The positional specificity of EXXK motifs within an amphipathic α-helix dictates preferential lysine modification by acrolein: Implications for the design of high-density lipoprotein mimetic peptides

Biochemistry

Volumn 51, Issue 32, 2012, Pages 6400-6412

  Zheng, Ying ^a   Kim, Sea H ^b   Patel, Arti B ^b   Narayanaswami, Vasanthy ^b,c   Iavarone, Anthony T ^d   Hura, Gregory L ^e   Bielicki, John K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA STATE UNIVERSITY   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC RESIDUES; AMINO ACID SUBSTITUTION; AMINO GROUP; AMPHIPATHIC; CHOLESTEROL EFFLUX; CONCENTRATION-DEPENDENT; HELICAL PEPTIDE; HELICAL STRANDS; HIGH-DENSITY LIPOPROTEINS; INHIBITORY EFFECT; LYSINE MODIFICATION; LYSINE RESIDUES; MOLAR RATIO; MOLECULAR BASIS; POSITIONAL SPECIFICITY; SITE-SPECIFIC; SITE-SPECIFIC MODIFICATIONS;

ALDEHYDES; BIOMIMETICS; CHOLESTEROL; HERBICIDES; MASS SPECTROMETRY; PEPTIDES;

AMINO ACIDS;

ACROLEIN; GLUTAMIC ACID; HIGH DENSITY LIPOPROTEIN; LYSINE; PEPTIDE DERIVATIVE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CROSS LINKING; MASS SPECTROMETRY; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE;

ACROLEIN; AMINO ACID MOTIFS; ANIMALS; APOLIPOPROTEIN A-I; APOLIPOPROTEINS E; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE; CHOLESTEROL; CROSS-LINKING REAGENTS; DRUG DESIGN; LIPOPROTEINS, HDL; LYSINE; MACROPHAGES; MICE; MOLECULAR MIMICRY; PEPTIDES;

EID: 84865117958     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300626g     Document Type: Article

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