Effects of MiRP1 and DPP6 β-subunits on the blockade induced by flecainide of K V4.3/KChIP2 channels

British Journal of Pharmacology

Volumn 154, Issue 4, 2008, Pages 774-786

  Radicke, S ^a,b   Vaquero, M ^a   Caballero, R ^a   Gomez R ^a   Nunez L ^a   Tamargo, J ^a   Ravens, U ^b   Wettwer, E ^b   Delpon E ^a  

^a SCHOOL OF MEDICINE   (Spain)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Cardiac; DPP6; Flecainide; K V4.3; KChIP2; MiRP1; Transient outward current

Indexed keywords

DPP6 PROTEIN; FLECAINIDE; KCHIP2 PROTEIN; KV CHANNEL INTERACTING PROTEIN; POTASSIUM CHANNEL KCNE2; VOLTAGE DEPENDENT ANION CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG BINDING SITE; ELECTRIC POTENTIAL; GENETIC TRANSFECTION; IC 50; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLECAINIDE; HUMANS; INHIBITORY CONCENTRATION 50; KV CHANNEL-INTERACTING PROTEINS; NERVE TISSUE PROTEINS; PATCH-CLAMP TECHNIQUES; PEPTIDE HYDROLASES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN SUBUNITS; SHAL POTASSIUM CHANNELS; TRANSFECTION;

EID: 44949086482     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.134     Document Type: Article

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