Biological evidence for the acute health effects of secondhand smoke exposure

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 1, 2010, Pages

  Flouris, Andreas D ^a   Vardavas, Constantine I ^b   Metsios, Giorgos S ^c   Tsatsakis, Aristidis M ^d   Koutedakis, Yiannis ^c,e  

^a INSTITUTE OF HUMAN PERFORMANCE AND REHABILITATION   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

^c UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

^d UNIVERSITY OF CRETE   (Greece)

^e UNIVERSITY OF THESSALY   (Greece)

Author keywords

Cardiovascular disease; Environmental tobacco smoke; Inflammatory markers; Passive smoking; Respiration

Indexed keywords

CIGARETTE SMOKE; TOBACCO SMOKE;

BRAIN CELL; BRAIN DEVELOPMENT; CARCINOGENICITY; CARDIOVASCULAR DISEASE; ENVIRONMENTAL EXPLOITATION; EXERCISE; HUMAN; LUNG ALVEOLUS; OXYGENATION; PASSIVE SMOKING; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

ACUTE DISEASE; CARCINOGENICITY TESTS; HUMANS; INHALATION EXPOSURE; TIME FACTORS; TOBACCO SMOKE POLLUTION;

EID: 73549109152     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00215.2009     Document Type: Review

References (134)

1. Akbartabartoori M, Lean ME, Hankey CR. Relationships between cigarette smoking, body size and body shape. Int J Obes 29: 236-243, 2005.
2. Alanko J, Riutta A, Mucha I, Kerttula T, Kaukinen S, Vapaatalo H, Metsa-Ketela T, Seppala E. Adrenaline stimulates thromboxane and inhibits leukotriene synthesis in man. Eicosanoids 5: 169-175, 1992.
3. Allred EN, Bleecker ER, Chaitman BR, Dahms TE, Gottlieb SO, Hackney JD, Pagano M, Selvester RH, Walden SM, Warren J. Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. N Engl J Med 321: 1426-1432, 1989.
4. Anderson R, Theron AJ, Richards GA, Myer MS, van Rensburg AJ. Passive smoking by humans sensitizes circulating neutrophils. Am Rev Respir Dis 144: 570-574, 1991.
5. Aronow WS. Effect of passive smoking on angina pectoris. N Engl J Med 299: 21-24, 1978.
6. Aronson D, Roterman I, Yigla M, Kerner A, Avizohar O, Sella R, Bartha P, Levy Y, Markiewicz W. Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects. Am J Respir Crit Care Med 174: 626-632, 2006.
7. Barnes PJ, Belvisi MG. Nitric oxide and lung disease. Thorax 48: 1034-1043, 1993.
8. Bascom R, Kagey-Sobotka A, Proud D. Effect of intranasal capsaicin on symptoms and mediator release. J Pharmacol Exp Ther 259: 1323-1327, 1991.
9. Bascom R, Kesavanathan J, Fitzgerald TK, Cheng KH, Swift DL. Sidestream tobacco smoke exposure acutely alters human nasal mucociliary clearance. Environ Health Perspect 103: 1026-1030, 1995.
10. Besaratinia A, Pfeifer GP. Second-hand smoke and human lung cancer. Lancet Oncol 9: 657-666, 2008.
11. California Environmental Protection Agency. Health Effects Assessment for Environmental Tobacco Smoke. Sacremento, CA: California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, 2005.
12. California Environmental Protection Agency. Proposed Identification of Environmental Tobacco Smoke as a Toxic Air Contaminant. Part B: Health Effects. Sacramento, CA: California Environmental Protection Agency, Office of Environmental Health Hazard Assessment, 2005.
13. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE. Passive smoking and impaired endotheliumdependent arterial dilatation in healthy young adults. N Engl J Med 334: 150-154, 1996.
14. Chang JS. Parental smoking and childhood leukemia. Methods Mol Biol 472: 103-137, 2009.
15. Chilmonczyk BA, Salmun LM, Megathlin KN, Neveux LM, Palomaki GE, Knight GJ, Pulkkinen AJ, Haddow JE. Association between exposure to environmental tobacco smoke and exacerbations of asthma in children. N Engl J Med 328: 1665-1669, 1993.
16. Churg A, Tai H, Coulthard T, Wang R, Wright JL. Cigarette smoke drives small airway remodeling by induction of growth factors in the airway wall. Am J Respir Crit Care Med 174: 1327-1334, 2006.
17. Collins LC, Walker J, Stamford BA. Smoking multiple high- versus low-nicotine cigarettes: impact on resting energy expenditure. Metabolism 45: 923-926, 1996.
18. Corrado D, Migliore F, Basso C, Thiene G. Exercise and the risk of sudden cardiac death. Herz 31: 553-558, 2006.
19. Corsico A, Milanese M, Baraldo S, Casoni GL, Papi A, Riccio AM, Cerveri I, Saetta M, Brusasco V. Small airway morphology and lung function in the transition from normality to chronic airway obstruction. J Appl Physiol 95: 441-447; discussion 435, 2003.
20. Davis JW, Shelton L, Watanabe IS, Arnold J. Passive smoking affects endothelium and platelets. Arch Intern Med 149: 386-389, 1989.
21. Edwards K, Braun KM, Evans G, Sureka AO, Fan S. Mainstream and sidestream cigarette smoke condensates suppress macrophage responsiveness to interferon gamma. Hum Exp Toxicol 18: 233-240, 1999.
22. Eisner MD, Wang Y, Haight TJ, Balmes J, Hammond SK, Tager IB. Secondhand smoke exposure, pulmonary function, and cardiovascular mortality. Ann Epidemiol 17: 364-373, 2007.
23. Ekins R. The free hormone hypothesis and measurement of free hormones. Clin Chem 38: 1289-1293, 1992.
24. Elwood PC, Renaud S, Sharp DS, Beswick AD, O'Brien JR, Yarnell JW. Ischemic heart disease and platelet aggregation. The Caerphilly Collaborative Heart Disease Study. Circulation 83: 38-44, 1991.
25. Farrelly MC, Nonnemaker JM, Chou R, Hyland A, Peterson KK, Bauer UE. Changes in hospitality workers' exposure to secondhand smoke following the implementation of New York's smoke-free law. Tob Control 14: 236-241, 2005.
26. Ferguson GT, Enright PL, Buist AS, Higgins MW. Office spirometry for lung health assessment in adults: a consensus statement from the National Lung Health Education Program. Chest 117: 1146 -1161, 2000.
27. Fernández E, Fu M, Pascual JA, López MJ, Pérez-Ríos M, Schiaffino A, Martínez-Sánchez JM, Ariza C, Saltó E, Nebot M; and the Spanish Smoking Law Evaluation Group. Impact of the Spanish smoking law on exposure to second-hand smoke and respiratory health in hospitality workers: a cohort study. PLoS One 4: e4244, 2009.
28. Flouris AD, Faught BE, Klentrou P. Cardiovascular disease risk in adolescent smokers: evidence of a 'smoker lifestyle'. J Child Health Care 12: 217-227, 2008.
29. Flouris AD, Metsios GS, Carrillo AE, Jamurtas AZ, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. Acute and short-term effects of secondhand smoke on lung function and cytokine production. Am J Respir Crit Care Med 179: 1029-1033, 2009.
30. Flouris AD, Metsios GS, Carrillo AE, Jamurtas AZ, Koutedakis Y, Tzatzarakis MN, Tsatsakis AM. Effects of passive smoking on resting and exercising humans (Abstract). Can J Appl Physiol 30: S28, 2005.
31. Flouris AD, Metsios GS, Jamurtas AZ, Koutedakis Y. Sexual dimorphism in the acute effects of secondhand smoke on thyroid hormone secretion, inflammatory markers and vascular function. Am J Physiol Endocrinol Metab 294: E456-E462, 2008.
32. Gariepy J, Denarie N, Chironi G, Salomon J, Levenson J, Simon A. Gender difference in the influence of smoking on arterial wall thickness. Atherosclerosis 153: 139-145, 2000.
33. Garner RC, Martin CN, Clayson DB. Carcinogenic aromatic amines and related compounds. In: Chemical Carcinogens, edited by Searle CE. Washington, DC: American Chemical Society, 1984, p. 175-276.
34. Guerin MR, Jenkins RA, Tomkins BA. Mainstream and sidestream cigarette smoke. In: The Chemistry of Environmental Tobacco Smoke: Composition and Measurement, edited by Eisenberg M. Chelsea, MI: Lewis Publishers, 1992, p. 43-62.
35. Gvozdjak J, Gvozdjakova A, Kucharska J, Bada V. The effect of smoking on myocardial metabolism. Czech Med 10: 47-53, 1987.
36. Hecht SS. Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol 11: 559-603, 1998.
37. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol 51: 1760-1771, 2008.
38. Henderson AJ. The effects of tobacco smoke exposure on respiratory health in school-aged children. Paediatr Respir Rev 9: 21-27; quiz 27-28, 2008.
39. Hirayama T. Non-smoking wives of heavy smokers have a higher risk of lung cancer: a study from Japan. Br Med J (Clin Res Ed) 282: 183-185, 1981.
40. Hirsch GL, Sue DY, Wasserman K, Robinson TE, Hansen JE. Immediate effects of cigarette smoking on cardiorespiratory responses to exercise. J Appl Physiol 58: 1975-1981, 1985.
41. Ho LP, Innes JA, Greening AP. Nitrite levels in breath condensate of patients with cystic fibrosis is elevated in contrast to exhaled nitric oxide. Thorax 53: 680-684, 1998.
42. Howard DJ, Ota RB, Briggs LA, Hampton M, Pritsos CA. Environmental tobacco smoke in the workplace induces oxidative stress in employees, including increased production of 8-hydroxy-2'-deoxyguanosine. Cancer Epidemiol Biomarkers Prev 7: 141-146, 1998.
43. Hutchison SJ, Sievers RE, Zhu BQ, Sun YP, Stewart DJ, Parmley WW, Chatterjee K. Secondhand tobacco smoke impairs rabbit pulmonary artery endothelium-dependent relaxation. Chest 120: 2004-2012, 2001.
44. International Agency for Research on Cancer. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans: Tobacco Smoke and Involuntary Smoking. Lyon, France: International Agency for Research on Cancer, vol. 83, 2004.
45. International Agency for Research on Cancer. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans: Tobacco Smoking. Lyon, France: International Agency for Research on Cancer, vol. 38, 1986.
46. Johnson FK, Johnson RA. Carbon monoxide promotes endotheliumdependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol 285: R536-R541, 2003.
47. Johnson KC. Accumulating evidence on passive and active smoking and breast cancer risk. Int J Cancer 117: 619-628, 2005.
48. Kato M, Roberts-Thomson P, Phillips BG, Narkiewicz K, Haynes WG, Pesek CA, Somers VK. The effects of short-term passive smoke exposure on endothelium-dependent and independent vasodilation. J Hypertens 17: 1395-1401, 1999.
49. Kerns WD, Pavkov KL, Donofrio DJ, Gralla EJ, Swenberg JA. Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res 43: 4382-4392, 1983.
50. Kharitonov SA, Robbins RA, Yates D, Keatings V, Barnes PJ. Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am J Respir Crit Care Med 152: 609-612, 1995.
51. Kjellman NI. Effect of parental smoking on IgE levels in children. Lancet 1: 993-994, 1981.
52. Kosecik M, Erel O, Sevinc E, Selek S. Increased oxidative stress in children exposed to passive smoking. Int J Cardiol 100: 61-64, 2005.
53. Larsson M, Boethius G, Axelsson S, Montgomery SM. Exposure to environmental tobacco smoke and health effects among hospitality workers in Sweden-before and after the implementation of a smoke-free law. Scand J Work Environ Health 34: 267-277, 2008.
54. Lee KM, Ward MH, Han S, Ahn HS, Kang HJ, Choi HS, Shin HY, Koo HH, Seo JJ, Choi JE, Ahn YO, Kang D. Paternal smoking, genetic polymorphisms in CYP1A1 and childhood leukemia risk. Leuk Res 33: 250-258, 2009.
55. Lee LY, Kwong K, Lin YS, Gu Q. Hypersensitivity of bronchopulmonary C-fibers induced by airway mucosal inflammation: cellular mechanisms. Pulm Pharmacol Ther 15: 199-204, 2002.
56. Lee LY, Widdicombe JG. Modulation of airway sensitivity to inhaled irritants: role of inflammatory mediators. Environ Health Perspect 109, Suppl 4: 585-589, 2001.
57. Lehr HA, Hubner C, Finckh B, Angermuller S, Nolte D, Beisiegel U, Kohlschutter A, Messmer K. Role of leukotrienes in leukocyte adhesion following systemic administration of oxidatively modified human low density lipoprotein in hamsters. J Clin Invest 88: 9-14, 1991.
58. Leone A, Mori L, Bertanelli F, Fabiano P, Filippelli M. Indoor passive smoking: its effect on cardiac performance. Int J Cardiol 33: 247-251, 1991.
59. Litonjua AA, Sparrow D, Guevarra L, O'Connor GT, Weiss ST, Tollerud DJ. Serum interferon-gamma is associated with longitudinal decline in lung function among asthmatic patients: the Normative Aging Study. Ann Allergy Asthma Immunol 90: 422-428, 2003.
60. Mackay J, Eriksen M. The Tobacco Atlas. Geneva: World Health Organization, 2008.
61. Mackay J, Eriksen M. The Tobacco Atlas. Geneva: World Health Organization, p. 1-39, 2002.
62. Mahmud A, Feely J. Effects of passive smoking on blood pressure and aortic pressure waveform in healthy young adults-influence of gender. Br J Clin Pharmacol 57: 37-43, 2004.
63. Matetzky S, Tani S, Kangavari S, Dimayuga P, Yano J, Xu H, Chyu KY, Fishbein MC, Shah PK, Cercek B. Smoking increases tissue factor expression in atherosclerotic plaques: implications for plaque thrombo-genicity. Circulation 102: 602-604, 2000.
64. McCusker K, Hoidal J. Selective increase of antioxidant enzyme activity in the alveolar macrophages from cigarette smokers and smoke-exposed hamsters. Am Rev Respir Dis 141: 678-682, 1990.
65. McGhee SM, Adab P, Hedley AJ, Lam TH, Ho LM, Fielding R, Wong CM. Passive smoking at work: the short-term cost. J Epidemiol Community Health 54: 673-676, 2000.
66. McMurray RG, Hicks LL, Thompson DL. The effects of passive inhalation of cigarette smoke on exercise performance. Eur J Appl Physiol Occup Physiol 54: 196-200, 1985.
67. Metsios GS, Flouris AD, Jamurtas AZ, Carrillo AE, Kouretas D, Germenis AE, Gourgoulianis K, Kiropoulos T, Tzatzarakis MN, Tsatsakis AM, Koutedakis Y. A brief exposure to moderate passive smoke increases metabolism and thyroid hormone secretion. J Clin Endocrinol Metab 92: 208-211, 2007.
68. Miyaura S, Eguchi H, Johnston JM. Effect of a cigarette smoke extract on the metabolism of the proinflammatory autacoid, platelet-activating factor. Circ Res 70: 341-347, 1992.
69. Mohtashamipur E, Mohtashamipur A, Germann PG, Ernst H, Norpoth K, Mohr U. Comparative carcinogenicity of cigarette mainstream and sidestream smoke condensates on the mouse skin. J Cancer Res Clin Oncol 116: 604-608, 1990.
70. Napoli C, de Nigris F, Palinski W. Multiple role of reactive oxygen species in the arterial wall. J Cell Biochem 82: 674-682, 2001.
71. National Research Council. Environmental Tobacco Smoke: Measuring Exposures and Assessing Health Effects. Washington, DC: National Academy Press, 1986.
72. Noronha-Dutra AA, Epperlein MM, Woolf N. Effect of cigarette smoking on cultured human endothelial cells. Cardiovasc Res 27: 774-778, 1993.
73. Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 91: 2546-2551, 1993.
74. Otsuka R, Watanabe H, Hirata K, Tokai K, Muro T, Yoshiyama M, Takeuchi K, Yoshikawa J. Acute effects of passive smoking on the coronary circulation in healthy young adults. JAMA 286: 436-441, 2001.
75. Panagiotakos DB, Pitsavos C, Chrysohoou C, Skoumas J, Masoura C, Toutouzas P, Stefanadis C. Effect of exposure to secondhand smoke on markers of inflammation: the ATTICA study. Am J Med 116: 145-150, 2004.
76. Pauwels RA, Rabe KF. Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364: 613-620, 2004.
77. Perkins KA. Individual variability in responses to nicotine. Behav Genet 25: 119-132, 1995.
78. Perkins KA, Sexton JE. Influence of aerobic fitness, activity level, and smoking history on the acute thermic effect of nicotine. Physiol Behav 57: 1097-1102, 1995.
79. Pimm PE, Shephard RJ, Silverman F. Physiological effects of acute passive exposure to cigarette smoke. Arch Environ Health 33: 201-213, 1978.
80. Pinto-Plata VM, Mullerova H, Toso JF, Feudjo-Tepie M, Soriano JB, Vessey RS, Celli BR. C-reactive protein in patients with COPD, control smokers and non-smokers. Thorax 61: 23-28, 2006.
81. Poehlman ET. A review: exercise and its influence on resting energy metabolism in man. Med Sci Sports Exerc 21: 515-525, 1989.
82. Pope CA 3rd, Eatough DJ, Gold DR, Pang Y, Nielsen KR, Nath P, Verrier RL, Kanner RE. Acute exposure to environmental tobacco smoke and heart rate variability. Environ Health Perspect 109: 711-716, 2001.
83. Preussmann R, Stewart BW. N-nitroso carcinogens. In: Chemical Carcinogens, edited by Searle CE. Washington, DC: American Chemical Society, 1984, p. 643-828.
84. Pryor WA, Prier DG, Church DF. Electron-spin resonance study of mainstream and sidestream cigarette smoke: nature of the free radicals in gas-phase smoke and in cigarette tar. Environ Health Perspect 47: 345-355, 1983.
85. Pryor WA, Stone K, Zang LY, Bermudez E. Fractionation of aqueous cigarette tar extracts: fractions that contain the tar radical cause DNA damage. Chem Res Toxicol 11: 441-448, 1998.
86. Rasmussen AK, Diamant M, Blichert-Toft M, Bendtzen K, Feldt-Rasmussen U. The effects of interleukin-1beta (IL-1beta) on human thyrocyte functions are counteracted by the IL-1 receptor antagonist. Endocrinology 138: 2043-2048, 1997.
87. Rasmussen AK, Feldt-Rasmussen U, Bendtzen K. The effect of interleukin-1 on the thyroid gland. Autoimmunity 16: 141-148, 1993.
88. Rasmussen AK, Kayser L, Feldt-Rasmussen U, Bendtzen K. Influence of tumour necrosis factor-alpha, tumour necrosis factor-beta and interferon-gamma, separately and added together with interleukin-1 beta, on the function of cultured human thyroid cells. J Endocrinol 143: 359-365, 1994.
89. Raupach T, Schafer K, Konstantinides S, Andreas S. Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm. Eur Heart J 27: 386-392, 2006.
90. Revis NW, Bull R, Laurie D, Schiller CA. The effectiveness of chemical carcinogens to induce atherosclerosis in the white Carneau pigeon. Toxicology 32: 215-227, 1984.
91. Roberts KA, Rezai AA, Pinkerton KE, Rutledge JC. Effect of environmental tobacco smoke on LDL accumulation in the artery wall. Circulation 94: 2248-2253, 1996.
92. Rushton L. Health impact of environmental tobacco smoke in the home. Rev Environ Health 19: 291-309, 2004.
93. Samet JM. Adverse effects of smoke exposure on the upper airway. Tob Control 13, Suppl 1: i57-i60, 2004.
94. Schmid P, Karanikas G, Kritz H, Pirich C, Stamatopoulos Y, Peskar BA, Sinzinger H. Passive smoking and platelet thromboxane. Thromb Res 81: 451-460, 1996.
95. Schoendorf KC, Kiely JL. Relationship of sudden infant death syndrome to maternal smoking during and after pregnancy. Pediatrics 90: 905-908, 1992.
96. Shen Y, Rattan V, Sultana C, Kalra VK. Cigarette smoke condensateinduced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol Heart Circ Physiol 270: H1624-H1633, 1996.
97. Sheps DS, Herbst MC, Hinderliter AL, Adams KF, Ekelund LG, O'Neil JJ, Goldstein GM, Bromberg PA, Dalton JL, Ballenger MN, Davis SM, Koch GG. Production of arrhythmias by elevated carboxyhemoglobin in patients with coronary artery disease. Ann Intern Med 113: 343-351, 1990.
98. Shimkin MB, Stoner GD. Lung tumors in mice: application to carcinogenesis bioassay. Adv Cancer Res 21: 1-58, 1975.
99. Sidorkewicz N, Carrillo AE, Metsios GS, Flouris AD, Jamurtas AZ, Koutedakis Y. Resting energy expenditure response following environmental tobacco smoke exposure. Med Sci Sports Exerc 38: S457-S458, 2006.
100. Siegel M. Is the tobacco control movement misrepresenting the acute cardiovascular health effects of secondhand smoke exposure? An analysis of the scientific evidence and commentary on the implications for tobacco control and public health practice. Epidemiol Perspect Innov 4: 12, 2007.
101. Simoncini T, Maffei S, Basta G, Barsacchi G, Genazzani AR, Liao JK, De Caterina R. Estrogens and glucocorticoids inhibit endothelial vascular cell adhesion molecule-1 expression by different transcriptional mechanisms. Circ Res 87: 19-25, 2000.
102. Sin DD, Man SF. Commentary: fuelling the fire-systemic inflammation and development of lung disease in the general community. Int J Epidemiol 35: 1008-1010, 2006.
103. Sinzinger H, Kefalides A. Passive smoking severely decreases platelet sensitivity to antiaggregatory prostaglandins. Lancet 2: 392-393, 1982.
104. Siullum J. For Your Own Good: The Anti-Smoking Crusade and the Tyranny of Public Health. New York: Free Press, 1998.
105. Stefanadis C, Vlachopoulos C, Tsiamis E, Diamantopoulos L, Toutouzas K, Giatrakos N, Vaina S, Tsekoura D, Toutouzas P. Unfavorable effects of passive smoking on aortic function in men. Ann Intern Med 128: 426-434, 1998.
106. Sturgis EM, Pytynia KB. After the smoke clears: environmental and occupational risks for carcinoma of the upper aerodigestive tract. Cancer J 11: 96-103, 2005.
107. Substance Abuse and Mental Health Services Administration. Results from the 2006 National Survey on Drug Use and Health: National Findings (Office of Applied Studies, NSDUH Series H-32, DHHS Publication No. SMA 07-4293). Rockville, MD: Substance Abuse and Mental Health Services Administration, 2007, p. 1-64.
108. Sumida H, Watanabe H, Kugiyama K, Ohgushi M, Matsumura T, Yasue H. Does passive smoking impair endothelium-dependent coronary artery dilation in women? J Am Coll Cardiol 31: 811-815, 1998.
109. Tang D, Warburton D, Tannenbaum SR, Skipper P, Santella RM, Cereijido GS, Crawford FG, Perera FP. Molecular and genetic damage from environmental tobacco smoke in young children. Cancer Epidemiol Biomarkers Prev 8: 427-431, 1999.
110. Tribble DL, Giuliano LJ, Fortmann SP. Reduced plasma ascorbic acid concentrations in nonsmokers regularly exposed to environmental tobacco smoke. Am J Clin Nutr 58: 886-890, 1993.
111. U.S. Department of Health and Human Services. 9th Report on Carcinogens. Research Triangle Park, NC: U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Environmental Health Sciences, National Toxicology Program, 2000.
112. U.S. Department of Health and Human Services. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers of Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, p. 12-136, 2006.
113. Valkonen M, Kuusi T. Passive smoking induces atherogenic changes in low-density lipoprotein. Circulation 97: 2012-2016, 1998.
114. van der Vaart H, Postma DS, Timens W, Hylkema MN, Willemse BW, Boezen HM, Vonk JM, de Reus DM, Kauffman HF, ten Hacken NH. Acute effects of cigarette smoking on inflammation in healthy intermittent smokers. Respir Res 6: 22, 2005.
115. Walker JF, Kane CJ. Effects of body mass on nicotine-induced thermogenesis and catecholamine release in male smokers. Sheng Li Xue Bao 54: 405-410, 2002.
116. Wang RD, Tai H, Xie C, Wang X, Wright JL, Churg A. Cigarette smoke produces airway wall remodeling in rat tracheal explants. Am J Respir Crit Care Med 168: 1232-1236, 2003.
117. Warren CW, Jones NR, Peruga A, Chauvin J, Baptiste JP, Costa de Silva V, el Awa F, Tsouros A, Rahman K, Fishburn B, Bettcher DW, Asma S. Global youth tobacco surveillance, 2000-2007. MMWR Surveill Summ 57: 1-28, 2008.
118. Widdicombe J, Lee LY. Airway reflexes, autonomic function, and cardiovascular responses. Environ Health Perspect 109, Suppl 4: 579-584, 2001.
119. Willes SR, Fitzgerald TK, Permutt T, Proud D, Haley NJ, Bascom R. Acute respiratory response to prolonged, moderate levels of sidestream tobacco smoke. J Toxicol Environ Health A 53: 193-209, 1998.
120. Witschi H, Espiritu I, Dance ST, Miller MS. A mouse lung tumor model of tobacco smoke carcinogenesis. Toxicol Sci 68: 322-330, 2002.
121. Witschi H, Espiritu I, Maronpot RR, Pinkerton KE, Jones AD. The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis 18: 2035-2042, 1997.
122. Witschi H, Espiritu I, Peake JL, Wu K, Maronpot RR, Pinkerton KE. The carcinogenicity of environmental tobacco smoke. Carcinogenesis 18: 575-586, 1997.
123. Witschi H, Espiritu I, Pinkerton KE. Pulmonary cell kinetics and morphometry after ozone exposure: day versus night and dose response in rats. Am J Physiol Lung Cell Mol Physiol 272: L1152-L1160, 1997.
124. Witschi H, Espiritu I, Uyeminami D. Chemoprevention of tobacco smoke-induced lung tumors in A/J strain mice with dietary myo-inositol and dexamethasone. Carcinogenesis 20: 1375-1378, 1999.
125. Witschi H, Espiritu I, Uyeminami D, Suffia M, Pinkerton KE. Lung tumor response in strain a mice exposed to tobacco smoke: some dose-effect relationships. Inhal Toxicol 16: 27-32, 2004.
126. Witschi H, Espiritu I, Yu M, Willits NH. The effects of phenethyl isothiocyanate, N-acetylcysteine and green tea on tobacco smoke-induced lung tumors in strain A/J mice. Carcinogenesis 19: 1789-1794, 1998.
127. Witschi H, Uyeminami D, Moran D, Espiritu I. Chemoprevention of tobacco-smoke lung carcinogenesis in mice after cessation of smoke exposure. Carcinogenesis 21: 977-982, 2000.
128. World Health Organization. WHO Consultation Report (Online). World Health Organization Division of Noncommunicable Disease, Tobacco Free Initiative. International Consultation on Environmental Tobacco Smoke (ETS) and Child Health. http://www.who.int/tobacco/ research/en/ets-report.pdf [12 Jun. 2009].
129. Xie Y, Garban H, Ng C, Rajfer J, Gonzalez-Cadavid NF. Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat. J Urol 157: 1121-1126, 1997.
130. Yates DH, Breen H, Thomas PS. Passive smoke inhalation decreases exhaled nitric oxide in normal subjects. Am J Respir Crit Care Med 164: 1043-1046, 2001.
131. Zach MS. The physiology of forced expiration. Paediatr Respir Rev 1: 36-39, 2000.
132. Zhu B, Sun Y, Sievers RE, Shuman JL, Glantz SA, Chatterjee K, Parmley WW, Wolfe CL. L-arginine decreases infarct size in rats exposed to environmental tobacco smoke. Am Heart J 132: 91-100, 1996.
133. Zhu BQ, Sun YP, Sievers RE, Glantz SA, Parmley WW, Wolfe CL. Exposure to environmental tobacco smoke increases myocardial infarct size in rats. Circulation 89: 1282-1290, 1994.
134. Zhu BQ, Sun YP, Sievers RE, Isenberg WM, Glantz SA, Parmley WW. Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits. J Am Coll Cardiol 21: 225-232, 1993.