-
1
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64.
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
2
-
-
0035421654
-
Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells
-
Piccirillo CA, Shevach EM. Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol 2001;167:1137-40.
-
(2001)
J Immunol
, vol.167
, pp. 1137-1140
-
-
Piccirillo, C.A.1
Shevach, E.M.2
-
3
-
-
1242295282
-
Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance
-
Piccirillo CA, Shevach EM. Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol 2004;16: 81-8.
-
(2004)
Semin Immunol
, vol.16
, pp. 81-88
-
-
Piccirillo, C.A.1
Shevach, E.M.2
-
4
-
-
25444497719
-
Cutting edge: direct suppression of B cells by CD4+CD25+ regulatory T cells
-
Lim HW, Hillsamer P, Banham AH, Kim CH. Cutting edge: direct suppression of B cells by CD4+CD25+ regulatory T cells. J Immunol 2005;175:4180-3.
-
(2005)
J Immunol
, vol.175
, pp. 4180-4183
-
-
Lim, H.W.1
Hillsamer, P.2
Banham, A.H.3
Kim, C.H.4
-
5
-
-
33845899100
-
Control of NK cell functions by CD4+CD25+ regulatory T cells
-
Ralainirina N, Poli A, Michel T et al. Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol 2007;81:144-53.
-
(2007)
J Leukoc Biol
, vol.81
, pp. 144-153
-
-
Ralainirina, N.1
Poli, A.2
Michel, T.3
-
6
-
-
0036669298
-
Cd4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
-
Malek TR, Yu A, Vincek V, Scibelli P, Kong L. Cd4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002;17:167-78.
-
(2002)
Immunity
, vol.17
, pp. 167-178
-
-
Malek, T.R.1
Yu, A.2
Vincek, V.3
Scibelli, P.4
Kong, L.5
-
7
-
-
4544241811
-
Tolerance, not immunity, crucially depends on IL-2
-
Malek TR, Bayer AL. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004;4:665-74.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 665-674
-
-
Malek, T.R.1
Bayer, A.L.2
-
8
-
-
0037026003
-
Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes
-
Annunziato F, Cosmi L, Liotta F et al. Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med 2002;196:379-87.
-
(2002)
J Exp Med
, vol.196
, pp. 379-387
-
-
Annunziato, F.1
Cosmi, L.2
Liotta, F.3
-
9
-
-
38449083826
-
IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells
-
Turka LA, Walsh PT. IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci 2008;13:1440-6.
-
(2008)
Front Biosci
, vol.13
, pp. 1440-1446
-
-
Turka, L.A.1
Walsh, P.T.2
-
10
-
-
0035806323
-
Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
-
Levings MK, Sangregorio R, Roncarolo MG. Human CD25(+)CD4(+) T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 2001;193:1295-302.
-
(2001)
J Exp Med
, vol.193
, pp. 1295-1302
-
-
Levings, M.K.1
Sangregorio, R.2
Roncarolo, M.G.3
-
11
-
-
0033985780
-
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific
-
Thornton AM, Shevach EM. Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol 2000;164:183-90.
-
(2000)
J Immunol
, vol.164
, pp. 183-190
-
-
Thornton, A.M.1
Shevach, E.M.2
-
12
-
-
4644369302
-
Interleukin-2 is essential for CD4+CD25+ regulatory T cell function
-
de la Rosa M, Rutz S, Dorninger H, Scheffold A. Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol 2004;34:2480-8.
-
(2004)
Eur J Immunol
, vol.34
, pp. 2480-2488
-
-
de la Rosa, M.1
Rutz, S.2
Dorninger, H.3
Scheffold, A.4
-
13
-
-
34247215187
-
Foxp3 controls regulatory T-cell function by interacting with aml1/runx1
-
Ono M, Yaguchi H, Ohkura N et al. Foxp3 controls regulatory T-cell function by interacting with aml1/runx1. Nature 2007;446:685-9.
-
(2007)
Nature
, vol.446
, pp. 685-689
-
-
Ono, M.1
Yaguchi, H.2
Ohkura, N.3
-
14
-
-
0019948507
-
Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus
-
Alcocer-Varela J, Alarcon-Segovia D. Decreased production of and response to interleukin-2 by cultured lymphocytes from patients with systemic lupus erythematosus. J Clin Invest 1982;69:1388-92.
-
(1982)
J Clin Invest
, vol.69
, pp. 1388-1392
-
-
Alcocer-Varela, J.1
Alarcon-Segovia, D.2
-
15
-
-
0021979083
-
Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells
-
Linker-Israeli M, Bakke AC, Quismorio FP Jr, Horwitz DA. Correction of interleukin-2 production in patients with systemic lupus erythematosus by removal of spontaneously activated suppressor cells. J Clin Invest 1985;75: 762-8.
-
(1985)
J Clin Invest
, vol.75
, pp. 762-768
-
-
Linker-Israeli, M.1
Bakke, A.C.2
Quismorio Jr., F.P.3
Horwitz, D.A.4
-
16
-
-
0031778158
-
Interleukin-2 and systemic lupus erythematosus-fifteen years later
-
Crispin JC, Alcocer-Varela J. Interleukin-2 and systemic lupus erythematosus-fifteen years later. Lupus 1998;7: 214-22.
-
(1998)
Lupus
, vol.7
, pp. 214-222
-
-
Crispin, J.C.1
Alcocer-Varela, J.2
-
17
-
-
0242403301
-
Quantification of regulatory T cells in patients with systemic lupus erythematosus
-
Crispin JC, Martinez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun 2003;21:273-6.
-
(2003)
J Autoimmun
, vol.21
, pp. 273-276
-
-
Crispin, J.C.1
Martinez, A.2
Alcocer-Varela, J.3
-
18
-
-
33645119478
-
Decrease of regulatory T cells in patients with systemic lupus erythematosus
-
Mellor-Pita S, Citores MJ, Castejon R et al. Decrease of regulatory T cells in patients with systemic lupus erythematosus. Ann Rheum Dis 2006;65:553-4.
-
(2006)
Ann Rheum Dis
, vol.65
, pp. 553-554
-
-
Mellor-Pita, S.1
Citores, M.J.2
Castejon, R.3
-
19
-
-
1842681797
-
A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen
-
Wu HY, Staines NA. A deficiency of CD4+CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen. Lupus 2004;13:192-200.
-
(2004)
Lupus
, vol.13
, pp. 192-200
-
-
Wu, H.Y.1
Staines, N.A.2
-
20
-
-
57149088827
-
Increased foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus
-
Abe J, Ueha S, Suzuki J et al. Increased foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol 2008;173:1682-92.
-
(2008)
Am J Pathol
, vol.173
, pp. 1682-1692
-
-
Abe, J.1
Ueha, S.2
Suzuki, J.3
-
21
-
-
42449123048
-
Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis
-
Bonelli M, von Dalwigk K, Savitskaya A, Smolen JS, Scheinecker C. Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. Ann Rheum Dis 2008;67:664-71.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 664-671
-
-
Bonelli, M.1
von Dalwigk, K.2
Savitskaya, A.3
Smolen, J.S.4
Scheinecker, C.5
-
23
-
-
77449143100
-
Defects in IL-2r signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
-
Long SA, Cerosaletti K, Bollyky PL et al. Defects in IL-2r signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes 2010;59:407-15.
-
(2010)
Diabetes
, vol.59
, pp. 407-415
-
-
Long, S.A.1
Cerosaletti, K.2
Bollyky, P.L.3
-
24
-
-
45349108357
-
Function of CD4+,CD25+ Treg cells in mrl/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells
-
Parietti V, Monneaux F, Decossas M, Muller S. Function of CD4+,CD25+ Treg cells in mrl/lpr mice is compromised by intrinsic defects in antigen-presenting cells and effector T cells. Arthritis Rheum 2008;58:1751-61.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 1751-1761
-
-
Parietti, V.1
Monneaux, F.2
Decossas, M.3
Muller, S.4
-
25
-
-
49649098563
-
Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15
-
Yang CH, Tian L, Ling GS et al. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. Eur J Immunol 2008;38:1664-76.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1664-1676
-
-
Yang, C.H.1
Tian, L.2
Ling, G.S.3
-
26
-
-
34848898991
-
Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus
-
Lyssuk EY, Torgashina AV, Soloviev SK, Nassonov EL, Bykovskaia SN. Reduced number and function of CD4+CD25highFoxP3+ regulatory T cells in patients with systemic lupus erythematosus. Adv Exp Med Biol 2007; 601:113-9.
-
(2007)
Adv Exp Med Biol
, vol.601
, pp. 113-119
-
-
Lyssuk, E.Y.1
Torgashina, A.V.2
Soloviev, S.K.3
Nassonov, E.L.4
Bykovskaia, S.N.5
-
27
-
-
33846900430
-
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
-
Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol 2007; 178:2579-88.
-
(2007)
J Immunol
, vol.178
, pp. 2579-2588
-
-
Valencia, X.1
Yarboro, C.2
Illei, G.3
Lipsky, P.E.4
-
28
-
-
45849145442
-
Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)
-
Bonelli M, Savitskaya A, von Dalwigk K et al. Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE). Int Immunol 2008;20:861-8.
-
(2008)
Int Immunol
, vol.20
, pp. 861-868
-
-
Bonelli, M.1
Savitskaya, A.2
von Dalwigk, K.3
-
29
-
-
43249122144
-
Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
-
Vargas-Rojas MI, Crispin JC, Richaud-Patin Y, Alcocer-Varela J. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus 2008;17:289-94.
-
(2008)
Lupus
, vol.17
, pp. 289-294
-
-
Vargas-Rojas, M.I.1
Crispin, J.C.2
Richaud-Patin, Y.3
Alcocer-Varela, J.4
-
30
-
-
46849087978
-
Clinical significance of increased CD4+CD25-foxp3+ T cells in patients with new-onset systemic lupus erythematosus
-
Zhang B, Zhang X, Tang FL et al. Clinical significance of increased CD4+CD25-foxp3+ T cells in patients with new-onset systemic lupus erythematosus. Ann Rheum Dis 2008;67:1037-40.
-
(2008)
Ann Rheum Dis
, vol.67
, pp. 1037-1040
-
-
Zhang, B.1
Zhang, X.2
Tang, F.L.3
-
31
-
-
62749109707
-
Feedback loop of immune regulation by CD4+CD25+ Treg
-
Jung YJ, Seoh JY. Feedback loop of immune regulation by CD4+CD25+ Treg. Immunobiology 2009;214:291-302.
-
(2009)
Immunobiology
, vol.214
, pp. 291-302
-
-
Jung, Y.J.1
Seoh, J.Y.2
-
32
-
-
84862792273
-
Immune homeostasis maintained by Tregs
-
In: Hayashi RS, ed. Regulatory T Cells. New York: Nova Science Publishers, 2011:201-23.
-
Jang MH, Jung YJ, Kim HR, Moon BI, Seoh JY. Immune homeostasis maintained by Tregs. In: Hayashi RS, ed. Regulatory T Cells. New York: Nova Science Publishers, 2011:201-23.
-
-
-
Jang, M.H.1
Jung, Y.J.2
Kim, H.R.3
Moon, B.I.4
Seoh, J.Y.5
-
33
-
-
77950555289
-
Adriamycin nephropathy: a failure of endothelial progenitor cell-induced repair
-
Yasuda K, Park HC, Ratliff B et al. Adriamycin nephropathy: a failure of endothelial progenitor cell-induced repair. Am J Pathol 2010;176:1685-95.
-
(2010)
Am J Pathol
, vol.176
, pp. 1685-1695
-
-
Yasuda, K.1
Park, H.C.2
Ratliff, B.3
-
34
-
-
33645466708
-
Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin
-
Wang YM, Zhang GY, Wang Y et al. Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from adriamycin. J Am Soc Nephrol 2006;17: 697-706.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 697-706
-
-
Wang, Y.M.1
Zhang, G.Y.2
Wang, Y.3
-
35
-
-
33749260151
-
Cd4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease
-
Mahajan D, Wang Y, Qin X et al. Cd4+CD25+ regulatory T cells protect against injury in an innate murine model of chronic kidney disease. J Am Soc Nephrol 2006;17: 2731-41.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2731-2741
-
-
Mahajan, D.1
Wang, Y.2
Qin, X.3
-
36
-
-
0026178213
-
X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
-
Godfrey VL, Wilkinson JE, Russell LB. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. Am J Pathol 1991;138:1379-87.
-
(1991)
Am J Pathol
, vol.138
, pp. 1379-1387
-
-
Godfrey, V.L.1
Wilkinson, J.E.2
Russell, L.B.3
-
37
-
-
0037436119
-
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
-
Pasare C, Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003;299:1033-6.
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
38
-
-
0028355713
-
Interleukin-6 exacerbates glomerulonephritis in (NZB X NZW)F1 mice
-
Ryffel B, Car BD, Gunn H et al. Interleukin-6 exacerbates glomerulonephritis in (NZB X NZW)F1 mice. Am J Pathol 1994;144:927-37.
-
(1994)
Am J Pathol
, vol.144
, pp. 927-937
-
-
Ryffel, B.1
Car, B.D.2
Gunn, H.3
-
39
-
-
73649123508
-
Interleukin 6 (IL-6) deficiency delays lupus nephritis in mrl-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
-
Cash H, Relle M, Menke J et al. Interleukin 6 (IL-6) deficiency delays lupus nephritis in mrl-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J Rheumatol 2010;37: 60-70.
-
(2010)
J Rheumatol
, vol.37
, pp. 60-70
-
-
Cash, H.1
Relle, M.2
Menke, J.3
-
40
-
-
33947215987
-
IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21r.Fc reduces disease progression
-
Herber D, Brown TP, Liang S et al. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21r.Fc reduces disease progression. J Immunol 2007; 178:3822-30.
-
(2007)
J Immunol
, vol.178
, pp. 3822-3830
-
-
Herber, D.1
Brown, T.P.2
Liang, S.3
-
41
-
-
0033002968
-
Inhibition of nuclear factor-kappab activation reduces cortical tubulointerstitial injury in proteinuric rats
-
Rangan GK, Wang Y, Tay YC, Harris DC. Inhibition of nuclear factor-kappab activation reduces cortical tubulointerstitial injury in proteinuric rats. Kidney Int 1999; 56:118-34.
-
(1999)
Kidney Int
, vol.56
, pp. 118-134
-
-
Rangan, G.K.1
Wang, Y.2
Tay, Y.C.3
Harris, D.C.4
-
42
-
-
0033802098
-
Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events
-
Wang Y, Wang YP, Tay YC, Harris DC. Progressive adriamycin nephropathy in mice: sequence of histologic and immunohistochemical events. Kidney Int 2000;58: 1797-804.
-
(2000)
Kidney Int
, vol.58
, pp. 1797-1804
-
-
Wang, Y.1
Wang, Y.P.2
Tay, Y.C.3
Harris, D.C.4
-
43
-
-
0020056772
-
Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events
-
Bertani T, Poggi A, Pozzoni R et al. Adriamycin-induced nephrotic syndrome in rats: sequence of pathologic events. Lab Invest 1982;46:16-23.
-
(1982)
Lab Invest
, vol.46
, pp. 16-23
-
-
Bertani, T.1
Poggi, A.2
Pozzoni, R.3
-
44
-
-
0026348165
-
Amelioration of glomerular injury in doxorubicin hydrochloride nephrosis by dimethylthiourea
-
Milner LS, Wei SH, Houser MT. Amelioration of glomerular injury in doxorubicin hydrochloride nephrosis by dimethylthiourea. J Lab Clin Med 1991;118:427-34.
-
(1991)
J Lab Clin Med
, vol.118
, pp. 427-434
-
-
Milner, L.S.1
Wei, S.H.2
Houser, M.T.3
-
45
-
-
2442484053
-
Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
-
Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22: 531-62.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 531-562
-
-
Sakaguchi, S.1
|