Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts

Biological and Pharmaceutical Bulletin

Volumn 27, Issue 4, 2004, Pages 504-509

  Woo, Je Tae ^a   Nakagawa, Hiroshi ^b   Notoya, Michitaka ^b   Yonezawa, Takayuki ^a   Udagawa, Nobuyuki ^c   Lee, In Seon ^d   Ohnishi, Motoko ^a   Hagiwara, Hiromi ^b   Nagai, Kazuo ^a  

^a CHUBU UNIVERSITY   (Japan)

^b TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^c MATSUMOTO DENTAL UNIVERSITY   (Japan)

^d Keimyung University   (South Korea)

Author keywords

Bone resorption; Osteoclast; Osteoclast activation; Osteoclast differentiation; Quercetin

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; QUERCETIN; ACID PHOSPHATASE; ACTIN; CARRIER PROTEIN; ISOENZYME; MEMBRANE PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TARTRATE-RESISTANT ACID PHOSPHATASE; TNFRSF11A PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE ATROPHY; BONE MARROW; CALCIUM TRANSPORT; CELL ACTIVATION; CELL CULTURE; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; LONG BONE; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; OSTEOCLAST; SPLEEN CELL; STEM CELL; ANIMAL; BONE MARROW CELL; CELL SURVIVAL; CYTOLOGY; DRUG EFFECT; IN VITRO STUDY; METABOLISM; MONOCYTE; OSTEOLYSIS; PATHOLOGY; ULTRASTRUCTURE;

ACID PHOSPHATASE; ACTINS; ANIMALS; BONE MARROW CELLS; BONE RESORPTION; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; ISOENZYMES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MONOCYTES; OSTEOCLASTS; QUERCETIN; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B;

EID: 8844267470     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.27.504     Document Type: Article

References (35)

1. Suda T., Takahashi T., Martin T. J., Endocr. Rev., 13, 66-80 (1992).
2. Chambers T. J., J. Pathol., 192, 4-13 (2000).
3. Suda T., Takahashi N., Udagawa N., Jimi E., Gillespie M. T., Martin T. J., Endocr. Rev., 20, 345-357 (1999).
4. Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Mochizuki S., Tomoyasu A., Yano K., Goto M., Murakami A., Tsuda E., Morinaga T., Higashio K., Udagawa N., Takahashi N., Suda T., Proc Natl. Acad. Sci. U.S.A., 95, 3597-3602 (1998).
5. Lancey D. L., Timms E., Tan H. L., Kelley M. J., Dunstan C. R., Burgess T., Elliott R., Colombero A., Elliott G., Scully S., Hsu H., Sullivan J., Hawkins N., Davy E., Capparelli C., Eli A., Qian Y. X., Kaufman S., Sarosi I., Shalhoub V., Senaldi G., Guo J., Delaney J., Boyle W. J., Cell, 93, 165-176 (1998).
6. Hsu H., Lacey D. L., Dunstan C. R., Solovyev I., Colombero A., Timms E., Tan H. L., Elliott G., Kelley M. J., Sarosi I., Wang L., Xia X. Z., Elliott R., Chiu L., Black T., Scully S., Capparelli C., Morony S., Shimamoto G., Bass M. B., Boyle W. J., Proc. Natl. Acad. Sci. U.S.A., 96, 3540-3545 (1999).
7. Muhlbauer R. C., Li F., Nature (London), 401, 343-344 (1999).
8. Li F., Muhlbauer R. C., J. Bone Miner. Res., 14, 1457-1465 (1999).
9. Wronski T. J., Walsh H., Ignaszewski L. A., Bone, 7, 119-123 (1986).
10. Cecchini M. G., Fleasch H., Muhlbauer R. C., Calcif. Tissue Int., 61, S9-S11 (1997).
11. Ingold P., Kneissel M., Muhlbauer R. C., Gasser J. A., Bone, 23 (Suppl.), S387 (1998).
12. Horcajada-Molteni M. N., Crespy V., Coxam V., Davicco M. J., Remesy C., Barlet J. P., J. Bone Miner. Res., 15, 2251-2258 (2000).
13. Hertog M. G., Hollman P. C. H., Katan M. B., Kromhout D., Nutr. Cancer, 20, 21-29 (1993).
14. Price K. R., Rhodes M. J. C., J. Sci. Food Agric., 74, 331-339 (1997).
15. Tamura G., Gold C., Fezz-Luzi A., Ames B. N., Proc. Natl. Acad. Sci. U.S.A., 77, 4961-4965 (1980).
16. Wani M. R., Fuller K., Kim N. S., Choi Y., Chambers T., Endocrinology, 140, 1927-1935 (1999).
17. Takahashi N., Akatsu T., Udagawa N., Sasaki T., Yamaguchi A., Moseley J. M., Martin T. J., Suda T., Endocrinology, 123, 2600-2602 (1988).
18. Hotokezaka H., Sakai E., Kanaoka K., Saito K., Matsuo K., Kitaura H., Yoshida N., Nakayama K., J. Biol. Chem., 277, 47366-47372 (2002).
19. Tamura T., Takahashi N., Akatsu T., Sasaki T., Udagawa N., Tanaka S., Suda T., J. Bone Miner. Res., 8, 953-960 (1993).
20. Wattel A., Kamel S., Mentaverri R., Lorget F., Prouillet C., Petit J. P., Fardelonne P., Brazier M., Biochem. Pharmacol., 65, 35-42 (2003).
21. Matsumoto M., Sudo T., Saito T., Osada H., Tsujimoto M., J. Biol. Chem., 275, 31155-31161 (2000).
22. Lee S. E., Woo K. M., Kim S. Y., Kim H. M., Kwack K., Lee Z. H., Kim H. H., Bone, 30, 71-77 (2002).
23. Hotokezaka H., Sakai E., Kanaoka K., Saito K., Matsuo K. I., Kitaura H., Yoshida N., Nakayama K., J. Biol. Chem., 277, 47366-47372 (2002).
24. Yoneda T., Lowe C., Lee C. H., Gutierrez G., Niewolna M., Williams P. J., Izbicka E., Uehara Y., Mundy G. R., J. Clin. Invest., 91, 2791-2795 (1993).
25. Hall T. J., Schaeublin M., Missbach M., Biochem. Biophys. Res. Commun., 199, 1237-1244 (1994).
26. Nakamura I., Sasaki T., Tanaka S., Takahashi N., Jimi E., Kurokawa T., Kita Y., Ihara S., Suda T., Fukui Y., J. Cell Physiol., 172, 230-239 (1997).
27. Nakamura I., Takahashi N., Sasaki T., Tanaka S., Udagawa N., Murakami H., Kimura K., Kabuyama Y., Kurokawa T., Suda T., Fukui Y., FEBS Lett., 361, 79-84 (1995).
28. Zhang D., Udagawa N., Nakamura I., Murakami H., Saito S., Yamasaki K., Shibasaki Y., Morii N., Narumiya S., Takahashi N., Suda T., J. Cell Sci., 108, 2285-2292 (1995).
29. Chellaiah M. A., Soga N., Swanson S., McAllister S., Alvarez U., Wang D., Dowdy S. F., Hruska K. A., J. Biol. Chem., 275, 11993-12002 (2000).
30. Suzuki H., Nakamura I., Takahashi N., Ikuhara T., Matsuzaki K., Isogai Y., Hori M., Suda T., Endocrinology, 137, 4685-4690 (1996).
31. Jacquemin-Sablon A., Agbotounou W. K., Pierre J., Pathol. Biol. (Paris), 43, 389-394 (1995).
32. Kobuchi H., Roy S., Sen C. K., Nguyen H. G., Packer L., Am. J. Physiol., 277, C403-C411 (1999).
33. Yoshizumi M., Tsuchiya K., Suzaki Y., Kirima K., Kyaw M., Moon J. H., Terao J., Tamaki T., Biochem. Biophys. Res. Commun., 293, 1458-1465 (2002).
34. Manach C., Morand C., Crespy V., Demigne C., Texier O., Regerat F., Remesy C., FEBS Lett., 426, 331-336 (1998).
35. Paganga G., Rice-Evans C. A., FEBS Lett., 401, 78-82 (1997).