SCOPUS 정보 검색 플랫폼

European Journal of Medicinal Chemistry

Volumn 46, Issue 6, 2011, Pages 2043-2057

Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives

(2) Shallal, Hassan M a Russu, Wade A a

a UNIVERSITY OF THE PACIFIC (United States)

Author keywords

Kinases; MDA MB 468; NCI 60; Piperazinylpyrimidine

Indexed keywords

(4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(3 (2 PHENYLQUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(3 (QUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 ((2 PHENYLQUINAZOLIN 4 YLAMINO)METHYL)PHENYL)METHANONE; (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 ((QUINAZOLIN 4 YLAMINO)METHYL)PHENYL)METHANONE; (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 (2 PHENYLQUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 (QUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(2 (3 PHENYLQUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(2 (4 PHENYLQUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(3 (QUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 ((2 PHENYLQUINAZOLIN 4 YLAMINO)METHYL)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 ((QUINAZOLIN 4 YLAMINO)METHYL)PHENYL)METHANONE; (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)(4 (QUINAZOLIN 4 YLAMINO)PHENYL)METHANONE; 3 (2 PHENYLQUINAZOLIN 4 YLAMINO)BENZOIC ACID; 3 (QUINAZOLIN 4 YLAMINO)BENZOIC ACID; 4 ((2 PHENYLQUINAZOLIN 4 YLAMINO)METHYL)BENZOIC ACID; 4 ((QUINAZOLIN 4 YLAMINO)METHYL)BENZOIC ACID; 4 (2 PHENYLQUINAZOLIN 4 YLAMINO)BENZOIC ACID; 4 (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL) 2 PHENYLQUINAZOLINE; 4 (4 (5 BENZYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)QUINAZOLINE; 4 (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL) 2 PHENYLQUINAZOLINE; 4 (4 (5 ETHYLPYRIMIDIN 2 YL)PIPERAZIN 1 YL)QUINAZOLINE; 4 (QUINAZOLIN 4 YLAMINO)BENZOIC ACID; 5 BENZYL 2 (PIPERAZIN 1 YL)PYRIMIDINE; 5 ETHYL 2 (PIPERAZIN 1 YL)PYRIMIDINE; PIPERAZINE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PYRIMIDINE DERIVATIVE; RAF PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG BINDING; DRUG INHIBITION; DRUG SELECTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MUTANT; PROTEIN FUNCTION; SENSITIVITY ANALYSIS; WILD TYPE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIMIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79955631503 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2011.02.057 Document Type: Article

Times cited : (45)

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