NF-κB inhibition is ineffective in blocking cytokine-induced IL-8 production but P38 and STAT1 inhibitors are effective

Inflammation Research

Volumn 61, Issue 9, 2012, Pages 977-985

  Wang, Quan ^a,b   Huber, Nathan ^b   Noel, Greg ^a   Haar, Lauren ^a   Shan, Yizhi ^a   Pritts, Timothy A ^b   Ogle, Cora K ^a,b  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Caco 2 cells; Cytokine; HEK blue cells; NF B; P38 MAPK; STAT1

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EPIGALLOCATECHIN GALLATE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NITRIC OXIDE; PROTEIN INHIBITOR; PYRROLIDINE DITHIOCARBAMATE; STAT1 PROTEIN; STAT1 PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; CATECHIN; CYTOKINE; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; NITRILE; PROLINE; PROLINEDITHIOCARBAMATE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; STAT1 PROTEIN, HUMAN; SULFONE; THIOCARBAMIC ACID DERIVATIVE;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; NF KAPPA B GENE; PROTEIN SYNTHESIS INHIBITION; REPORTER GENE; TRANSCRIPTION INITIATION; CELL LINE; CELL STRAIN CACO 2; DRUG ANTAGONISM; GENETICS; METABOLISM;

CACO-2 CELLS; CATECHIN; CELL LINE; CYTOKINES; GENES, REPORTER; HUMANS; IMIDAZOLES; NF-KAPPA B; NITRIC OXIDE; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROLINE; PROTEIN KINASE INHIBITORS; PYRIDINES; STAT1 TRANSCRIPTION FACTOR; SULFONES; THIOCARBAMATES;

EID: 84865126526     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0490-2     Document Type: Article

References (36)

1. Jijon HB, Panenka WJ, Madsen KL, Parsons HG. MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism. Am J Physiol Cell Physiol. 2002;283:C31-41. (Pubitemid 34670545)
2. Parhar K, Ray A, Steinbrecher U, Nelson C, Salh B. The p38 mitogen-activated protein kinase regulates interleukin-1betainduced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells. Immunology. 2003;108:502-12. (Pubitemid 36469688)
3. Akhtar M, Watson JL, Nazli A, McKay DM. Bacterial DNA evokes epithelial IL-8 production by a MAPK-dependent NFkappaB- independent pathway. FASEB J. 2003;17:1319-21.
4. Kim JM, Cho SJ, Oh YK, Jung HY, Kim YJ, Kim N. Nuclear factor-kappa B activation pathway in intestinal epithelial cells is a major regulator of chemokine gene expression and neutrophil migration induced by Bacteroides fragilis enterotoxin. Clin Exp Immunol. 2002;130:59-66.
5. Otte JM, Podolsky DK. Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol. 2004;286:G613-26. (Pubitemid 38374981)
6. Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol. 1994;56:559-64. (Pubitemid 24348812)
7. Bao Z, Ye Q, Gong W, Xiang Y, Wan H. Humanized monoclonal antibody against the chemokine CXCL-8 (IL-8) effectively prevents acute lung injury. Int Immunopharmacol. 2010;10:259-63.
8. Osman MO, Kristensen JU, Jacobsen NO, Lausten SB, Deleuran B, Deleuran M, Gesser B, Matsushima K, Larsen CG, Jensen SL. A monoclonal anti-interleukin 8 antibody (WS-4) inhibits cytokine response and acute lung injury in experimental severe acute necrotizing pancreatitis in rabbits. Gut. 1998;43:232-9. (Pubitemid 28348327)
9. Seydel KB, Li E, Zhang Z, Stanley SL Jr. Epithelial cell-initiated inflammation plays a crucial role in early tissue damage in amebic infection of human intestine. Gastoenterology. 1998;115: 1446-53. (Pubitemid 28545995)
10. Sansonetti PJ, Arondel J, Huerre M, Harada A, Matsushima K. Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis. Infect Immun. 1999;67:1471-80. (Pubitemid 29108531)
11. Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol. 2002;72:847-55. (Pubitemid 35365158)
12. Garat C, Arend WP. Intracellular IL-1Ra type 1 inhibits IL-1- induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-kappaB pathways. Cytokine. 2003;23:31-40. (Pubitemid 36937198)
13. Jijon HB, Walker J, Hoentjen F, Diaz H, Ewaschuk J, Jobin C, Madsen KL. Adenosine is a negative regulator of NF-kappaB and MAPK signaling in human intestinal epithelial cells. Cell Immunol. 2005;237:86-95. (Pubitemid 43117204)
14. Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH. A role for NFkappa B subunits p50 and p65 in the inhibition of lipopolysaccharide- induced shock. J Immunol. 2004;173:5786-93. (Pubitemid 39392168)
15. Kawamura N, Kubota T, Kawano S, Monden Y, Feldman AM, Tsutsui H, Takeshita A, Sunagawa K. Blockade of NF-kappaB improves cardiac function and survival without affecting inflammation in TNF-alpha-induced cardiomyopathy. Cardiovasc Res. 2005;66:520-9. (Pubitemid 40725764)
16. Sousa LP, Lopes F, Silva DM, Tavares LP, Vieira AT, Rezende BM, Carmo AF, Russo RC, Garcia CC, Bonjardim CA, Alessandri AL, Rossi AG, Pinho V, Teixeira MM. PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-kappaB-independent manner. J Leukoc Biol. 2010;87:895-904.
17. Munoz C, Pascual-Salcedo D, Castellanos MC, Alfranca A, Aragones J, Vara A, Redondo JM, de Landazuri MO. Pyrrolidine dithiocarbamate inhibits the production of interleukin-6, interleukin- 8, and granulocyte-macrophage colony-stimulating factor by human endothelial cells in response to inflammatory mediators: modulation of NF-kappa B and AP-1 transcription factors activity. Blood. 1996;88:3482-90. (Pubitemid 26365583)
18. Wang Q, Guo XL, Wells-Byrum D, Noel G, Pritts TA, Ogle CK. Cytokine-induced epithelial permeability changes are regulated by the activation of the p38 mitogen-activated protein kinase pathway in cultured Caco-2 cells. Shock. 2008;29:531-7. (Pubitemid 351416808)
19. Tedeschi E, Menegazzi M, Yao Y, Suzuki H, Forstermann U, Kleinert H. Green tea inhibits human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha activation. Mol Pharmacol. 2004;65:111-20. (Pubitemid 38113891)
20. Nemeth ZH, Deitch EA, Szabo C, Hasko G. Pyrrolidinedithiocarbamate inhibits NF-kappaB activation and IL-8 production in intestinal epithelial cells. Immunol Lett. 2003;85:41-6. (Pubitemid 36009422)
21. Ganster RW, Taylor BS, Shao L, Geller DA. Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proc Natl Acad Sci USA. 2001;8: 8638-43. (Pubitemid 32678080)
22. Sunil Y, Ramadori G, Raddatzc D. Influence of NFkappaB inhibitors on IL-1beta-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC. Int J Colorectal Dis. 2010;25:323-33.
23. Song GY, Chung CS, Chaudry IH, Ayala A. MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis. Am J Physiol Cell Physiol. 2001;281:C662-9.
24. Liu SF, Ye X, Malik AB. In vivo inhibition of nuclear factorkappa B activation prevents inducible nitric oxide synthase expression and systemic hypotension in a rat model of septic shock. J Immunol. 1997;159:3976-83. (Pubitemid 127469654)
25. Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Goktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, Duyster J, Schmid RM, Eckmann L, Karin M. NF-kappaB is a negative regulator of IL- 1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 2007;130:918-31. (Pubitemid 47332565)
26. Lauzurica P, Martinez-Martinez S, Marazuela M, Gomez del Arco P, Martinez C, Sanchez-Madrid F, Redondo JM. Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-alpha. Eur J Immunol. 1999;29:1890-900. (Pubitemid 29265544)
27. Chavez AM, Menconi MJ, Hodin RA, Fink MP. Cytokineinduced intestinal epithelial hyperpermeability: role of nitric oxide. Crit Care Med. 1999;27:2246-51. (Pubitemid 29508346)
28. Grandjean-Laquerriere A, Gangloff SC, Le Naour R, Trentesaux C, Hornebeck W, Guenounou M. Relative contribution of NFkappaB and AP-1 in the modulation by curcumin and pyrrolidine dithiocarbamate of the UVB-induced cytokine expression by keratinocytes. Cytokine. 2002;18:168-77. (Pubitemid 34775439)
29. Netsch MI, Gutmann H, Aydogan C, Drewe J. Green tea extract induces interleukin-8 (IL-8) mRNA and protein expression but specifically inhibits IL-8 secretion in caco-2 cells. Planta Med. 2006;72:697-702. (Pubitemid 44073452)
30. Porath D, Riegger C, Drewe J, Schwager J. Epigallocatechin-3- gallate impairs chemokine production in human colon epithelial cell lines. J Pharmacol Exp Ther. 2005;315:1172-80. (Pubitemid 41635405)
31. Magro F, Fraga S, Ribeiro T, Soares-da-Silva P. Intestinal Na ? -K ? -ATPase activity and molecular events downstream of interferon-gamma receptor stimulation. Br J Pharmacol. 2004;142:1281-92. (Pubitemid 39178882)
32. Intra J, Kuo SM. Physiological levels of tea catechins increase cellular lipid antioxidant activity of vitamin C and vitamin E in human intestinal caco-2 cells. Chem Biol Interact. 2007; 169:91-9. (Pubitemid 47125871)
33. Navarro-Peran E, Cabezas-Herrera J, Sanchez-del-Campo L, Garcia-Canovas F, Rodriguez-Lopez JN. The anti-inflammatory and anti-cancer properties of epigallocatechin-3-gallate are mediated by folate cycle disruption, adenosine release and NF-kappaB suppression. Inflamm Res. 2008;57:472-8.
34. Kim SJ, Jeong HJ, Lee KM, Myung NY, An NH, Yang WM, Park SK, Lee HJ, Hong SH, Kim HM, Um JY. Epigallocatechin-3- gallate suppresses NF-kappaB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells. J Nutr Biochem. 2007;18:587-96.
35. Edelson MB, Bagwell CE, Rozycki HJ. Circulating pro- and counterinflammatory cytokine levels and severity in necrotizing enterocolitis. Pediatrics. 1999;103:766-71. (Pubitemid 29274469)
36. Daig R, Andus T, Aschenbrenner E, Falk W, Scholmerich J, Gross V. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut. 1996;38: 216-22.