in women

Journal of Bone and Mineral Research

Volumn 27, Issue 9, 2012, Pages 1872-1878

  Welch, Ailsa ^a   MacGregor, Alex ^a   Jennings, Amy ^a   Fairweather Tait, Sue ^a   Spector, Tim ^b   Cassidy, Aedín ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

ANTHOCYANINS; BONE DENSITY; FLAVONOIDS; OSTEOPOROSIS; POLYPHENOLS

Indexed keywords

ANTHOCYANIN; FLAVAN 3 OL; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL DERIVATIVE; FLAVONONE; POLYMER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE DENSITY; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HIP; HUMAN; MAJOR CLINICAL STUDY; OBSERVATIONAL STUDY; SPINE; UNITED KINGDOM;

ADOLESCENT; ADULT; AGED; BONE DENSITY; FEMALE; FLAVONOIDS; FOOD HABITS; HIP; HUMANS; MIDDLE AGED; SPINE; TWINS; YOUNG ADULT;

EID: 84865272112     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1649     Document Type: Article

References (45)

1. Rachner TD, Khosla S, Hofbauer LC,. Osteoporosis: now and the future. Lancet. 2011 Apr 9; 377 (9773): 1276-87.
2. Hamidi M, Boucher BA, Cheung AM, Beyene J, Shah PS,. Fruit and vegetable intake and bone health in women aged 45 years and over: a systematic review. Osteoporos Int. 2011 Jun; 22 (6): 1681-93.
3. Erdman JW, Balentine D, Arab L, Beecher G, Dwyer JT, Folts J, Harnly J, Hollman P, Keen CL, Mazza G, Messina M, Scalbert A, Vita J, Williamson G, Burrowes J,. Flavonoids and heart health: Proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007 March 1, 2007; 137 (3): 718S-37S. (Pubitemid 46397511)
4. Hardcastle AC, Aucott L, Reid DM, Macdonald HM,. Associations between dietary flavonoid intakes and bone health in a Scottish population. J Bone Miner Res. 2011 May; 26 (5): 941-7.
5. Williamson G, Manach C,. Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr. 2005 Jan; 81 (1 Suppl): 243S-55S.
6. Manach C, Williamson G, Morand C, Scalbert A, Remesy C,. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005 Jan; 81 (1 Suppl): 230S-42S.
7. Chiba H, Uehara M, Wu J, Wang X, Masuyama R, Suzuki K, Kanazawa K, Ishimi Y,. Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice. J Nutr. 2003 Jun; 133 (6): 1892-7. (Pubitemid 36666531)
8. Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, Kato S, Terao J, Inakuma T, Takeda E,. Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J Bone Miner Metab. 2009; 27 (6): 673-81.
9. Shen CL, Yeh JK, Cao JJ, Chyu MC, Wang JS,. Green tea and bone health: evidence from laboratory studies. Pharmacol Res. 2011 Aug; 64 (2): 155-61.
10. Pang WY, Wang XL, Mok SK, Lai WP, Chow HK, Leung PC, Yao XS, Wong MS,. Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells. Br J Pharmacol. 2010 Apr; 159 (8): 1693-703.
11. Deyhim F, Garica K, Lopez E, Gonzalez J, Ino S, Garcia M, Patil BS,. Citrus juice modulates bone strength in male senescent rat model of osteoporosis. Nutrition. 2006 May; 22 (5): 559-63.
12. Deyhim F, Mandadi K, Faraji B, Patil BS,. Grapefruit juice modulates bone quality in rats. J Med Food. 2008 Mar; 11 (1): 99-104. (Pubitemid 351450497)
13. Wattel A, Kamel S, Prouillet C, Petit JP, Lorget F, Offord E, Brazier M,. Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1. J Cell Biochem. 2004 May 15; 92 (2): 285-95.
14. Kim TH, Jung JW, Ha BG, Hong JM, Park EK, Kim HJ, Kim SY,. The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem. 2011 Jan; 22 (1): 8-15.
15. Woo JT, Nakagawa H, Notoya M, Yonezawa T, Udagawa N, Lee IS, Ohnishi M, Hagiwara H, Nagai K,. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr; 27 (4): 504-9. (Pubitemid 41701834)
16. Prouillet C, Maziere JC, Maziere C, Wattel A, Brazier M, Kamel S,. Stimulatory effect of naturally occurring flavonols quercetin and kaempferol on alkaline phosphatase activity in MG-63 human osteoblasts through ERK and estrogen receptor pathway. Biochem Pharmacol. 2004 Apr 1; 67 (7): 1307-13. (Pubitemid 38315096)
17. Ko CH, Lau KM, Choy WY, Leung PC,. Effects of tea catechins, epigallocatechin, gallocatechin, and gallocatechin gallate, on bone metabolism. J Agric Food Chem. 2009 Aug 26; 57 (16): 7293-7.
18. Yang L, Takai H, Utsunomiya T, Li X, Li Z, Wang Z, Wang S, Sasaki Y, Yamamoto H, Ogata Y,. Kaempferol stimulates bone sialoprotein gene transcription and new bone formation. J Cell Biochem. 2010 Aug 15; 110 (6): 1342-55.
19. Coxam V,. Phyto-oestrogens and bone health. Proc Nutr Soc. 2008 May; 67 (2): 184-95. (Pubitemid 351543400)
20. Ma DF, Qin LQ, Wang PY, Katoh R,. Soy isoflavone intake increases bone mineral density in the spine of menopausal women: meta-analysis of randomized controlled trials. Clin Nutr. 2008 Feb; 27 (1): 57-64.
21. Liu J, Ho SC, Su YX, Chen WQ, Zhang CX, Chen YM,. Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials. Bone. 2009 May; 44 (5): 948-53.
22. de Kleijn MJ, van der Schouw YT, Wilson PW, Adlercreutz H, Mazur W, Grobbee DE, Jacques PF,. Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study (1-4). J Nutr. 2001 Jun; 131 (6): 1826-32. (Pubitemid 32520453)
23. Mulligan AA, Welch AA, McTaggart AA, Bhaniani A, Bingham SA,. Intakes and sources of soya foods and isoflavones in a UK population cohort study (EPIC-Norfolk). Eur J Clin Nutr. 2007 Feb; 61 (2): 248-54.
24. Shen CL, Yeh JK, Cao JJ, Wang JS,. Green tea and bone metabolism. Nutr Res. 2009 Jul; 29 (7): 437-56.
25. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ,. Are twins and singletons comparable? A study of disease-related and lifestyle characteristics in adult women. Twin Res. 2001 Dec; 4 (6): 464-77. (Pubitemid 34042172)
26. Cassidy A, Skidmore P, Rimm EB, Welch A, Fairweather-Tait S, Skinner J, Burling K, Richards JB, Spector TD, MacGregor AJ,. Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins. J Nutr. 2009 Feb; 139 (2): 353-8.
27. Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, Surdulescu GL, Kimura M, Lu X, Spector TD, Aviv A,. The association between physical activity in leisure time and leukocyte telomere length. Arch Intern Med. 2008 Jan 28; 168 (2): 154-8. (Pubitemid 351185881)
28. McKeown NM, Day NE, Welch AA, Runswick SA, Luben RN, Mulligan AA, McTaggart A, Bingham SA,. Use of biological markers to validate self-reported dietary intake in a random sample of the European Prospective Investigation into Cancer United Kingdom Norfolk cohort. Am J Clin Nutr. 2001 Aug; 74 (2): 188-96. (Pubitemid 32702484)
29. Welch AA, Luben R, Khaw KT, Bingham SA,. The CAFE computer program for nutritional analysis of the EPIC-Norfolk food frequency questionnaire and identification of extreme nutrient values. J Hum Nutr Diet. 2005 Apr; 18 (2): 99-116. (Pubitemid 40514896)
30. Bhagwat SA, Haytowitz DB, Prior RL, Gu L, Hammerstone J, Gebhardt SE, Kelm M, Cunningham D, Beecher GR, Holden JM,. USDA database for proanthocyanidin content of selected foods. USDA. 2004.
31. Bhagwat SA, Gebhardt SE, Haytowitz DB, Holden JM, Harnly JM,. USDA database for the flavonoid content of selected foods. USDA. 2007.
32. Schewe T, Steffen Y, Sies H,. How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys. 2008 Aug 15; 476 (2): 102-6.
33. Mandadi K, Ramirez M, Jayaprakasha GK, Faraji B, Lihono M, Deyhim F, Patil BS,. Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats. Phytomedicine. 2009 Jun; 16 (6-7): 513-20.
34. Trzeciakiewicz A, Habauzit V, Mercier S, Barron D, Urpi-Sarda M, Manach C, Offord E, Horcajada MN,. Molecular mechanism of hesperetin-7-O-glucuronide, the main circulating metabolite of hesperidin, involved in osteoblast differentiation. J Agric Food Chem. 2010 Jan 13; 58 (1): 668-75.
35. Prynne CJ, Mishra GD, O'Connell MA, Muniz G, Laskey MA, Yan L, Prentice A, Ginty F,. Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts. Am J Clin Nutr. 2006 Jun; 83 (6): 1420-8. (Pubitemid 44713075)
36. Macdonald HM, New SA, Golden MH, Campbell MK, Reid DM,. Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr. 2004 Jan; 79 (1): 155-65. (Pubitemid 41132077)
37. Macdonald HM, Black AJ, Aucott L, Duthie G, Duthie S, Sandison R, Hardcastle AC, Lanham New SA, Fraser WD, Reid DM,. Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. Am J Clin Nutr. 2008 Aug; 88 (2): 465-74.
38. Kaptoge S, Welch A, McTaggart A, Mulligan A, Dalzell N, Day NE, Bingham S, Khaw KT, Reeve J,. Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age. Osteoporos Int. 2003 Jun; 14 (5): 418-28. (Pubitemid 36919224)
39. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP,. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999 Apr; 69 (4): 727-36. (Pubitemid 29193397)
40. Chen YM, Ho SC, Woo JL,. Greater fruit and vegetable intake is associated with increased bone mass among postmenopausal Chinese women. Br J Nutr. 2006 Oct; 96 (4): 745-51. (Pubitemid 46470199)
41. Cassidy A, O'Reilly ÉJ, Kay C, Sampson L, Franz M, Forman JP, Curhan G, Rimm EB,. Habitual intake of flavonoid subclasses and incident hypertension in adults. Am J Clin Nutr. 2011 Feb; 93 (2): 338-47.
42. Zamora-Ros R, Knaze V, Luján-Barroso L, Slimani N, Romieu I, Fedirko V, de Magistris MS, Ericson U, Amiano P, Trichopoulou A, Dilis V, Naska A, Engeset D, Skeie G, Cassidy A, Overvad K, Peeters PH, Huerta JM, Sánchez MJ, Quirõs JR, Sacerdote C, Grioni S, Tumino R, Johansson G, Johansson I, Drake I, Crowe FL, Barricarte A, Kaaks R, Teucher B, Bueno-de-Mesquita HB, van Rossum CT, Norat T, Romaguera D, Vergnaud AC, Tjønneland A, Halkjær J, Clavel-Chapelon F, Boutron-Ruault MC, Touillaud M, Salvini S, Khaw KT, Wareham N, Boeing H, Förster J, Riboli E, González CA,. Estimated dietary intakes of flavonols, flavanones and flavones in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24 hour dietary recall cohort. Br J Nutr. 2011 Dec; 106 (12): 1915-25.
43. Fairweather-Tait SJ, Skinner J, Guile GR, Cassidy A, Spector TD, MacGregor AJ,. Diet and bone mineral density study in postmenopausal women from the TwinsUK registry shows a negative association with a traditional English dietary pattern and a positive association with wine. Am J Clin Nutr. 2011 Nov; 94 (5): 1371-5.
44. Willett WC, Reynolds RD, Cottrell-Hoehner S, Sampson L, Browne ML,. Validation of a semi-quantitative food frequency questionnaire: comparison with a 1-year diet record. J Am Diet Assoc. 1987 Jan; 87 (1): 43-7. (Pubitemid 17000788)
45. Spencer JP,. Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain. Proc Nutr Soc. 2010 May; 69 (2): 244-60.