Breast cancer-specific mutations in CK1ε inhibit Wnt/β-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration

Breast Cancer Research

Volumn 12, Issue 3, 2010, Pages

  Foldynová Trantírková, Silvie ^a   Sekyrová, Petra ^a   Tmejová, Kateřina ^b,c   Brumovská, Eva ^a   Bernatík, Ondřej ^b   Blankenfeldt, Wulf ^d   Krejčí, Pavel ^b,c   Kozubík, Alois ^b,c   Doležal, Tomáš ^a   Trantírek, Lukáš ^a,e   Bryja, Vítězslav ^b,c  

^a UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^b MASARYK UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^e UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASEIN KINASE IEPSILON; DISHEVELLED 2; GUANOSINE TRIPHOSPHATASE; LYMPHOID ENHANCER FACTOR 1; RAC1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; T CELL FACTOR PROTEIN; THREONINE; TRANSCRIPTION FACTOR NFAT; WNT PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; RAC1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CELL ADHESION; CELL MIGRATION; COMPUTER MODEL; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO CULTURE; MAMMAL CELL; POINT MUTATION; SIGNAL TRANSDUCTION; BREAST TUMOR; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; FEMALE; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MUTATION; PAGET NIPPLE DISEASE; PATHOLOGY; PHOSPHORYLATION; PROTEIN CONFORMATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

BETA CATENIN; BLOTTING, WESTERN; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CASEIN KINASE IEPSILON; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; FEMALE; HUMANS; IMMUNOPRECIPITATION; MAP KINASE KINASE 4; MUTATION; NFATC TRANSCRIPTION FACTORS; PHOSPHORYLATION; PROTEIN CONFORMATION; RAC1 GTP-BINDING PROTEIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; WNT PROTEINS;

EID: 78149481137     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2581     Document Type: Article

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