Immune homeostasis maintained by tregs

Regulatory T Cells

Volumn , Issue , 2011, Pages 201-223

  Jang, Myoung Ho ^a,b   Jung, Yun Jae ^c   Kim, Hyung Ran ^d   Moon, Byung In ^d   Seoh, Ju Young ^d  

^a OSAKA UNIVERSITY   (Japan)

^b Pohang University of Science and Technology (POSTECH)   (South Korea)

^c Gachon University College of Medicine   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862792273     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (37)

1. Piccirillo, C. A. (2008). Regulatory T cells in health and disease. Cytokine, 43, 395-401.
2. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. (1995). Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol, 155, 1151-1164.
3. Sakaguchi, S., Toda, M., Asano, M., Itoh, M., Morse, S. S. & Sakaguchi, N. (1996). T cell-mediated maintenance of natural self-tolerance: its breakdown as a possible cause of various autoimmune diseases. J Autoimmun, 9, 211-220.
4. Sakaguchi, S. (2004). Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol, 22, 531-562.
5. Piccirillo, C. A. & Shevach, E. M. (2004). Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol, 16, 81-88.
6. Piccirillo, C. A. & Shevach, E. M. (2001). Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells. J Immunol, 167, 1137-1140.
7. Lim, H. W., Hillsamer, P., Banham, A. H. & Kim, C. H. (2005). Cutting edge: direct suppression of B cells by CD4+ CD25+ regulatory T cells. J Immunol, 175, 4180-4183.
8. Ralainirina, N., Poli, A., Michel, T., Poos, L., Andres, E., Hentges, F. & Zimmer, J. (2007). Control of NK cell functions by CD4+CD25+ regulatory T cells. J Leukoc Biol 81, 144-153.
9. Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T. & Sakaguchi, S. (2008). CTLA-4 control over Foxp3+ regulatory T cell function. Science, 322, 271-275.
10. Oliveira, V., Agua-Doce, A., Duarte, J., Soares, M. P. & Graca, L. (2006). Regulatory T cell maintenance of dominant tolerance: induction of tissue self-defense? Transpl Immunol, 17, 7-10.
11. Sakaguchi, S., Wing, K., Onishi, Y., Prieto-Martin, P. & Yamaguchi, T. (2009). Regulatory T cells: how do they suppress immune responses? Int Immunol, 21, 1105-1111.
12. Scheffold, A., Huhn, J. & Hofer, T. (2005). Regulation of CD4+CD25+ regulatory T cell activity: it takes (IL-)two to tango. Eur J Immunol, 35, 1336-1341.
13. Malek, T. R., Yu, A., Vincek, V., Scibelli, P. & Kong, L. (2002). CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity, 17, 167-178.
14. Malek, T. R. & Bayer, A. L. (2004). Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol, 4, 665-674.
15. Annunziato, F., Cosmi, L., Liotta, F., Lazzeri, E., Manetti, R., Vanini, V., Romagnani, P., Maggi, E. & Romagnani, S. (2002). Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes. J Exp Med, 196, 379-387.
16. Turka, L. A. & Walsh, P. T. (2008). IL-2 signaling and CD4+ CD25+ Foxp3+ regulatory T cells. Front Biosci, 13, 1440-1446.
17. Levings, M. K., Sangregorio, R. & Roncarolo, M. G. (2001). Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med, 193, 1295-1302.
18. Thornton, A. M. & Shevach, E. M. (2000). Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol, 164, 183-190.
19. de la Rosa, M., Rutz, S., Dorninger, H. & Scheffold, A. (2004). Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol, 34, 2480-2488.
20. Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T. & Sakaguchi, S. (2007). Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature, 446, 685-689.
21. Jung, Y. J. & Seoh, J. Y. (2009). Feedback loop of immune regulation by CD4+CD25+ Treg. Immunobiology, 214, 291-302.
22. Takahashi, T., Kuniyasu, Y., Toda, M., Sakaguchi, N., Itoh, M., Iwata, M., Shimizu, J. & Sakaguchi, S. (1998). Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol, 10, 1969-1980.
23. Baecher-Allan, C., Brown, J. A., Freeman, G. J., Hafler, D. A. (2001). CD4+CD25high regulatory cells in human peripheral blood. J Immunol, 167, 1245-1253.
24. Taams, L. S., van Rensen, A. J., Poelen, M. C., van Els, C. A., Besseling, A. C., Wagenaar, J. P., van Eden, W. & Wauben, M. H. (1998). Anergic T cells actively suppress T cell responses via the antigen-presenting cell. Eur J Immunol, 28, 2902-2912.
25. Yamazaki, S., Iyoda, T., Tarbell, K., Olson, K., Velinzon, K., Inaba, K. & Steinman, R. M. (2003). Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med, 198, 235-247.
26. Walker, L. S., Chodos, A., Eggena, M., Dooms, H. & Abbas, A. K. (2003). Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. J Exp Med, 198, 249-258.
27. Klein, L., Khazaie, K. & von Boehmer, H. (2003). In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc Natl Acad Sci, U S A, 100, 8886-8891.
28. Oberg, H. H., Wesch, D., Lenke, J. & Kabelitz, D. (2006). An optimized method for the functional analysis of human regulatory T cells. Scand J Immunol, 64, 353-360.
29. Suchin, E. J., Langmuir, P. B., Palmer, E., Sayegh, M. H., Wells, A. D., Turka, L. A. (2001). Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J Immunol, 166, 973-981.
30. Yarkoni, S., Kaminitz, A., Sagiv, Y., Yaniv, I. & Askenasy, N. (2008). Involvement of IL-2 in homeostasis of regulatory T cells: the IL-2 cycle. Bioessays 30, 875-888.
31. Rubin, L. A., Kurman, C. C., Fritz, M. E., Biddison, W. E., Boutin, B., Yarchoan, R. & Nelson, D. L. (1985). Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol, 135, 3172-3177.
32. Sojka, D. K., Hughson, A., Sukiennicki, T. L. & Fowell, D. J. (2005). Early kinetic window of target T cell susceptibility to CD25+ regulatory T cell activity. J Immunol, 175, 7274-7280.
33. Rubin, L. A., Jay, G. & Nelson, D. L. (1986). The released interleukin 2 receptor binds interleukin 2 efficiently. J Immunol, 137, 3841-3844.
34. Pandiyan, P., Zheng, L., Ishihara, S., Reed, J. & Lenardo, M. J. (2007). CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol, 8, 1353-1362.
35. Thornton, A. M. & Shevach, E. M. (1998). CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med, 188, 287-296.
36. Lehner, T. (2008). Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation. Immunology, 123, 40-44.
37. Pasare, C. & Medzhitov, R. (2003). Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science, 299, 1033-1036.