메뉴 건너뛰기




Volumn 90, Issue 2, 2006, Pages 500-509

Characterizing the ovotoxicity of cyclophosphamide metabolites on cultured mouse ovaries

Author keywords

Chemotherapy; Cyclophosphamide; Follicle; In vitro; Mouse; Ovarian toxicity; Phosphoramide mustard

Indexed keywords

4 HYDROPEROXYCYCLOPHOSPHAMIDE; 4 OXOCYCLOPHOSPHAMIDE; ACROLEIN; CASPASE 3; CYCLOPHOSPHAMIDE; DRUG METABOLITE; PHOSPHORAMIDE MUSTARD;

EID: 33645119762     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj086     Document Type: Article
Times cited : (112)

References (38)
  • 1
    • 0029154091 scopus 로고
    • Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
    • Anderson, D., Bishop, J. B., Garner, R. C., Ostrosky-Wegman, P., and Selby, P. B. (1995). Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks. Mutat. Res. 330, 115-181.
    • (1995) Mutat. Res. , vol.330 , pp. 115-181
    • Anderson, D.1    Bishop, J.B.2    Garner, R.C.3    Ostrosky-Wegman, P.4    Selby, P.B.5
  • 2
    • 0033058645 scopus 로고    scopus 로고
    • Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry
    • Baumann, F., Lorenz, C., Jaehde, U., and Preiss, R. (1999). Determination of cyclophosphamide and its metabolites in human plasma by high-performance liquid chromatography-mass spectrometry. J. Chromatogr B Biomed. Sci. Appl. 729, 297-305.
    • (1999) J. Chromatogr B Biomed. Sci. Appl. , vol.729 , pp. 297-305
    • Baumann, F.1    Lorenz, C.2    Jaehde, U.3    Preiss, R.4
  • 3
    • 0034287446 scopus 로고    scopus 로고
    • Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases
    • Cai, Y., Wu, M. H., Xu-Welliver, M., Pegg, A. E., Ludeman, S. M., and Dolan, M. E. (2000). Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. Cancer Res. 60, 5464-5469.
    • (2000) Cancer Res. , vol.60 , pp. 5464-5469
    • Cai, Y.1    Wu, M.H.2    Xu-Welliver, M.3    Pegg, A.E.4    Ludeman, S.M.5    Dolan, M.E.6
  • 6
    • 4444383348 scopus 로고    scopus 로고
    • Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinyl-cyclohexene diepoxide
    • Devine, P. J., Sipes, I. G., and Hoyer, P. B. (2004). Initiation of delayed ovotoxicity by in vitro and in vivo exposures of rat ovaries to 4-vinyl-cyclohexene diepoxide. Reprod. Toxicol. 19, 71-77.
    • (2004) Reprod. Toxicol. , vol.19 , pp. 71-77
    • Devine, P.J.1    Sipes, I.G.2    Hoyer, P.B.3
  • 7
    • 0020333289 scopus 로고
    • 31P NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amine
    • Engle, T. W., Zon, G., and Egan, W. (1982). 31P NMR kinetic studies of the intra- and intermolecular alkylation chemistry of phosphoramide mustard and cognate N-phosphorylated derivatives of N,N-bis(2-chloroethyl)amine. J. Med. Chem. 25, 1347-1357.
    • (1982) J. Med. Chem. , vol.25 , pp. 1347-1357
    • Engle, T.W.1    Zon, G.2    Egan, W.3
  • 8
    • 0036858810 scopus 로고    scopus 로고
    • Immunohistochemical localization of active caspase-3 in the mouse ovary: Growth and atresia of small follicles
    • Fenwick, M. A., and Hurst, P. R. (2002). Immunohistochemical localization of active caspase-3 in the mouse ovary: Growth and atresia of small follicles. Reproduction 124, 659-665.
    • (2002) Reproduction , vol.124 , pp. 659-665
    • Fenwick, M.A.1    Hurst, P.R.2
  • 9
    • 33645114549 scopus 로고    scopus 로고
    • First line physicians Canadian Fertility and Andrology Society consensus document for the investigation of infertility
    • First line physicians (2002). Canadian Fertility and Andrology Society consensus document for the investigation of infertility.
    • (2002)
  • 11
    • 0019952476 scopus 로고
    • Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein
    • Hales, B. F. (1982). Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard, and acrolein. Cancer Res. 42, 3016-3021.
    • (1982) Cancer Res. , vol.42 , pp. 3016-3021
    • Hales, B.F.1
  • 12
    • 24644484429 scopus 로고    scopus 로고
    • The stress response in gametes and embryos after paternal chemical exposures
    • Hales, B. F., Aguilar-Mahecha, A., and Robaire, B. (2005). The stress response in gametes and embryos after paternal chemical exposures. Toxicol. Appl. Pharmacol. 27, 514-520.
    • (2005) Toxicol. Appl. Pharmacol. , vol.27 , pp. 514-520
    • Hales, B.F.1    Aguilar-Mahecha, A.2    Robaire, B.3
  • 13
    • 0026356114 scopus 로고
    • Development of follicles in the mammalian ovary
    • Hirshfield, A. N. (1991). Development of follicles in the mammalian ovary. Int. Rev. Cytol. 124, 43-101.
    • (1991) Int. Rev. Cytol. , vol.124 , pp. 43-101
    • Hirshfield, A.N.1
  • 14
    • 27944462127 scopus 로고    scopus 로고
    • Endocrinology and toxicology: The female reproductive system
    • (M. J. Derelank, Ed.), Boca Raton, Hollinger MA
    • Hoyer, P. B., and Devine, P. J. (2002). Endocrinology and toxicology: The female reproductive system. In Handbook of Toxicology, (M. J. Derelank, Ed.), pp. 573-596, Boca Raton, Hollinger MA.
    • (2002) Handbook of Toxicology , pp. 573-596
    • Hoyer, P.B.1    Devine, P.J.2
  • 15
    • 0029892634 scopus 로고    scopus 로고
    • Assessment of follicle destruction in chemical-induced ovarian toxicity
    • Hoyer, P. B., and Sipes, I. G. (1996). Assessment of follicle destruction in chemical-induced ovarian toxicity. Annu. Rev. Pharmacol. Toxicol. 36, 307-331.
    • (1996) Annu. Rev. Pharmacol. Toxicol. , vol.36 , pp. 307-331
    • Hoyer, P.B.1    Sipes, I.G.2
  • 16
    • 0034761212 scopus 로고    scopus 로고
    • Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats
    • Hu, X., Christian, P., Sipes, I. G., and Hoyer, P. B. (2001a). Expression and redistribution of cellular Bad, Bax, and Bcl-X(L) protein is associated with VCD-induced ovotoxicity in rats. Biol. Reprod. 65, 1489-1495.
    • (2001) Biol. Reprod. , vol.65 , pp. 1489-1495
    • Hu, X.1    Christian, P.2    Sipes, I.G.3    Hoyer, P.B.4
  • 17
    • 0034967420 scopus 로고    scopus 로고
    • Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades
    • Hu, X., Christian, P. J., Thompson, K. E., Sipes, I. G., and Hoyer, P. B. (2001b). Apoptosis induced in rats by 4-vinylcyclohexene diepoxide is associated with activation of the caspase cascades. Biol. Reprod. 65, 87-93.
    • (2001) Biol. Reprod. , vol.65 , pp. 87-93
    • Hu, X.1    Christian, P.J.2    Thompson, K.E.3    Sipes, I.G.4    Hoyer, P.B.5
  • 18
    • 0033980183 scopus 로고    scopus 로고
    • Elimination of atretic follicles from the mouse ovary: A TEM and immunohistochemical study in mice
    • Inoue, S., Watanabe, H., Saito, H., Hiroi, M., and Tonosaki, A. (2000). Elimination of atretic follicles from the mouse ovary: A TEM and immunohistochemical study in mice. J. Anat. 196, 103-110.
    • (2000) J. Anat. , vol.196 , pp. 103-110
    • Inoue, S.1    Watanabe, H.2    Saito, H.3    Hiroi, M.4    Tonosaki, A.5
  • 19
    • 0032566949 scopus 로고    scopus 로고
    • The bottleneck: Mitochondrial imperatives in oogenesis and ovarian follicular fate
    • Jansen, R. P., and de Boer, K. (1998). The bottleneck: Mitochondrial imperatives in oogenesis and ovarian follicular fate. Mol. Cell. Endocrinol. 145, 81-88.
    • (1998) Mol. Cell. Endocrinol. , vol.145 , pp. 81-88
    • Jansen, R.P.1    de Boer, K.2
  • 20
    • 0026275590 scopus 로고
    • The short-term reproductive toxicity of cyclophosphamide in the female rat
    • Jarrell, J. F., Bodo, L., YoungLai, E. V., Barr, R. D., and O'Connell, G. J. (1991). The short-term reproductive toxicity of cyclophosphamide in the female rat. Reprod. Toxicol. 5, 481-485.
    • (1991) Reprod. Toxicol. , vol.5 , pp. 481-485
    • Jarrell, J.F.1    Bodo, L.2    YoungLai, E.V.3    Barr, R.D.4    O'Connell, G.J.5
  • 21
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist, M., and Jaattela, M. (2101). Four deaths and a funeral: From caspases to alternative mechanisms. Nat. Rev. Mol. Cell. Biol. 2, 589-598.
    • (2101) Nat. Rev. Mol. Cell. Biol. , vol.2 , pp. 589-598
    • Leist, M.1    Jaattela, M.2
  • 22
    • 0032849465 scopus 로고    scopus 로고
    • The chemistry of the metabolites of cyclophosphamide
    • Ludeman, S. M. (1999). The chemistry of the metabolites of cyclophosphamide. Curr. Pharm. Des. 5, 627-643.
    • (1999) Curr. Pharm. Des. , vol.5 , pp. 627-643
    • Ludeman, S.M.1
  • 23
    • 0026553810 scopus 로고
    • Carboxyphosphamide: NMR studies of its stability and cell membrane permeability
    • Ludeman, S. M., Ho, C. K., Boal, J. H., Sweet, E. M., and Chang, Y. H. (1992). Carboxyphosphamide: NMR studies of its stability and cell membrane permeability. Drug Metab. Dispos. 20, 337-338.
    • (1992) Drug Metab. Dispos. , vol.20 , pp. 337-338
    • Ludeman, S.M.1    Ho, C.K.2    Boal, J.H.3    Sweet, E.M.4    Chang, Y.H.5
  • 24
    • 0035017876 scopus 로고    scopus 로고
    • Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary
    • Matikainen, T., Perez, G. I., Zheng, T. S., Kluzak, T. R., Rueda, B. R., Flavell, R. A., and Tilly, J. L. (2001). Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology 142, 2468-2480.
    • (2001) Endocrinology , vol.142 , pp. 2468-2480
    • Matikainen, T.1    Perez, G.I.2    Zheng, T.S.3    Kluzak, T.R.4    Rueda, B.R.5    Flavell, R.A.6    Tilly, J.L.7
  • 25
    • 0032772302 scopus 로고    scopus 로고
    • Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: Clinical importance and proposed accurate investigative tool
    • Meirow, D., Lewis, H., Nugent, D., and Epstein, M. (1999). Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: Clinical importance and proposed accurate investigative tool. Hum. Reprod. 14, 1903-1907.
    • (1999) Hum. Reprod. , vol.14 , pp. 1903-1907
    • Meirow, D.1    Lewis, H.2    Nugent, D.3    Epstein, M.4
  • 27
    • 0032751186 scopus 로고    scopus 로고
    • Treating multiple-risk hypertensive populations
    • Oparil, S. (1999). Treating multiple-risk hypertensive populations. Am. J. Hypertens. 12, 121S-129S.
    • (1999) Am. J. Hypertens. , vol.12
    • Oparil, S.1
  • 28
    • 0028085516 scopus 로고
    • Estrogen deficiency and risk of Alzheimer's disease in women
    • Paganini-Hill, A., and Henderson, V. W. (1994). Estrogen deficiency and risk of Alzheimer's disease in women. Am. J. Epidemiol. 140, 256-261.
    • (1994) Am. J. Epidemiol. , vol.140 , pp. 256-261
    • Paganini-Hill, A.1    Henderson, V.W.2
  • 29
    • 0030694255 scopus 로고    scopus 로고
    • Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction
    • Perez, G. I., Knudson, C. M., Leykin, L., Korsmeyer, S. J., and Tilly, J. L. (1997). Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat. Med. 3, 1228-1232.
    • (1997) Nat. Med. , vol.3 , pp. 1228-1232
    • Perez, G.I.1    Knudson, C.M.2    Leykin, L.3    Korsmeyer, S.J.4    Tilly, J.L.5
  • 30
    • 0032935519 scopus 로고    scopus 로고
    • Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes
    • Perez, G. I., Tao, X. J., and Tilly, J. L. (1999). Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes. Mol. Hum. Reprod. 5, 414-420.
    • (1999) Mol. Hum. Reprod. , vol.5 , pp. 414-420
    • Perez, G.I.1    Tao, X.J.2    Tilly, J.L.3
  • 31
    • 0026100751 scopus 로고
    • Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide
    • Plowchalk D. R., and Mattison, D. R. (1991). Phosphoramide mustard is responsible for the ovarian toxicity of cyclophosphamide. Toxicol. Appl. Pharmacol. 107, 472-481.
    • (1991) Toxicol. Appl. Pharmacol. , vol.107 , pp. 472-481
    • Plowchalk, D.R.1    Mattison, D.R.2
  • 32
    • 0027022877 scopus 로고
    • Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 1. Effects on ovarian structure and function
    • Plowchalk, D. R., and Mattison, D. R. (1992). Reproductive toxicity of cyclophosphamide in the C57BL/6N mouse: 1. Effects on ovarian structure and function. Reprod. Toxicol. 6, 411-421.
    • (1992) Reprod. Toxicol. , vol.6 , pp. 411-421
    • Plowchalk, D.R.1    Mattison, D.R.2
  • 34
    • 0023262622 scopus 로고
    • Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial
    • Struck, R. F., Alberts, D. S., Horne, K., Phillips, J. G., Peng, Y. M., and Roe, D. J. (1987). Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous versus oral administration in a randomized, crossover trial. Cancer Res. 47, 2723-2726.
    • (1987) Cancer Res. , vol.47 , pp. 2723-2726
    • Struck, R.F.1    Alberts, D.S.2    Horne, K.3    Phillips, J.G.4    Peng, Y.M.5    Roe, D.J.6
  • 37
    • 0025837254 scopus 로고
    • Involvement of apoptosis in ovarian follicular atresia and postovulatory regression
    • Tilly, J. L., Kowalski, K. I., Johnson, A. L., and Hsueh, A. J. (1991). Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Endocrinology 129, 2799-2801.
    • (1991) Endocrinology , vol.129 , pp. 2799-2801
    • Tilly, J.L.1    Kowalski, K.I.2    Johnson, A.L.3    Hsueh, A.J.4
  • 38
    • 0021238317 scopus 로고
    • NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways
    • Zon, G., Ludeman, S. M., Brandt, J. A., Boyd, V. L., Ozkan, G., Egan, W., and Shao, K. L. (1984). NMR spectroscopic studies of intermediary metabolites of cyclophosphamide. A comprehensive kinetic analysis of the interconversion of cis- and trans-4-hydroxycyclophosphamide with aldophosphamide and the concomitant partitioning of aldophosphamide between irreversible fragmentation and reversible conjugation pathways. J. Med. Chem. 27, 466-485.
    • (1984) J. Med. Chem. , vol.27 , pp. 466-485
    • Zon, G.1    Ludeman, S.M.2    Brandt, J.A.3    Boyd, V.L.4    Ozkan, G.5    Egan, W.6    Shao, K.L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.