Exploiting the MDM2-CK1α protein-protein interface to develop novel biologics that induce UBL-kinase-modification and inhibit cell growth

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Huart, Anne Sophie ^a   MacLaine, Nicola J ^a   Narayan, Vikram ^a   Hupp, Ted R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN KINASE IALPHA; NEDD8 PROTEIN; PROTEIN KINASE; PROTEIN MDM2; PROTEIN P53; RECOMBINANT PROTEIN; SMALL INTERFERING RNA; UBIQUITIN;

ARTICLE; BINDING SITE; CELL CYCLE ARREST; CELL DEATH; CELL GROWTH; CELL LYSATE; CELL SURVIVAL; CELL VIABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MODIFICATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; NEDDYLATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UBIQUITINATION;

BLOTTING, WESTERN; CASEIN KINASE IALPHA; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; RNA, SMALL INTERFERING; UBIQUITINATION;

EID: 84865175012     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043391     Document Type: Article

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