An extract of chokeberry attenuates weight gain and modulates insulin, adipogenic and inflammatory signalling pathways in epididymal adipose tissue of rats fed a fructose-rich diet

British Journal of Nutrition

Volumn 108, Issue 4, 2012, Pages 581-587

  Qin, Bolin ^a,b   Anderson, Richard A ^a  

^a BELTSVILLE HUMAN NUTRITION RESEARCH CENTER   (United States)

^b Integrity Nutraceuticals International   (United States)

Author keywords

Adipogenesis; Chokeberry extract; Inflammation; Insulin signalling

Indexed keywords

ADIPONECTIN; ANTHOCYANIN; CHOKEBERRY EXTRACT; DRINKING WATER; FAS ANTIGEN; FATTY ACID BINDING PROTEIN 4; FRUCTOSE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PLANT EXTRACT; TRIACYLGLYCEROL; TRISTETRAPROLIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARONIA MELANOCARPA; ARTICLE; CARBOHYDRATE DIET; CHOKEBERRY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; EPIDIDYMIS FAT; FOOD INTAKE; FRUCTOSE RICH DIET; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; INFLAMMATION; INSULIN RESISTANCE; INSULIN SIGNALING; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; NONHUMAN; OBESITY; PLANT; PROTEIN EXPRESSION; RAT; RISK FACTOR; SIGNAL TRANSDUCTION; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN; WISTAR RAT;

ADIPONECTIN; ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-OBESITY AGENTS; CYTOKINES; DIETARY SUPPLEMENTS; FRUCTOSE; FRUIT; INSULIN RECEPTOR SUBSTRATE PROTEINS; MALE; METABOLIC SYNDROME X; OBESITY; PHOTINIA; PLANT EXTRACTS; PPAR GAMMA; RANDOM ALLOCATION; RATS; RATS, WISTAR; RNA, MESSENGER; SIGNAL TRANSDUCTION; WEIGHT GAIN;

EID: 84865262410     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451100599X     Document Type: Article

References (57)

1. Kokotkiewicz A, Jaremicz Z & Luczkiewicz M (2010) Aronia plants: a review of traditional use, biological activities, and perspectives for modern medicine. J Med Food 13, 255-269.
2. Wu X, Gu L, Prior RL, et al. (2004) Characterization of anthocyanins and proanthocyanidins in some cultivars of Ribes, Aronia, and Sambucus and their antioxidant capacity. J Agric Food Chem 52, 7846-7856. (Pubitemid 40053666)
3. Wu X, Beecher GR, Holden JM, et al. (2006) Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 54, 4069-4075. (Pubitemid 44030592)
4. Zheng W & Wang SY (2003) Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 51, 502-509.
5. Bell DR & Gochenaur K (2006) Direct vasoactive and vasoprotective properties of anthocyanin-rich extracts. J Appl Physiol 100, 1164-1170. (Pubitemid 43671473)
6. Utzschneider KM, Carr DB, Barsness SM, et al. (2004) Diet-induced weight loss is associated with an improvement in beta-cell function in older men. J Clin Endocrinol Metab 89, 2704-2710. (Pubitemid 38766353)
7. Valcheva-Kuzmanova S, Kuzmanov K, Mihova V, et al. (2007) Antihyperlipidemic effect of Aronia melanocarpa fruit juice in rats fed a high-cholesterol diet. Plant Foods Hum Nutr 62, 19-24. (Pubitemid 46327408)
8. Naruszewicz M, Laniewska I, Millo B, et al. (2007) Combination therapy of statin with flavonoids rich extract from chokeberry fruits enhanced reduction in cardiovascular risk markers in patients after myocardial infarction (MI). Atherosclerosis 194, e179-e184. (Pubitemid 47513116)
9. Cao G, Muccitelli HU, Sanchez-Moreno C, et al. (2001) Anthocyanins are absorbed in glycated forms in elderly women: a pharmacokinetic study. Am J Clin Nutr 73, 920-926. (Pubitemid 32405989)
10. Kay CD, Mazza GJ & Holub BJ (2005) Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr 135, 2582-2588. (Pubitemid 43156599)
11. Talavera S, Felgines C, Texier O, et al. (2004) Anthocyanins are efficiently absorbed from the small intestine in rats. J Nutr 134, 2275-2279. (Pubitemid 39201596)
12. Felgines C, Texier O, Garcin P, et al. (2009) Tissue distribution of anthocyanins in rats fed a blackberry anthocyanin-enriched diet. Mol Nutr Food Res 53, 1098-1103.
13. Hajer GR, van Haeften TW & Visseren FL (2008) Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29, 2959-2971.
14. Blüher M (2009) Adipose tissue dysfunction in obesity. Exp Clin Endocrinol Diabetes 117, 241-250.
15. Tsuda T, Ueno Y, Aoki H, et al. (2004) Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes. Biochem Biophys Res Commun 316, 149-157. (Pubitemid 38304941)
16. Tsuda T, Ueno Y, Kojo H, et al. (2005) Gene expression profile of isolated rat adipocytes treated with anthocyanins. Biochim Biophys Acta 1733, 137-147. (Pubitemid 40603657)
17. 2-terminal kinase activation. Biochem Pharmacol 75, 1393-1401.
18. Tsuda T, Horio F, Uchida K, et al. (2003) Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 133, 2125-2130. (Pubitemid 36841527)
19. Prior RL, Wu X, Gu L, et al. (2009) Purified berry anthocyanins but not whole berries normalize lipid parameters in mice fed an obesogenic high fat diet. Mol Nutr Food Res 53, 1406-1418.
20. Qin B, Polansky MM, Harry D, et al. (2010) Green tea polyphenols improve cardiac muscle mRNA and protein levels of signal pathways related to insulin and lipid metabolism and inflammation in insulin-resistant rats. Mol Nutr Food Res 54, Suppl. 1, S14-S23.
21. Qin B, Anderson RA & Adeli K (2008) Tumor necrosis factoralpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling. Am J Physiol Gastrointest Liver Physiol 294, G1120-G1129.
22. Elliott SS, Keim NL, Stern J, et al. (2002) Fructose, weight gain, and the insulin resistance syndrome. Am J Clin Nutr 76, 911-922. (Pubitemid 35244659)
23. Qin B, Nagasaki M, Ren M, et al. (2004) Cinnamon extract prevents the insulin resistance induced by a high-fructose diet. Horm Metab Res 36, 119-125. (Pubitemid 38392254)
24. Qin B, Polansky MM & Anderson RA (2010) Cinnamon extract regulates plasma levels of adipose-derived factors and expression of multiple genes related to carbohydrate metabolism and lipogenesis in adipose tissue of fructosefed rats. Horm Metab Res 42, 187-193.
25. Alzamendi A, Giovambattista A, Raschia A, et al. (2009) Fructose-rich diet-induced abdominal adipose tissue endocrine dysfunction in normal male rats. Endocrine 35, 227-232.
26. Havel PJ (2004) Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism. Diabetes 53, Suppl. 1, S143-S151. (Pubitemid 38168707)
27. Guilherme A, Virbasius JV, Puri V, et al. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 9, 367-377. (Pubitemid 351574198)
28. Bogardus C, Ravussin E, Robbins DC, et al. (1984) Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and noninsulin- dependent diabetes mellitus. Diabetes 33, 311-318. (Pubitemid 14169529)
29. Kong WH, Oh SH, Ahn YR, et al. (2008) Antiobesity effects and improvement of insulin sensitivity by 1-deoxynojirimycin in animal models. J Agric Food Chem 56, 2613-2619.
30. Taghibiglou C, Rashid-Kolvear F, van Iderstine SC, et al. (2002) Hepatic very low density lipoprotein-ApoB overproduction is associated with attenuated hepatic insulin signaling and overexpression of protein-tyrosine phosphatase 1B in a fructose-fed hamster model of insulin resistance. J Biol Chem 277, 793-803. (Pubitemid 34952120)
31. Komazawa N, Matsuda M, Kondoh G, et al. (2004) Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice. Nat Med 10, 1208-1215. (Pubitemid 39540437)
32. Eldar-Finkelman H, Schreyer SA, Shinohara MM, et al. (1999) Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes 48, 1662-1666. (Pubitemid 29356878)
33. Ukkola O & Santaniemi M (2002) Adiponectin: a link between excess adiposity and associated comorbidities? J Mol Med 80, 696-702. (Pubitemid 35352035)
34. Hu E, Liang P & Spiegelman BM (1996) AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271, 10697-10703. (Pubitemid 26145805)
35. Berg AH, Combs TP & Scherer PE (2002) ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13, 84-89. (Pubitemid 36740452)
36. Hotta K, Funahashi T, Arita Y, et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20, 1595-1599. (Pubitemid 30353893)
37. Hotta K, Funahashi T, Bodkin NL, et al. (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126-1133. (Pubitemid 32374544)
38. Combs TP, Pajvani UB, Berg AH, et al. (2004) A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 145, 367-383. (Pubitemid 38094532)
39. Rodriguez-Acebes S, Palacios N, Botella-Carretero JI, et al. (2010) Gene expression profiling of subcutaneous adipose tissue in morbid obesity using a focused microarray: distinct expression of cell-cycle- and differentiation- related genes. BMC Med Genomics 3, 61.
40. Tontonoz P, Hu E, Graves RA, et al. (1994) mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer. Genes Dev 8, 1224-1234.
41. Tontonoz P & Spiegelman BM (2008) Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 77, 289-312.
42. Rosen ED & MacDougald OA (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885-896. (Pubitemid 44871415)
43. Shih CC, Lin CH, Lin WL, et al. (2009) Momordica charantia extract on insulin resistance and the skeletal muscle GLUT4 protein in fructose-fed rats. J Ethnopharmacol 123, 82-90.
44. Tso AW, Xu A, Sham PC, et al. (2007) Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care 30, 2667-2672. (Pubitemid 47547818)
45. Xu A, Tso AW, Cheung BM, et al. (2007) Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 115, 1537-1543. (Pubitemid 46648638)
46. Boord JB, Maeda K, Makowski L, et al. (2004) Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110, 1492-1498. (Pubitemid 39238029)
47. Makowski L, Boord JB, Maeda K, et al. (2001) Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 7, 699-705. (Pubitemid 32588026)
48. Guichard C, Dugail I, Le LX, et al. (1992) Genetic regulation of fatty acid synthetase expression in adipose tissue: overtranscription of the gene in genetically obese rats. J Lipid Res 33, 679-687.
49. LeeMS, KimCT & KimY (2009) Green tea (2)-epigallocatechin- 3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice. Ann Nutr Metab 54, 151-157.
50. Ibrahimi A & Abumrad NA (2002) Role of CD36 in membrane transport of long chain fatty acids. Curr Opin Clin Nutr Metab Care 5, 139-145.
51. Memon RA, Fuller J, Moser A, et al. (1999) Regulation of putative fatty acid transporters and acyl-CoA synthetase in liver and adipose tissue in ob/ob mice. Diabetes 48, 121-127. (Pubitemid 29019362)
52. Hotamisligil GS (2003) Inflammatory pathways and insulin action. Int J Obes Relat Metab Disord 27, Suppl. 3, S53-S55. (Pubitemid 38019190)
53. Schenk S, Saberi M & Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118, 2992-3002.
54. Wilson PW (2008) Evidence of systemic inflammation and estimation of coronary artery disease risk: a population perspective. Am J Med 121, S15-S20.
55. Zhang B, Berger J, Hu E, et al. (1996) Negative regulation of peroxisome proliferator-activated receptor-gamma gene expression contributes to the antiadipogenic effects of tumor necrosis factor-alpha. Mol Endocrinol 10, 1457-1466. (Pubitemid 26423234)
56. Carballo E, Lai WS & Blackshear PJ (1998) Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science 281, 1001-1005. (Pubitemid 28399252)
57. Bouchard L, Vohl MC, Deshaies Y, et al. (2007) Visceral adipose tissue zinc finger protein 36 mRNA levels are correlated with insulin, insulin resistance index, and adiponectinemia in women. Eur J Endocrinol 157, 451-457. (Pubitemid 350018448)