Apolipoprotein E·dipalmitoylphosphatidylcholine particles are ellipsoidal in solution

Journal of Lipid Research

Volumn 48, Issue 5, 2007, Pages 1035-1044

  Peters Libeu, Clare A ^a   Newhouse, Yvonne ^a   Hall, Steven C ^a   Witkowska, H Ewa ^a   Weisgraber, Karl H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apolipoprotein A I; Lipoprotein; Phospholipid; Small angle X ray scattering

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN E; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ALPHA HELIX; ALZHEIMER DISEASE; ARTICLE; CARDIOVASCULAR DISEASE; DISEASE PREDISPOSITION; GENETIC POLYMORPHISM; LIGHT SCATTERING; MASS SPECTROMETRY; MICELLE; NERVE DEGENERATION; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LIPID INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; HUMAN; ISOLATION AND PURIFICATION; MOLECULAR GENETICS; SOLUTION AND SOLUBILITY; SPECTROSCOPY;

1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE; AMINO ACID SEQUENCE; APOLIPOPROTEINS E; CRYSTALLOGRAPHY, X-RAY; HUMANS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; SOLUTIONS; SPECTRUM ANALYSIS;

EID: 34248233497     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M600545-JLR200     Document Type: Article

References (43)

1. Mahley, R. W., and Y. Huang. 1999. Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Curr. Opin. Lipidol. 10: 207-217.
2. Mahley, R. W., and S. C. Rall, Jr. 2000. Apolipoprotein E: far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1: 507-537.
3. Pitas, R. E., T. L. Innerarity, and R. W. Mahley. 1980. Cell surface receptor binding of phospholipidIprotein complexes containing different ratios of receptor-active and -inactive E apoprotein. J. Biol. Chem. 255: 5454-5460.
4. Koo, C., T. L. Innerarity, and R. W. Mahley. 1985. Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins. J. Biol. Chem. 260: 11934-11943.
5. Saunders, A. M., W. J. Strittmatter, D. Schmechel, P. H. St George-Hyslop, M. A. Pericak-Vance, S. H. Joo, B. L. Rosi, J. F. Gusella, D. R. Crapper-MacLachlan, M. J. Alberts, et al. 1993. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43: 1467-1472.
6. rd edition. K. L. Becker, editor. Lippincott Williams & Wilkins, Philadelphia. 1503-1513.
7. Weisgraber, K. H. 1994. Apolipoprotein E: structure-function relationships. Adv. Protein Chem. 45: 249-302.
8. Wilson, C., M. R. Wardell, K. H. Weisgraber, R. W. Mahley, and D. A. Agard. 1991. Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science. 252: 1817-1822.
9. Ajees, A. A., G. M. Anantharamaiah, V. K. Mishra, M. M. Hussain, and H. M. K. Murthy. 2006. Crystal structure of human apolipoprotein A-I: insights into its protective effect against cardiovascular diseases. Proc. Natl. Acad. Sci. USA. 103: 2126-2131.
10. Lu, B., J. A. Morrow, and K. H. Weisgraber. 2000. Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. J. Biol. Chem. 275: 20775-20781.
11. Hatters, D. M., C. A. Peters-Libeu, and K. H. Weisgraber. 2006. Apolipoprotein E structure: insights into function. Trends Biochem. Sci. 31: 445-454.
12. Mahley, R. W., Y. Huang, and K. H. Weisgraber. 2006. Putting cholesterol in its place: apoE and reverse cholesterol transport. J. Clin. Invest. 116: 1226-1229.
13. Segrest, J. P., M. K. Jones, H. De Loof, and N. Dashti. 2001. Structure of apolipoprotein B-100 in low density lipoproteins. J. Lipid Res. 42: 1346-1367.
14. Tall, A. R., D. M. Small, R. J. Deckelbaum, and G. G. Shipley. 1977. Structure and thermodynamic properties of high density lipoprotein recombinants. J. Biol. Chem. 252: 4701-4711.
15. Assmann, G., and H. B. Brewer, Jr. 1974. A molecular model of high density lipoproteins. Proc. Natl. Acad. Sci. USA. 71: 1534-1538.
16. Wlodawer, A., J. P. Segrest, B. H. Chung, R. Chiovetti, Jr., and J. N. Weinstein. 1979. High-density lipoprotein recombinants: evidence for a bicycle tire micelle structure obtained by neutron scattering and electron microscopy. FEBS Lett. 104: 231-235.
17. Atkinson, D., and G. G. Shipley. 1984. Structural studies of plasma lipoproteins. Basic Life Sci. 27: 211-226.
18. Segrest, J. P., L. Li, G. M. Anantharamaiah, S. C. Harvey, K. N. Liadaki, and V. Zannis. 2000. Structure and function of apolipoprotein A-I and high-density lipoprotein. Curr. Opin. Lipidol. 11: 105-115.
19. Gursky, O. 2005. Apolipoprotein structure and dynamics. Curr. Opin. Lipidol. 16: 287-294.
20. Peters-Libeu, C. A., Y. Newhouse, D. M. Hatters, and K. H. Weisgraber. 2006. Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. J. Biol. Chem. 281: 1073-1079.
21. Morrow, J. A., K. S. Arnold, and K. H. Weisgraber. 1999. Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expr. Purif. 16: 224-230.
22. Newhouse, Y., C. Peters-Libeu, and K. H. Weisgraber. 2005. Crystallization and preliminary x-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles. Acta Crystallograph. Sect. F Struct. Biol. Cryst. Commun. 61: 981-984.
23. Saito, H., P. Dhanasekaran, D. Nguyen, P. Holvoet, S. Lund-Katz, and M. C. Phillips. 2003. Domain structure and lipid interaction in human apolipoproteins A-I and E, a general model. J. Biol. Chem. 278: 23227-23232.
24. Atkinson, D., H. M. Smith, J. Dickson, and J. P. Austin. 1976. Interaction of apoprotein from porcine high-density lipoprotein with dimyristoyl lecithin. 1. The structure of the complexes. Eur. J. Biochem. 64: 541-547.
25. Svergun, D. I. 1992. Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J. Appl. Crystallogr. 25: 495-503.
26. Svergun, D. I., V. V. Volkov, M. B. Kozin, and H. B. Stuhrmann. 1996. New developments in direct shape determination from smallangle scattering. 2. Uniqueness. Acta Crystallogr. A. 52: 419-426.
27. Svergun, D., C. Barberato, and M. H. J. Koch. 1995. CRYSOL - a program to evaluate x-ray solution scattering of biological macromolecules from atomic coordinates. J. Appl. Crystallogr. 28: 768-773.
28. Konarev, P. V., M. V. Petoukhov, and D. I. Svergun. 2001. MASSHA -a graphics system for rigid-body modelling of macromolecular complexes against solution scattering data. J. Appl. Crystallogr. 34: 527-532.
29. Borhani, D. W., D. P. Rogers, J. A. Engler, and C. G. Brouillette. 1997. Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation. Proc. Natl. Acad. Sci. USA. 94: 12291-12296.
30. Feigin, L. A., and D. I. Svergun. 1987. Structure Analysis by Small-Angle X-Ray and Neutron Scattering. Plenum Press, New York.
31. Denisov, I. G., Y. V. Grinkova, A. A. Lazarides, and S. G. Sligar. 2004. Directed self-assembly of monodisperse phospholipid bilayer nanodiscs with controlled size. J. Am. Chem. Soc. 126: 3477-3487.
32. Nagle, J. F., and S. Tristram-Nagle. 2000. Structure of lipid bilayers. Biochim. Biophys. Acta. 1469: 159-195.
33. Moore, P. B., D. M. Engelman, and B. P. Schoenborn. 1974. Asymmetry in the 50S ribosomal subunit of Escherichia coli. Proc. Natl. Acad. Sci. USA. 71: 172-176.
34. Hatters, D. M., C. A. Peters-Libeu, and K. H. Weisgraber. 2005. Engineering conformational destabilization into mouse apolipoprotein E. A model for a unique property of human apolipoprotein E4. J. Biol. Chem. 280: 26477-26482.
35. Jayaraman, S., D. L. Gantz, and O. Gursky. 2004. Poly(ethylene glycol)-induced fusion and destabilization of human plasma highdensity lipoproteins. Biochemistry. 43: 5520-5531.
36. Catte, A., J. C. Patterson, M. K. Jones, W. G. Jerome, D. Bashtovyy, Z. Su, F. Gu, J. Chen, M. P. Aliste, S. C. Harvey, et al. 2006. Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study. Biophys. J. 90: 4345-4360.
37. Schneeweis, L. A., V. Koppaka, S. Lund-Katz, M. C. Phillips, and P. H. Axelsen. 2005. Structural analysis of lipoprotein E particles. Biochemistry. 44: 12525-12534.
38. King, J. L., and T. H. Jukes. 1969. Non-Darwinian evolution. Science. 164: 788-798.
39. Shore, B., and V. Shore. 1974. An apolipoprotein preferentially enriched in cholesteryl ester-rich very low density lipoproteins. Biochem. Biophys. Res. Commun. 58: 1-7.
40. Roque, A. C. A., and C. R. Lowe. 2005. Lessons from nature: on the molecular recognition elements of the phosphoprotein bindingdomains. Biotechnol. Bioeng. 91: 546-555.
41. Segrest, J. P., R. L. Jackson, J. D. Morrisett, and A. M. Gotto, Jr. 1974. A molecular theory of lipid-protein interactions in the plasma lipoproteins. FEBS Lett. 38: 247-253.
42. MacRaild, C. A., G. J. Howlett, and P. R. Gooley. 2004. The structure and interactions of human apolipoprotein C-II in dodecyl phosphocholine. Biochemistry. 43: 8084-8093.
43. Getie, M., C. E. H. Schmelzer, and R. H. H. Neubert. 2005. Characterization of peptides resulting from digestion of human skin elastin with elastase. Proteins. 61: 649-657.